Programmable drug delivery profiles of tumor-targeted bacteria

ABSTRACT

The present invention relates to composition comprising at least one non-pathogenic bacterial cell, wherein the non-pathogenic bacterial cell comprises at least a first and a second nucleic acid sequence, the first nucleic acid sequence comprising at least one non-constitutive promoter operably linked to the second nucleic acid sequence that encodes therapeutic agent, wherein the non-constitutive promoter is an inducible promoter responsive to at least one stimuli and the at least one stimuli comprises the presence of a certain density or a certain number of bacterial cells comprising the first and second nucleic acid sequences.

CROSS REFERENCE TO RELATED APPLICATIONS

This application is a continuation of U.S. application Ser. No. 14/428,341, filed Mar. 13, 2015, which is a United States National Stage filing under 35 U.S.C. § 371 of International PCT Application Serial No. PCT/US2013/059832, filed Sep. 13, 2013, that claims priority to U.S. Provisional Application Ser. No. 61/700,663, filed Sep. 13, 2012, entitled “Programmable Drug Delivery Profiles Of Tumor-Targeted Bacteria, each of which is incorporated herein by reference in its entirety.

SUBMISSION OF SEQUENCE LISTING

The Sequence Listing associated with this application is filed in electronic format via EFS-Web and hereby incorporated by reference into the specification in its entirety. The name of the text file containing the Sequence Listing is 127299_00411_Sequence_Listing. The size of the text file is 27 KB, and the text file was created on Aug. 29, 2018.

FIELD OF THE INVENTION

This disclosure relates to compositions capable of programmed delivery of therapeutic agents to cancer cells or other cells related to a hyperproliferative disorder in a subject. This disclosure further relates to method of programming at least one bacteria comprising an inducible promoter and a nucleic acid sequence encoding a cellular toxin that modulates the delivery of a therapeutic agent or is itself a therapeutic agent. The bacteria of the invention can be genetically engineered for use in the methods or other aspects of the invention described herein.

BACKGROUND OF THE INVENTION

The engineering of bacteria to controllably deliver therapeutics is an attractive application for synthetic biology. While most synthetic gene networks have been explored within microbes, there is a need for further characterization of in vivo circuit behavior in the context of applications where the host microbes are actively being investigated for efficacy and safety, such as tumor drug delivery. One major hurdle in is that culture-based selective pressures are absent in vivo, leading to strain-dependent instability of plasmid-based networks over time. Here, we experimentally characterize the dynamics of in vivo plasmid instability using attenuated strains of S. typhimurium and real-time monitoring of luminescent reporters. Computational modeling described the effects of growth rate and dosage on live-imaging signals generated by internal bacterial populations. This understanding will allow us to harness the transient nature of plasmid-based networks to create tunable temporal release profiles that reduce dosage requirements and increase the safety of bacterial therapies.

Over the past century, the ability of bacteria to accumulate preferentially in tumors has prompted the investigation of the use of a number of strains for cancer therapy, including C. novyi, E. coli, V. cholorae, B. longum, and S. typhimurium ([3], [12], [2], [24], [15], [21]). Attenuated strains of S. typhimurium have generated particular interest as they can innately home in on tumors and colonize a variety of sizes, and have exhibited safety and tolerance in human clinical trials ([22], [5], [19], [8]]). S. typhimurium were initially shown to have anti-tumor effects through recruitment of the host immune system and competition with cancer cells for nutrients. Subsequently, engineered production of therapeutic cargo was added through simple genetic modifications. While these studies represent important advances in the use of bacteria for tumor therapies, the majority have relied on constitutive, “always on” cargo production ([9], [23], [14], [6]) that typically results in high dosages, off-target effects, and development of host resistance.

As a next step, synthetic biology seeks to add controlled and dynamic production of cargo by utilizing computationally-designed “circuits” that have sophisticated sensing and delivery capability ([7], [4], [17]s[1]). These circuits can be designed to act as delivery systems that sense tumor-specific stimuli and self-regulate cargo production as accessory. Since plasmids are the common framework for synthetic circuits, we begin by characterizing the dynamics of plasmid-based gene expression in vivo by utilizing real-time luminescence imaging, quantitative biodistribution measurement, and computational modeling. Together, these approaches provide a framework for exploiting the inherent instability of plasmid-based networks, which will facilitate the generation of specific temporal release profiles directly within the tumor environment.

SUMMARY OF THE INVENTION

The invention relates to a method of delivering a therapeutic agent to a cancer cell by administering at least one bacterial cell to a subject, the bacterial cell comprising a therapeutic agent operably linked to at least one transcriptional element or promoter, wherein the transcriptional element modulates the expression or secretion of the therapeutic agent in response to the presence of a density or quantity of bacteria comprising the at least one transcriptional element or promoter. In some embodiments, the transcriptional element or promoter is non-constitutive.

The invention relates to a composition comprising at least one non-pathogenic bacterial cell, wherein the non-pathogenic bacterial cell comprises at least a first and a second nucleic acid sequence, the first nucleic acid sequence comprising at least one non-constitutive promoter operably linked to the second nucleic acid sequence, the second nucleic acid encoding at least one therapeutic agent, wherein the non-constitutive promoter is an inducible promoter responsive to at least one stimuli and the at least one stimuli comprises the presence of a certain density or a certain number of bacterial cells comprising the first and second nucleic acid sequences.

In some embodiments, the composition comprises at least one bacterial cell, wherein the at least one non-pathogenic bacterial cell is chosen from one or a combination of bacterial cells of the genera chosen from: Salmonella, Escherichia, Firmicutes, Bacteroidetes, Lactobacillus, Bifidobacteria, or Acidopholus.

In some embodiments, the composition disclosed herein, wherein the bacterial cell comprises no more than five exogenous nucleic acid sequences that are coding sequences, wherein the first exogenous nucleic acid sequence comprises at least one non-constitutive promoter operably linked to the second exogenous nucleic acid sequence that encodes the at least one therapeutic agent.

In some embodiments, the invention relates to a composition comprising at least one bacterial cell, wherein the bacterial cell comprises a first, a second, and a third exogenous nucleic acid sequence, wherein the first exogenous nucleic acid sequence comprises at least one inducible promoter, the second exogenous nucleic acid sequence encodes at least one therapeutic agent, and the third exogenous nucleic acid sequence encodes at least one amino acid sequence that directs targeting of the at least one therapeutic to a cancer cell or a cell associated with a hyperprolierative disorder. In some embodiments the promoter is operably linked to the nucleic acid sequence encoding a therapeutic agent and/or to the nucleic acid sequence encoding an amino acid that directs targeting of the at least one therapeutic agent to a cancer cell or a cell associated with a hyperprolierative disorder.

In some embodiments, the invention relates to a composition comprising at least one bacterial cell, wherein the bacterial cell comprises a first, a second, and a third exogenous nucleic acid sequence, wherein the first exogenous nucleic acid sequence comprises an inducible promoter, the second exogenous nucleic acid sequence encodes a therapeutic agent, and the third exogenous nucleic acid sequence encodes an amino acid sequence that directs targeting of the at least one therapeutic to the a cancer cell or a cell associated with a hyperproliferative disorder, and wherein the first, second, and third nucleic acid sequences reside on a single DNA plasmid.

In some embodiments, the invention relates to a composition comprising at least one bacterial cell, wherein the at least one bacterial cell comprises either: (a) a first, a second, and a third exogenous nucleic acid sequence, wherein the first exogenous nucleic acid sequence comprises an inducible promoter, the second exogenous nucleic acid sequence encodes a therapeutic agent, and the third exogenous nucleic acid sequence encodes an amino acid sequence that directs targeting of the at least one therapeutic to the a cancer cell or a cell associated with a hyperproliferative disorder, and wherein the first, second, and third nucleic acid sequences reside on at least one DNA plasmid; or (b) a first and a second exogenous nucleic acid sequence, wherein the first exogenous nucleic acid sequence comprises an inducible promoter, and the second exogenous nucleic acid sequence encodes a therapeutic agent, and the third exogenous nucleic acid sequence encodes an amino acid sequence that directs targeting of the at least one therapeutic to the a cancer cell or a cell associated with a hyperproliferative disorder, and wherein the first and second exogenous nucleic acid sequences reside on at least one DNA plasmid.

In some embodiments, the composition comprises at least one bacterial cell comprising a nucleic acid sequence that is an inducible and non-constitutive promoter, wherein the promoter is responsive to a single stimulus, wherein the stimulus comprises the presence of a certain density or a certain number of bacterial cells comprising the first and second exogenous nucleic acid sequences. In some embodiments, the composition disclosed herein, the at least one stimuli are generated naturally by a microenvironment or tissue of a subject. In some embodiments, the microenvironment or tissue of the subject is a solid tumor in the subject.

In some embodiments, the composition disclosed herein, wherein the at least one stimuli comprise the presence of a bio film of bacteria.

In some embodiments, the composition comprises at least one bacterial cell comprising a nucleic acid sequence that encodes a therapeutic agent, wherein the therapeutic agent is a fusion protein encoded by the second nucleic acid sequence, the fusion protein comprising at least a first and second moiety, wherein the first moiety is a cellular toxin and the second moiety is a targeting sequence, the composition comprises at least one bacterial cell comprising a nucleic acid sequence that encodes a therapeutic agent, wherein the therapeutic agent is a fusion protein encoded by the second nucleic acid sequence, the fusion protein comprising at least a first and second moiety, wherein the first moiety is at least 70% homologous to SEQ ID NO:6 and the second moiety is at least 70% homologous to SEQ ID NO:5.

In some embodiments, the composition comprises at least one bacterial cell comprising a plasmid at least 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98%, or 99% homologous to SEQ ID NO:1. In some embodiments, the composition comprises at least one bacterial cell comprising a plasmid at least 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98%, or 99% homologous to SEQ ID NO:7. In some embodiments, a single plasmid encodes all of the exogenous nucleic acid sequences. In some embodiments, the at least one bacterial cells comprises or consists of SEQ ID NO:1 or SEQ ID NO:7.

In some embodiments, the composition comprises at least one bacterial cell comprising one or more exogenous nucleic acid sequences wherein at least one of the exogenous nucleic acid sequences is a coding sequence, and wherein each one or more exogenous nucleic acid sequences reside on a single plasmid.

In some embodiments, the composition comprises at least one bacterial cell comprising one or more exogenous nucleic acid sequences wherein each one or more exogenous nucleic acid sequences reside on a single plasmid consisting of or consisting essentially of SEQ ID NO:1.

In some embodiments, the invention relates to a composition comprising at least one bacteria cell disclosed herein, wherein the at least bacterial cell comprises at least two lux genes operably linked to one or more therapeutic agents. In some embodiments, the one or more therapeutic agents are one or more cellular toxins. In some embodiments, the composition comprises at least one bacterial cell, wherein the at least bacterial cell comprises at least two lux genes and one or more cellular toxins that is are least 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98%, or 99% homologous to SEQ TD NO:6. In some embodiments, the cellular toxin is an amino acid encoded by a nucleic acid sequence at least 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98%, or 99% homologous to SEQ ID NO:6 optionally fused to an amino acid encoded by a nucleic acid sequence at least 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98%, or 99% homologous to SEQ ID NO:5. In some embodiments, the therapeutic agent is linked by a linker amino acid sequence at least 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98%, or 99% homologous to SEQ ID NO:4.

In some embodiments, the invention relates to a composition comprising at least one bacterial cell disclosed herein, wherein the at least bacterial cell further comprises: (a) at least one exogenous nucleic acid sequence that encodes a marker amino acid sequence, and wherein the at least one exogenous nucleic acid sequences that encode a marker amino acid are optionally operably linked to the inducible promoter; or (b) at least one selectable marker.

In some embodiments, the invention relates to a pharmaceutical composition comprising: (a) the composition comprising any of the compositions disclosed herein, and (b) a pharmaceutically acceptable carrier or a pharmaceutically acceptable salt thereof. In some embodiments, the pharmaceutical composition disclosed herein, further comprises: (c) a chemotherapeutic compound.

In some embodiments, the invention relates to a pharmaceutical composition disclosed herein, wherein the pharmaceutical composition comprises one more radioactive isotopes, optionally incorporated into the at least bacterial cell. In some embodiments, the pharmaceutical composition comprises a therapeutically effective dose of the at least one bacterial cell. As used herein the terms “therapeutically effective dose” means the number of cells per dose administered to a subject in need thereof sufficient in number to ameliorate or reduce the burden of disease symptoms of the subject. In some embodiments, the terms “therapeutically effective dose” means the number of cells per dose administered to a subject in need thereof sufficient in number to reduce the rate of growth of a tumor or cancer cell or cell associated with a hyperproliferative disease, reduce the size of a tumor, or prevent the metastases of a tumor. In some embodiments, the pharmaceutical composition disclosed herein, wherein the therapeutically effective dose is from about 1×10⁴ to about 1×10⁷ bacterial cells. In some embodiments, the therapeutically effective dose is from about 1×10¹ to about 1×10⁷ bacterial cells. In some embodiments, the therapeutically effective dose is from about 1×10² to about 1×10⁷ bacterial cells. In some embodiments, the therapeutically effective dose is from about 1×10³ to about 1×10⁷ bacterial cells. In some embodiments, the therapeutically effective dose is from about 1×10⁴ to about 1×10⁷ bacterial cells. In some embodiments, the therapeutically effective dose is from about 1×10⁵ to about 1×10⁷ bacterial cells. In some embodiments, the therapeutically effective dose is from about 1×10⁶ to about 1×10⁷ bacterial cells.

In some embodiments, the therapeutically effective dose is from about 1×10¹ to about 1×10⁶ bacterial cells. In some embodiments, the therapeutically effective dose is from about 1×10² to about 1×10⁶ bacterial cells. In some embodiments, the therapeutically effective dose is from about 1×10³ to about 1×10⁶ bacterial cells. In some embodiments, the therapeutically effective dose is from about 1×10⁴ to about 1×10⁶ bacterial cells. In some embodiments, the therapeutically effective dose is from about 1×10⁵ to about 1×10⁶ bacterial cells.

In some embodiments, the therapeutically effective dose is from about 1×10¹ to about 1×10⁵ bacterial cells. In some embodiments, the therapeutically effective dose is from about 1×10² to about 1×10⁵ bacterial cells. In some embodiments, the therapeutically effective dose is from about 1×10³ to about 1×10⁵ bacterial cells. In some embodiments, the therapeutically effective dose is from about 1×10⁴ to about 1×10⁵ bacterial cells. In some embodiments, the therapeutically effective dose is from about 1×10¹ to about 1×10⁴ bacterial cells. In some embodiments, the therapeutically effective dose is from about 1×10² to about 1×10⁴ bacterial cells. In some embodiments, the therapeutically effective dose is from about 1×10¹ to about 1×10³ bacterial cells. In some embodiments, the therapeutically effective dose is from about 1×10³ to about 1×10⁴ bacterial cells. In some embodiments, the therapeutically effective dose is from about 1×10² to about 1×10³ bacterial cells. In some embodiments, the therapeutically effective dose is from about 1×10¹ to about 1×10² bacterial cells. In some embodiments, the therapeutically effective dose is from about 1×10° to about 1×10² bacterial cells. In some embodiments, the therapeutically effective dose is from about 1×10° to about 1×10⁸ bacterial cells. In some embodiments, the therapeutically effective dose is from about 1×10° to about 1×10⁹ bacterial cells. In some embodiments, the therapeutically effective dose of bacterial cells is more than 1×10⁹ bacterial cells. In some embodiments, the therapeutically effective dose of bacterial cells is less than 10 cells.

In some embodiments, a food product comprising the composition comprising at least one non-pathogenic bacterial cell, wherein the non-pathogenic bacterial cell comprises at least a first and a second nucleic acid sequence, the first nucleic acid sequence comprising at least one non-constitutive promoter operably linked to the second nucleic acid sequence, the second nucleic acid encoding at least one therapeutic agent, wherein the non-constitutive promoter is an inducible promoter responsive to at least one stimuli and the at least one stimuli comprises the presence of a certain density or a certain number of bacterial cells comprising the first and second nucleic acid sequences. In some embodiments, the food product further comprises a natural or non-natural food additive.

The invention also relates to a kit comprising the composition disclosed herein, or the pharmaceutical composition disclosed herein, or the food product disclosed herein. In some embodiments, the kit disclosed herein, further comprises a bacterial culture vessel. In some embodiments, the kit disclosed herein, further comprises a bacterial cell growth media.

In some embodiments, the at least one bacterial cell comprises at least a first and a second nucleic acid sequence, the first nucleic acid sequence comprising at least one non-constitutive promoter operably linked to the second nucleic acid sequence, the second nucleic acid encoding at least one therapeutic agent, wherein the non-constitutive promoter is an inducible promoter responsive to at least one stimuli and the at least one stimuli comprises the presence of a certain density or a certain number of bacterial cells comprising the first and second nucleic acid sequences. In some embodiments, the at least one bacterial cell comprises a selectable marker or marker amino acid sequence. In some embodiments, the at least one bacterial cell comprises a marker amino acid sequence that is a luciferase gene or a functional fragment thereof.

In some embodiments, the at least one bacterial cell disclosed herein, wherein the at least one bacterial cell is a non-pathogenic bacterial cell. In some embodiments, the at least one bacterial cell disclosed herein, further comprising: (a) at least a third exogenous nucleic acid sequence that encodes at least one marker amino acid sequence; and (b) at least one selectable marker.

In some embodiments, the at least one bacterial cell comprises is a strain of bacteria chosen from Salmonella, Escherichia, Firmicutes, Bacteroidetes, Lactobacillus, Bifidobacteria, or Acidopholus. In some embodiments, the at least one bacterial cell disclosed herein, wherein the at least one cell is a strain of Salmonella typhimurium. In some embodiments, the at least one bacterium is a non-pathogenic bacterium. In some embodiments, the bacterium is attenuated or rendered non-pathogenic by mutating one or more virulence factors. In some embodiments, the at least one bacterium is chosen from any species listed on Table 1. In some embodiments, the at least one bacterium is chosen from any species listed on Table 1 and the strain is mutated to attenuate one or more virulence factors. In some embodiments, the non-pathogenic bacterium is a pro-biotic bacterium.

In some embodiments, the invention relates to a method of treating or preventing cancer comprising administering to a subject in need thereof the a composition comprising at least one non-pathogenic bacterial cell, wherein the non-pathogenic bacterial cell comprises at least a first and a second nucleic acid sequence, the first nucleic acid sequence comprising at least one inducible and/or non-constitutive promoter operably linked to the second nucleic acid sequence, the second nucleic acid encoding at least one therapeutic agent, wherein the at least one inducible and/or non-constitutive promoter is responsive to at least one stimuli and the at least one stimuli comprises the presence of a certain density or a certain number of bacterial cells comprising the first and second nucleic acid sequences. In some embodiments, the method further comprises a step of administering one or more stimuli external to the subject in order to induce expression of the at least one therapeutic agent in the subject. In some embodiments, the method does not comprise administering any stimuli external to the body of the subject in order to induce expression of the at least one therapeutic agent in the subject. In some embodiments, the method further comprises a step of measuring the presence, absence or quantity of therapeutic agent in the subject one or more times subsequent to administration of the composition disclosed herein, or the pharmaceutical composition disclosed herein, or the food product disclosed herein. In some embodiments, the compositions, pharmaceutical compositions or food products are delivered to a subject in need thereof per os, per anus, per muscosal lavage, via intravenous injection, subcutaneous injection, via any form of injection.

In some embodiments, the invention relates to a method of reducing the growth of a cancer cell, solid tumor, or cell associated with a hyperproliferative disorder comprising administering to a subject in need thereof the composition disclosed herein, or the pharmaceutical composition disclosed herein, or the food product disclosed in paragraph herein. In some embodiments, the method further comprises a step of administering one or more stimuli external to the subject in order to induce expression of the at least one therapeutic agent in the subject.

In some embodiments, the invention relates to a method disclosed herein, wherein the method does not comprise administering any stimuli external to the body of the subject in order to induce expression of the at least one therapeutic agent in the subject. In some embodiments, the invention relates to a method disclosed herein, wherein the method further comprises a step of measuring the presence, absence or quantity of therapeutic agent in the subject one or more times subsequent to administration of the composition disclosed herein, or the pharmaceutical composition disclosed herein, or the food product disclosed herein.

In some embodiments, the invention relates to a method of delivering one or more therapeutic agents to a tumor in a subject comprising administering the composition comprising at least one non-pathogenic bacterial cell, wherein the non-pathogenic bacterial cell comprises at least a first and a second nucleic acid sequence, the first nucleic acid sequence comprising at least one non-constitutive promoter operably linked to the second nucleic acid sequence, the second nucleic acid encoding at least one therapeutic agent, wherein the non-constitutive promoter is an inducible promoter responsive to at least one stimuli and the at least one stimuli comprises the presence of a certain density or a certain number of bacterial cells comprising the first and second nucleic acid sequences; or the pharmaceutical composition disclosed herein, or the food product disclosed herein to the subject in need thereof. In some embodiments, the only stimulus for inducing expression of the therapeutic agent is the density or quantity of bacteria in a given microenvironment where the at least one bacterial cell colonizes. In some embodiments, the microenvironment is chosen from at or around a cancer cell, a cell associated with a hyperproliferative disorder, a solid tumor, or a metastatic tumor, or a grafted tumor.

In some embodiments, the invention relates to a method disclosed herein, wherein the method further comprises a step of administering one or more stimuli external to the subject in order to induce expression of the at least one therapeutic agent in the subject. In some embodiments, the invention relates to a method disclosed herein, wherein the method does not comprise administering any stimuli external to the body of the subject in order to induce expression of the at least one therapeutic agent in the subject. In some embodiments, the invention relates to a method disclosed herein, wherein the method docs not comprise administering any light to the body of the subject in order to induce expression of the at least one therapeutic agent in the subject. In some embodiments, the invention relates to a method disclosed herein, wherein the method does not comprise administering any chemical agent to the body of the subject in order to induce expression of the at least one therapeutic agent in the subject prior to, simultaneously with, or subsequent to administration of the at least one bacterial cell.

In some embodiments, the invention relates to any of the methods disclosed herein, wherein the method comprises a step of measuring the presence, absence or quantity of therapeutic agent in the subject in need thereof one or more times subsequent to administration of the composition disclosed in herein, or the pharmaceutical composition disclosed herein, or the food product disclosed herein.

The invention also relates to a method of reducing tolerance to a therapeutic agent in a subject in need thereof comprising administering the composition disclosed in herein, or the pharmaceutical composition disclosed herein, or the food product disclosed herein to the subject in need thereof. In some embodiments, the method of reducing tolerance to a therapeutic agent further comprises a step of administering one or more stimuli external to the subject in order to induce expression of the at least one therapeutic agent in the subject.

In some embodiments, the method of reducing tolerance to a therapeutic agent does not comprise administering any stimuli external to the body of the subject in order to induce expression of the at least one therapeutic agent in the subject.

In some embodiments, the invention also relates to a method of manufacturing the composition disclosed herein, or the pharmaceutical composition disclosed herein, or the food product disclosed herein comprising transforming at least one of nucleic acid comprising at least one inducible and/or non-constitutive promoter into at least one or a combination of bacterial cells. In some embodiments, the method of manufacturing the compositions and food products herein further comprises culturing any of the at least one or a combination of bacterial cells in a tissue culture vessel.

The invention also relates to a pharmaceutical composition comprising the at least one bacterial cell disclosed herein for treatment or prevention of cancer, growth of cells associated with a hyperproliferative disorder, or metastases.

The invention also relates to a pharmaceutical composition comprising the at least one bacterial cell disclosed herein manufactured in a medicament for cancer, growth of cells associated with a hyperproliferative disorder, or metastases.

Embodiments include methods of using tumor-targeted bacteria to identify a therapeutically effective dose of therapeutic agent in a solid tumor, the method comprising administering any of the compositions, pharmaceutical compositions, or food products disclosed herein to a subject in need thereof, in some embodiments, the subject is suspected of having or has been diagnosed with cancer or metastatic cancer.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1A depicts Plasmid map of the pTD106CDD-iRGD vector. The vector consists of a quorum sensing promoter driving both a luciferase expression cassette (luxCDABE) and a therapeutic (CDD-iRGD). The additional iRGD attached to the CDD gives a stronger internalization of the therapeutic into cells.

FIG. 1B depicts plasmid pB33eCPX-NC-IRGD.

FIGS. 2A, 2B, 2C and 2D depict a schematic of an embodiment. (FIG. 2A) Schematic showing programmed bacteria being introduced systemically via tail-vein injection in a mouse model. (FIG. 2B) Variable dosage of bacteria yield different peak onset times of therapeutic agent expression. (FIG. 2C, FIG. 2D) The bacterial cells at different dosages produce dynamioc and temporal expression profiles in vivo.

FIGS. 3A, 3B, 3C and 3D depict the population dynamics of bacteria inside tumor environments. (FIG. 3A) Schematic showing tumor extraction, homogenization and plating to count internal populations of bacteria. Plating on antibiotics reveals the number of plasmid-containing bacteria while plating without antibiotics gives the total number of bacteria. (FIG. 3B) Measured number of positive and negative containing bacteria per organ calculated for plasmid containing bacteria (light grey) and non-plasmid containing bacteria (dark grey). Bacteria with the plasmid reach a steady state around 24 hours while the non-plasmid bacteria continue to grow. (FIG. 3C) Percentage of cells containing the plasmid as a function of time showing a constant loss rate over the course of 72 hours. (FIG. 3D) Ratio for total number of bacteria in the tumor vs. the spleen. This number is typically reported as a measure of specificity of the tumor-targeting strain.

FIGS. 4A, 4B and 4C depict Characterization of Strain A and Strain B in vivo expression profiles. (FIG. 4A and FIG. 4B) Time-course trajectories for Strain A (FIG. 4A) and Strain B (FIG. 4B) over the course of 60 hours normalized to their maximum value across the trajectory. Light grey lines indicate individual trajectories and the solid black line indicates the average trajectories. (FIG. 4C, Left Panel) Full-width at half-maximum and the area (FIG. 4C, Right Panel) under the curve for the average trajectory of both strains. These parameters characterize the dosage and duration of transient gene-expression.

FIGS. 5A, 5B, 5C, 5D, 5E, 5F, 5G, 5H, 5I, 5J and 5K depict computational modeling of bacterial dynamics inside of tumor environments. (FIG. 5A) Schematic of mathematical model. Bacteria containing plasmids are injected at a dosage N₀. Plasmids are lost from cells at a rate x and growth of resulting plasmid containing and non-containing cells continues at μ+ and μ−, respectively. (FIG. 5B) Modeling results (solid lines) for the number of plasmid containing (dark grey) and non-plasmid containing (light grey) bacterial population data from FIG. 3B. Open circles indicate experimental points. (FIG. 5C) Typical rime course of an IVIS trajectory indicating parameters co and area for characterizing transient gene expression. The relative IVIS trajectory is typically measured experimentally due to mouse-to-mouse variability while the absolute IVIS trajectories are used to calculate co and area. (FIG. 5D, FIG. 5E, FIG. 5F, FIG. 5G) The effect of growth rate on transient gene expression. Decreasing growth rate shifts the absolute IVIS signals to a lower value and longer peak times and therefore increasing co and decreasing the area under the curve. (FIG. 5H, FIG. 5I, FIG. 5J, FIG. 5K) The effect of initial dosage on transient gene expression. Increasing the dosage shifts the absolute IVIS signals to a higher level, increasing the area under the curve, but does not change the relative IVIS trajectory shape or co value.

FIG. 6 depicts quorum sensing bacteria injected intravenously into nude mice bearing OVCAR-8 xenograft hind flank tumors.

FIG. 7 depicts IVIS imaging of mice bearing subcutaneous ovarian cancer cell lines that have been injected with 1×10⁶ bacteria.

FIG. 8 depicts signal intensity from therapeutic effect of quorum sensing circuit.

FIG. 9A, left panel, depicts a plot of a substrate concentration as a function of time. FIG. 9A, right panel, depicts a plot of saturating functions of the model. The dark grey line depicts the consumption of tumor substrate as a function of time. The light grey depicts the growth rate of plasmid-containing cells as a function of time.

FIG. 9B depicts correlations between in vivo and ex vivo imaging of tumors. High correlations are observed for each step of the process.

FIG. 9C depicts the effect of increasing tau (τ) on gene expression dynamics.

DETAILED DESCRIPTION OF THE INVENTION

Some embodiments relate to bacteria which comprise heterologous nucleic acid sequences. The bacteria colonize tumors. In some embodiments, the non-pathogenic bacteria are non-pathogenic bacteria that colonize tumor cells or cancer cells, or cell associated with a hyperproliferative disorder, and, at a certain concentration or cell density, the bacteria secrete, release, or enhance the activation of a therapeutic agent. In some embodiments, the bacteria that comprise heterologous nucleic acid sequences comprise at least one inducible promoter or non-constitutive promoter. Some embodiments provide compositions comprising at least one bacterial cell disclosed herein.

In some embodiments, the compositions are pharmaceutical compositions that comprise at least one bacterial cell disclosed herein and at least one pharmaceutically acceptable carrier. Some embodiments provide pharmaceutical compositions of the claimed invention that are useful to treat and/or prevent cancer. Some embodiments are useful to treat or prevent metastases. Some embodiments are useful to treat or prevent tumor growth.

Some embodiments provide compositions comprising at least one bacterial cell that comprises one or more exogenous plasmids, wherein at least one plasmid comprises a heterologous nucleic acid sequence that encodes a therapeutic agent operably linked to an non-constitutive and/or inducible promoter; such non-constitutive and/or inducible promoter modulates the expression of the nucleic acid encoding the therapeutic agent in the presence of at least one stimulus. In some embodiments, the inducible and non-constitutive promoter only induces the expression of the nucleic acid encoding the therapeutic agent in the presence of a certain density or number of bacterial cells comprising the inducible promoter and/or the nucleic acid that encodes the therapeutic agent. When such a bacterial cell reproduces in vivo, such as when the bacterial cell colonizes a tumor in an animal, the clonally derived progeny of the at least one bacterial cells may reach a certain density or number that such density or number triggers the expression of the therapeutic agent. The ability of a bacterial cell to modulate expression of a gene in the presence of a certain number or density of cells is quorum sensing. In some embodiments, the non-constitutive or inducible promoter has only a single stimulus that is a certain number or density of cells. In some embodiments, the non-constitutive and/or inducible promoter responds to at least one, two, three, four, five or more stimuli but none of the stimuli require administration or exposure of the stimulus or stimuli external to the subject. In some embodiments, the stimulus or stimuli necessary to induce expression of the nucleic acid encoding the therapeutic agent require exposure to or administration of a cofactor before, simultaneously to, or after administration of the at least one bacterial cell.

In some embodiments, the at least one bacterial cell optionally comprises a nucleic acid sequence that encodes a polarization protein or functional fragment thereof and/or a nucleic acid sequence that encodes a combination of a toxin and an antidote. When such microorganism reproduces in vivo, such as when they are colonizing a tumor in an animal, a greater proportion of the resulting progeny remain plasmid-bearing compared to the proportion of resulting progeny from bacteria which do not comprise a nucleic acid sequence that encodes a polarization protein, or functional fragment thereof and/or a nucleic acid sequence that encode a combination of a toxin and an antidote. The polarization protein, or optionally, the combination of the polarization protein and a toxin and an antidote, reduces plasmid loss that occurs during cell division and facilitates the inclusion of both the plasmids in the at least one bacterial cell and its progeny upon cellular division. This feature of improves therapeutics that use bacteria that target and colonize tumors and release therapeutics or products involved in tumor detection. In some embodiments, the bacteria further comprise a nucleic acid sequence that encodes a protein used in therapeutic methods that cause slowed or inhibit tumor growth or reduce or eliminate tumors.

Specific preferred embodiments of the present invention have been described here in sufficient detail to enable those skilled in the art to practice the full scope of invention. However it is to be understood that many possible variations of the present invention, which have not been specifically described, still fall within the scope of the present invention and the appended claims. Hence these descriptions given herein are added only by way of example and are not intended to limit, in any way, the scope of this invention. More generally, those skilled in the art will readily appreciate that all parameters, dimensions, materials, and configurations described herein are meant to be exemplary and that the actual parameters, dimensions, materials, and/or configurations will depend upon the specific application or applications for which the teachings of the present invention is/are used. Those skilled in the art will recognize, or be able to ascertain using no more than routine experimentation, many equivalents to the specific embodiments of the invention described herein. It is, therefore, to be understood that the foregoing embodiments are presented by way of example only and that, within the scope of the appended claims and equivalents thereto, the invention may be practiced otherwise than as specifically described and claimed. The present invention is directed to each individual feature, system, article, material, kit, and/or method ‘described herein. In addition, any combination of two or more such features, systems, articles, materials, kits, and/or methods, if such features, systems, articles, materials, kits, and/or methods are not mutually inconsistent, is included within the scope of the present invention.

Various terms relating to the methods and other aspects of the present invention are used throughout the specification and claims. Such terms are to be given their ordinary meaning in the art unless otherwise indicated. Other specifically defined terms are to be construed in a manner consistent with the definition provided herein.

The term “about” as used herein when referring to a measurable value such as an amount, a temporal duration, and the like, is meant to encompass variations of ±20%, ±10%, ±5%, ±1%, or ±0.1% from the specified value, as such variations are appropriate to perform the disclosed methods.

The indefinite articles “a” and “an,” as used herein in the specification and in the claims, unless clearly indicated to the contrary, should be understood to mean “at least one.” The phrase “and/or,” as used herein in the specification and in the claims, should be understood to mean “either or both” of the elements so conjoined, i.e., elements that are conjunctively present in some cases and disjunctively present in other cases. Other elements may optionally be present other than the elements specifically identified by the “and/or” clause, whether related or unrelated to those elements specifically identified unless clearly indicated to the contrary. Thus, as a non-limiting example, a reference to “A and/or B,” when used in conjunction with open-ended language such as “comprising” can refer, in one embodiment, to A without B (optionally including elements other than B); in another embodiment, to B without A (optionally including elements other than A); in yet another embodiment, to both A and B (optionally including other elements); etc.

As used herein in the specification and in the claims, “or” should be understood to have the same meaning as “and/or” as defined above. For example, when separating items in a list, “or” or “and/or” shall be interpreted as being inclusive, i.e., the inclusion of at least one, but also including more than one, of a number or list of elements, and, optionally, additional unlisted items. Only terms clearly indicated to the contrary, such as “only one of or “exactly one of,” or, when used in the claims, “consisting of,” will refer to the inclusion of exactly one element of a number or list of elements. In general, the term “or” as used herein shall only be interpreted as indicating exclusive alternatives (i.e. “one or the other but not both”) when preceded by terms of exclusivity, such as “either,” “one of,” “only one of,” or “exactly one of “Consisting essentially of,” when used in the claims, shall have its ordinary meaning as used in the field of patent law.

In the claims, as well as in the specification above, all transitional phrases such as “comprising,” “including,” “carrying,” “having,” “containing,” “involving,” “holding,” and the like are to be understood to be open-ended, i.e., to mean including but not limited to. Only the transitional phrases “consisting of and “consisting essentially of shall be closed or semi-closed transitional phrases, respectively.

The terms “amino acid” refer to a molecule containing both an amino group and a carboxyl group bound to a carbon which is designated the a-carbon. Suitable amino acids include, without limitation, both the D- and L-isomers of the naturally-occurring amino acids, as well as non-naturally occurring amino acids prepared by organic synthesis or other metabolic routes. In some embodiments, a single “amino acid” might have multiple sidechain moieties, as available per an extended aliphatic or aromatic backbone scaffold. Unless the context specifically indicates otherwise, the term amino acid, as used herein, is intended to include amino acid analogs including non-natural analogs.

The terms “exogenous gene” means a nucleic acid that has been recombinantly introduced into a cell, which encodes the synthesis of RNA and/or protein. In some embodiments, the exogenous gene is introduced by transformation. In some embodiments, the exogenous gene is introduced into the cell by electroporation. A transformed cell may be referred to as a recombinant cell, into which additional exogenous gene(s) may be introduced. The exogenous gene put into the host species may be taken from a different species (this is called heterologous), or it may naturally occur within the same species (this is homologous as defined below). Therefore, exogenous genes subsume homologous genes that are integrated within or introduced to regions of the genome, episome, or plasmid that differ from the locations where the gene naturally occurs. Multiple copies of the exogenous gene may be introduced into the cell. An exogenous gene may be present in more than one copy within the host cell or transformed cell. In some embodiments, the microorganism comprises between and including 1 and 10,000 copies of the nucleic acid that encodes an exogenous protein. In some embodiments, the microorganism comprises between and including 1 and 1,000 copies of the nucleic acid that encodes an exogenous protein. In some embodiments, the microorganism comprises between and including 1 and 10,000 copies of the nucleic acid that encodes an exogenous protein. In some embodiments, the microorganism comprises between and including 1 and 1,000 copies of the nucleic acid that encodes an exogenous protein. In some embodiments, the microorganism comprises between and including 1 and 500 copies of the nucleic acid that encodes an exogenous protein. In some embodiments, the exogenous gene is maintained by a cell as an insertion into the genome or as an episomal molecule. In some embodiments, the microorganism comprises no more than 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 20, 30, 40, 50, 60, 70, 80, 90, 100, or 1000 copies of the one or more nucleic acids that encode one or more exogenous proteins.

The terms “functional fragment” means any portion of a polypeptide or nucleic acid sequence from which the respective full-length polypeptide or nucleic acid relates that is of a sufficient length and has a sufficient structure to confer a biological affect that is similar or substantially similar to the full-length polypeptide or nucleic acid upon which the fragment is based. In some embodiments, a functional fragment is a portion of a full-length or wild-type nucleic acid sequence that encodes any one of the nucleic acid sequences disclosed herein, and said portion encodes a polypeptide of a certain length and/or structure that is less than full-length but encodes a domain that still biologically functional as compared to the full-length or wild-type protein. In some embodiments, the functional fragment may have a reduced biological activity, about equivalent biological activity, or an enhanced biological activity as compared to the wild-type or full-length polypeptide sequence upon which the fragment is based. In some embodiments, the functional fragment is derived from the sequence of an organism, such as a human. In such embodiments, the functional fragment may retain 99%, 98%, 97%, 96%, 95%, 94%, 93%, 92%, 91%, or 90% sequence identity to the wild-type human sequence upon which the sequence is derived. In some embodiments, the functional fragment may retain 85%, 80%, 75%, 70%, 65%, or 60% sequence homology to the wild-type sequence upon which the sequence is derived. The present invention also comprises functional fragments of nucleotide sequences that encode a polypeptide capable of enzymatic activity, substrate activity, polarization activity, toxin activity, or antidote to toxin activity as disclosed herein in an animal. In some embodiments, the functional fragment are DNA or amino acid fragments selected from at least one of the various encoding nucleotide sequences of the present invention, including SEQ ID NO: 1, 7, 5, 6, 4, 2, or 3 and can be any of the following described DNA fragments, as it applies to the specific encoding nucleic acid sequence provided herein. In some embodiments, DNA fragments can comprise 30 or more, 45 or more, 60 or more, 75 or more, 90 or more, 120 or more, 150 or more, 180 or more, 210 or more, 240 or more, 270 or more, 300 or more, 360 or more, 420 or more, 480 or more, 540 or more, 600 or more, 660 or more, 720 or more, 780 or more, 840 or more, 900 or more, 960 or more, 1020 or more, 1080 or more, 1140 or more, 1200 or more, 1260 or more, 1320 or more, 1380 or more, 1440 or more, 1500 or more, 1560 or more, 1620 or more, 1680 or more, or 1740 or more, 1800 or more, 2000 or more, 2100 or more, 2200 or more, 2300 or more, 2400 or more, 2500 or more, 2600 or more, 2700 or more, 2800 or more, 2900 or more, 3000 or more, 4000 or more, 4500 or more, 5000 or more, 5500 or more, 6000 or more, 6500 or more, 7000 or more, 7500 or more, 8000 or more, 8500 or more, 9000 or more, 9500 or more, 10000 or more, 10100 or more nucleotides. In some embodiments, DNA fragments can comprise coding sequences for accessory proteins such as known ligands to tumor associated antigens expressed on the surface of tumor cells. In some embodiments, DNA fragments can comprise fewer than 60, fewer than 75, fewer than 90, fewer than 120, fewer than 150, fewer than 180, fewer than 210, fewer than 240, fewer than 270, fewer than 300, fewer than 360, fewer than 420, fewer than 480, fewer than 540, fewer than 600, fewer than 660, fewer than 720, fewer than 780, fewer than 840, fewer than 900, fewer than 960, fewer than 1020, fewer than 1080, fewer than 1140, fewer than 1200, fewer than 1260, fewer than 1320, fewer than 1380, fewer than 1440, fewer than 1500, fewer than 1560, fewer than 1620, fewer than 1680, or fewer than 1740, fewer than 1800, fewer than 1900, fewer than 2000, fewer than 2100, fewer than 2200, fewer than 2300, fewer than 2400, fewer than 2500, fewer than 2600, fewer than 2700, fewer than 2800, fewer than 2900, fewer than 3000, fewer than 4000, fewer than 5000, fewer than 6000, fewer than 7000, fewer than 8000, fewer than 9000, or fewer than 10000 nucleotides. In some embodiments, the functional fragments are nucleic acid fragments of SEQ ID NO:1 and include one or more nucleic acid derivatives. In some embodiments, the functional fragments are nucleic acid fragments of SEQ ID NO: 1, 2, 3, 7 and include more than about 5, 10, 15, 20, 25, or 30 nucleic acid derivatives.

The terms “hyperproliferative disorder” refer to a disorder characterized by abnormal proliferation, abnormal growth, abnormal senescence, abnormal quiescence, or abnormal removal of cells any or in an organism, and includes include hyperplasias, neoplasias, cancer, fibroproliferative disorders (such as involving connective tissues, as well as other disorders characterized by fibrosis, including for example, rheumatoid arthritis, insulin dependent diabetes mellitus, glomerulonephritis, cirrhosis, and scleroderma), smooth muscle proliferative disorders (such as atherosclerosis and restinosis), chronic inflammation, and epithelial cell proliferative disorders (for example, psoriasis; keratosis; acne; comedogenic lesions; verracous lesions such as verruca plana, plantar warts, verruca acuminata, and other verruciform lesions marked by proliferation of epithelial cells; folliculitis and pseudofolliculitis; keratoacanthoma; callosities; Darier's disease; ichthyosis; lichen planus; molluscous contagiosum; melasma; Fordyce disease; and keloids or hypertrophic scars). In some embodiments, the hyperproliferative disease is a cancer derived from the gastrointestinal tract or urinary system. In some embodiments, a hyperproliferative disease is a cancer of the adrenal gland, bladder, bone, bone marrow, brain, spine, breast, cervix, gall bladder, ganglia, gastrointestinal tract, stomach, colon, heart, kidney, liver, lung, muscle, ovary, pancreas, parathyroid, penis, prostate, salivary glands, skin, spleen, testis, thymus, thyroid, or uterus. In some embodiments, the term hyperproliferative disease is a cancer chosen from: lung cancer, bone cancer, CMML, pancreatic cancer, skin cancer, cancer of the head and neck, cutaneous or intraocular melanoma, uterine cancer, ovarian cancer, rectal cancer, cancer of the anal region, stomach cancer, colon cancer, breast cancer, testicular, gynecologic tumors (e.g., uterine sarcomas, carcinoma of the fallopian tubes, carcinoma of the endometrium, carcinoma of the cervix, carcinoma of the vagina or carcinoma of the vulva), Hodgkin's disease, cancer of the esophagus, cancer of the small intestine, cancer of the endocrine system (e.g., cancer of the thyroid, parathyroid or adrenal glands), sarcomas of soft tissues, cancer of the urethra, cancer of the penis, prostate cancer, chronic or acute leukemia, solid tumors of childhood, lymphocytic lymphomas, cancer of the bladder, cancer of the kidney or ureter (e.g., renal cell carcinoma, carcinoma of the renal pelvis), or neoplasms of the central nervous system (e.g., primary CNS lymphoma, spinal axis tumors, brain stem gliomas or pituitary adenomas).

As used herein, the term “genetic construct” refers to the DNA or RNA molecules that comprise a nucleotide sequence that encodes one or more of the polypeptides. In some embodiments, the genetic construct encodes one or more of the polypeptides described herein. In some embodiments, the nucleotide sequence that encodes a one or more of the polypeptides described herein, or coding sequence, includes initiation and termination signals operably linked to regulatory elements including a bacterial promoter and polyadenylation signal capable of directing expression in the cells of the bacteria in which the nucleic acid molecule is transformed.

The terms “effective amount” refers to an amount of a compound, material, or composition, as described herein effective to achieve a particular biological result such as, but not limited to, biological results disclosed, described, or exemplified herein. Such results may include, but are not limited to colonization of a tumor by administration of a composition disclosed herein, or production of an amount of a therapeutic agent, portion thereof, or a reaction product after exposure of the substrate with an enzyme such that the presence, absence or quantity of substrate, portion thereof, or a reaction product determined by any means suitable in the art. In some embodiments, the biological result is an amount of a substrate, portion thereof, or a reaction product after exposure of the substrate with an enzyme such that the presence, absence or quantity of substrate, portion thereof, or a reaction product determined by visual inspection of urine excreted by a subject administered any one or more compositions disclosed herein. The effective amount of the composition may be dependent on any number of variables, including without limitation, the species, breed, size, height, weight, age, overall health of the subject, the type of formulation, the mode or manner of administration, the type and/or severity of the particular condition being treated.

The terms “electroporation,” “electro-permeabilization,” or “electro-kinetic enhancement” (“EP”) as used interchangeably herein refer to the use of a transmembrane electric field pulse to induce microscopic pathways (pores) in a bio-membrane; their presence allows biomolecules such as plasmids, oligonucleotides, siRNA, drugs, ions, and water to pass from one side of the cellular membrane to the other.

As used herein, the term “expressible form” refers to gene constructs that contain the necessary regulatory elements operably linked to a coding sequence that encodes one or more proteins described herein, such that, when present in a transformed or transfected cell, the coding sequence will be expressed.

In some embodiments, the compositions, kits, methods comprise at least one non-pathogenic bacteria. As used herein, the term “non-pathogenic” refers to a bacteria that is not capable of causing a disease or disorder in an animal when administered to an animal, including a human. In some embodiments, the microorganism is incapable of causing a disease or disorder when administered to a mammal. In some embodiments, the microorganism is a non-pathogenic microorganism incapable of causing a disease or disorder when administered to a human or domesticated animal (such as a dog, cat, horse, sheep, cow, goat, pig, etc.). In some embodiments, the microorganism is non-pathogenic microorganism incapable of causing a disease or disorder when administered to a human. In some embodiments, the microorganism is non-pathogenic microorganism is chosen from any one of the bacterial species identified in Table 1. In some embodiments, the non-pathogenic microorganism is not at least one of species listed on Table 1. In some embodiments, the non-pathogenic microorganism is an attenuated bacterial strain. In some embodiments, the non-pathogenic microorganism is an attenuated bacterial strain listed on Table 1. In some embodiments, the non-pathogenic microorganism is an attenuated bacterial strain genetically modified to silence, remove, or mutate a virulence factor.

The term “nucleic acid” refers to a molecule comprising two or more linked nucleotides. “Nucleic acid” and “nucleic acid molecule” are used interchangeably and refer to oligoribonucleotides as well as oligodeoxyribonucleotides. The terms also include polynucleosides (i.e., a polynucleotide minus a phosphate) and any other organic base containing nucleic acid. The organic bases include adenine, uracil, guanine, thymine, cytosine and inosine. The nucleic acids may be single or double stranded. The nucleic acid may be naturally or non-naturally occurring. Nucleic acids can be obtained from natural sources, or can be synthesized using a nucleic acid synthesizer (i.e., synthetic). Isolation of nucleic acids are routinely performed in the art and suitable methods can be found in standard molecular biology textbooks. (See, for example, Maniatis' Handbook of Molecular Biology.) The nucleic acid may be DNA or RNA, such as genomic DNA, mitochondrial DNA, mRNA, cDNA, rRNA, miRNA, PNA or LNA, or a combination thereof, as described herein. Non-naturally occurring nucleic acids such as bacterial artificial chromosomes (BACs) can also be used in accordance with some aspects of this invention.

Some aspects of this invention relate to the use of nucleic acid derivatives. The use of certain nucleic acid derivatives may increase the stability of the nucleic acids of the invention by preventing their digestion, particularly when they are exposed to biological samples that may contain nucleases. As used herein, a nucleic acid derivative is a non-naturally occurring nucleic acid or a unit thereof. Nucleic acid derivatives may contain non-naturally occurring elements such as non-naturally occurring nucleotides and non-naturally occurring backbone linkages. Nucleic acid derivatives according to some aspects of this invention may contain backbone modifications such as but not limited to phosphorothioate linkages, phosphodiester modified nucleic acids, combinations of phosphodiester and phosphorothioate nucleic acid, methylphosphonate, alkylphosphonates, phosphate esters, alkylphosphonothioates, phosphoramidates, carbamates, carbonates, phosphate triesters, acetamidates, carboxymethyl esters, methylphosphorothioate, phosphorodithioate, p-ethoxy, and combinations thereof. The backbone composition of the nucleic acids may be homogeneous or heterogeneous. Nucleic acid derivatives according to some aspects of this invention may contain substitutions or modifications in the sugars and/or bases. For example, some nucleic acid derivatives may include nucleic acids having backbone sugars which are covalently attached to low molecular weight organic groups other than a hydroxyl group at the 3′ position and other than a phosphate group at the 5′ position (e.g., an 2′-O-alkylated ribose group). Nucleic acid derivatives may include non-ribose sugars such as arabinose. Nucleic acid derivatives may contain substituted purines and pyrimidines such as C-5 propyne modified bases, 5-methylcytosine, 2-aminopurine, 2-amino-6-chloropurine, 2,6-diaminopurine, hypoxanthine, 2-thiouracil and pseudoisocytosine. In some embodiments, a nucleic acid may comprise a peptide nucleic acid (PNA), a locked nucleic acid (LNA), DNA, RNA, or a co-nucleic acids of the above such as DNA-LNA co-nucleic acid.

As used herein the term “isolated nucleic acid molecule” refers to a nucleic acid that is not in its natural environment, for example a nucleic acid that has been (i) extracted and/or purified from a cell or microbe, for example, a bacteria or yeast, by methods known in the art, for example, by alkaline lysis of the host cell and subsequent purification of the nucleic acid, for example, by a silica adsorption procedure; (ii) amplified in vitro, for example, by polymerase chain reaction (PCR); (iii) recombinantly produced by cloning, for example, a nucleic acid cloned into an expression vector; (iv) fragmented and size separated, for example, by enzymatic digest in vitro or by shearing and subsequent gel separation; or (v) synthesized by, for example, chemical synthesis. In some embodiments, the term “isolated nucleic acid molecule” refers to (vi) an nucleic acid that is chemically markedly different from any naturally occurring nucleic acid. In some embodiments, an isolated nucleic acid can readily be manipulated by recombinant DNA techniques well known in the art.

Accordingly, a nucleic acid cloned into a vector, or a nucleic acid delivered to a host cell and integrated into the host genome is considered isolated but a nucleic acid in its native state in its natural host, for example, in the genome of the host, is not. An isolated nucleic acid may be substantially purified, but need not be. For example, a nucleic acid that is isolated within a cloning or expression vector is not pure in that it may comprise only a small percentage of the material in the cell in which it resides. Such a nucleic acid is isolated, however, as the term is used herein.

“Sequence homology” or “sequence identity” or “homolgous to” are used herein interchangeably for nucleotides and amino acids sequences determined using FASTA, BLAST and Gapped BLAST (Altschul et al., Nuc. Acids Res., 1997, 25, 3389, which is incorporated herein by reference in its entirety) and PAUP* 4,ObIO software (D. L. Swofford, Sinauer Associates, Massachusetts). Briefly, the BLAST algorithm, which stands for Basic Local Alignment Search Tool is suitable for determining sequence similarity (Altschul et al., J. Mol. Biol, 1990, 215, 403-410, which is incorporated herein by reference in its entirety). Software for performing BLAST analyses is publicly available through the National Center for Biotechnology Information (http://www.ncbi.nlm.nih.gov). One measure of similarity provided by the BLAST algorithm is the smallest sum probability (P(N)), which provides an indication of the probability by which a match between two nucleotide sequences would occur by chance. For example, a nucleic acid is considered similar to another if the smallest sum probability in comparison of the test nucleic acid to the other nucleic acid is less than about 1, preferably less than about 0.1, more preferably less than about 0.01, and most preferably less than about 0.001. “Percentage of similarity” or percentage of sequence identity” can be calculated using PAUP* 4,ObIO software (D. L. Swofford, Sinauer Associates, Massachusetts). The average similarity of the consensus sequence is calculated compared to all sequences in the phylogenic tree. In some embodiments, the compositions disclosed herein comprise nucleic acid sequences that are at least 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99% homologous to SEQ ID NO:1, SEQ ID NO: 5, SEQ ID NO: 6, and/or SEQ ID NO:7. In some embodiments, the compositions disclosed herein comprise nucleic acid or amino acid sequences that are at least 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99% homologous to SEQ ID NOS:1-7.

As used herein, “conservative” amino acid substitutions may be defined as set out in Tables A, B, or C below. In some embodiments, the at least one bacterial cell of the present invention comprises any of the nucleic acid sequences or amino acid sequences disclosed herein with one or more conservative amino acid or nucleic acid mutations. The mutation may include those wherein conservative substitutions have been introduced by modification of polynucleotides encoding polypeptides of the invention. Amino acids can be classified according to physical properties and contribution to secondary and tertiary protein structure. A conservative substitution is recognized in the art as a substitution of one amino acid for another amino acid that has similar properties. Exemplary conservative substitutions are set out in Table A.

TABLE A Conservative Substitutions I Side Chain Characteristics Amino Acid Aliphatic Non-polar G A P I L V F Polar - uncharged C S T M N Q Polar - charged D E K R Aromatic H F W Y Other N Q D E

Alternately, conservative amino acids can be grouped as described in Lehninger, (Biochemistry, Second Edition; Worth Publishers, Inc. NY, N.Y. (1975), pp. 71-77) as set forth in Table B.

TABLE B Conservative Substitutions II Side Chain Characteristic Amino Acid Non-polar (hydrophobic) Aliphatic: A L I V P. Aromatic: F W Y Sulfur-containing: M Borderline: G Y Uncharged-polar Hydroxyl: S T Y Amides: N Q Sulfhydryl: C Borderline: G Y Positively Charged (Basic): K R H Negatively Charged (Acidic): D E

Alternately, exemplary conservative substitutions are set out in Table C.

TABLE C Conservative Substitutions III Original Residue Exemplary Substitution Ala (A) Val Leu He Met Arg (R) Lys His Asn (N) Gin Asp (D) Glu Cys (C) Ser Thr Gin (Q) Asn Glu (E) Asp Gly(G) Ala Val Leu Pro His (H) Lys Arg He (I) Leu Val Met Ala Phe Leu (L) He Val Met Ala Phe Lys (K) Arg His Met (M) Leu He Val Ala Phe(F) Trp Tyr He Pro (P) Gly Ala Val Leu He Ser(S) Thr Thr (T) Ser Trp(W) Tyr Phe He Tyr(Y) Trp Phe Thr Ser Val (V) He Leu Met Ala

It should be understood that the polypeptides comprising polypeptide sequences associated with the extracellular matrix described herein are intended to include polypeptides bearing one or more insertions, deletions, or substitutions, or any combination thereof, of amino acid residues as well as modifications other than insertions, deletions, or substitutions of amino acid residues.

The term “subject” is used throughout the specification to describe an animal to whom treatment with the compositions according to the present invention is provided or administered. For treatment of those conditions which are specific for a specific subject, such as a human being or such as a mammal, the term “patient” may be interchangeably used. In some instances in the description of the present invention, the term “patient” will refer to human patients. In some embodiments, the subject may be a mammal to whom the present invention is provided or administered. In some embodiments, the subject may be a domesticated mammal to whom the present invention is provided or administered such as a horse, dog, cat, pig, cow, goat, sheep, llama, or other non-human animal. In some embodiments, the subject is non-human. In some embodiments, the subject is a mammal suspected of having a hyperproliferative disorder. In some embodiments, the subject is an animal diagnosed with cancer and suspected of having cancer.

As used herein, the term “therapeutic agent” is any chemical compound, amino acid sequence, radioisotope, or combination thereof that can be used to reduce symptom burden or correct dysfunctional components of cellular pathways responsible for disease or improve a subject's prognosis or kill a cancer cell or cells. In some embodiments, the therapeutic agent treats or prevents metastatic cancer cell growth. In some embodiments, the therapeutic agent is an amino acid sequence that kills cancer cells or cells associated with a hyperproliferative disease. In some embodiments, the therapeutic agent is an amino acid sequence that enhances the ability of another molecule present in a particular microenvironment to kill cancer cells or cells associated with a hyperproliferative disease. In some embodiments, the therapeutic agent is an amino acid sequence that contains a cellular death domain and/or is a cellular toxin. In some embodiments, the cellular toxin in CDD or an amino acid analog thereof that is 70, 85 80, 85, 90, 95, 96, 97, 98, or 99% homolgous to CDD. In some embodiments, the therapeutic agent comprises a first and second moiety wherein the first moiety comprises one or more amino acid sequences that are cellular toxins and the second moiety comprises one or more targeting sequences. A targeting sequence for purposes of this invention is an amino acid sequence that directs delivery of a therapeutic agent to a target cell or microenvironment within a cell. In some embodiments, the therapeutic agent comprises a linker that fuses the first and second moieties. In some embodiments, the targeting moiety or targeting sequence comprises an amino acid sequence 70, 85 80, 85, 90, 95, 96, 97, 98, or 99% homolgous to iRGD or like proteins. In some embodiments, the therapeutic agent can kill or enhance killing of colorectal cancer cells and/or ovarian cancer cells. In some embodiments, the at least one bacterial cell is administered sequentially, simultaneously, or subsequently to dosing with one or more of the following chemotherapeutic agents:

-   Trabectedin® -   Belotecan® -   Cisplatin® -   Carboplatin® -   Bevacizumab® -   Pazopanib® -   Colorectal Cancer: -   5-Fluorouracil -   Capecitabine® -   Irinotecan® -   Oxaliplatin®

In some embodiments, pharmaceutical compositions of the present invention comprise at least one bacterial cell disclosed herein, a pharmaceutical acceptable carrier, and at least one additional therapeutic agent. Combination products are contemplated by this invention. Many therapeutic agents are known. For instance, in some embodiments, the pharmaceutical compositions of the claimed invention comprise at least one additional therapeutic agent comprising any of the agents disclosed in U.S. Pat. Nos. 8,343,498, 6,849,272, 8,257,714, 8,466,110, 7,655,444, 6,693,112, 6,428,968, and 5,633,274, each of which are incorporated herein by reference in their entireties.

As used herein, the term “promoter” means at least a first nucleic acid sequence that regulates or mediates transcription of a second nucleic acid sequence. In some embodiments, the second nucleic acid sequence encodes a cellular toxin or an amino acid sequence that enhances cellular toxicity of a microenvironment in the absence or presence of a substance being secreted by a cell. In some embodiments, the second nucleic acid sequence encodes a cellular toxin or an amino acid sequence that enhances cellular toxicity of a microenvironment in the absence or presence of a substance being secreted by a cancer cell or cell associated with a hyperproliferative disorder. For purposes of the invention, a promoter may comprise nucleic acid sequences near the start site of transcription that are required for proper function of the promoter. As an example, a TATA element for a promoter of polymerase II type. Promoters of the present invention can include distal enhancer or repressor elements that may lie in positions from about 1 to about 5,000 base pairs from the initiation site. Promoters of the present invention can include distal enhancer or repressor elements that may lie in positions from about 1 to about 10,000 base pairs or more from the initiation site. Promoters of the present invention can include distal enhancer or repressor elements that may lie in positions from about 1 to about 1,000 base pairs from the initiation site. Promoters of the present invention can include distal enhancer or repressor elements that may lie in positions from about 1 to about 500 base pairs from the initiation site. The term “inducible promoter” refers to an operable linkage between a promoter and a nucleic acid sequence, whereby the promoter mediates the nucleic acid transcription in the presence or absence of at least one specific stimulus. In some embodiments, the inducible promoter mediates transcription of a nucleic acid sequence in the presence or absence of at least one, two, three, four, or five or more stimuli. In some embodiments, the one or more stimuli are not external stimuli in reference to the body of the subject to whom the at least one bacterial cell or compositions disclosed herein are administered. In some embodiments, the one or more stimuli are natural stimuli secreted or presented by the subject to whom the disclosed compositions or at least one bacterial cells are administered. In some embodiments, the at least one stimuli do not comprise light or a chemical molecule administered to the body of a subject before, simultaneously with, or after administration of the disclosed compositions or at least one bacterial cell. In some embodiments, the at least one stimuli is not administered to the body of a subject before, simultaneously with, or after administration of the disclosed compositions or at least one bacterial cell, but is a product or molecule found in the subject of a patient. In some embodiments, the none of the stimuli are administered to the body of a subject before, simultaneously with, or after administration of the disclosed compositions or at least one bacterial cell, but rather the stimulus is a product or molecule found in the subject of a patient. In some embodiments, the only stimulus of the promoter is presence of a certain density of bacteria found in the subject of a patient. In some embodiments, the only stimulus of the promoter is presence of a certain density of bacteria found in the subject of a patient.

In some embodiments, the inducible promoter mediates transcription of a nucleic acid that enhances cellular toxicity either by encoding an amino acid that is toxic to a cell or encoding an amino acid sequence that increases the toxicity of a microenvironment in which the at least one bacterial cell colonizes and grows. In some embodiments, the inducible promoter mediates transcription of a nucleic acid that enhances cellular toxicity either by encoding an amino acid that is toxic to a cell or encoding an amino acid sequence that increases the toxicity of a microenvironment in the absence of presence of a cellular factor natively produced by the body of the subject. In some embodiments, the at least one specific stimulus is a certain density of bacteria carrying the inducible promoter in a tissue of a subject. In some embodiments, the at least one specific stimulus is the presence of absence of a cofactor. In some embodiments, the at least one specific stimulus is the presence of absence of a cofactor that is a tumor associated antigen. In some embodiments, the inducible promoter does not require any external stimulus other than the presence of a certain density of bacteria within a cofactor which can be added to the environment of the composition comprising the nucleic acid sequence that contains the inducible promoter. An “operable linkage” refers to an operative connection between nucleic acid sequences, such as for example between a control sequence (e.g. a promoter) and another nucleic acid sequence that codes for a protein i.e. a coding sequence. If a promoter can regulate transcription of an exogenous nucleic acid sequence then it is in operable linkage with the gene.

Bacterial Strains

The invention relates to bacterial cells comprising any one or more of the nucleic acid sequences of the disclosed herein. In some embodiments, the at least one bacterial cell comprises one or combination of any two or more bacterial species chosen from Table 1. In some embodiments, the bacteria are non-pathogenic. In some embodiments, the bacteria are attenuated. In some embodiments, the bacteria are attenuate and non-pathogenic. One of ordinary skill in the art would know how to attenuate pathogenic bacteria to create non-pathogenic bacteria. In some embodiments, the bacteria are attenuated by removing, knocking out, or mutating a virulence gene such as altering genetic components of the bacterial secretion system. In some embodiments, at least one bacterial cell is a Machl (E. coli strain), E. coli Nissle, E. coli DH5alpha, or S. Typhimurium (strains SL7207, ELH430, ELH1301). In other embodiments, the bacterial strain is chosen from: Bifidobacterium, Vibrio fischeri, and Bifidolongum.

In some embodiments, the invention relates to a composition comprising at least one bacterial cell that comprises a first nucleic acid sequence that encodes a therapeutic amino acid sequence or functional fragment thereof operably linked to a second nucleic acid sequence that comprise one or more inducible promoters or functional fragments thereof operably linked to the first nucleic acid sequence, wherein the inducible promoter or functional fragment thereof mediates the non-constitutive expression of the first nucleic acid sequence. In some embodiments, the invention relates to a composition comprising at least one bacterial cell that comprises a first nucleic acid sequence that encodes a therapeutic amino acid sequence or functional fragment thereof operably linked to a second nucleic acid sequence encoding one or more inducible promoters or functional fragments thereof, wherein the inducible promoter or functional fragment thereof is a non-constitutive promoter that responds only to a single stimulus. In some embodiments, the invention relates to a composition comprising at least one bacterial cell that comprises a first nucleic acid sequence that encodes a therapeutic amino acid sequence or functional fragment thereof operably linked to a second nucleic acid sequence encoding one or more inducible promoters or functional fragments thereof, wherein the inducible promoter or functional fragment thereof is a non-constitutive promoter that mediates expression of the first nucleic acid sequence only in the presence or absence of a certain density of a bacterial cells comprising the first and second nucleic acid sequences.

In some embodiments, the invention relates to a composition comprising at least one bacterial cell that comprises a first nucleic acid sequence encoding an death domain or functional fragment thereof operably linked to a second nucleic acid sequence comprising one or more inducible promoters or functional fragments thereof, wherein the inducible promoter or functional fragments thereof are non-constitutive promoter. In some embodiments, the invention relates to a composition comprising at least one bacterial cell that comprises a first nucleic acid sequence encoding an death domain or functional fragment thereof operably linked to a second nucleic acid sequence encoding one or more inducible promoters or functional fragments thereof, wherein the inducible promoter is a non-constitutive promoter and responds to the density of bacteria in a tissue.

Some embodiments of the invention further comprise third nucleic acid sequence encoding a bacterial toxin or functional fragment thereof, and a fourth nucleic acid sequence encoding an antidote to the bacterial toxin. In order to manufacture or produce such a non-pathogenic microorganism, one of ordinary skill in the art would contact the microorganism with a composition comprising each of the first, second, third, or fourth nucleic acid sequences. Methods to deliver expression vectors or expression constructs into microbes, for example, into non-pathogenic bacteria, are well known to those of skill in the art. Nucleic acids, including expression vectors, can be delivered to prokaryotic microbes by various methods well known to those of skill in the relevant biological arts. Methods for the delivery of nucleic acids to a microbe in accordance to some aspects of this invention, include, but are not limited to, different chemical, electrochemical and biological approaches, for example, heat shock transformation, electroporation, transfection, for example liposome-mediated transfection, DEAE-Dextran-mediated transfection or calcium phosphate transfection. In some embodiments, a nucleic acid construct, for example an expression construct comprising any combination of the first, second, third, and/or fourth nucleic acid sequences disclosed herein, is introduced into the host microbe using a vehicle, or vector, for transferring genetic material. Vectors for transferring genetic material to microbes are well known to those of skill in the art and include, for example, plasmids, artificial chromosomes, and viral vectors. Methods for the construction of nucleic acid constructs, including expression constructs comprising constitutive or inducible heterologous promoters, knockout and knockdown constructs, as well as methods and vectors for the delivery of a nucleic acid or nucleic acid construct to a microbe are well known to those of skill in the art, and are described, for example, in J. Sambrook and D. Russell, Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory Press; 3rd edition (Jan. 15, 2001); David C. Amberg, Daniel J. Burke; and Jeffrey N. Strathern, Methods in Yeast Genetics: A Cold Spring Harbor Laboratory Course Manual, Cold Spring Harbor Laboratory Press (April 2005); John N. Abelson, Melvin I. Simon, Christine Guthrie, and Gerald R. Fink, Guide to Yeast Genetics and Molecular Biology, Part A, Volume 194 (Methods in Enzymology Series, 194), Academic Press (Mar. 11, 2004); Christine Guthrie and Gerald R. Fink, Guide to Yeast Genetics and Molecular and Cell Biology, Part B, Volume 350 (Methods in Enzymology, Vol 350), Academic Press; 1st edition (Jul. 2, 2002); Gregory N. Stephanopoulos, Aristos A. Aristidou and Jens Nielsen, Metabolic Engineering: Principles and Methodologies, Academic Press; 1 edition (Oct. 16, 1998); and Christina Smolke, The Metabolic Pathway Engineering Handbook: Fundamentals, CRC Press; 1 edition (Jul. 28, 2009), all of which are incorporated by reference herein in their entireties.

Some aspects of this invention relate to cultures of genetically modified microbes provided herein. In some embodiments, the culture comprises a genetically modified microbe provided herein and a medium, for example, a liquid medium. In some embodiments, the culture comprises a genetically modified microbe provided herein and a carbon source, for example, a carbohydrate source, or an organic acid or salt thereof. In some embodiments, the culture comprises a genetically modified microbe provided herein and a salt and/or buffer establishing conditions of salinity, osmolarity, and pH, that are amenable to survival, growth, and/or catalytic activity of the encoded enzyme. In some embodiments, the culture comprises an additional component, for example, an additive. Non-limiting examples of additives are nutrients, amino acids, albumin, growth factors, enzyme inhibitors (for example protease inhibitors), fatty acids, lipids, hormones (e.g., dexamethasone and gibberellic acid), trace elements, inorganic compounds (e.g., reducing agents, such as manganese), redox-regulators (e.g., antioxidants), stabilizing agents (e.g., dimethylsulfoxide), polyethylene glycol, polyvinylpyrrolidone (PVP), gelatin, antibiotics (e.g., Brefeldin A), salts (e.g., NaCl), chelating agents (e.g., EDTA, EGTA), and enzymes (e.g., cellulase, dispase, hyaluronidase, or DNase). In some embodiments, the culture may comprise a drug inducing or inhibiting transcription from a conditional or inducible promoter, for example doxicycline, tetracycline, tamoxifen, IPTG, hormones, or metal ions. While the specific culture conditions, for example, the concentration of the carbon source, will depend upon the respective engineered microorganism to be cultured, general methods and culture conditions for the generation of microbial cultures are well known to those of skill in the art, and are described, for example, in J. Sambrook and D. Russell, Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory Press; 3rd edition (Jan. 15, 2001); David C. Amberg, Daniel J. Burke; and Jeffrey N. Strathern, Methods in Yeast Genetics: A Cold Spring Harbor Laboratory Course Manual, Cold Spring Harbor Laboratory Press (April 2005); John N. Abelson, Melvin I. Simon, Christine Guthrie, and Gerald R. Fink, Guide to Yeast Genetics and Molecular Biology, Part A, Volume 194 (Methods in Enzymology Series, 194), Academic Press (Mar. 11, 2004), all of which are incorporated by reference herein.

In some embodiments, the genetically modified non-pathogenic microbe or microorganism exhibits a growth advantage over wild type microbes of the same kind and/or over other microbes, for example, microbes commonly found to contaminate microbial cultures for scaling up production of cultures to large volumes. In some embodiments, the growth and/or proliferation advantage of an engineered microbe provided by aspects of this invention translates into the possibility of using non-sterile culturing and fermentation conditions for production, because the problem of culture overgrowth by contaminating microbes is mitigated or completely abolished. In some embodiments, an engineered microbe provided by aspects of this invention is cultured under non-sterile conditions. For example, in some embodiments, non-sterilized feedstock, non-sterilized culture media, non-sterilized supplements, or a non-sterilized bioreactor (e.g. an open reactor under non-sterile conditions) is used for microorganism division.

A variety of different microbes can be genetically modified according to some aspects of this invention and used for scale-up and/or isolation for eventual animal ingestion, for example, various strains of non-pathogenic E. Coli. In some embodiments, the invention provides for a composition comprising one or a combination of non-pathogenic bacteria chosen from: probiotic bacteria is chosen from Salmonella spp., Escherichia spp., Firmicutes spp., Bacteroidetes spp., Lactobacillus spp., Bifidobacteria spp., or Adalopholus spp. In some embodiments, the probiotic is selected from Lactobacillus, Bifidobacteria, and Acidopholus. In some embodiments, the bacteria is harvested from a human or animal sample and transformed as described herein, with our system. The samples may be from stool samples (probiotics) or human/mouse tumor samples (bacteria that have potential to be very tumor selective). In some embodiments, the non-pathogenic microorganism is E. coli Nissle 1917 (EcN). In some embodiments, the non-pathogenic microorganism is a strain of E. coli but not the Nissle 1917 (EcN). In some embodiments, the compositions, pharmaceutical compositions, kits or cells disclosed herein comprise at least one E. coli strain Machl. Expanding upon this we have shown the E. coli Nissle, E. coli DH5alpha, and S. Typhimurium. In some embodiments, the compositions, pharmaceutical compositions, kits or cells disclosed herein comprise at least one bacterial cell chosen from SL7207, ELH430, and ELH130 strains of S. Typhimurium. In some embodiments, the compositions, pharmaceutical compositions, kits or cells disclosed herein comprise at least one bacterial cell chosen from Salmonella spp., Escherichia spp., Firmicutes spp., Bacteroidetes spp., Lactobacillus spp., Bifidobacteria spp., or Acidopholus spp.

The present invention relates to compositions comprising any one or combination of non-pathogenic bacteria disclosed herein wherein at least one of the bacteria comprises a first, second, third, and/or fourth nucleic acid sequences disclosed herein either alone or in combination. In some embodiments, the invention relates to compositions comprising any one or combination of non-pathogenic bacteria disclosed herein wherein at least one of the bacteria comprises a nucleotide sequence encoding a mutated virulence factor. For instance, in some embodiments, the non-pathogenic microorganism comprises a mutation in its Type I, II, III, IV, V, or VI secretion system which does not allow transport of host toxins and/or host immunogenic proteins out of the cell.

In some embodiments, the invention relates to a system comprising at least one of the bacterial cells disclosed herein and bacterial growth media. In some embodiments, the invention relates to a system comprising at least one of the bacterial cells disclosed herein and a cell culture vessel or biorcactor.

In some embodiments, the invention relates to a system comprising at least one of the bacterial cells disclosed herein, bacterial growth media, and a cell culture vessel or bioreactor. fermentation processes for large-scale microbe cell division may be carried out in bioreactors, isolated and then resuspended in an amount or dosage form disclosed herein. As used herein, the terms “bioreactor” and “fermentor”, which are interchangeably used, refer to an enclosure, or partial enclosure, in which a biological and/or chemical reaction takes place, at least part of which involves a living organism or part of a living organism. A “large-scale bioreactor” or “industrial-scale bioreactor” is a bioreactor that is used to generate large volumes of non-pathogenic bacteria for large scale isolation. Large scale bioreactors typically have volumes in the range of liters, hundreds of liters, thousands of liters, or more.

Other examples of bacteria that can be modified for use in the invention include food-grade bacterial strains. In some embodiments, the non-pathogenic bacteria is chosen from the bacterials strains identified in Humaran et al., Microbial Cell Factories 2011, 10(Suppl 1):S4; Shrivastava et al., PlosOne, August 2008, Volume 3, Issue 8: e2955; and T. Danino et al., ACS Synth. Biol. 2012, 1, 465-470, each of which are incorporated by reference in their entireties.

The invention relates to compositions comprising any of the bacteria disclosed herein, wherein the compositions are in a solid or liquid dosage form an wherein the bacteria are in an amount effective to colonize a tumor. The invention relates to compositions comprising any of the bacteria disclosed herein, wherein the compositions are in a solid or liquid dosage form an wherein the bacteria are in an amount effective to colonize a tumor upon administration of the compositions or bacteria to the subject in need thereof. The invention relates to compositions comprising any of the bacteria disclosed herein, wherein the compositions are in a solid or liquid dosage form an wherein the bacteria are in an effective amount to colonize a tumor and adequate produce enzyme or substrate in quantities detectable in urine. The invention relates to compositions comprising any of the non-pathogenic bacteria disclosed herein, wherein the compositions are in a solid or liquid dosage form an wherein the bacteria are in an effective amount to colonize a tumor and adequate produce enzyme or substrate in quantities detectable in urine by visual inspection. The invention relates to compositions comprising any of the non-pathogenic bacteria disclosed herein wherein the compositions are in a solid or liquid dosage form. In addition to the compositions disclosed in either solid or liquid form, the formulations and compositions of the present invention may also contain optional ingredients to enhance the characteristics of the solid dosage form, maintain the integrity of bacteria (in dried, lyophilized, dormant or sporulated forms) during the formulation process, and/or enhance the safety of the formulation. Any additional components may be compatible with the other ingredients in the formulations of the invention, in particular the active ingredients, and may be inert. If inert, the additional component does not adversely affect the osmolarity, osmolality, or isotoncity of the formulations or interfere, to a measureable degree, with the biological function of the non-pathogenic microorganism. Additional optional ingredients that may be used in the formulations of the invention include, for example, coatings, diluents, binders, glidants, lubricants, colors, disintegrants, flavors, sweeteners, polymers or waxes.

Non-limiting examples of diluents include various types of starch, cellulose, crystalline cellulose, microcrystalline cellulose, lactose, fructose, sucrose, mannitol or other sugar alcohols, kaolin, calcium phosphate or sulfate, inorganic salts such as sodium chloride and powdered sugar. Powdered cellulose derivatives are also useful. In some embodiments of the invention, the formulation does not include a diluent.

Lubricants, for example, may be included in the formulations of the invention. Such lubricants include, but are not limited to, magnesium stearate, potassium stearate, talc, stearic acid, sodium lauryl sulphate, and paraffin. In some embodiments of the invention, the colonic purgative formulation further comprises magnesium stearate. Lubricants serve to facilitate the manufacturing of a solid dosage form. In some embodiments of the invention, the formulation does not comprise a lubricant.

Additional suitable ingredients also include, but are not limited to, carriers, such as sodium citrate and dicalcium phosphate; fillers or extenders, such as stearates, silicas, gypsum, starches, lactose, sucrose, glucose, mannitol, talc, and silicic acid; binders, such as hydroxypropyl methylcellulose, hydroxymethyl-cellulose, alginates, gelatin, polyvinyl pyrrolidone, sucrose, and acacia; humectants, such as glycerol; disintegrating agents, such as agar, calcium carbonate, potato and tapioca starch, alginic acid, certain silicates, colloidal silicon dioxide, sodium starch glycolate, crospovidone, and sodium carbonate; solution retarding agents, such as paraffin; absorption accelerators, such as quaternary ammonium compounds; wetting agents, such as cetyl alcohol and glycerol monostearate; absorbents, such as kaolin and bentonite clay; stabilizers, such as fumaric acid; coloring agents; buffering agents; dispersing agents; preservatives; organic acids; and organic bases.

In some embodiments of the instant invention, the tablet or capsules may also include inert dispersal agents which will facilitate dissolution of the a solid dosage form of the non-pathogenic bacteria in the stomach of the patient. Preferably, the dispersal agent is a pharmaceutically acceptable dispersant and is one which also produces no appreciable osmotic effects. Examples of acceptable dispersants include microcrystalline cellulose (which is also useful as a compacting agent) and anhydrous lactose. In some embodiments, the dispersal agent is AC-DI-SOL, a cross-linked starch.

In some embodiments of the present invention, the formulation or composition may also include a buffering agent to minimize any acid imbalance which may accompany ingestion of the compositions disclosed herein. Suitable buffering agents include magnesium hydroxide, aluminum hydroxide, calcium carbonate and magnesium carbonate. In some embodiments, the formulation does not include a buffering agent.

In some embodiments of the invention, an additional component in the formulations of the invention may function to maintain the electrolyte balance in a subject after ingestion of a liquid dosage form of the compositions disclosed herein. For example, formulations of the invention may further comprise calcium, phosphate, potassium, magnesium, other anions, or salts thereof.

In some embodiments, the composition comprises at least one bacterium that comprises stably transfected nucleic acid molecules. In some embodiment, the nucleic acid molecules are DNA or RNA. In some embodiments, the nucleic acid molecules are DNA plasmids.

Culture System

The invention generally relates to a culture system that comprises at least one culture vessel comprising any one or combination of bacteria or compositions disclosed herein. Microbial culturing in the present invention is performed both for the sake of implementing genetic modifications, and for scaled up production of the bacteria disclosed herein. In some embodiments, the invention relates to the method of culturing at least one bacterium disclosed herein comprising inoculating a growth medium with the at least one bacterium disclosed herein.

Microbial culturing with the aim of genetic manipulation is generally performed at a small benchtop scale and often under conditions that select for genetically modified traits. Microbial culturing aimed at the commercial production of bacteria suitable for use in a subject can be performed in bioreactors at much greater scale (e.g., 1 L, 10 L, 500 L, 1,000 L 5,000 L, 10,000 L, 50,000 L, 100,000 L bioreactor volumes and higher). In certain embodiments the bacteria of the present invention are grown in a liquid media inside a bioreactor using the methods of the invention. In some embodiments of the present invention steel fermentors 50,000 liter and greater in volume are utilized. In some embodiments of the present invention egg-shape or cylindrical digestrors 3,000,000 liters and greater in volume are utilized. In some embodiments, the bioreactor comprising the microorganism does not allow light to penetrate its interior.

The bioreactor or fermentor is used to culture cells through the various phases of their physiological cycle. A bioreactor is utilized for the cultivation of cells, which may be maintained at particular phases in their growth curve. Generally the control of growth conditions including dissolved carbon dioxide, oxygen, and other gases such as hydrogen, as well as other dissolved nutrients, trace elements, temperature and pH are facilitated in a bioreactor.

Nutrient media as well as gases can be added to the bioreactor as either a batch addition, or periodically, or in response to a detected depletion or programmed set point, or continuously over the period the culture is grown and/or maintained. For certain embodiments, the bioreactor at inoculation is filled with a starting batch of nutrient media and/or gases at the beginning of growth, and no additional nutrient media and/or gases is added after inoculation. For certain embodiments, nutrient media and/or gases are added periodically after inoculation. For certain embodiments, nutrient media and/or gas is added after inoculation in response to a detected depletion of nutrient and/or gas. For certain embodiments, nutrient media and/or gas is added continuously after inoculation.

In some embodiments, the bioreactors comprise a mechanisms to mix of the nutrient media that include but are not limited to spinning stir bars, blades, impellers, or turbines, spinning, rocking, or turning vessels, gas lifts and sparging. The culture media may be mixed continuously or intermittently.

The ports that are standard in bioreactors may be utilized to deliver, or withdraw, gases, liquids, solids, and/or slurries, into the bioreactor vessel enclosing the microbes of the present invention. Many bioreactors have multiple ports for different purposes (e.g. ports for media addition, gas addition, probes for pH and DO, sampling), and a given port may be used for various purposes during the course of a fermentation run. As an example, a port might be used to add nutrient media to the bioreactor at one point in time and at another time might be used for sampling. Preferably, the multiple use of a sampling port can be performed without introducing contamination or invasive species into the growth environment. A valve or other actuator enabling control of the sample flow or continuous sampling can be provided to a sampling port. For certain embodiments the bioreactors are equipped with at least one port suitable for culture inoculation that can additionally serve other uses including the addition of media or gas. Bioreactors ports enable control of the gas composition and flow rate into the culture environment. For example the ports can be used as gas inlets into the bioreactor through which gases are pumped. For some embodiments gases that may be pumped into a bioreactor include hydrogen gas, CO₂, air, air/CO₂ mixtures, ammonia, nitrogen, noble gases, such as argon, as well as other gases. Raising the gas flow rate into a bioreactor can enhance mixing of the culture and produce turbulence if the gas inlet is positioned under the surface of the liquid media such that gas bubbles or sparges up through the media. In some embodiments, a bioreactor comprises gas outlet ports for gas escape and pressure release. In some embodiments, gas inlets and outlets are preferably equipped with check valves to prevent gas backflow.

The nucleic acid sequences of the present invention may be components of one, two or more, three or more, four or more than three different plasmid molecules. Each individual nucleica acid sequence may reside on its own nucleic acid molecule or plasmid. In some embodiments, each exogenous nucleic acid resides on a single DNA plasmid. In some embodiments, the nucleic acid sequence that is an inducible promoter comprises at least one, two, three, four or more exogenous nucleic acid sequences whose presence individually or in combination control the expression of one or more coding sequences. In some embodiments, the coding sequence is a therapeutic agent, cell death amino acid sequence, cancer cell targeting sequence (e.g. ligand of a tumor associated antigen), or a selectable marker or marker amino acid sequence. Example of marker amino acid sequences comprise amino acid sequences that, upon exposure to a light, emit a detectable wavelength of light. One of ordinary skill in the art can measure the emission of light from the marker amino acid sequence by known techniques such as fluorescent microscopy, FRET or other, wavelength detection equipment.

Kits

In some embodiments, the present disclosure provides kits for cell administration and treatment of cancer in a subject in need thereof comprising at least one bacterial cell disclosed herein. In some embodiments, the kit comprises cell growth media. In some embodiments, the kit comprises cell growth media in a separate vessel from the at least one bacterial cell. In some embodiments, the kit further comprises cells of the cell type of interest. In some embodiments, the kits provide

Methods

The present invention relates to methods of treating and preventing cancer. In some embodiments, the methods comprise the step of administering the pharmaceutical compositions, compositions or food disclosed herein to treat or prevent cancer of the adrenal gland, bladder, bone, bone marrow, brain, spine, breast, cervix, gall bladder, ganglia, gastrointestinal tract, stomach, colon, heart, kidney, liver, lung, muscle, ovary, pancreas, parathyroid, penis, prostate, salivary glands, skin, spleen, testis, thymus, thyroid, or uterus. In some embodiments, the methods comprise the step of administering a therapeutically effective dose of at least one bacterial cell as a component of the pharmaceutical compositions, compositions or food disclosed herein to treat or prevent cancer of the adrenal gland, bladder, bone, bone marrow, brain, spine, breast, cervix, gall bladder, ganglia, gastrointestinal tract, stomach, colon, heart, kidney, liver, lung, muscle, ovary, pancreas, parathyroid, penis, prostate, salivary glands, skin, spleen, testis, thymus, thyroid, or uterus. In some embodiments, the methods comprise the step of administering a therapeutically effective dose of the pharmaceutical compositions, compositions or food disclosed herein to treat or prevent cancer of the adrenal gland, bladder, bone, bone marrow, brain, spine, breast, cervix, gall bladder, ganglia, gastrointestinal tract, stomach, colon, heart, kidney, liver, lung, muscle, ovary, pancreas, parathyroid, penis, prostate, salivary glands, skin, spleen, testis, thymus, thyroid, or uterus. In some embodiments, the methods comprise the step of administering a therapeutically effective dose of at least one bacterial cell as a component of the pharmaceutical compositions, compositions or food disclosed herein to treat or prevent the growth or spread of metastatic cancer. In some embodiments, the invention relates to any of the disclosed methods comprising the step of administering a therapeutically effective dose of at least one bacterial cell as a component of the pharmaceutical compositions, compositions or food disclosed herein.

Embodiments include methods of using tumor-targeted bacteria to identify a therapeutically effective dose of therapeutic agent in a solid tumor, the method comprising administering any of the compositions, pharmaceutical compositions, or food products disclosed herein to a subject in need thereof. In some embodiments, the subject is suspected of having or has been diagnosed with cancer or metastatic cancer.

Embodiments also include methods of using tumor-targeted bacteria to deliver a timed therapeutically effective dose of therapeutic agent in regular intervals in a solid tumor, the method comprising administering any of the compositions, pharmaceutical compositions, or food products disclosed herein to a subject in need thereof. In some embodiments, the subject is suspected of having or has been diagnosed with cancer or metastatic cancer. In some embodiments, the methods herein comprise administering one or more stimuli that activate the promoter sequence or sequences and induce expression of one or more coding sequence on the one or more nucleic acid sequences residing in the at least one bacterial cell. Based upon the time administration of the one or more stimuli, bacteria that colonize cancer cells, solid tumors, or cells associated with hyperproliferative disorders may release, secrete, or express cellular toxins, therapeutic agents, or amino acids comprising one or more cell death domains.

The invention also relates to a method of predicting the quantitative expression or dosage of a therapeutic agent in a subject, the method comprising: administering any of the compositions, pharmaceutical compositions or food stuff disclosed herein.

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EXAMPLES Example 1

A single plasmid, p-TD106-DD was generated by subcloning coding sequences into a synthesized DNA molecule by known molecular biology techniques. We transformed the DNA into bacteria to use for quorum sensing as means to deliver therapeutic payloads to a cancer cell. A restriction enzyme map of the plasmid is depicted in FIG. 1A.

The sequence of the plasmid (SEQ ID NO:1) follows:

ctcgagttaatttttaaagtatgggcaatcaattgctcctgttaaaattg ctttagaaatactttggcagcggtttgttgtattgagtttcatttgcgca ttggttaaatggaaagtgacagtacgctcactgcagcctaatatttttga aatatcccaagagctttttccttcgcatgcccacgctaaacattcttttt ctcttttggttaaatcgttgtttgatttattatttgctatatttattttt cgataattatcaactagagaaggaacaattaatggtatgttcatacacgc atgtaaaaataaactatctatatagttgtctttttctgaatgtgcaaaac taagcattccgaagccattgttagccgtatgaatagggaaactaaaccca gtgataagacctgatgttttcgcttctttaattacatttggagatttttt atttacagcattgttttcaaatatattccaattaattggtgaatgattgg agttagaataatctactataggatcatattttattaaattagcgtcatca taatattgcctccattttttagggtaattatctagaattgaaatatcaga tttaaccatagaatgaggataaatgatcgcgagtaaataatattcacaat gtaccattttagtcatatcagataagcattgattaatatcattattgctt ctacaagctttaattttattaattattctgtatgtgtcgtcggcatttat gtttttcatacccatctctttatccttacctattgtttgtcgcaagtttt gcgtgttatatatcattaaaacggtaatggattgacatttgattctaata aattggatttttgtcacactattgtatcgctgggaatacaattacttaac ataagcacctgtaggatcgtacaggtttacgcaagaaaatggtttgttat agtcgaatgaattcattaaagaggagaaaggtaccatgactataatgata aaaaaatcggattttttggcaattccatcggaggagtataaaggtattct aagtcttcgttatcaagtgtttaagcaaagacttgagtgggacttagttg tagaaaataaccttgaatcagatgagtatgataactcaaatgcagaatat atttatgcttgtgatgatactgaaaatgtaagtggatgctggcgtttatt acctacaacaggtgattatatgctgaaaagtgtttttcctgaattgcttg gtcaacagagtgctcccaaagatcctaatatagtcgaattaagtcgtttt gctgtaggtaaaaatagctcaaagataaataactctgctagtgaaattac aatgaaactatttgaagctatatataaacacgctgttagtcaaggtatta cagaatatgtaacagtaacatcaacagcaatagagcgatttttaaagcgt attaaagttccttgtcatcgtattggagacaaagaaattcatgtattagg tgatactaaatcggttgtattgtctatgcctattaatgaacagtttaaaa aagcagtcttaaatgcagcgaacgacgaaaattacgcccttgcagcgtaa acgcgtgctagaggcatcaaataaaacgaaaggctcagtcgaaagactgg gcctttcgttttatctgttgtttgtcggtgaacgctctcctgagtaggac aaatccgccgccctagacctagcatttttaaagtatgggcaatcaattgc tcctgttaaaattgctttagaaatactttggcagcggtttgttgtattga gtttcatttgcgcattggttaaatggaaagtgacagtacgctcactgcag cctaatatttttgaaatatcccaagagctttttccttcgcatgcccacgc taaacattctttttctcttttggttaaatcgttgtttgatttattatttg ctatatttatttttcgataattatcaactagagaaggaacaattaatggt atgttcatacacgcatgtaaaaataaactatctatatagttgtctttttc tgaatgtgcaaaactaagcattccgaagccattgttagccgtatgaatag ggaaactaaacccagtgataagacctgatgttttcgcttctttaattaca tttggagattttttatttacagcattgttttcaaatatattccaattaat tggtgaatgattggagttagaataatctactataggatcatattttatta aattagcgtcatcataatattgcctccattttttagggtaattatctaga attgaaatatcagatttaaccatagaatgaggataaatgatcgcgagtaa ataatattcacaatgtaccattttagtcatatcagataagcattgattaa tatcattattgcttctacaagctttaattttattaattattctgtatgtg tcgtcggcatttatgtttttcatacccatctctttatccttacctattgt ttgtcgcaagttttgcgtgttatatatcattaaaacggtaatggattgac atttgattctaataaattggatttttgtcacactattgtatcgctgggaa tacaattacttaacataagcacctgtaggatcgtacaggtttacgcaaga aaatggtttgttatagtcgaatgaattcattaaagaggagaaaggtacca tgactaaaaaaatttcattcattattaacggccaggttgaaatctttccc gaaagtgatgatttagtgcaatccattaattttggtgataatagtgttta cctgccaatattgaatgactctcatgtaaaaaacattattgattgtaatg gaaataacgaattacggttgcataacattgtcaattttctctatacggta gggcaaagatggaaaaatgaagaatactcaagacgcaggacatacattcg tgacttaaaaaaatatatgggatattcagaagaaatggctaagctagagg ccaattggatatctatgattttatgttctaaaggcggcctttatgatgtt gtagaaaatgaacttggttctcgccatatcatggatgaatggctacctca ggatgaaagttatgttcgggcttttccgaaaggtaaatctgtacatctgt tggcaggtaatgttccattatctgggatcatgtctatattacgcgcaatt ttaactaagaatcagtgtattataaaaacatcgtcaaccgatccttttac cgctaatgcattagcgttaagttttattgatgtagaccctaatcatccga taacgcgctctttatctgttatatattggccccaccaaggtgatacatca ctcgcaaaagaaattatgcgacatgcggatgttattgtcgcttggggagg gccagatgcgattaattgggcggtagagcatgcgccatcttatgctgatg tgattaaatttggttctaaaaagagtctttgcattatcgataatcctgtt gatttgacgtccgcagcgacaggtgcggctcatgatgtttgtttttacga tcagcgagcttgtttttctgcccaaaacatatattacatgggaaatcatt atgaggaatttaagttagcgttgatagaaaaacttaatctatatgcgcat atattaccgaatgccaaaaaagattttgatgaaaaggcggcctattcttt agttcaaaaagaaagcttgtttgctggattaaaagtagaggtggatattc atcaacgttggatgattattgagtcaaatgcaggtgtggaatttaatcaa ccacttggcagatgtgtgtaccttcatcacgtcgataatattgagcaaat attgccttatgttcaaaaaaataagacgcaaaccatatctatttttcctt gggagtcatcatttaaatatcgagatgcgttagcattaaaaggtgcggaa aggattgtagaagcaggaatgaataacatatttcgagttggtggatctca tgacggaatgagaccgttgcaacgartagtgacatatatttctcatgaaa ggccatctaactatacggctaaggatgttgcggttgaaatagaacagact cgattcctggaagaagataagttccttgtatttgtcccataataggtaaa agtatggaaaatgaatcaaaatataaaaccatcgaccacgttatttgtgt tgaaggaaataaaaaaattcatgtttgggaaacgctgccagaagaaaaca gcccaaagagaaagaatgccattattattgcgtctggttttgcccgcagg atggatcattttgctggtctggcggaatatttatcgcggaatggatttca tgtgatccgctatgattcgcttcaccacgttggattgagttcagggacaa ttgatgaatttacaatgtctataggaaagcagagcttgttagcagtggtt gattggttaactacacgaaaaataaataacttcggtatgttggcttcaag cttatctgcgcggatagcttatgcaagcctatctgaaatcaatgcttcgt ttttaatcaccgcagtcggtgttgttaacttaagatattctcttgaaaga gctttagggtttgattatctcagtctacccattaatgaattgccggataa tctagattttgaaggccataaattgggtgctgaagtctttgcgagagatt gtcttgattttggttgggaagatttagcttctacaattaataacatgatg tatcttgatataccgtttattgcttttactgcaaataacgataattgggt caagcaagatgaagttatcacattgttatcaaatattcgtagtaatcgat gcaagatatattctttgttaggaagttcgcatgacttgagtgaaaattta gtggtcctgcgcaatttttatcaatcggttacgaaagccgctatcgcgat ggataatgatcatctggatattgatgttgatattactgaaccgtcatttg aacatttaactattgcgacagtcaatgaacgccgaatgagaattgagatt gaaaatcaagcaatttctctgtcttaaaatctattgagatattctatcac tcaaatagcaatataaggactctctatgaaatttggaaactttttgctta cataccaacctccccaattttctcaaacagaggtaatgaaacgtttggtt aaattaggtcgcatctctgaggagtgtggttttgataccgtatggttact ggagcatcatttcacggagtttggtttgcttggtaacccttatgtcgctg ctgcatatttacttggcgcgactaaaaaattgaatgtaggaactgccgct attgttcttcccacagcccatccagtacgccaacttgaagatgtgaattt attggatcaaatgtcaaaaggacgatttcggtttggtatttgccgagggc tttacaacaaggactttcgcgtattcggcacagatatgaataacagtcgc gccttagcggaatgctggtacgggctgataaagaatggcatgacagaggg atatatggaagctgataatgaacatatcaagttccataaggtaaaagtaa accccgcggcgtatagcagaggtggcgcaccggtttatgtggtggctgaa tcagcttcgacgactgagtgggctgctcaatttggcctaccgatgatatt aagttggattataaatactaacgaaaagaaagcacaacttgagctttata atgaagtggctcaagaatatgggcacgatattcataatatcgaccattgc ttatcatatataacatctgtagatcatgactcaattaaagcgaaagagat ttgccggaaatttctggggcattggtatgattcttatgtgaatgctacga ctatttttgatgattcagaccaaacaagaggttatgatttcaataaaggg cagtggcgtgactttgtattaaaaggacataaagatactaatcgccgtat tgattacagttacgaaatcaatcccgtgggaacgccgcaggaatgtattg acataattcaaaaagacattgatgctacaggaatatcaaatatttgttgt ggatttgaagctaatggaacagtagacgaaattattgcttccatgaagct cttccagtctgatgtcatgccatttcttaaagaaaaacaacgttcgctat tatattagctaaggagaaagaaatgaaatttggattgttcttccttaact tcatcaattcaacaactgttcaagaacaaagtatagttcgcatgcaggaa ataacggagtatgttgataagttgaattttgaacagattttagtgtatga aaatcatttttcagataatggtgttgtcggcgctcctctgactgtttctg gttttctgctcggtttaacagagaaaattaaaattggttcattaaatcac atcattacaactcatcatcctgtcgccatagcggaggaagcttgcttatt ggatcagttaagtgaagggagatttattttagggtttagtgattgcgaaa aaaaagatgaaatgcatttttttaatcgcccggttgaatatcaacagcaa ctatttgaagagtgttatgaaatcattaacgatgctttaacaacaggcta ttgtaatccagataacgatttttatagcttccctaaaatatctgtaaatc cccatgcttatacgccaggcggacctcggaaatatgtaacagcaaccagt catcatattgttgagtgggcggccaaaaaaggtattcctctcatctttaa gtgggatgattctaatgatgttagatatgaatatgctgaaagatataaag ccgttgcggataaatatgacgttgacctatcagagatagaccatcagtta atgatattagttaactataacgaagatagtaataaagctaaacaagagac gcgtgcatttattagtgattatgttcttgaaatgcaccctaatgaaaatt tcgaaaataaacttgaagaaataattgcagaaaacgctgtcggaaattat acggagtgtataactgcggctaagttggcaattgaaaagtgtggtgcgaa aagtgtattgctgtcctttgaaccaatgaatgatttgatgagccaaaaaa atgtaatcaatattgttgatgataatattaagaagtaccacatggaatat acctaatagatttcgagttgcagcgaggcggcaagtgaacgaatccccag gagcatagataactatgtgactggggtgagtgaaagcagccaacaaagca gcagcttgaaagatgaagggtataaaagagtatgacagcagtgctgccat actttctaatattatcttgaggagtaaaacaggtatgacttcatatgttg ataaacaagaaattacagcaagctcagaaattgatgatttgattttttcg agcgatccattagtgtggtcttacgacgagcaggaaaaaatcagaaagaa acttgtgcttgatgcatttcgtaatcattataaacattgtcgagaatatc gtcactactgtcaggcacacaaagtagatgacaatattacggaaattgat gacatacctgtattcccaacatcggtttttaagtttactcgcttattaac ttctcaggaaaacgagattgaaagttggtttaccagtagcggcacgaatg gtttaaaaagtcaggtggcgcgtgacagattaagtattgagagactctta ggctctgtgagttatggcatgaaatatgttggtagttggtttgatcatca aatagaattagtcaatttgggaccagatagatttaatgctcataatattt ggtttaaatatgttatgagtttggtggaattgttatatcctacgacattt accgtaacagaagaacgaatagattttgttaaaacattgaatagtcttga acgaataaaaaatcaagggaaagatctttgtcttattggttcgccatact ttatttatttactctgccattatatgaaagataaaaaaatctcattttct ggagataaaagcctttatatcataaccggaggcggctggaaaagttacga aaaagaatctctgaaacgtgatgatttcaatcatcttttatttgatactt tcaatctcagtgatattagtcagatccgagatatatttaatcaagttgaa ctcaacacttgtttctttgaggatgaaatgcagcgtaaacatgttccgcc gtgggtatatgcgcgagcgcttgatcctgaaacgttgaaacctgtacctg atggaacgccggggttgatgagttatatggatgcgtcagcaaccagttat ccagcatttattgttaccgatgatgtcgggataattagcagagaatatgg taagtatcccggcgtgctcgttgaaattttacgtcgcgtcaatacgagga cgcagaaagggtgtgctttaagcttaaccgaagcgtttgatagttgataa acgcgtgctagaggcatcaaataaaacgaaaggctcagtcgaaagactgg gcctttcgttttatctgttgtttgtcggtgaacgctctcctgagtaggac aaatccgccgcctagctaatttttaaagtatgggcaatcaattgctcctg ttaaaartgctttagaaatactttggcagcggtttgttgtattgagtttc atttgcgcattggttaaatggaaagtgacagtacgctcactgcagcctaa tatttttgaaatatcccaagagctttttccttcgcatgcccacgctaaac attctttttctcttttggttaaatcgttgtttgatttattatttgctata tttatttttcgataattatcaactagagaaggaacaattaatggtatgtt catacacgcatgtaaaaataaactatctatatagttgtctttttctgaat gtgcaaaactaagcattccgaagccattgttagccgtatgaatagggaaa ctaaacccagtgataagacctgatgttttcgcttctttaattacatttgg agattttttatttacagcattgttttcaaatatattccaattaattggtg aatgattggagttagaataatctactataggatcatattttattaaatta gcgtcatcataatattgcctccattttttagggtaattatctagaattga aatatcagatttaaccatagaatgaggataaatgatcgcgagtaaataat attcacaatgtaccattttagtcatatcagataagcattgattaatatca ttattgcttctacaagctttaattttattaattattctgtatgtgtcgtc ggcatttatgtttttcatacccatctctttatccttacctattgtttgtc gcaagttttgcgtgttatatatcattaaaacggtaatggattgacatttg attctaataaattggatttttgtcacactattgtatcgctgggaatacaa ttacttaacataagcacctgtaggatcgtacaggtttacgcaagaaaatg gtttgttatagtcgaatgaattcattaaagaggagaaaggtaccatgccc tccaaatccttggttatggaatatttggctcatcccagtacactcggctt ggctgttggagttgcttgtggcatgtgcctgggctggagccttcgagtat gctttgggatgctccccaaaagcaagacgagcaagacacacacagatact gaaagtgaagcaagcatcttgggagacagctctcgaggtaccggcggcgg cagcctgggcgatccgaacagcggctgccgcggcgataaaggcccggatt gctaaaagcttaattagctgatctagacgcgtgctagaggcatcaaataa aacgaaaggctcagtcgaaagactgggcctttcgttttatctgttgtttg tcggtgaacgctctcctgagtaggacaaatccgccgccctagacctaggg gatatattccgcttcctcgctcactgactcgctacgctcggtcgttcgac tgcggcgagcggaaatggcttacgaacggggcggagatttcctggaagat gccaggaagatacttaacagggaagtgagagggccgcggcaaagccgttt ttccataggctccgcccccctgacaagcatcacgaaatctgacgctcaaa tcagtggtggcgaaacccgacaggactataaagataccaggcgtttcccc ctggcggctccctcgtgcgctctcctgttcctgcctttcggtttaccggt gtcattccgctgttatggccgcgtttgtctcattccacgcctgacactca gttccgggtaggcagttcgctccaagctggactgtatgcacgaacccccc gttcagtccgaccgctgcgccttatccggtaactatcgtcttgagtccaa cccggaaagacatgcaaaagcaccactggcagcagccactggtaattgat ttagaggagttagtcttgaagtcatgcgccggttaaggctaaactgaaag gacaagttttggtgactgcgctcctccaagccagttacctcggttcaaag agttggtagctcagagaaccttcgaaaaaccgccctgcaaggcggttttt tcgttttcagagcaagagattacgcgcagaccaaaacgatctcaagaaga tcatcttattaatcagataaaatatttctagatttcagtgcaatttatct cttcaaatgtagcacctgaagtcagccccatacgatataagttgttacta gtgcttggattctcaccaataaaaaacgcccggcggcaaccgagcgttct gaacaaatccagatggagttctgaggtcattactggatctatcaacagga gtccaagcactcacgttaagggattttggtcatgactagtgcttggattc tcaccaataaaaaacgcccggcggcaaccgagcgttctgaacaaatccag atggagttctgaggtcattactggatctatcaacaggagtccaagcgagc tctcgaaccccagagtcccgctcagaagaactcgtcaagaaggcgataga aggcgatgcgctgcgaatcgggagcggcgataccgtaaagcacgaggaag cggtcagcccattcgccgccaagctcttcagcaatatcacgggtagccaa cgctatgtcctgatagcggtccgccacacccagccggccacagtcgatga atccagaaaagcggccattttccaccatgatattcggcaagcaggcatcg ccatgggtcacgacgagatcctcgccgtcgggcatgcgcgccttgagcct ggcgaacagttcggctggcgcgagcccctgatgctcttcgtccagatcat cctgatcgacaagaccggcttccatccgagtacgtgctcgctcgatgcga tgtttcgcttggtggtcgaatgggcaggtagccggatcaagcgtatgcag ccgccgcattgcatcagccatgatggatactttctcggcaggagcaaggt gagatgacaggagatcctgccccggcacttcgcccaatagcagccagtcc cttcccgcttcagtgacaacgtcgagcacagctgcgcaaggaacgcccgt cgtggccagccacgatagccgcgctgcctcgtcctgcagttcattcaggg caccggacaggtcggtcttgacaaaaagaaccgggcgcccctgcgctgac agccggaacacggcggcatcagagcagccgattgtctgttgtgcccagtc atagccgaatagcctctccacccaagcggccggagaacctgcgtgcaatc catcttgttcaatcatgcgaaacgatcctcatcctgtctcttgatcagat cttgatcccctgcgccatcagatccttggcggcaagaaagccatccagtt tactttgcagggcttcccaaccttaccagagggcgccccagctggcaatt ccgacgtctaagaaaccattattatcatgacattaacctataaaaatagg cgtatcacgaggccctttcgtcttcac

Embodiments of the invention optionally include at least one bacterial cells comprising a plasmid optionally including one or more of the following sequences:

SEQ ID NO: 2 luxR: atttttaaagtatgggcaatcaattgctcctgttaaaattgctt tagaaatactttggcagcggtttgttgtattgagtttcatttgcgcattg gttaaatggaaagtgacagtacgctcactgcagcctaatatttttgaaat atcccaagagctttttccttcgcatgcccacgctaaacattctttttctc ttttggttaaatcgttgtttgatttattatttgctatatttatttttcga taattatcaactagagaaggaacaattaatggtatgttcatacacgcatg taaaaataaactatctatatagttgtctttttctgaatgtgcaaaactaa gcattccgaagccattgttagccgtatgaatagggaaactaaacccagtg ataagacctgatgttttcgcttctttaattacatttggagattttttatt tacagcattgttttcaaatatattccaattaattggtgaatgattggagt tagaataatctactataggatcatattttattaaattagcgtcatcataa tattgcctccattttttagggtaattatctagaattgaaatatcagattt aaccatagaatgaggataaatgatcgcgagtaaataatattcacaatgta ccattttagtcatatcagataagcattgattaatatcattattgcttcta caagctttaattttattaattattctgtatgtgtcgtcggcatttatgtt tttcatacccatctctttatccttacctattgtttgtcgcaagttttgcg tgttatatatcattaaaacggtaatggattgacatttgattctaataaat tggatttttgtcac luxI: SEQ ID NO: 3 atgactataatgataaaaaaatcggattttttggcaattccatcggagga gtataaaggtattctaagtcttcgttatcaagtgtttaagcaaagacttg agtgggacttagttgtagaaaataaccttgaatcagatgagtatgataac tcaaatgcagaatatatttatgcttgtgatgatactgaaaatgtaagtgg atgctggcgtttattacctacaacaggtgattatatgctgaaaagtgttt ttcctgaattgcttggtcaacagagtgctcccaaagatcctaatatagtc gaattaagtcgttttgctgtaggtaaaaatagctcaaagataaataactc tgctagtgaaattacaatgaaactatttgaagctatatataaacacgctg ttagtcaaggtattacagaatatgtaacagtaacatcaacagcaatagag cgatttttaaagcgtattaaagttccttgtcatcgtattggagacaaaga aattcatgtattaggtgatactaaatcggttgtattgtctatgcctatta atgaacagtttaaaaaagcagtcttaaatgcagcgaacgacgaaaattac gcccttgcagcg linker cdd to irgd: SEQ ID NO: 4 GGGGSGGGGSGGGGSLGDPNSGCRGDKGPDC iRGD: SEQ ID NO: 5 ggcggcggcggcagcggcggcggcggcagcggcggcggcggcagcctggg cgatccgaacagcggctgccgcggcgataaaggcccgga ttgctaa CDD: SEQ ID NO: 6 atgcc ctccaaatcc ttggttatgg aatatttggc tcatcccagt acactcggcttggctgttgg agttgcttgt ggcatgtgcc tgggctggag ccttcgagta tgctttgggatgctccccaa aagcaagacg agcaagacac acacagatac tgaaagtgaa gcaagcatcttgggagacag c

In some embodiments, the at least one bacterial cell comprises SEQ ID NO:7 or a nucleci acid sequence 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98%, or 99% homolgous to SEQ ID NO:7.

SEQ ID NO: 7 is plasmid pB33eCPX-NC-IRGD gcaaactattaactggcgaactacttactctagcttcccggcaacaatta atagactggatggaggcggataaagttgcaggaccacttctgcgctcggc ccttccggctggctggtttattgctgataaatctggagccggtgagcgtg ggtctcgcggtatcattgcagcactggggccagatggtaagccctcccgt atcgtagttatctacacgacggggagtcaggcaactatggatgaacgaaa tagacagatcgctgagataggtgcctcactgattaagcattggtaactgt cagaccaagtttactcatatatactttagattgatttacgcgccctgtag cggcgcattaagcgcggcgggtgtggtggttacgcgcagcgtgaccgcta cacttgccagcgccctagcgcccgctcctttcgctttcttcccttccttt ctcgccacgttcgccggctttccccgtcaagctctaaatcgggggctccc tttagggttccgatttagtgctttacggcacctcgaccccaaaaaacttg atttgggtgatggttcacgtagtgggccatcgccctgatagacggttttt cgccctttgacgttggagtccacgttctttaatagtggactcttgttcca aacttgaacaacactcaaccctatctcgggctattcttttgatttataag ggattttgccgatttcggcctattggttaaaaaatgagctgatttaacaa aaatttaacgcgaattttaacaaaatattaacgtttacaatttaaaagga tctaggtgaagatcctttttgataatctcatgaccaaaatcccttaacgt gagttttcgttccactgagcgtcagaccccgtagaaaagatcaaaggatc ttcttgagatcctttttttctgcgcgtaatctgctgcttgcaaacaaaaa aaccaccgctaccagcggtggtttgtttgccggatcaagagctaccaact ctttttccgaaggtaactggcttcagcagagcgcagataccaaatactgt ccttctagtgtagccgtagttaggccaccacttcaagaactctgtagcac cgcctacatacctcgctctgctaatcctgttaccagtcaggcatttgaga agcacacggtcacactgcttccggtagtcaataaaccggtaaaccagcaa tagacataagcggctatttaacgaccctgccctgaaccgacgaccgggtc gaatttgctttcgaatttctgccattcatccgcttattatcacttattca ggcgtagcaccaggcgtttaagggcaccaataactgccttaaaaaaatta cgccccgccctgccactcatcgcagtactgttgtaattcattaagcattc tgccgacatggaagccatcacagacggcatgatgaacctgaatcgccagc ggcatcagcaccttgtcgccttgcgtataatatttgcccatggtgaaaac gggggcgaagaagttgtccatattggccacgtttaaatcaaaactggtga aactcacccagggattggctgagacgaaaaacatattctcaataaaccct ttagggaaataggccaggttttcaccgtaacacgccacatcttgcgaata tatgtgtagaaactgccggaaatcgtcgtggtattcactccagagcgatg aaaacgtttcagtttgctcatggaaaacggtgtaacaagggtgaacacta tcccatatcaccagctcaccgtctttcattgccatacggaattccggatg agcattcatcaggcgggcaagaatgtgaataaaggccggataaaacttgt gcttatttttctttacggtctttaaaaaggccgtaatatccagctgaacg gtctggttataggtacattgagcaactgactgaaatgcctcaaaatgttc tttacgatgccattgggatatatcaacggtggtatatccagtgatttttt tctccattttagcttccttagctcctgaaaatctcgataactcaaaaaat acgcccggtagtgatcttatttcattatggtgaaagttggaacctcttac gtgccgatcaacgtctcattttcgccaaaagttggcccagggcttcccgg tatcaacagggacaccaggatttatttattctgcgaagtgatcttccgtc acaggtatttattcggcgcaaagtgcgtcgggtgatgctgccaacttact gatttagtgtatgatggtgtttttgaggtgctccagtggcttctgtttct atcagctgtccctcctgttcagctactgacggggtggtgcgtaacggcaa aagcaccgccggacatcagcgctagcggagtgtatactggcttactatgt tggcactgatgagggtgtcagtgaagtgcttcatgtggcaggagaaaaaa ggctgcaccggtgcgtcagcagaatatgtgatacaggatatattccgctt cctcgctcactgactcgctacgctcggtcgttcgactgcggcgagcggaa atggcttacgaacggggcggagatttcctggaagatgccaggaagatact taacagggaagtgagagggccgcggcaaagccgtttttccataggctccg cccccctgacaagcatcacgaaatctgacgctcaaatcagtggtggcgaa acccgacaggactataaagataccaggcgtttccccctggcggctccctc gtgcgctctcctgttcctgcctttcggtttaccggtgtcattccgctgtt atggccgcgtttgtctcattccacgcctgacactcagttccgggtaggca gttcgctccaagctggactgtatgcacgaaccccccgttcagtccgaccg ctgcgccttatccggtaactatcgtcttgagtccaacccggaaagacatg caaaagcaccactggcagcagccactggtaattgatttagaggagttagt cttgaagtcatgcgccggttaaggctaaactgaaaggacaagttttggtg actgcgctcctccaagccagttacctcggttcaaagagttggtagctcag agaaccttcgaaaaaccgccctgcaaggcggttttttcgttttcagagca agagattacgcgcagaccaaaacgatctcaagaagatcatcttattaatc agataaaatatttgctcatgagcccgaagtggcgagcccgatcttcccca tcggtgatgtcggcgatataggcgccagcaaccgcacctgtggcgccggt gatgccggccacgatgcgtccggcgtagaggatctgctcatgtttgacag cttatcatcgatgcataatgtgcctgtcaaatggacgaagcagggattct gcaaaccctatgctactccgtcaagccgtcaattgtctgattcgttacca attatgacaacttgacggctacatcattcactttttcttcacaaccggca cggaactcgctcgggctggccccggtgcattttttaaatacccgcgagaa atagagttgatcgtcaaaaccaacattgcgaccgacggtggcgataggca tccgggtggtgctcaaaagcagcttcgcctggctgatacgttggtcctcg cgccagcttaagacgctaatccctaactgctggcggaaaagatgtgacag acgcgacggcgacaagcaaacatgctgtgcgacgctggcgatatcaaaat tgctgtctgccaggtgatcgctgatgtactgacaagcctcgcgtacccga ttatccatcggtggatggagcgactcgttaatcgcttccatgcgccgcag taacaattgctcaagcagatttatcgccagcagctccgaatagcgccctt ccccttgcccggcgttaatgatttgcccaaacaggtcgctgaaatgcggc tggtgcgcttcatccgggcgaaagaaccccgtattggcaaatattgacgg ccagttaagccattcatgccagtaggcgcgcggacgaaagtaaacccact ggtgataccattcgcgagcctccggatgacgaccgtagtgatgaatctct cctggcgggaacagcaaaatatcacccggtcggcaaacaaattctcgtcc ctgatttttcaccaccccctgaccgcgaatggtgagattgagaatataac ctttcattcccagcggtcggtcgataaaaaaatcgagataaccgttggcc tcaatcggcgttaaacccgccaccagatgggcattaaacgagtatcccgg cagcaggggatcattttgcgcttcagccatacttttcatactcccgccat tcagagaagaaaccaattgtccatattgcatcagacattgccgtcactgc gtcttttactggctcttctcgctaaccaaaccggtaaccccgcttattaa aagcattctgtaacaaagcgggaccaaagccatgacaaaaacgcgtaaca aaagtgtctataatcacggcagaaaagtccacattgattatttgcacggc gtcacactttgctatgccatagcatttttatccataagattagcggatcc tacctgacgctttttatcgcaactctctactgtttctccatacccgtttt tttgggctagcgaattcgagctcggtacctttgaggtggttatgaaaaaa attgcatgtctttcagcactggccgcagttctggctttcaccgcaggtac ttccgtagctggccagtctggccagtgtcgtggtgataaacgtggtcctg atgaatgtggagggcagtctgggcagtctggtgactacaacaaaaaccag tactacggcatcactgctggtccggcttaccgcattaacgactgggcaag catctacggtgtagtgggtgtgggttatggtaaattccagaccactgaat acccgacctacaaacacgacaccagcgactacggtttctcctacggtgcg ggtctgcagttcaacccgatggaaaacgttgctctggacttctcttacga gcagagccgtattcgtagcgttgacgtaggcacctggattttgtctgttg gttaccgcttcgggagtaaatcgcgtcgcgcgacttctactgtaactggc ggttacgcacagagcgacgctcagggccaaatgaacaaaatgggcggttt caacctgaaataccgctatgaagaagacaacagcccgctgggtgtgatcg gttctttcacttacaccgagaaaagccgtactgcaagctgtcgtggtgat aaacgtggtcctgatgaatgttaataaggccaaggtggccaagcttggct gttttggcggatgagagaagattttcagcctgatacagattaaatcagaa cgcagaagcggtctgataaaacagaatttgcctggcggcagtagcgcggt ggtcccacctgaccccatgccgaactcagaagtgaaacgccgtagcgccg atggtagtgtggggtctccccatgcgagagtagggaactgccaggcatca aataaaacgaaaggctcagtcgaaagactgggcctttcgttttatctgtt gtttgtcggtgaacgctctcctgagtaggacaaatccgccgggagcggat ttgaacgttgcgaagcaacggcccggagggtggcgggcaggacgcccgcc ataaactgccaggcatcaaattaagcagaaggccatcctgacggatggcc tttttgcgtttctacaaactcttttgtttatttttctaaatacattcaaa tatgtatccgctcatgagacaataaccctgataaatgcttcaataatatt gaaaaaggaagagtatgagtattcaacatttccgtgtcgcccttattccc ttttttgcggcattttgccttcctgtttttgctcacccagaaacgctggt gaaagtaaaagatgctgaagatcagttgggtgca The restriction map of SEQ ID NO:7 is depicted in FIG. IB.

Example 2

Synthetic biology seeks to add controlled and dynamic production of cargo by utilizing computationally-designed “circuits” that have sophisticated sensing and delivery capability. These circuits can be designed to act as delivery systems that sense tumor-specific stimuli and self-regulate cargo production as accessary. Since plasmids are the common framework for synthetic circuits, we begin by characterizing the dynamics of plasmid-based gene expression in an in vivo mouse model by utilizing real-time luminescence imaging, quantitative biodistribution measurement, and computational modeling. Together, these approaches provide a framework for exploiting the inherent instability of plasmid-based networks, which will facilitate the generation of specific temporal release profiles directly within the tumor environment.

In the context of drug delivery, a critical parameter is the rate at which a device releases drug into the surrounding environment. For instance, materials have been investigated that generate “burst”, “delayed”, or “sustained” release characteristics. The transient plasmid-based system we have developed here can generate a similar variety of expression dynamics. For instance, Strain A produces an expression profile analogous to, burst release due to its fast growth rate and high rate of plasmid loss. In contrast, Strain B yields a sustained release profile owing to its slow growth rate and moderate rate of plasmid loss. Bacteria are unique in the context of drug-delivery vehicles in that they produce their own cargo, in contrast to other devices that are pre-loaded and depleted. This allows them to deliver a time-varying concentration of cargo in a designed profile directly on site. In the future, this work will enable a variety of drug-release profiles from engineered bacteria for therapeutic applications.

Developing both experimental and computational techniques in concert will be critical to engineering in vivo genetic circuits. Computational modeling can rapidly probe system parameters to explore potential outputs but must remain closely tied to experimental results to remain relevant. On the other hand, in vivo experiments present the most direct application of engineered circuits, but involve long timescales and the results often difficult to interpret. Here, we have utilized plasmid instability to generate transient expression profiles in tumor environments. In our computational model, we can predict how dosage, strain growth rate, and plasmid loss rate combine to yield differing expression dynamics. Then, these designs can be implemented experimentally by varying plasmid type, copy number, and maintenance system or by modifying the strain growth rate. Building on this platform, future applications will include engineered gene circuits that further extend the range of expression dynamics, sensing tumor-specific stimuli and self-regulating cargo production.

Materials and Methods

S. typhimurium strains Strain A (SL1344 PhoPQ-) and Strain B (SL1344 PhoPQ- aroA-) were provided by Elizabeth Hohmann (MGH) ([10]). The constitutive plasmid bearing luxCDABE genes was received as a gift ([12]). On the day of injection, bacteria containing plasmids were diluted 1/1000× into fresh LB media (Difco, 0.22 um filtered) with antibiotics (Ampicillin 100 ug/mL) and grown up to OD600=0.4-0.6. Cells were then prepared by washing 4 times with PBS (0.22 um filtered) and measured for OD₆₀₀. Colony counts were performed on the preparation as a calibration and cells were prepared at various concentrations for 100 μL injections.

Subcutaneous human xenograft tumors were generated by injecting 5×10⁶ OVCAR-8 cells (NCI DCTD Tumor Repository, Frederick, Md.) bilaterally into the hind flanks of 4-week old female Ncr/Nu mice. Cells were grown to 80-100% confluency in RPMI1640 media supplemented with 10% fetal bovine serum and antibiotics (100 I.U./mL penicillin and 100 μg/mL streptomycin) before injection. Cells were pelleted, resuspended in phenol, red-free DMEM with 15% reduced growth factor Matrigel (BD Biosciences). Tumors were allowed to grow for 10-20 days until tumor diameters of 200-400 mm were reached.

Colony counts were measured by dissecting tumors and organs from mice, homogenizing using a Tissue-Tearor (BioSpec), and plating serial dilutions on LB and LB Ampicillin plates. Prior to imaging, mice were anesthetized with 2-3% isoflurane. IVIS signals were measured using the IVIS Spectrum imaging system (Caliper Life Sciences) with 1-60 second exposure times, and Living Image software (Caliper Life Sciences) was used for analysis. Data where the tumor had ulcerated or had low signal (maximum of trajectory did not reach above 10⁶ radiance, or approximately 5-10× initial background) were not included.

In FIG. 2: Tumor homing bacteria and dosage variation, (a) S. typhimurium are injected via tail-vein into nude mice and localize to subcutaneous tumors where they replicate, (b) Dosages between 10⁴ and 5×10⁶ bacteria are injected into mice and IVIS images were taken after 24 hours. Higher initial dosages show an increasing signal and a minimum value of 5×10⁵ bacteria required to visualize tumor colonization at 24 hours, (c) Sequence of TVTS images for strain Strain A at 10⁶ dosage over the course of 60 hours, (d) Total flux of left (light grey) and right (dark grey) tumors as a function of time normalized to the maximum value across the trajectory. The IVIS signal rises due to rapid bacterial growth and then decays due to plasmid loss and luciferase instability.

These circuits can be designed to act as delivery systems that sense tumor-specific stimuli and self-regulate cargo production as accessary. Since plasmids are the common framework for synthetic circuits, we begin by characterizing the dynamics of plasmid-based gene expression in an in vivo mouse model by utilizing real-time luminescence imaging, quantitative biodistribution measurement, and computational modeling. Together, these approaches provide a framework for exploiting the inherent instability of plasmid-based networks, which will facilitate the generation of specific temporal release profiles directly within the tumor environment.

We began by transforming two different attenuated strains of S. typhimurium with a constitutively expressed luciferase (luxCDABE) plasmid to allow for real-time monitoring of luminescence with an in vivo imaging system (IVIS). Strain A (ELH430:SL1344 phoPQ-) is attenuated for the PhoPQ regulon which is known to activate a number of genes related to virulence while Strain B (ELH1301:SL1344 phoPQ-aroA-) contains an additional aromatic amino acid synthesis mutation which effectively allows it to grow only in nutrient-rich environments. Importantly, while these strains are derived from the same parent (SL1344), their growth rates, and therefore plasmid-loss characteristics, differ significantly. To investigate the in vivo gene expression dynamics of these strains, we generated model xenograft tumors in mice by subcutaneous injection of a human ovarian cancer cell line (OVCAR-8). After measurable tumors were established, bacterial strains were injected intravenously via tail vein (FIG. 2 A) with dosages varying from 10⁴ to 5×10⁶ bacteria. Once injected, bacteria specifically colonized tumors at a rate proportional to the dosage administered, as measured by IVIS signal at 24 hours post-injection (FIG. 2B).

We then monitored tumor signal over the course of 60 hours using time-lapse IVIS imaging (FIG. 2C,D). These trajectories followed the specific pattern of an initial steep increase followed by a gradual decrease back to baseline (FIG. 2D). We hypothesized that this waveform was the result of the initial exponential growth of plasmid-containing bacteria followed by increasing rates of plasmid loss in the absence of antibiotic selection. Eventually, the rate of luciferase production by the remaining plasmid-containing bacteria is overtaken by luciferase decay, and signal begins to decline. To test this hypothesis, we counted the number of plasmid-containing and non-plasmid containing bacteria in tumors over time by observing bacterial growth on selective media. FIG. 3:

Characterization of Strain A and Strain B IVIS Profiles.

Each measurement was compared to counts taken in the spleen, a control tissue where there is a stable sub-population as the bacteria accumulate but do not grow or die. At each time point, organs were excised from the mouse and then homogenized and plated with or without antibiotic selection (FIG. 3A, n=3-5 tumors). Colony counting on these plates yielded an accurate measure of the plasmid-state of the bacterial population over time (FIG. 3B). After 2 hours, roughly 3×10³ plasmid-containing bacteria reside in the tumor, or about 0.3% of the injected dose. After 12 hours, plasmid-containing bacteria grow to a level of 10⁶, and the number of non plasmid-containing bacteria reaches a similar level. This corresponds to a doubling time of approximately 75 minutes. Growth rate declined further over time, presumably due to nutrient limitation, ultimately resulting in a 300 minute doubling time for non-plasmid containing bacteria (FIG. 3B).

While the total population of bacteria grew throughout the course of the experiment (60 hours), the number of plasmid-containing bacteria reaches a maximum at 24 hours (FIG. 3B). By taking the ratio of these populations, we can calculate the percentage of plasmid-containing bacteria over time (FIG. 3C). After 12 hours, roughly 50% of the population retains the plasmid, a fraction that drops to 10% after 24 hours (FIG. 3C). The slope of this line remains constant throughout the 60-hour experiment and represents the rate of plasmid loss in the tumor environment.

The tumor-spleen ratio is commonly reported as a characteristic measure of specificity and tumor-homing ability for a given strain. Bacteria accumulate in the spleen from the initial dosing yet do not subsequently grow and divide. Given that we observed essentially no increase in the bacterial count in the spleen throughout the duration of our experiments, the tumor-spleen ratio increased over time (FIG. 3D). Since this ratio is typically reported as a fixed number in the literature, its time-dependence may help to explain the wide range of reported values.

Example 3

Modeling Bacterial Dynamics Inside of Tumor Environments

The tumor-spleen ratio is commonly reported as a characteristic measure of specificity and tumor-homing ability for a given strain. Bacteria accumulate in the spleen from the initial dosing yet do not subsequently grow and divide. Given that we observed essentially no increase in the bacterial count in the spleen throughout the duration of our experiments, the tumor-spleen ratio increased over time (FIG. 3d ). Since this ratio is typically reported as a fixed number in the literature, its time-dependence may help to explain the wide range of reported values. To explore how bacterial growth rate affects the dynamics of plasmid instability over time, we injected two groups of mice with Strain A and B (at a dosage of 10⁶) and monitored their signal over the course of 60 h. The two strains displayed markedly different profiles, with Strain A peaking and decaying sharply and the slower growing Strain B peaking broadly over a longer period of time before decaying (FIG. 4a,4b ). We plot the average trajectories for Strains A and B on an absolute luminescence scale in FIG. 4c for comparison. To quantify these differences, we measured the width at half-maximum and total area under each curve for the average trajectories (FIG. 4d ). These measurements illustrate that Strain A produces more luminescence quickly while Strain B produces less luminescence over a longer period of time (FIG. 4d ). Additionally, to confirm that signal intensity is a representative measure of the population of plasmid-containing bacteria, we compared counts of antibiotic resistant bacteria with absolute IVIS values at the 72-h time point and found them to be highly correlated (R=0.832).

Developing a fully tunable dynamic expression platform will require a more complete understanding of the underlying processes. Plasmid-loss dynamics have been well described in a variety of in vitro and in vivo contexts; however, modeling of population or gene-expression dynamics has not yet been studied for in vivo tumor environments. Specifically, we hope to learn how expression dynamics are dictated by the rates of growth and plasmid-loss for a given strain. To accomplish this, we developed an ordinary differential equation (ODE) model describing internal plasmid and non-plasmid-containing bacteria and their respective expression of luciferase signal (FIG. 5a ). Initially, No bacteria are injected. These plasmid-containing bacteria replicate and lose their plasmids at rate x, resulting in populations of plasmid (N⁺) and non-plasmid (N) containing bacteria that continue to grow at rates μ+ and μ−, respectively (FIG. 5a ). Both populations grow exponentially for 24 h until available nutrients become limiting, a process modeled by including a finite quantity of tumor substrate that is consumed according to Michaelis-Menten kinetics. The tumor environment is also spatially restrictive of bacterial growth, with bacteria in the center consuming nutrients more slowly than bacteria on the rapidly growing periphery. Thus, despite a nearly constant population of plasmid-containing bacteria, TVTS signal fails to increase after 24 h since most of these bacteria reside in the non-growing center of the colony. We accounted for this behavior by limiting the amount of bacteria that can consume the tumor substrate, which effectively limits plasmid-containing bacterial growth and allows luciferase decay to dominate.

Our ODE model produced dynamics that were consistent with our experimental observations, where IVIS signal is taken to be proportional to the plasmid-containing population (FIG. 5b ). We define the full-width at half-maximum, co, and area under the curve as important parameters that characterize the duration and magnitude of dosage, respectively (FIG. 5 c). To understand how to tune in vivo expression profiles according to these parameters, we varied growth rate and dosage level and modeled the effects on IVIS signal in each case (FIGS. 5d, 5e, 5f, 5g and 5h, 5i, 5j, 5k ). Lower growth rates yield IVIS curves that are shifted toward later times with broader widths and lower areas (FIG. 5d, 5e, 5f, 5g ). In contrast, larger initial dosages result in a linear increase of IVIS signal that increases area but does not alter the width (FIG. 5h, 5i, 5j, 5k ). The latter linear increase in area as a function of dosage is reflective of doses much lower than the carrying capacity of the system. Finally, decreasing the plasmid-loss rate resulted in an increase in area under the curve as well as a slight shift in the width and time to peak of the gene expression profile.

These effects correlate with experimental observations that can be explained based on differences in strain growth rate. Since plasmids are lost during cell division, the faster a cell replicates, the more frequently it loses plasmid. Thus, the faster growing Strain A accumulates luciferase quickly but loses a comparatively larger fraction of plasmids per day, resulting in higher IVIS values that peak at earlier time points than Strain B (FIG. 4a,b ). In contrast, Strain B grows more slowly, producing less luciferase but maintaining its plasmids much longer, yielding a broader expression profile compared to Strain A (FIG. 4a,b ).

In the context of drug delivery, a critical parameter is the rate at which a device releases drug into the surrounding environment. For instance, materials have been investigated that generate “burst”, “delayed”, or “sustained” release characteristics. The transient plasmid-based system we have developed here can generate a similar variety of expression dynamics. For instance, Strain A produces an expression profile analogous to burst release due to its fast growth rate and high rate of plasmid loss. In contrast, Strain B yields a sustained release profile owing to its slow growth rate and moderate rate of plasmid loss. Bacteria are unique in the context of drug-delivery vehicles in that they produce their own cargo, in contrast to other devices that are preloaded and depleted. This difference allows them to deliver a time-varying concentration of cargo in a designed profile directly on site. In the future, this work will enable a variety of drug-release profiles from engineered bacteria for therapeutic applications.

Developing both experimental and computational techniques in concert will be critical to engineering in vivo genetic circuits. Computational modeling can rapidly probe system parameters to explore potential outputs but must remain closely tied to experimental results to remain relevant. On the other hand, in vivo experiments present the most direct application of engineered circuits, but involve long time scales and the results are often difficult to interpret. Here, we have utilized plasmid instability to generate transient expression profiles in tumor environments. In our computational model, we can predict how dosage, strain growth rate, and plasmid loss rate combine to yield differing expression dynamics. Subsequently, these designs can be implemented experimentally by varying plasmid type, copy number, and maintenance system or by modifying the strain growth rate. Building on this platform, future applications will include engineered gene circuits that further extend the range of expression dynamics, sensing tumor-specific stimuli and self-regulating cargo production.

Computational models are further explained by way of functions that can be used to determine rate of plasmid loss in a function of concentration of substrate for bacterial growth. Our ordinary differential equation model is presented below in non-dimensional form. The model describes the dynamics of two populations of bacteria, those containing the luminescent plasmid (n+) and those who have lost the plasmid (n−). The two populations grow inside the tumor environment and consume a substrate (S) which is in limited supply.

$\begin{matrix} {\frac{{dn}^{+}}{dt} = {{\left( {1 - \tau} \right)\mu^{+}n^{+}} - {\gamma \text{?}}}} & (1) \\ {\frac{{dn}^{-}}{dt} = {{\mu^{-}n^{-}} + {\tau \text{?}}}} & (2) \\ {\frac{dS}{dt} = {- {\left\lbrack {\frac{\mu^{- n^{-}}}{A^{-}} - \frac{\mu^{+}n^{+}}{A^{+}}} \right\rbrack \left\lbrack \frac{1}{1 + {q \cdot \left( {n_{-} + n_{+}} \right)}} \right\rbrack}}} & (3) \\ {{{\mu^{-} = {{\frac{\mu_{\max}^{+}S}{K + S}\mspace{20mu} \mu^{-}} = \frac{\mu_{\max}^{-}S}{K + S}}}{\text{?}\text{indicates text missing or illegible when filed}}}\mspace{284mu}} & (4) \end{matrix}$

The parameters above are x, the rate at which cells lose plasmid, (μ+max and μ−max, the maximal growth of plasmid and non-plasmid containing cells respectively. K, the Michaelis-saturation constant of growth rate, A+ and A−, the depletion rate constants of substrate S by μ+ and μ−cells. γ+ and γ−, the death rates of the bacteria, and q, the rate at which tumor substrate depletion is limited by the maximal amount of cells. This last term is to account for the fact that a limited number of bacteria (those on the outward growing rim) can contribute to the decay of the tumor substrate. The model is non-dimensionalized by hours, 1 bacteria, and a substrate concentration of μM.

The total in vivo system (IVIS) signal is reflective of the number of luciferase enzymes and hence the number of actively expressing luciferase bacteria. As an approximation to this signal, we modeled the signal to be proportional to the number of plasmid containing cells (dominant contribution to the IVIS signal) minus the first-order decay of the luciferase enzyme. We assume that each bacterium containing a plasmid contributes equally to the IVIS signal although there is likely variability due to the distribution of plasmids per cell in a population as well as contributions from non-plasmid containing bacteria where luciferase is not yet significantly diluted. Another approximation in the IVIS signal arises in that plasmid-containing bacteria initially populate the tumor core and express luciferase, but as bacteria grow radially to a larger population, less nutrients are left for the bacteria in the center to express any of the luxCDABE genes (either luciferase or luciferin substrates), which are the main contributors to the IVIS signal. This results in colony counts reaching a nearly steady-state as a function of time but expression level plateauing, causing an decay in IVIS signal due luciferase instability. The rate of change of the luciferase enzymes is given by:

$\frac{d\; L}{dt} - {Bn} + \mu + \left( {1 - \tau - \gamma + {/\mu} +} \right) - {\gamma_{L}L}$

where B represents the number of rate of expression of luciferase per cell and gL represents the luciferase decay. The IVIS signal (I) is proportional to the luciferase signal, i.e., I=xL, which scales parameters B and γL accordingly. The value of k contains physical properties 1 such as the permitivity of skin to luciferase enzymes and number of photons emitted per enzyme. The lumped parameters chosen for the data presented in FIGS. 9A, 9B, and 9C are: t=0.2, kB=10, A+=A−=0.01, K=1000, kgL=0.3, g−=0.001, g+=0.075, q=1.6 with initial conditions n+=3365, n=0.1=0, S=1000. Supplementary FIG. 9 shows the substrate (all of Eq 3), growth rate for plasmid containing cells (Eq 4, light grey), and substrate limitation function (right bracket Eq 3, dark grey) as a function of time.

Example 4

Dose limiting toxicity of bacterial therapies is considered to be an important factor which limits the ability of bacteria to colonize tumors. Here we constructed a plasmid which expresses iRGD, a peptide known to internalize or internalize conjugated nanoparticles into tumors. We genetically expressed iRGD as a fusion to a receptor of an outer-membrane protein known as eCPX at both the N and C terminus. The expression of eCPX-iRGD depicted in Figure IB is controlled by induction with arabinose, which allows us to tune the level of iRGD expressed on the surface of the bacterial cells.

FIG. 7 depicts IVIS imaging of mice bearing subcutaneous ovarian cancer cell lines that have been injected with 1×10⁶ bacteria. Bacteria were grown in different concentrations of arabinose beforehand, giving the bacteria different levels of expression of eCPX-iRGD on their outer surfaces. An 8× increase is shown when an optimal level of arabinose is induced. This experiment demonstrates that cancer cell toxicity can be induced and controlled by tuning the bacteria with a stimulus after transformation of a plasmid with an inducible promoter.

Quorum Sensing bacteria injected intravenously into nude mice bearing OVCAR-8 xenograft hind flank tumors at a concentration of 1×10⁶ bacteria comprising the pTD106CDD plasmid construct (FIG. 1 A) are depicted in FIG. 6. A patchy spatial pattern is seen for luciferase expression from quorum sensing, due to the QS system only turning on in the densest parts of the tumor. In comparison the constitutively expressing luciferase plasmid appears to be more uniform. Using quorum sensing inhibitors in the drinking water for mice, we've seen that no luciferase expression appears, while adding AHL, a quorum sensing inducer, can shift the pattern from patchy to uniform.

FIG. 8 depicts signal intensity from therapeutic effect of quorum sensing circuit. After 1 day, the relative tumor size is measured by IVIS imaging. Using our pTD106CDD construct, we've shown quorum sensing prevents increase of the tumor size. Inducing our pTD106CDD system with AHL, we see a decrease in tumor size, indicating stronger expression. As controls, tumors with either no bacteria or no therapeutic continue to grow, the bacterial cells described in FIG. 6.

Programming drug expression and release can lead to more efficacious and safe therapies from live bacteria or other vectors. Here we employed a quorum sensing approach as an example of how programming bacteria can make improvements over current methods. Quorum sensing (QS) is a system bacteria use to trigger behavior when a colony reaches a certain level. We programmed our bacteria to produce a therapeutic called CDD, Cell Death Domain, which is a previously known peptide that causes cell death by apoptosis, upon reaching a quorum. CDD is a toxic peptide that would not be possible to administer systemically, thus a programmed delivery vehicle would be necessary to get it to the tumor. Our QS system ensures that many bacteria have to be present to produce CDD, and since bacterial therapies can have bacteria lodged in other organs, this allows for only the high concentration of bacteria seen in the tumor to produce CDD locally in the tumor, reducing systemic side effects. In addition, QS produces drugs with a different dynamical program, which is more in a burst fashion, while previous methods only used a constitutive always-ON method of production. This can potentially have implications in generating less drug resistance, since longer, constant exposures to a drug often lead to tumor drug resistance.

TABLE 1 Genus: Salmonella bongori Salmonella enterica subsp. enterica serovar 1,4,(5),12:i:- Salmonella bongori N268-08 Salmonella enterica subsp. enterica serovar 3,10:e,h:- Salmonella bongori NCTC 12419 Salmonella enterica subsp. enterica serovar 3,10:l,v:e,n,x Salmonella bongori serovar 40:z35:- Salmonella enterica subsp. enterica serovar 4,12:-:- Salmonella bongori serovar 40:z35:- str. 95-0123 Salmonella enterica subsp. enterica serovar 4,1 2:a:- Salmonella bongori serovar 48:i:- Saimoneiia enterica subsp. enterica serovar 4,12:i:- Salmonella bongori serovar 48:z35:- Salmonella enterica subsp. enterica serovar 4,12:r:- Salmonella bongori serovar 48:z41:— Salmonella enterica subsp. enterica serovar 4,5,12:b:- Salmonella bongori serovar 48:z41:— str. RKS3044 Salmonella enterica subsp. enterica serovar 4 [5],12:i:- Salmonella bongori serovar 60:z41:- Salmonella enterica subsp. enterica serovar 4,[5],12:r:- Salmonella bongori serovar 66:z35:- Salmonella enterica subsp. enterica serovar 4,[5]:b:- Salmonella bongori serovar 66:z41:- Salmonella enterica subsp. enterica serovar 6,7:-:- Salmonella bongori serovar 66:z41:- str. SA19983605 Salmonella enterica subsp. enterica serovar 6,7:-:1,5 Salmonella enterica Salmonella enterica subsp. enterica serovar 6,7:-:l,w Salmonella enterica subsp. arizonae Salmonella enterica subsp. enterica serovar 6,7:d:- Salmonella enterica subsp. arizona serovar Untypable str. 73711 Salmonella enterica subsp. enterica serovar 6,7:k:- Salmonella enterica subsp. arizonae serovar 17:z29:- Salmonella enterica subsp. enterica serovar 6,7:l,v:- Salmonella enterica subsp. arizonae serovar 18:z4,z23:- Salmonella enterica subsp. enterica serovar 8,(20):-:z6 Salmonella enterica subsp. arizonae serovar 41:z4,z23:- Salmonella enterica subsp. enterica serovar 8,(20):i:- Salmonella enterica subsp. arizonae serovar 48:z4,z23:- Salmonella enterica subsp. enterica serovar 9,12:-:- Salmonella enterica subsp. arizonae serovar 53:-:- Salmonella enterica subsp. enterica serovar 9,12:l,v:- Salmonella enterica subsp. arizonae serovar 53:g,z51:- Salmonella enterica subsp. enterica serovar Abaetetuba Salmonella enterica subsp. arizonae serovar 56:z4,z23:- Salmonella enterica subsp. enterica serovar Aberdeen Salmonella enterica subsp. arizonae serovar 62:z36:- Salmonella enterica subsp. enterica serovar Abony Salmonella enterica subsp. arizonae serovar 62:z4,z23:- Salmonella enterica subsp. enterica serovar Abortus Salmonella enterica subsp. arizonae str. SARC 5 Salmonella enterica subsp. enterica serovar Abortusequi Salmonella enterica subsp. diarizonae Salmonella enterica subsp. enterica serovar Abortusovis Salmonella enterica subsp. diarizonae serovar ‘OMG’ l,v:l,5 Salmonella enterica subsp. enterica serovar Adelaide Salmonella enterica subsp. diarizonae serovar 35:i:z35 Salmonella enterica subsp. enterica serovar Aesch Salmonella enterica subsp. diarizonae serovar 38:z10:z53 Salmonella enterica subsp. enterica serovar Agama Salmonella enterica subsp. diarizonae serovar 38[k]:z35:- Salmonella enterica subsp. enterica serovar Agona Salmonclla enterica subsp. diarizonae serovar 42:l,v:l,5,7 Salmonella enterica subsp. enterica serovar Alabama Salmonella enterica subsp. diarizonae serovar 42:l,v:e,n,x,z15 Salmonella enterica subsp. enterica serovar Alachua Salmonella enterica subsp. diarizonae serovar 47:k:z35 Salmonella enterica subsp. enterica serovar Albany Salmonella enterica subsp. diarizonae serovar 47:l,v ‘HMG’ Salmonella enterica subsp. enterica serovar Altona Salmonella enterica subsp. diarizonae serovar 47:l,v:l,5,(7) Salmonella enterica subsp. enterica serovar Amsterdam Salmonella enterica subsp. diarizonae serovar 48:i:z Salmonella enterica subsp. enterica serovar Anatum Salmonella enterica subsp. diarizonae serovar 48:k:z35 Salmonella enterica subsp. enterica serovar Ank Salmonella enterica subsp. diarizonae serovar 50:l,2,3:k:z Salmonella enterica subsp. enterica serovar Antsalova Salmonella enterica subsp. diarizonae serovar 50:k:z Salmonella enterica subsp. enterica serovar Apapa Salmonella enterica subsp. diarizonae serovar 50:l,v:e,n,x,z15 Salmonella enterica subsp. enterica serovar Aqua Salmonella enterica subsp. diarizonae serovar 50:r:l,5 Salmonella enterica subsp. enterica serovar Arechavaleta Salmonella enterica subsp. diarizonae serovar 58:z52:z35 Salmonella enterica subsp. enterica serovar Arizona Salmonella enterica subsp. diarizonae serovar 59:zl0:- Salmonella enterica subsp. enterica serovar Augustenborg Salmonella enterica subsp. diarizonae serovar 59:zl0:z53 Salmonella enterica subsp. enterica serovar Austin Salmonella enterica subsp. diarizonae serovar 60:r:e,n,x,zl5 Salmonella enterica subsp. enterica serovar Azteca Salmonella enterica subsp. diarizonae serovar 60:r:enxzl5 Salmonella enterica subsp. enterica serovar Baildon Salmonella enterica subsp. diarizonae serovar 60:z52:l,5 Salmonella enterica subsp. enterica serovar Banana Salmonella enterica subsp. diarizonae serovar 60:z55:e,n,x Salmonella enterica subsp. enterica serovar Bangkok Salmonella enterica subsp. diarizonae serovar 61:-:1,5,7 Salmonella enterica subsp. enterica serovar Bangui Salmonella enterica subsp. diarizonae serovar 61:c:l,5,(7) Salmonella enterica subsp. enterica serovar Bardo Salmonella enterica subsp. diarizonae serovar 61:k:l,5,7 Salmonella enterica subsp. enterica serovar Bareilly Salmonella enterica subsp. diarizonae serovar 61:k:l,5,77 Salmonella enterica subsp. enterica serovar Barranquilla Salmonella enterica subsp. diarizonae serovar 65:c:l,5,7 Salmonella enterica subsp. enterica serovar Bergen Salmonella enterica subsp. diarizonae serovar 65:c:z Salmonella enterica subsp. enterica serovar Berta Salmonella enterica subsp. diarizonae serovar 061:k:l,5 Salmonella enterica subsp. enterica serovar Binza Salmonella enterica subsp. diarizonae str. 01-005 Salmonella enterica subsp. enterica serovar Bispebjerg Salmonella enterica subsp. diarizonae str. 36806 Salmonella enterica subsp. enterica serovar Bissau Salmonella enterica subsp. diarizonae str. ATCC BAA-1579 Salmonella enterica subsp. enterica serovar Blegdam Salmonella enterica subsp. enterica str. 77231 Salmonella enterica subsp. enterica serovar Blockley Salmonella enterica subsp. enterica Salmonella enterica subsp. enterica serovar Bonaricnsis Salmonella enterica subsp. enterica serovar ‘02-6026 18:1 v-z- Salmonella enterica subsp. enterica serovar Bonn Arizona’ Salmonella enterica subsp. enterica serovar Borreze Saimoneila enterica subsp. enterica serovar Bovismorbificans Salmonella enterica subsp. enterica serovar Hvittingfoss Salmonella enterica subsp. enterica serovar Braenderup Salmonella enterica subsp. enterica serovar Idikan Salmonella enterica subsp. enterica serovar Brandenburg Salmonella enterica subsp. enterica serovar India Salmonella enterica subsp. enterica serovar Bredeney Salmonella enterica subsp. enterica serovar Indiana Salmonella enterica subsp. enterica serovar Bron Salmonella enterica subsp. enterica serovar Infantis Salmonella enterica subsp. enterica serovar Brunei Salmonella enterica subsp. enterica serovar Inverness Salmonella enterica subsp. enterica serovar Bsilla Salmonella enterica subsp. enterica serovar Isangi Salmonella enterica subsp. enterica serovar Budapest Salmonella enterica subsp. enterica serovar Istanbul Salmonella enterica subsp. enterica serovar Bury Salmonella enterica subsp. enterica serovar Itami Salmonella enterica subsp. enterica serovar California Salmonella enterica subsp. enterica serovar Javiana Salmonella enterica subsp. enterica serovar Canada Salmonella enterica subsp. enterica serovar Jericho Salmonella enterica subsp. enterica serovar Caracas Salmonella enterica subsp. enterica serovar Johannesburg Salmonella enterica subsp. enterica serovar Carrau Salmonella enterica subsp. enterica serovar Kahla Salmonella enterica subsp. enterica serovar Cerro Salmonella enterica subsp. enterica serovar Kedougou Salmonella enterica subsp. enterica serovar Champaign Salmonella enterica subsp. enterica serovar Kentucky Salmonella enterica subsp. enterica serovar Chester Salmonella enterica subsp. enterica serovar Keurmassar Salmonella enterica subsp. enterica serovar Chincol Salmonella enterica subsp. enterica serovar Kiambu Salmonella enterica subsp. enterica serovar Chingola Salmonella enterica subsp. enterica serovar Kiel Salmonella enterica subsp. enterica serovar Choleraesuis Salmonella enterica subsp. enterica serovar Kinshasa Salmonella enterica subsp. enterica serovar Coeln Salmonella enterica subsp. enterica serovar Kintambo Salmonella enterica subsp. enterica serovar Concord Salmonella enterica subsp. enterica serovar Kisangani Salmonella enterica subsp. enterica serovar Coogee Salmonella enterica subsp. enterica serovar Kitenge Salmonella enterica subsp. enterica serovar Copenhagen Salmonella enterica subsp. enterica serovar Kocsscn Salmonella enterica subsp. enterica serovar Corvallis Salmonella enterica subsp. enterica serovar Kottbus Salmonella enterica subsp. enterica serovar Crossness Salmonella enterica subsp. enterica serovar Krefeld Saimoneila enterica subsp. enterica serovar Cubana Salmonella enterica subsp. enterica serovar Kundunchi Salmonella enterica subsp. enterica serovar Dakar Salmonella enterica subsp. enterica serovar Kunzendorf Salmonella enterica subsp. enterica serovar Decatur Salmonella enterica subsp. enterica serovar Lansing Salmonella enterica subsp. enterica serovar Derby Salmonella enterica subsp. enterica serovar Lexington Salmonella enterica subsp. enterica serovar Djakarta Salmonella enterica subsp. enterica serovar Lille Salmonella enterica subsp. enterica serovar Doorn Salmonella enterica subsp. enterica serovar Limete Salmonella enterica subsp. enterica serovar Dowd Salmonella enterica subsp. enterica serovar Lindenburg Salmonella enterica subsp. enterica serovar Dublin Salmonella enterica subsp. enterica serovar Litchfield Salmonella enterica subsp. enterica serovar Duesseldorf Salmonella enterica subsp. enterica serovar Liverpool Salmonella enterica subsp. enterica serovar Duisburg Salmonella enterica subsp. enterica serovar Livingstone Salmonella enterica subsp. enterica serovar Durban Salmonella enterica subsp. enterica serovar Lomita Salmonella enterica subsp. enterica serovar Eastbourne Salmonella enterica subsp. enterica serovar London Salmonella enterica subsp. enterica serovar Edinburgh Salmonella enterica subsp. enterica serovar Macclesfield Salmonella enterica subsp. enterica serovar Emek Salmonella enterica subsp. enterica serovar Madelia Salmonella enterica subsp. enterica serovar Enteritidis Salmonella enterica subsp. enterica serovar Madjorio Salmonella enterica subsp. enterica serovar Epinay Salmonella enterica subsp. enterica serovar Manchester Salmonella enterica subsp. enterica serovar Eschberg Salmonella enterica subsp. enterica serovar Manhattan Salmonella enterica subsp. enterica serovar Essen Salmonella enterica subsp. enterica serovar Maracaibo Salmonella enterica subsp. enterica serovar Etterbeek Salmonella enterica subsp. enterica serovar Maregrosso Salmonella enterica subsp. enterica serovar Farsta Salmonella enterica subsp. enterica serovar Marrtens Salmonella enterica subsp. enterica serovar Fischerhuette Salmonella enterica subsp. enterica serovar Matopeni Salmonella enterica subsp. enterica serovar Fischerkietz Salmonella enterica subsp. enterica serovar Mbandaka Salmonella enterica subsp. enterica serovar Flottbek Salmonella enterica subsp. enterica serovar Mcleagridis Salmonella enterica subsp. enterica serovar Freetown Salmonella enterica subsp. enterica serovar Mgulani Salmonella enterica subsp. enterica serovar Fresno Salmonella enterica subsp. enterica serovar Miami Salmonella enterica subsp. enterica serovar Fulica Salmonella enterica subsp. enterica serovar Michigan Salmonella enterica subsp. enterica serovar Gallinarum Salmonella enterica subsp. enterica serovar Mikawasima Salmonella enterica subsp. enterica serovar Gallinarum/pullorum Salmonella enterica subsp. enterica serovar Milwaukee Salmonella enterica subsp. enterica serovar Gamaba Salmonella enterica subsp. enterica serovar Minneapolis Salmonella enterica subsp. enterica serovar Gaminara Salmonella enterica subsp. enterica serovar Minnesota Salmonella enterica subsp. enterica serovar Garoli Salmonella enterica subsp. enterica serovar Mississippi Salmonella enterica subsp. enterica serovar Gatuni Salmonella enterica subsp. enterica serovar Molade Salmonella enterica subsp. enterica serovar Give Salmonella enterica subsp. enterica serovar Monophasic Saimoneila enterica subsp. enterica serovar Glostrup Salmonella enterica subsp. enterica serovar Monschaui Salmonella enterica subsp. enterica serovar Goettingen Salmonella enterica subsp. enterica serovar Montevideo Salmonella enterica subsp. enterica serovar Goldcoast Salmonella enterica subsp. enterica serovar Moscow Salmonella enterica subsp. enterica serovar Grumpensis Salmonella enterica subsp. enterica serovar Muenchen Salmonella enterica subsp. enterica serovar Gueuletapee Salmonella enterica subsp. enterica serovar Muenster Salmonella enterica subsp. enterica serovar Hadar Salmonella enterica subsp. enterica serovar Mygdal Salmonella enterica subsp. enterica serovar Haifa Salmonella enterica subsp. enterica serovar Naestved Salmonella enterica subsp. enterica serovar Hartford Salmonella enterica subsp. enterica serovar Napoli Salmonella enterica subsp. enterica serovar Havana Salmonella enterica subsp. enterica serovar Nchanga Salmonella enterica subsp. enterica serovar Heidelberg Salmonella enterica subsp. enterica serovar Neukoelln Salmonella enterica subsp. enterica serovar Ilessarek Salmonella enterica subsp. enterica serovar Newbrunswick Salmonella enterica subsp. enterica serovar Hillingdon Salmonella enterica subsp. enterica serovar Newington Saimoneila enterica subsp. enterica serovar Newlands Salmonella enterica subsp. enterica serovar Tennessee Salmonella enterica subsp. enterica serovar Newmexico Salmonella enterica subsp. enterica serovar Tennyson Salmonella enterica subsp. enterica serovar Newport Salmonella enterica subsp. enterica serovar Texas Salmonella enterica subsp. enterica serovar Ngili Salmonella enterica subsp. enterica serovar Thompson Salmonella enterica subsp. enterica serovar Niarembe Salmonella enterica subsp. enterica serovar Tinda Salmonella enterica subsp. enterica serovar Nima Salmonella enterica subsp. enterica serovar Togba Salmonella enterica subsp. enterica serovar Nitra Salmonella enterica subsp. enterica serovar Tonev Salmonella enterica subsp. enterica serovar Norwich Salmonella enterica subsp. enterica serovar Toronto Salmonella enterica subsp. enterica serovar Nottingham Salmonella enterica subsp. enterica serovar Toulon Salmonella enterica subsp. enterica serovar O rough Salmonella enterica subsp. enterica serovar Travis Salmonella enterica subsp. enterica serovar O rough O:r:l,2 Salmonella enterica subsp. enterica serovar Tripoli Salmonella enterica subsp. enterica serovar 07:Hc:l,5 Salmonella enterica subsp. enterica serovar Tshiongwe Salmonella enterica subsp. enterica serovar 07:Hh:l,5 Salmonella enterica subsp. enterica serovar Tucson Salmonella enterica subsp. enterica serovar Ohio Salmonella enterica subsp. enterica serovar Typhi Salmonella enterica subsp. Enterica serovar Ondcrstcpoort Salmonella enterica subsp. enterica serovar Typhimurium Salmonella enterica subsp. enterica serovar Oranienburg Salmonella enterica subsp. enterica serovar Typhisuis Salmonella enterica subsp. enterica serovar Ordonez Salmonella enterica subsp. enterica serovar Uganda Salmonella enterica subsp. enterica serovar Orion Salmonella enterica subsp. enterica serovar Untypable str. 75788 Salmonella enterica subsp. enterica serovar Oslo Salmonella enterica subsp. enterica serovar Untypable str. 77116 Salmonella enterica subsp. enterica serovar Osnabrueck Salmonella enterica subsp. enterica serovar Untypable str. 77132 Salmonella enterica subsp. enterica serovar Othmarschen Salmonella enterica subsp. enterica serovar Untypable str. 77528 Salmonella enterica subsp. enterica serovar Ouakam Salmonella enterica subsp. enterica serovar Untypable str. 81146 Salmonella enterica subsp. enterica serovar Ovcrvccht Salmonella enterica subsp. enterica serovar Untypable str. 83332 Salmonella enterica subsp. enterica serovar Panama Salmonella enterica subsp. enterica serovar Untypable str. 83987 Salmonella enterica subsp. enterica serovar Paratyphi A Salmonella enterica subsp. enterica serovar Untypable str. 91013 Saimoneila enterica subsp. enterica serovar Paratyphi B Salmonella enterica subsp. enterica serovar Untypable str. 91510 Salmonella enterica subsp. enterica serovar Paratyphi C Salmonella enterica subsp. enterica serovar Untypable str. 92055 Salmonella enterica subsp. enterica serovar Pensacola Salmonella enterica subsp. enterica serovar Uphill Salmonella enterica subsp. enterica serovar Poano Salmonella enterica subsp. enterica serovar Urbana Salmonella enterica subsp. enterica serovar Poeseldorf Salmonella enterica subsp. enterica serovar Utrecht Salmonella enterica subsp. enterica serovar Pomona Salmonella enterica subsp. enterica serovar Vellore Salmonella enterica subsp. enterica serovar Poona Salmonella enterica subsp. enterica serovar Virchow Salmonella enterica subsp. enterica serovar Portedeslilas Salmonella enterica subsp. enterica serovar Virginia Salmonella enterica subsp. enterica serovar Potsdam Salmonella enterica subsp. enterica serovar Wagenia Salmonella enterica subsp. enterica serovar Pullorum Salmonella enterica subsp. enterica serovar Wandsworth Salmonella enterica subsp. enterica serovar Putten Salmonella enterica subsp. enterica serovar Wangata Salmonella enterica subsp. enterica serovar Quebec Salmonella enterica subsp. enterica serovar Washington Salmonella enterica subsp. enterica serovar Rachaburi Salmonella enterica subsp. enterica serovar Waycross Salmonella enterica subsp. enterica serovar Reading Salmonella enterica subsp. enterica serovar Weltevreden Salmonella enterica subsp. enterica serovar Richmond Salmonella enterica subsp. enterica serovar Weslaco Salmonella enterica subsp. enterica serovar Rissen Salmonella enterica subsp. enterica serovar Westhampton Salmonella enterica subsp. enterica serovar Rosenberg Salmonella enterica subsp. enterica serovar Wien Salmonella enterica subsp. enterica serovar Rostock Salmonella enterica subsp. enterica serovar Worthington Salmonella enterica subsp. enterica serovar Rubislaw Salmonella enterica subsp. enterica serovar York Salmonella enterica subsp. enterica serovar Saintpaul Salmonella enterica subsp. enterica serovar Yovokome Salmonella enterica subsp. enterica serovar Salford Salmonella enterica subsp. enterica serovar Zaiman Salmonella enterica subsp. enterica serovar Sandiego Salmonella enterica subsp. enterica serovar Zanzibar Salmonella enterica subsp. enterica serovar Sangcra Salmonella enterica subsp. enterica str. 01-11525 Salmonella enterica subsp. enterica serovar Sanjuan Salmonella enterica subsp. enterica str. 09-06166 Salmonella enterica subsp. enterica serovar Sanktgeorg Salmonella enterica subsp. enterica str. 11-01213 Salmonella enterica subsp. enterica serovar Sarajane Salmonella enterica subsp. enterica str. 11-01214 Salmonella enterica subsp. enterica serovar Schlcisshcim Salmonella enterica subsp. enterica str. 11-01216-1 Salmonella enterica subsp. enterica serovar Schwarzengrund Salmonella enterica subsp. enterica str. 609458-2604314 2-2 Salmonella enterica subsp. enterica serovar Sendai Salmonella enterica subsp. enterica str. 85356 Salmonella enterica subsp. enterica serovar Senftenberg Salmonella enterica subsp. enterica str. CFSAN004167 Salmonella enterica subsp. enterica serovar Setubal Salmonella enterica subsp. enterica str. S703 Salmonella enterica subsp. enterica serovar Shomron Salmonella enterica subsp. enterica str. xld Salmonella enterica subsp. enterica serovar Simsbury Salmonella enterica subsp. houtenae Saimoneila enterica subsp. enterica serovar Singapore Salmonella enterica subsp. houtenae serovar l,40:g,z51:- Salmonella enterica subsp. enterica serovar Sloterdijk Salmonella enterica subsp. houtenae serovar I,40:z4,z24:- Salmonella enterica subsp. enterica serovar Soalianina Salmonella enterica subsp. houtenae serovar 16:z4,z32:- Salmonella enterica subsp. enterica serovar Soerenga Salmonella enterica subsp. houtenae serovar 16:z4,z32:-- Salmonella enterica subsp. enterica serovar Stanley Salmonella enterica subsp. houtenae serovar 40:z4,z24:- Salmonella enterica subsp. enterica serovar Stanleyville Salmonella enterica subsp. houtenae serovar 43:z4,z23:- Salmonella enterica subsp. enterica serovar Stellingen Salmonella enterica subsp. houtenae serovar 44:a:- Salmonella enterica subsp. enterica serovar Stourbridge Salmonella enterica subsp. houtenae serovar 44:z4,z23:- Salmonella enterica subsp. enterica serovar Taksony Salmonella enterica subsp. houtenae serovar 45a,b:g,z51:- Salmonella enterica subsp. enterica serovar Tallahassee Salmonella enterica subsp. houtenae serovar 48:g,z51:- Salmonella enterica subsp. enterica serovar Tejas Salmonella enterica subsp. houtenae serovar 50:g,z51:- Salmonella enterica subsp. enterica serovar Telaviv Salmonella enterica subsp. houtenae serovar 6,7:z4,z24:- Saimoneila enterica subsp. houtenae serovar Houten Salmonella sp. APK1 Salmonella enterica subsp. houtenae str. ATCC BAA-1580 Salmonella sp. ATK1 Salmonella enterica subsp. houtenae str. ATCC BAA-1581 Salmonella sp. AV(2010) Salmonella enterica subsp. indica Salmonella sp. BSCC 29 Salmonella enterica subsp. indica serovar l,6,14,25:a:e,n,x Salmonella sp. BV10 Salmonella enterica subsp. indica serovar ll:b:l,7 Salmonella sp. BV34 Salmonella enterica subsp. indica serovar ll:b:e,n,x Salmonella sp. BV37 Salmonella enterica subsp. indica serovar 45:a:e,n,x Salmonella sp. Bz21 Salmonella enterica subsp. indica serovar 6,14,25:zl0:l,(2),7 Salmonella sp. CASMBAUKKAGK2 Salmonella enterica subsp. indica serovar 6,7:z41:l,7 Salmonella sp. CDC 156-87 Salmonella enterica subsp. indica str. ATCC BAA-1576 Salmonella sp. CMCC50041 Salmonella enterica subsp. indica str. ATCC BAA-1578 Salmonella sp. Co9901 Salmonella enterica subsp. salamae Salmonella sp. Co9936 Salmonella enterica subsp. salamae serovar l,4,12,27:a:e,n,x Salmonella sp. Co9937 Salmonella enterica subsp. salamae serovar l,4,12,27:b:c,n,x Salmonella sp. CRMB13 Salmonella enterica subsp. salamae serovar l,40:zl0:e,n,x Salmonella sp. CRMB68 Salmonella enterica subsp. salamae serovar l,9,12:d:e,n,x Salmonella sp. CRTB1 Salmonella enterica subsp. salamae serovar 1,9,12:l,w:e,n,x Salmonella sp. CRTB29 Salmonella enterica subsp. salamae serovar 1 l:l,z28:e,n,x Salmonella sp. CRTB7 Salmonella enterica subsp. salamae serovar 35:g,z62:e,n,x Salmonella sp. D187-2 Salmonella enterica subsp. salamae serovar 35:m,t:e,n,x Salmonella sp. D194-1 Salmonella enterica subsp. salamae serovar 4,12,27:i:z35 Salmonella sp. D194-2 Salmonella enterica subsp. salamae serovar 4,12:z:l,7 Salmonella sp. D76 Salmonella enterica subsp. salamae serovar 40:zl0:e,n,x Salmonella sp. DAPS Salmonella enterica subsp. salamae serovar 42:f,g,t:-- Salmonella sp. DSPV 002PSA Saimoneila enterica subsp. salamae serovar 42:l,v:e,n,x,zl5 Salmonella sp. ES-B43 Salmonella enterica subsp. salamae serovar 48:d:z6 Salmonella sp. H16-244 Salmonella enterica subsp. salamae serovar 55:k:z39 Salmonella sp. H17-62 Salmonella enterica subsp. salamae serovar 56:zl:enx Salmonella sp. H3 Salmonella enterica subsp. salamae serovar 57:z42:l,6:z53 Salmonella sp. H48 Salmonella enterica subsp. salamae serovar 58:l,zl3,z28:z6 Salmonella sp. ICMP 15669 Salmonella enterica subsp. salamae serovar 6,7:l,w:l,5,7 Salmonella sp. Inspire71 Salmonella enterica subsp. salamae serovar 9,12:d:e,n,x Salmonella sp. Inspire72 Salmonella enterica subsp. salamae serovar 9,12:l,v:e,n,x Salmonella sp. Inspire73 Salmonella enterica subsp. salamae serovar Greenside Salmonella sp. Inspire74 Salmonella enterica subsp. salamae serovar Sofia Salmonella sp. Inspire75 Salmonella enterica subsp. salamae str. 3588/07 Salmonella sp. JPunkl-2 Salmonella enterica subsp. salamae str. ATCC BAA-15 82 Salmonella sp. LCN1-13 Salmonella enterica subsp. salamae str. ATCC BAA-15 83 Salmonella sp. LFW070403 Salmonella enterica subsp. salamae str. DMA-1 Salmonella sp. Lorraine road_2007_01 Salmonella enterica subsp. VII Salmonella sp. Lorraine road_2007_03 Salmonella enterica VII l,40:g,z51:-- Salmonella sp. Lorraine road_2007_07 Salmonella enterica VII 40:z4,z24:-- Salmonella sp. Lorraine road_2007_08 Salmonella subterranea Salmonella sp. Lorraine road_2007_14 Salmonella sp. Salmonella sp. Lorraine road_2007_16 Salmonella sp. ‘group B’ Salmonella sp. Lorraine road_2007_17 Salmonella sp. 10 Salmonella sp. Lorraine road_2007_19 Salmonella sp. 14 Salmonella sp. M9 Salmonella sp. 2 Salmonella sp. M9397 Salmonella sp. 30 Salmonella sp. MRT3 Salmonella sp. 40 Salmonella sp. Pratt ave_2007_03 Salmonella sp. 4063 Salmonella sp. Pratt ave_2007_06 Salmonella sp. 4064 Salmonella sp. Pratt ave_2007_10 Salmonella sp. 4065 Salmonella sp. Pratt ave_2007_11 Salmonella sp. 4066 Salmonella sp. Pratt ave_2007_12 Salmonella sp. 4071 Salmonella sp. Pratt ave_2007_14 Salmonella sp. 4072 Salmonella sp. Pratt ave_2007_15 Salmonella sp. 4182 Salmonella sp. Pratt ave_2007_16 Saimoneila sp. 45 Salmonella sp. RG-14/07 Salmonella sp. 467 Salmonella sp. RPWA1.6 Salmonella sp. 53 Salmonella sp. RV_A06_3c Salmonella sp. 56 Salmonella sp. s010 Salmonella sp. 577 Salmonella sp. s084 Salmonella sp. 6R Salmonella sp. S126 Salmonella sp. 77 Salmonella sp. S138 Salmonella sp. 85 MP Salmonella sp. S14 Salmonella sp. 8R Salmonella sp. S191 Salmonella sp. 9 Salmonella sp. S1a Salmonella sp. 96A-29192 Salmonella sp. SAM2 Salmonella sp. AHL 6 Salmonella sp. sc-S Salmonella sp. SSBC3 Salmonella sp. Trautman ave_2007_26 Salmonella sp. STM13 Salmonella sp. Trautman ave_2007_27 Salmonella sp. Tla Salmonella sp. Trautman ave_2007_28 Salmonella sp. TC67 Salmonella sp. Trautman ave_2007_29 Salmonella sp. TR-95 Salmonella sp. Vetaran hospital_2007_03 Salmonella sp. Trautman ave_2007_01 Salmonella sp. Vetaran hospital_2007_20 Salmonella sp. Trautman ave_2007_02 Salmonella sp. Veteran hospital_2007_01 Salmonella sp. Trautman ave_2007_03 Salmonella sp. Veteran hospital_2007_02 Salmonella sp. Trautman ave_2007_04 Salmonella sp. Veteran hospital_2007_07 Salmonella sp. Trautman ave_2007_05 Salmonella sp. Veteran hospital_2007_08 Salmonella sp. Trautman ave_2007_06 Salmonella sp. Veteran hospital_2007_11 Salmonella sp. Trautman ave_2007_07 Salmonella sp. Veteran hospital_2007_14 Salmonella sp. Trautman ave_2007_08 Salmonella sp. VI11 Salmonella sp. Trautman ave_2007_09 Salmonella sp. VII Salmonella sp. Trautman ave_2007_10 Salmonella sp. WT Salmonella sp. Trautman ave_2007_11 Salmonella sp. XJ-ZG1 Salmonella sp. Trautman ave_2007_12 Salmonella sp. YLA4 Salmonella sp. Trautman ave_2007_13 Salmonella sp. YLD3 Salmonella sp. Trautman ave_2007_14 Salmonella sp. ZKC20 Salmonella sp. Trautman ave_2007_15 Salmonella sp. ZZ-4 Salmonella sp. Trautman ave_2007_16 environmental samples Salmonella sp. Trautman ave_2007_17 Salmonella sp. enrichment culture clone CL107 Salmonella sp. Trautman ave_2007_18 Salmonella sp. enrichment culture clone NEP50 Salmonella sp. Trautman ave_2007_19 Salmonella sp. enrichment culture clone NJ-8 Salmonella sp. Trautman ave_2007_20 Salmonella sp. enrichment culture clone TB43_1 Salmonella sp. Trautman ave_2007_21 Salmonella sp. enrichment culture clone TB43_2 Salmonella sp. Trautman ave_2007_22 Salmonella sp. enrichment culture clone TB43_3 Salmonella sp. Trautman ave_2007_23 Salmonella sp. enrichment culture clone TB43_4 Salmonella sp. Trautman ave_2007_24 uncultured Salmonella sp. Salmonella sp. Trautman ave_2007_25 Genus: Escherichia Escherichia albertii Escherichia coli 10.0833 Escherichia albertii B090 Escherichia coli 10.0869 Escherichia albertii B1 56 Escherichia coli 13B01 Escherichia albertii NBRC 107761 Escherichia coli 1412 Escherichia albertii TW07627 Escherichia coli 14A Escherichia albertii TW08933 Escherichia coli 19B05 Escherichia albertii TW11588 Escherichia coli 113290 Escherichia albertii TW15818 Escherichia coli 113302 Escherichia coli Escherichia coli 113303 Escherichia coli O.1288 Escherichia coli 1303 Escherichia coli #1/H766 Escherichia coli 2.3941 Escherichia coli ‘BL21-Gold(DE3)pLysS AG’ Escherichia coli 2.4168 Escherichia coli O8BKT055439 Escherichia coli 2.41 74 Escherichia coli O8BKT77219 Escherichia coli 201600.1 Escherichia coli O.1197 Escherichia coli 20B05 Escherichia coli O7798 Escherichia coli 2254-75 (11a) Escherichia coli 101-1 Escherichia coli 229_11 Escherichia coli 110957 Escherichia coli 2362-75 Escherichia coli O9BKT078844 Escherichia coli 23B03 Escherichia coli 1.0080 Escherichia coli 24B05 Escherichia coli 1.2264 Escherichia coli 2534-86 Escherichia coli 1.2741 Escherichia coli 2719100 Escherichia coli O9BKT024447 Escherichia coli 2720900 Escherichia coli O9BKT076207 Escherichia coli 179100 Escherichia coli O.1304 Escherichia coli 179550 Escherichia coli 151_06 Escherichia coli 180050 Escherichia coli 1520 Escherichia coli 180200 Escherichia coli 174750 Escherichia coli 180600 Escherichia coli 174900 Escherichia coli 1827-70 Escherichia coli 178200 Escherichia coli 199900.1 Escherichia coli 178850 Escherichia coli 2733950 Escherichia coli 178900 Escherichia coli 2735000 Escherichia coli 112469215-isolatel Escherichia coli 2741950 Escherichia coli 112469218-isolatel Escherichia coli 2747800 Escherichia coli 10.0562 Escherichia coli 2749250 Escherichia coli 10.0821 Escherichia coli 2756500 Escherichia coli 2762100 Escherichia coli 2860650 Escherichia coli 2770900 Escherichia coli 2861200 Escherichia coli 2780750 Escherichia coli 55989 Escherichia coli 2785200 Escherichia coli 576-1 Escherichia coli 2788150 Escherichia coli 5905 Escherichia coli 2845350 Escherichia coli 6.0172 Escherichia coli 2845650 Escherichia coli 6.168 Escherichia coli 2846750 Escherichia coli 7.1485 Escherichia coli 2846750-DM-A Escherichia coli 7.1495 Escherichia coli 2846750-DM-B Escherichia coli 7.1575 Escherichia coli 2846750-DM-B-A Escherichia coli 7.3192 Escherichia coli 2846750-DM-B-B Escherichia coli 75 Escherichia coli 2848050 Escherichia coli 754_10 Escherichia coli 2850400 Escherichia coli 79 Escherichia coli 2850750 Escherichia coli 8.0416 Escherichia coli 2851500 Escherichia coli 8.0566 Escherichia coli 2853500 Escherichia coli 8.0569 Escherichia coli 1E14 Escherichia coli 8.0586 Escherichia coli 2.073 1 Escherichia coli 8.2256 Escherichia coli 2.0966 Escherichia coli 8.2524 Escherichia coli 2.3916 Escherichia coli 83972 Escherichia coli 2862600 Escherichia coli 85.0143 Escherichia coli 2864350 Escherichia coli 85.1284 Escherichia coli 2865200 Escherichia coli 8624 Escherichia coli 2866350 Escherichia coli 87-1713(10i) Escherichia coli 2722950 Escherichia coli 88.0221 Escherichia coli 2726800 Escherichia coli 88.1042 Escherichia coli 2726950 Escherichia coli 88.1467 Escherichia coli 2729250 Escherichia coli 88817 (10j) Escherichia coli 2729250-DM-A Escherichia coli 89.0511 Escherichia coli 2729250-DM-B Escherichia coli 9.0111 Escherichia coli 2729250-DM-B-A Escherichia coli 9.1649 Escherichia coli 2729250-DM-B-B Escherichia coli 2866450 Escherichia coli 2730350 Escherichia coli 908616 Escherichia coli 2730450 Escherichia coli 908624 Escherichia coli 2731150 Escherichia coli 908632 Escherichia coli 2866550 Escherichia coli 908658 Escherichia coli 2866750 Escherichia coli 908675 Escherichia coli 2867750 Escherichia coli 908691 Escherichia coli 2871950 Escherichia coli 909945-2 Escherichia coli 2872000 Escherichia coli 53638 Escherichia coli 2872800 Escherichia coli 541-1 Escherichia coli 2875000 Escherichia coli 541-15 Escherichia coli 2875150 Escherichia coli 5412 Escherichia coli 2886-75 Escherichia coli 93-001 Escherichia coli 290 10 Escherichia coli 93-111 Escherichia coli 3.0190 Escherichia coli 93.0055 Escherichia coli 3.2303 Escherichia coli 93.0056 Escherichia coli 3.2608 Escherichia coli 93.0624 Escherichia coli 3.3884 Escherichia coli 94.0618 Escherichia coli 3.4870 Escherichia coli 95.0183 Escherichia coli 3.4871 Escherichia coli 95.0941 Escherichia coli 3003 Escherichia coli 95.0943 Escherichia coli 3006 Escherichia coli 95.1288 Escherichia coli 3030-1 Escherichia coli 95JB1 Escherichia coli 3350-73 (13a) Escherichia coli 95NR1 Escherichia coli 3431 Escherichia coli 96.0107 Escherichia coli 371 08 Escherichia coli 96.0109 Escherichia coli 4.0522 Escherichia coli 96.0427 Escherichia coli 4.0967 Escherichia coli 96.0428 Escherichia coli 4_1_47FAA Escherichia coli 96.0497 Escherichia coli 5.0588 Escherichia coli 96.0932 Escherichia coli 5.0959 Escherichia coli 96.0939 Escherichia coli 5.2219 Escherichia coli 96.154 Escherichia coli 5.2239 Escherichia coli 97.0003 Escherichia coli 5.2246 Escherichia coli 97.0007 Escherichia coli 5.3169 Escherichia coli 97.0010 Escherichia coli 536 Escherichia coli 97.0246 Escherichia coli 2854350 Escherichia coli 97.0259 Escherichia coli 2860050 Escherichia coli 97.0264 Escherichia coli 97.1742 Escherichia coli C40_11 Escherichia coli 98NK2 Escherichia coli C418_89 Escherichia coli 99.0670 Escherichia coli C458_10 Escherichia coli 99.0672 Escherichia coli C48807 Escherichia coli 99.0678 Escherichia coli C496_10 Escherichia coli 99.0713 Escherichia coli C497_10 Escherichia coli 99.0741 Escherichia coli C527_94 Escherichia coli 99.0814 Escherichia coli C54-58 (lb) Escherichia coli 99.0815 Escherichia coli C581_05 Escherichia coli 99.0816 Escherichia coli C586_05 Escherichia coli 99.0839 Escherichia coli C58_11 Escherichia coli 99.0848 Escherichia coli C595_09 Escherichia coli 99.1753 Escherichia coli C639_08 Escherichia coli 99.1762 Escherichia coli C652_10 Escherichia coli 99.1775 Escherichia coli C654_09 Escherichia coli 99.1781 Escherichia coli C666_01 Escherichia coli 99.1793 Escherichia coli C691-71 (14b) Escherichia coli 99.1805 Escherichia coli C717_10 Escherichia coli A-03_34 Escherichia coli C725_88 Escherichia coli A25922R Escherichia coli C732_98 Escherichia coli A35218R Escherichia coli C743_03 Escherichia coli A9619-c2 (11c) Escherichia coli C751_03 Escherichia coli AA86 Escherichia coli C77_OS Escherichia coli AB42410445-isolate1 Escherichia coli C78_09C Escherichia coli AB4255441 8-isolate1 Escherichia coli C792_92 Escherichia coli AB42602061 -isolate1 Escherichia coli C796_10 Escherichia coli AB43739056-isolate1 Escherichia coli C799_92 Escherichia coli ABU 83972 Escherichia coli C79_08 Escherichia coli AD30 Escherichia coli C807_09 Escherichia coli ADL-218 Escherichia coli C80_08 Escherichia coli ADL-223 Escherichia coli C824_10 Escherichia coli ADL-226 Escherichia coli C82_11 Escherichia coli ADL-304 Escherichia coli C838_10 Escherichia coli ADL-305 Escherichia coli C842_97 Escherichia coli ADL-306 Escherichia coli C844_97 Escherichia coli ADL-307 Escherichia coli ADL-309 Escherichia coli ADL-308 Escherichia coli ADL-310 Escherichia coli 9.1796 Escherichia coli ADL-311 Escherichia coli 90.0039 Escherichia coli ADL-312 Escherichia coli 90.0091 Escherichia coli ADL-313 Escherichia coli 90.2281 Escherichia coli ADL-314 Escherichia coli 900105 (10e) Escherichia coli ADL-316 Escherichia coli 902034 (7b) Escherichia coli ADL-324 Escherichia coli 907357 Escherichia coli ADL-327 Escherichia coli 907391 Escherichia coli AI27 Escherichia coli 907446 Escherichia coli APEC IMT5155 Escherichia coli 907672 Escherichia coli APEC 01 Escherichia coli 907700 Escherichia coli APEC 078 Escherichia coli 907701 Escherichia coli ARL10/167 Escherichia coli 907710 Escherichia coli ARS4.2123 Escherichia coli 907713 Escherichia coli ATCC 25922 Escherichia coli 907715 Escherichia coli ATCC 35150 Escherichia coli 907779 Escherichia coli B Escherichia coli 907889 Escherichia coli B str. REL606 Escherichia coli 907892 Escherichia coli B str. REL607 Escherichia coli 908519 Escherichia coli B-04_28 Escherichia coli 908521 Escherichia coli B088 Escherichia coli 908522 Escherichia coli B093 Escherichia coli 908524 Escherichia coli B102 Escherichia coli 908525 Escherichia coli B103 Escherichia coli 908541 Escherichia coli B104 Escherichia coli 908555 Escherichia coli B105 Escherichia coli 908573 Escherichia coli B106 Escherichia coli 908585 Escherichia coli B107 Escherichia coli C33_11 Escherichia coli B108 Escherichia coli C341_10 Escherichia coli B109 Escherichia coli C343_08 Escherichia coli B112 Escherichia coli C347_93 Escherichia coli B113 Escherichia coli C353_09 Escherichia coli B114 Escherichia coli C354_03B Escherichia coli B1167 Escherichia coli 909957 Escherichia coli BIDMC 39 Escherichia coli 910096-2 Escherichia coli BIDMC 6 Escherichia coli 92.0144 (F03) Escherichia coli BIDMC 9 Escherichia coli 929-78 Escherichia coli BL21 Escherichia coli B185 Escherichia coli BL21(DE3) Escherichia coli B26-1 Escherichia coli BWH 24 Escherichia coli B26-2 Escherichia coli BWII 32 Escherichia coli B28-1 Escherichia coli BWH 34 Escherichia coli B28-2 Escherichia coli BWH 40 Escherichia coli B29-1 Escherichia coli C Escherichia coli B29-2 Escherichia coli ATCC 8739 Escherichia coli B354 Escherichia coli C-04_22 Escherichia coli B36-1 Escherichia coli C-34666 Escherichia coli B36-2 Escherichia coli C1214 90 Escherichia coli B367 Escherichia coli C1244 91 Escherichia coli B40-1 Escherichia coli C12_92 Escherichia coli B40-2 Escherichia coli C154_11 Escherichia coli B41 Escherichia coli C155_11 Escherichia coli B49-1 Escherichia coli C157_11 Escherichia coli B49-2 Escherichia coli C161_11 Escherichia coli B5-1 Escherichia coli C166_11 Escherichia coli B5-2 Escherichia coli C170_11 Escherichia coli B574 Escherichia coli C186-61 (10h) Escherichia coli B671 Escherichia coli C2139_99 Escherichia coli B7-1 Escherichia coli C213_10 Escherichia coli B7-2 Escherichia coli C238_91 Escherichia coli B706 Escherichia coli C240-52 (9c) Escherichia coli B799 Escherichia coli C260_92 Escherichia coli B7A Escherichia coli C262_10 Escherichia coli B83 Escherichia coli C283_09 Escherichia coli B84 Escherichia coli C295_10 Escherichia coli B85 Escherichia coli C309-64 (lOg) Escherichia coli B86 Escherichia coli DH5[alpha] Escherichia coli B89 Escherichia coli DSM 30083 = JCM 1649 Escherichia coli B90 Escherichia coli E-01_37 Escherichia coli B91 Escherichia coli E1002 Escherichia coli B92 Escherichia coli E101 Escherichia coli B921 Escherichia coli E110019 Escherichia coli B93 Escherichia coli E1114 Escherichia coli B94 Escherichia coli E1118 Escherichia coli B95 Escherichia coli E1167 Escherichia coli Bal225 Escherichia coli E128010 Escherichia coli BCE001_MS16 Escherichia coli E1492 Escherichia coli BCE002_MS12 Escherichia coli E1520 Escherichia coli BCE006_MS-23 Escherichia coli E1777 Escherichia coli BCE007_MS-11 Escherichia coli E2265 Escherichia coli BCE008_MS-01 Escherichia coli E24377A Escherichia coli BCE008_MS-13 Escherichia coli E267 Escherichia coli BCEO11_MS-01 Escherichia coli E482 Escherichia coli BCEO19_MS-13 Escherichia coli E560 Escherichia coli BCE030_MS-09 Escherichia coli E704 Escherichia coli BCE032-DM-A Escherichia coli E74/68 Escherichia coli BCE032-DM-B Escherichia coli E851/71 Escherichia coli BCE032-DM-B-A Escherichia coli Ec 1 1-9450 Escherichia coli BCE032-DM-B-B Escherichia coli Ec 11-9941 Escherichia coli BCE032 MS-12 Escherichia coli Ec 11-9990 Escherichia coli BCE034 MS-14 Escherichia coli EC096/10 Escherichia coli Bd5610_99 Escherichia coli Eel 1-4986 Escherichia coli B1DMC 15 Escherichia coli ECT734 Escherichia coli BIDMC 17A Escherichia coli EC1735 Escherichia coli BIDMC 17B Escherichia coli EC1736 Escherichia coli BIDMC 19A Escherichia coli EC1737 Escherichia coli BIDMC 19B Escherichia coli EC 1738 Escherichia coli BIDMC 19C Escherichia coli EC1845 Escherichia coli BIDMC 20A Escherichia coli EC 1846 Escherichia coli BIDMC 20B Escherichia coli EC 1847 Escherichia coli BIDMC 2B Escherichia coli EC 1848 Escherichia coli BIDMC 3 Escherichia coli EC 1849 Escherichia coli BIDMC 37 Escherichia coli EC1850 Escherichia coli BIDMC 38 Escherichia coli EC1856 Escherichia coli EC 1862 Escherichia coli FR1K920 Escherichia coli EC 1863 Escherichia coli FVEC1302 Escherichia coli EC 1864 Escherichia coli FVEC1412 Escherichia coli EC 1865 Escherichia coli FVEC1465 Escherichia coli EC 1866 Escherichia coli G5101 Escherichia coli EC 1868 Escherichia coli G58-1 Escherichia coli EC 1869 Escherichia coli GEMS_EPEC1 Escherichia coli EC 1870 Escherichia coli H001 Escherichia coli EC302/04 Escherichia coli H120 Escherichia coli EC4013 Escherichia coli H16 Escherichia coli EC4100B Escherichia coli H185 Escherichia coli EC4196 Escherichia coli H218 Escherichia coli EC4203 Escherichia coli H220 Escherichia coli EC4402 Escherichia coli H223 Escherichia coli EC4421 Escherichia coli H252 Escherichia coli EC4422 Escherichia coli H260 Escherichia coli EC4436 Escherichia coli C87_11 Escherichia coli EC4437 Escherichia coli C887_10 Escherichia coli EC4439 Escherichia coli C900_01 Escherichia coli EC4448 Escherichia coli C93_11 Escherichia coli EC96038 Escherichia coli C9_92 Escherichia coli ECA-0157 Escherichia coli CB7326 Escherichia coli ECA-727 Escherichia coli B15 Escherichia coli ECC-1470 Escherichia coli B17 Escherichia coli ECC-7 Escherichia coli B171 Escherichia coli EcN DM1 Escherichia coli B175 Escherichia coli ED la Escherichia coli CE418 Escherichia coli EDM 106 Escherichia coli CE516 Escherichia coli EDM 116 Escherichia coli CE549 Escherichia coli EDM530 Escherichia coli CFT073 Escherichia coli Envira 10/1 Escherichia coli chi7122 Escherichia coli Envira 8/11 Escherichia coli cloneA_il Escherichia coli EPEC 32/73 Escherichia coli Combat2D2 Escherichia coli EPEC C342-62 Escherichia coli CTJMT8 Escherichia coli EPEC 11 Escherichia coli D-04_27 Escherichia coli EPECa12 Escherichia coli DEC10A Escherichia coli EPECa14 Escherichia coli DEC 10B Escherichia coli ER2796 Escherichia coli DEC10C Escherichia coli ES699 Escherichia coli DEC10D Escherichia coli ETEC 1392/75 Escherichia coli DEC10E Escherichia coli ETEC DS168-1 Escherichia coli DEC 1 OF Escherichia coli ETEC HI0407 Escherichia coli DEC11A Escherichia coli H10407_1968 Escherichia coli DEC11B Escherichia coli HI0407_1970 Escherichia coli DEC11C Escherichia coli ETEC TW03439 Escherichia coli DEC11D Escherichia coli ETEC TW03452 Escherichia coli DEC11E Escherichia coli ETEC TW03574 Escherichia coli DEC12A Escherichia coli ETEC TW03576 Escherichia coli DEC12B Escherichia coli ETEC TW03585 Escherichia coli DEC12C Escherichia coli ETEC TW03741 Escherichia coli DEC12D Escherichia coli ETEC TW 14691 Escherichia coli DEC12E Escherichia coli ETEC WS1896A Escherichia coli DEC13A Escherichia coli ETEC WS2068A Escherichia coli DEC13B Escherichia coli ETEC WS3080A Escherichia coli DEC13C Escherichia coli F11 Escherichia coli DEC13D Escherichia coli F18+ Escherichia coli DEC13E Escherichia coli F576 Escherichia coli DEC14A Escherichia coli FDA504 Escherichia coli DEC14B Escherichia coli FDA505 Escherichia coli DEC14C Escherichia coli FDA506 Escherichia coli DEC14D Escherichia coli FDA507 Escherichia coli DEC15A Escherichia coli FDA517 Escherichia coli DEC15B Escherichia coli FREP Escherichia coli DECT5C Escherichia coli FRIK1985 Escherichia coli DEC15D Escherichia coli FRIK1990 Escherichia coli DEC15E Escherichia coli FRIK1996 Escherichia coli DEC1A Escherichia coli FRIK1997 Escherichia coli DECTB Escherichia coli FRIK1999 Escherichia coli DEC1C Escherichia coli FRIK2001 Escherichia coli DEC ID Escherichia coli FRIK523 Escherichia coli DEC1E Escherichia coli DEC2A Escherichia coli HVH 223 (4-2976528) Escherichia coli DEC2B Escherichia coli HVH 225 (4-1273116) Escherichia coli DEC2C Escherichia coli HVH 227 (4-2277670) Escherichia coli DEC2D Escherichia coli HVH 228 (4-7787030) Escherichia coli DEC2E Escherichia coli HVH 23 (4-6066488) Escherichia coli DEC3A Escherichia coli HVH 24 (4-5985145) Escherichia coli DEC3B Escherichia coli IIVII 25 (4-5851939) Escherichia coli DEC3C Escherichia coli HVH 26 (4-5703913) Escherichia coli DEC3D Escherichia coli HVH 27 (4-7449267) Escherichia coli DEC3E Escherichia coli HVH 28 (4-0907367) Escherichia coli DEC3F Escherichia coli HVH 29 (4-3418073) Escherichia coli DEC4A Escherichia coli HVH 3 (4-7276001) Escherichia coli DEC4B Escherichia coli HVH 30 (4-2661829) Escherichia coli DEC4C Escherichia coli HVH 31 (4-2602156) Escherichia coli DEC4D Escherichia coli HVH 32 (4-3773988) Escherichia coli DEC4E Escherichia coli HVH 33 (4-2174936) Escherichia coli DEC4F Escherichia coli HVH 35 (4-2962667) Escherichia coli DEC5A Escherichia coli HVH 36 (4-5675286) Escherichia coli DEC5B Escherichia coli HVH 37 (4-2773848) Escherichia coli DEC5C Escherichia coli HVH 38 (4-2774682) Escherichia coli DEC5D Escherichia coli HVH 39 (4-2679949) Escherichia coli DEC5E Escherichia coli HVH 4 (4-7276109) Escherichia coli DEC6A Escherichia coli HVH 40 (4-1219782) Escherichia coli DEC6B Escherichia coli HVH 41 (4-2677849) Escherichia coli DEC6C Escherichia coli HVH 42 (4-21 00061) Escherichia coli DEC6D Escherichia coli HVH 43 (4-2173468) Escherichia coli DEC6E Escherichia coli HVH 44 (4-2298570) Escherichia coli DEC7A Escherichia coli HVH 45 (4-3129918) Escherichia coli DEC7B Escherichia coli HVH 46 (4-2758776) Escherichia coli DEC7C Escherichia coli HVH 48 (4-2658593) Escherichia coli DEC7D Escherichia coli HVH 5 (4-7148410) Escherichia coli DEC7E Escherichia coli HVH 50 (4-2593475) Escherichia coli DEC8A Escherichia coli HVH 51 (4-2172526) Escherichia coli DEC8B Escherichia coli HVH 53 (4-0631051) Escherichia coli DEC8C Escherichia coli HVH 54 (4-2723514) Escherichia coli DEC8D Escherichia coli IIVII 55 (4-2646161) Escherichia coli DEC8E Escherichia coli HVH 56 (4-2153033) Escherichia coli DEC9A Escherichia coli HVH 58 (4-2839709) Escherichia coli DEC9B Escherichia coli HVH 59 (4-1119338) Escherichia coli DEC9C Escherichia coli IIVII 6 (3-8296502) Escherichia coli DEC9D Escherichia coli HVH 61 (4-2736020) Escherichia coli DEC9E Escherichia coli HVH 63 (4-2542528) Escherichia coli DH1 Escherichia coli HVH 65 (4-2262045) Escherichia coli HVH 199 (4-5670322) Escherichia coli HVH 68 (4-0888028) Escherichia coli HVH 2 (4-6943160) Escherichia coli HVH 69 (4-2837072) Escherichia coli HVH 20 (4-5865042) Escherichia coli HVH 7 (4-7315031) Escherichia coli HVH 200 (4-4449924) Escherichia coli HVH 70 (4-2963531) Escherichia coli HVH 201 (4-4459431) Escherichia coli HVH 73 (4-2393174) Escherichia coli HVH 202 (4-3163997) Escherichia coli HVH 74 (4-1034782) Escherichia coli HVH 203 (4-3126218) Escherichia coli HVH 76 (4-2538717) Escherichia coli HVH 204 (4-3112802) Escherichia coli HVH 77 (4-2605759) Escherichia coli HVH 205 (4-3094677) Escherichia coli HVH 78 (4-2735946) Escherichia coli HVH 206 (4-3128229) Escherichia coli HVH 79 (4-2512823) Escherichia coli HVH 207 (4-3113221) Escherichia coli HVH 80 (4-2428830) Escherichia coli HVH 208 (4-3112292) Escherichia coli HVH 82 (4-2209276) Escherichia coli HVH 209 (4-3062651) Escherichia coli HVH 83 (4-2051087) Escherichia coli HVH 21 (4-4517873) Escherichia coli HVH 84 (4-1021478) Escherichia coli HVH 21 0 (4-3042480) Escherichia coli HVH 85 (4-0792144) Escherichia coli HVH 211 (4-3041891) Escherichia coli HVH 86 (4-7026218) Escherichia coli HVH 212 (3-9305343) Escherichia coli HVH 87 (4-5977630) Escherichia coli HVH 213 (4-3042928) Escherichia coli HVH 88 (4-5854636) Escherichia coli HVH 214 (4-3062198) Escherichia coli HVH 89 (4-5885604) Escherichia coli HVH 215 (4-3008371) Escherichia coli HVH 9 (4-6942539) Escherichia coli HVH 216 (4-3042952) Escherichia coli HVH 90 (4-3191362) Escherichia coli HVH 217 (4-1022806) Escherichia coli HVH 91 (4-4638751) Escherichia coli HVH 218 (4-4500903) Escherichia coli HVH 92 (4-5930790) Escherichia coli HVH 22 (4-2258986) Escherichia coli HVH 93 (4-5851025) Escherichia coli HVH 220 (4-5876842) Escherichia coli HVH 95 (4-6074464) Escherichia coli IIVII 221 (4-3136817) Escherichia coli IIVII 96 (4-5934869) Escherichia coli HVH 222 (4-2977443) Escherichia coli HVH 97 (4-6859038) Escherichia coli HVH 98 (4-5799287) Escherichia coli KTE115 Escherichia coli HVH 99 (4-6745172) Escherichia coli KTE116 Escherichia coli IAI1 Escherichia coli KTE117 Escherichia coli IAI39 Escherichia coli KTE118 Escherichia coli IHE3034 Escherichia coli KTE119 Escherichia coli IMT8073 Escherichia coli KTE12 Escherichia coli J53 Escherichia coli KTE120 Escherichia coli J96 Escherichia coli KTE121 Escherichia coli JB1-95 Escherichia coli KTE122 Escherichia coli JC2722 Escherichia coli KTE123 Escherichia coli JC5048 Escherichia coli KTE124 Escherichia coli JCL16 Escherichia coli KTE125 Escherichia coli JCMA Escherichia coli KTE126 Escherichia coli Jurua 18/11 Escherichia coli KTE127 Escherichia coli Jurua 20/10 Escherichia coli KTE128 Escherichia coli K-12 Escherichia coli KTE129 Escherichia coli BW25113 Escherichia coli KTE13 Escherichia coli BW2952 Escherichia coli KTE130 Escherichia coli BW38028 Escherichia coli KTE131 Escherichia coli LW1655F+ Escherichia coli KTE132 Escherichia coli MC1061 Escherichia coli KTEI33 Escherichia coli NC-7 Escherichia coli KTE134 Escherichia coli str. K-12 substr. DH10B Escherichia coli KTE135 Escherichia coli str. K-12 substr. MDS42 Escherichia coli KTE136 Escherichia coli str. K-12 substr. MG1655 Escherichia coli KTEI37 Escherichia coli str. K-12 substr. W3110 Escherichia coli KTE138 Escherichia coli Kl Escherichia coli KTE139 Escherichia coli K2 Escherichia coli KTE14 Escherichia coli K71 Escherichia coli KTE140 Escherichia coli KD1 Escherichia coli KTE141 Escherichia coli KD2 Escherichia coli KTE142 Escherichia coli KO11FL Escherichia coli KTE143 Escherichia coli KOEGE 10 (25a) Escherichia coli KTE144 Escherichia coli KOEGE 118 (317a) Escherichia coli KTE145 Escherichia coli KOEGE 131 (358a) Escherichia coli KTE146 Escherichia coli KOEGE 3 (4a) Escherichia coli KTE147 Escherichia coli KOEGE 30 (63a) Escherichia coli KTE148 Escherichia coli KOEGE 32 (66a) Escherichia coli KTE149 Escherichia coli KOEGE 33 (68a) Escherichia coli KTE15 Escherichia coli KOEGE 40 (102a) Escherichia coli KTE150 Escherichia coli KOEGE 43 (105a) Escherichia coli KTE153 Escherichia coli KOEGE 44 (106a) Escherichia coli KTE154 Escherichia coli KOEGE 56 (169a) Escherichia coli KTE155 Escherichia coli KOEGE 58 (171a) Escherichia coli KTE156 Escherichia coli KOEGE 61 (174a) Escherichia coli KTE157 Escherichia coli KOEGE 62 (175a) Escherichia coli KTE158 Escherichia coli KOEGE 68 (182a) Escherichia coli KTE159 Escherichia coli KOEGE 7 (16a) Escherichia coli KTE16 Escherichia coli KOEGE 70 (185a) Escherichia coli KTE160 Escherichia coli KOEGE 71 (186a) Escherichia coli KTE161 Escherichia coli KOEGE 73 (195a) Escherichia coli KTE162 Escherichia coli KOEGE 77 (202a) Escherichia coli KTE163 Escherichia coli KTE1 Escherichia coli KTE165 Escherichia coli KTE10 Escherichia coli KTE166 Escherichia coli KTE100 Escherichia coli KTE167 Escherichia coli KTE101 Escherichia coli KTE168 Escherichia coli KTE102 Escherichia coli KTE169 Escherichia coli KTE1 03 Escherichia coli KTE1 7 Escherichia coli KTE104 Escherichia coli KTE170 Escherichia coli KTE105 Escherichia coli KTE171 Escherichia coli KTE106 Escherichia coli KTE172 Escherichia coli KTE107 Escherichia coli KTE173 Escherichia coli KTE108 Escherichia coli KTE174 Escherichia coli KTE109 Escherichia coli KTE175 Escherichia coli KTE11 Escherichia coli KTE176 Escherichia coli KTE110 Escherichia coli KTE177 Escherichia coli KTE111 Escherichia coli KTE178 Escherichia coli KTE112 Escherichia coli KTE179 Escherichia coli KTE113 Escherichia coli KTE18 Escherichia coli KTE114 Escherichia coli KTE180 Escherichia coli KTE181 Escherichia coli H489 Escherichia coli KTE182 Escherichia coli H494 Escherichia coli KTE183 Escherichia coli H504 Escherichia coli KTE184 Escherichia coli H588 Escherichia coli KTE185 Escherichia coli H591 Escherichia coli KTE186 Escherichia coli H593 Escherichia coli KTE187 Escherichia coli II605 Escherichia coli KTE188 Escherichia coli H617 Escherichia coli KTE189 Escherichia coli H660 Escherichia coli KTE19 Escherichia coli H730 Escherichia coli KTE190 Escherichia coli H736 Escherichia coli KTE191 Escherichia coli HB101 Escherichia coli KTE192 Escherichia coli HM26 Escherichia coli KTE193 Escherichia coli HM27 Escherichia coli KTE194 Escherichia coli HM46 Escherichia coli KTE195 Escherichia coli HM605 Escherichia coli KTE196 Escherichia coli HM65 Escherichia coli KTE197 Escherichia coli HM69 Escherichia coli KTE198 Escherichia coli HP20A2007 Escherichia coli KTE199 Escherichia coli HUSEC41 Escherichia coli KTE2 Escherichia coli HVH 1 (4-6876161) Escherichia coli KTE20 Escherichia coli HVH 10 (4-6832164) Escherichia coli KTE200 Escherichia coli HVH 100 (4-2850729) Escherichia coli KTE201 Escherichia coli HVH 101 (4-6859844) Escherichia coli KTE202 Escherichia coli HVH 102 (4-6906788) Escherichia coli KTE203 Escherichia coli HVH 103 (4-5904188) Escherichia coli KTE204 Escherichia coli HVH 104 (4-6977960) Escherichia coli KTE205 Escherichia coli HVH 105 (4-6748473) Escherichia coli KTE206 Escherichia coli HVH 106 (4-6881831) Escherichia coli KTE207 Escherichia coli HVH 107 (4-5860571) Escherichia coli KTE208 Escherichia coli HVH 108 (4-6924867) Escherichia coli KTE209 Escherichia coli HVH 109 (4-6977162) Escherichia coli KTE21 Escherichia coli HVH 110 (4-6978754) Escherichia coli KTE210 Escherichia coli HVH 111 (4-7039018) Escherichia coli KTE211 Escherichia coli HVH 112 (4-5987253) Escherichia coli KTE212 Escherichia coli HVH 113 (4-7535473) Escherichia coli KTE213 Escherichia coli HVH 114 (4-7037740) Escherichia coli KTE214 Escherichia coli HVH 115 (4-4465989) Escherichia coli KTE215 Escherichia coli HVH 115 (4-4465997) Escherichia coli KTE216 Escherichia coli HVH 116 (4-6879942) Escherichia coli KTE217 Escherichia coli HVH 117 (4-6857191) Escherichia coli KTE218 Escherichia coli HVH 118 (4-7345399) Escherichia coli KTE219 Escherichia coli HVH 119 (4-6879578) Escherichia coli KTE22 Escherichia coli HVH 12 (4-7653042) Escherichia coli KTE220 Escherichia coli HVH 120 (4-6978681) Escherichia coli KTE221 Escherichia coli HVH 121 (4-6877826) Escherichia coli KTE222 Escherichia coli HVH 122 (4-6851606) Escherichia coli KTE223 Escherichia coli HVH 125 (4-2634716) Escherichia coli KTE224 Escherichia coli HVH 126 (4-6034225) Escherichia coli KTE225 Escherichia coli HVH 127 (4-7303629) Escherichia coli KTE226 Escherichia coli HVH 128 (4-7030436) Escherichia coli KTE227 Escherichia coli HVH 13 (4-7634056) Escherichia coli KTE228 Escherichia coli HVH 130 (4-7036876) Escherichia coli KTE229 Escherichia coli HVH 132(4-6876862) Escherichia coli KTE23 Escherichia coli HVH 133 (4-4466519) Escherichia coli H263 Escherichia coli HVH 134 (4-6073441) Escherichia coli H288 Escherichia coli HVH 135 (4-4449320) Escherichia coli H296 Escherichia coli HVH 136(4-5970458) Escherichia coli H299 Escherichia coli HVH 137 (4-2124971) Escherichia coli H30 Escherichia coli HVH 138 (4-6066704) Escherichia coli H305 Escherichia coli HVH 139 (4-3192644) Escherichia coli H378 Escherichia coli HVH 140(4-5894387) Escherichia coli H383 Escherichia coli HVH 141 (4-5995973) Escherichia coli H3 86 Escherichia coli HVH 142 (4-5627451) Escherichia coli H397 Escherichia coli HVH 143 (4-5674999) Escherichia coli H413 Escherichia coli HVH 144 (4-4451937) Escherichia coli H420 Escherichia coli HVH 145 (4-5672112) Escherichia coli H442 Escherichia coli HVH 146 (4-3189767) Escherichia coli II454 Escherichia coli HVH 147 (4-5893887) Escherichia coli H461 Escherichia coli HVH 148 (4-3192490) Escherichia coli HVH 149 (4-4451880) Escherichia coli MP021552.12 Escherichia coli HVH 150 (4-3258106) Escherichia coli MP021552.7 Escherichia coli HVH 151 (4-5755573) Escherichia coli MP021552.8 Escherichia coli HVH 152 (4-3447545) Escherichia coli MP021561.2 Escherichia coli HVH 153 (3-9344314) Escherichia coli MP021561.3 Escherichia coli HVH 154 (4-5636698) Escherichia coli MP021566.1 Escherichia coli IIVII 155 (4-4509048) Escherichia coli MP 1 Escherichia coli HVH 156 (4-3206505) Escherichia coli MS 107-1 Escherichia coli HVH 157 (4-3406229) Escherichia coli MS 110-3 Escherichia coli HVH 158 (4-3224287) Escherichia coli MS 115-1 Escherichia coli HVH 159 (4-5818141) Escherichia coli MS 116-1 Escherichia coli HVH 16 (4-7649002) Escherichia coli MS 117-3 Escherichia coli HVH 160 (4-5695937) Escherichia coli MS 119-7 Escherichia coli HVH 161 (4-3119890) Escherichia coli MS 124-1 Escherichia coli HVH 162 (4-5627982) Escherichia coli MS 145-7 Escherichia coli HVH 163 (4-4697553) Escherichia coli MS 146-1 Escherichia coli HVH 164 (4-5953081) Escherichia coli MS 153-1 Escherichia coli HVH 167 (4-6073565) Escherichia coli MS 16-3 Escherichia coli HVH 169 (4-1075578) Escherichia coli MS 175-1 Escherichia coli HVH 17 (4-7473087) Escherichia coli MS 182-1 Escherichia coli HVH 170 (4-3026949) Escherichia coli MS 185-1 Escherichia coli HVH 171 (4-3191958) Escherichia coli MS 187-1 Escherichia coli HVH 172 (4-3248542) Escherichia coli MS 196-1 Escherichia coli HVH 173 (3-9175482) Escherichia coli MS 198-1 Escherichia coli HVH 175 (4-3405184) Escherichia coli MS 200-1 Escherichia coli HVH 176 (4-3428664) Escherichia coli MS 21-1 Escherichia coli HVH 177 (4-2876612) Escherichia coli MS 45-1 Escherichia coli HVH 178 (4-3189163) Escherichia coli MS 57-2 Escherichia coli HVH 18 (4-8589585) Escherichia coli MS 60-1 Escherichia coli HVH 180 (4-3051617) Escherichia coli MS 69-1 Escherichia coli HVH 182 (4-0985554) Escherichia coli MS 78-1 Escherichia coli HVH 183 (4-3205932) Escherichia coli MS 79-10 Escherichia coli HVH 184 (4-3343286) Escherichia coli MS 84-1 Escherichia coli HVH 185 (4-2876639) Escherichia coli MS 85-1 Escherichia coli HVH 186 (4-3405044) Escherichia coli N1 Escherichia coli IIVII 187 (4-4471660) Escherichia coli NA114 Escherichia coli HVH 188 (4-2356988) Escherichia coli NC101 Escherichia coli HVH 189 (4-3220125) Escherichia coli NCCP 15653 Escherichia coli HVH 19 (4-7154984) Escherichia coli NCCP 15655 Escherichia coli IIVII 190 (4-3255514) Escherichia coli NCCP 15656 Escherichia coli HVH 191 (3-9341900) Escherichia coli NCCP15647 Escherichia coli HVH 192 (4-3054470) Escherichia coli NCCP 15648 Escherichia coli HVH 193 (4-3331423) Escherichia coli NCCP 15657 Escherichia coli HVH 194 (4-2356805) Escherichia coli NCCP 15658 Escherichia coli HVH 195 (3-7155360) Escherichia coli NCTC 86 Escherichia coli HVH 196 (4-4530470) Escherichia coli NDMlDok01 Escherichia coli HVH 197 (4-4466217) Escherichia coli NE037 Escherichia coli HVH 198 (4-3206106) Escherichia coli NE098 Escherichia coli MA6 Escherichia coli NE1487 Escherichia coli MCI9 Escherichia coli Nissle 1917 Escherichia coli MC21 Escherichia coli NT:H19 Escherichia coli MC23 Escherichia coli NT:H40 Escherichia coli MC6002 Escherichia coli NU14 Escherichia coli MC6003 Escherichia coli O08 Escherichia coli MG1657 Escherichia coli O10 Escherichia coli MGR194 Escherichia coli O10 str. Bi8337-41 Escherichia coli MP020940.1 Escherichia coli O10EH33 Escherichia coli MP020980.1 Escherichia coli O103 Escherichia coli MP020980.2 Escherichia coli O103 str. RM10042 Escherichia coli MP021017.1 Escherichia coli O103 str. RM8385 Escherichia coli MP021017.10 Escherichia coli O103:H2 Escherichia coli MP021017.il Escherichia coli E22 Escherichia coli MP021017.12 Escherichia coli O103:H2 str. 12009 Escherichia coli MP021017.2 Escherichia coli O103:H2 str. CVM9450 Escherichia coli MP021017.3 Escherichia coli O103:H25 Escherichia coli MP021017.4 Escherichia coli O103:H25 str. 6582 Escherichia coli MP021017.5 Escherichia coli O103:H25 str. CVM9340 Escherichia coli MP021017.6 Escherichia coli O103:H25 sir. NIPH-11060424 Escherichia coli MP021017.9 Escherichia coli O103:IINM Escherichia coli MP021552.11 Escherichia coli O103:K+ Escherichia coii O104:H12 Escherichia coli O109:H9 Escherichia coli O104:H21 Escherichia coli O10:K5(L):H4 Escherichia coli O104:H21 str. CFSAN002236 Escherichia coli O10:K5(L):H4 str. ATCC 23506 Escherichia coli O104:H21 str. CFSAN002237 Escherichia coli O11 Escherichia coli O104:H4 Escherichia coli O11 str. Bi632-42 Escherichia coli O104:H4 str. 01-09591 Escherichia coli O11 1 Escherichia coli O104:114 str. 04-8351 Escherichia coli O11 1 str. RM9322 Escherichia coli O104:H4 str. 09-7901 Escherichia coli O111:B4 Escherichia coli O104:H4 str. 11-02030 Escherichia coli O111:H− Escherichia coli O104:H4 str. 11-02033-1 Escherichia coli O111:H− str. 11128 Escherichia coli O104:H4 str. 11-02092 Escherichia coli O111:H11 Escherichia coli O104:H4 str. 11-02093 Escherichia coli O111:H11 str. CFSAN001630 Escherichia coli O104:H4 str. 11-02281 Escherichia coli O111H11 str. CVM9455 Escherichia coli O104:H4 str. 11-02318 Escherichia coli O111:H11 str. CVM9534 Escherichia coli O104:H4 str. 11-02913 Escherichia coli O111:H11 str. CVM9545 Escherichia coli O104:H4 sir. 11-03439 Escherichia coli O111:H11 sir. CVM9553 Escherichia coli O104:H4 str. 11-03943 Escherichia coli O111:H19 Escherichia coli O104:H4 str. 11-04080 Escherichia coli O111:H2 Escherichia coli O104:H4 str. 11-3677 Escherichia coli O111:H21 Escherichia coli O104:H4 str. 11-3798 Escherichia coli O111:H21 str. 226 Escherichia coli O1 04:H4 str. 11-4404 Escherichia coli O111:H8 Escherichia coli O104:H4 str. 11-4522 Escherichia coli O111:H8 str. 1074 Escherichia coli O104:H4 str. 11-4623 Escherichia coli O111:H8 str. 9662 Escherichia coli O104:H4 str. 11-4632 CI Escherichia coli O111:H8 str. CFSAN001632 Escherichia coli O104:H4 str. 1 1-4632 C2 Escherichia coli O111:H8 str. CVM9570 Escherichia coli O104:H4 str. 11-4632 C3 Escherichia coli O111:H8 str. CVM9574 Escherichia coli O104:H4 str. 11-4632 C4 Escherichia coli O111:H8 str. CVM9602 Escherichia coli O104:H4 str. 11-4632 C5 Escherichia coli O111:H8 str. CVM9634 Escherichia coli O104:H4 str. 2009EL-2050 Escherichia coli O111:NM Escherichia coli O104:H4 str. 2009EL-2071 Escherichia coli O113 Escherichia coli O104:H4 str. 2011C-3493 Escherichia coli O113:H19 Escherichia coli O104:H4 str. C227-11 Escherichia coli O113:H21 Escherichia coli O104:H4 str. C236-11 Escherichia coli O113:H21 str. CL-3 Escherichia coli O104:H4 str. C237-11 Escherichia coli O115:H− Escherichia coli O104:H4 str. E101/11 Escherichia coli O115:HMN Escherichia coli O104:114 str. E103/11 Escherichia coli O115:K+ Escherichia coli O104:H4 str. E107/11 Escherichia coli O117:Kl:H7 Escherichia coli O104:H4 str. El 12/10 Escherichia coli O119:H6 Escherichia coli O104:H4 str. E83/11 Escherichia coli O119:UT Escherichia coli O104:114 str. E84/11 Escherichia coli O120:IINM Escherichia coli O104:H4 str. E90/11 Escherichia coli O121 Escherichia coli O104:H4 str. E92/11 Escherichia coli O121 str. RM8352 Escherichia coli O104:H4 str. E94/11 Escherichia coli O12EH19 Escherichia coli O104:H4 str. Eel 1-4984 Escherichia coli O12EH19 str. 9918 Escherichia coli O104:H4 str. Eel 1-4986 Escherichia coli O12EH19 str. MT#2 Escherichia coli O104:H4 str. Eel 1-4987 Escherichia coli O12EH46 Escherichia coli O104:H4 str. Eel 1-4988 Escherichia coli O124:H− Escherichia coli O104:H4 str. Eel 1-5536 Escherichia coli O124:H40 Escherichia coli O104:H4 str. Eel 1-5537 Escherichia coli O126:H27 Escherichia coli O104:H4 str. Eel 1-5538 Escherichia coli O127:B8 Escherichia coli O104:H4 str. Eel 1-5603 Escherichia coli O127:H21 Escherichia coli O104:H4 str. Eel 1-5604 Escherichia coli O127:H27 Escherichia coli O104:H4 str. Eel 1-6006 Escherichia coli O127:H27 str. C43/90 Escherichia coli O104:Ft4 str. Eel 1 -9450 Escherichia coli O127:H6 Escherichia coli O104:H4 str. Eel 1-9941 Escherichia coli O127:H6 str. E2348/69 Escherichia coli O104:H4 str. Eel 1-9990 Escherichia coli O127a:H6 Escherichia coli O104:H4 str. Eel2-0465 Escherichia coli O128:H2 Escherichia coli O104:H4 str. Eel 2-0466 Escherichia coli O131:H25 Escherichia coli O104:H4 str. GOS1 Escherichia coli O136:H− Escherichia coli O104:H4 sir. GOS2 Escherichia coli O138:NM Escherichia coli O104:H4 str. HI 12180280 Escherichia coli O138:H11 Escherichia coli O104:H4 str. HI 12180282 Escherichia coli O142:H6 Escherichia coli O104:H4 str. HI 12180283 Escherichia coli O145 Escherichia coli O104:H4 str. HI 12180540 Escherichia coli O145 str. RM9872 Escherichia coli O104:H4 str. HI 12180541 Escherichia coli O145:H− Escherichia coli O104:H4 str. LB226692 Escherichia coli O145:H28 Escherichia coli O104:H4 str. ON2010 Escherichia coli O145:H28 str. 4865/96 Escherichia coli O104:H4 str. ON2011 Escherichia coli O145:H28 str. RM12581 Escherichia coli O104:114 str. TY-2482 Escherichia coli O145:1128 str. RM12761 Escherichia coli O108:H25 Escherichia coli O145:H28 str. RM13514 Escherichia coli O145:H28 str. RM13516 Escherichia coli O157:H7 str. Sakai Escherichia coli O145:NM Escherichia coli O157:H7 str. SS17 Escherichia coli O145:NM str. 2012C-4474 Escherichia coli O157:H7 str. SS52 Escherichia coli O145:NM str. 2012C-4477 Escherichia coli O157:H7 str. TW14359 Escherichia coli O145:NM str. 2012C-4478 Escherichia coli O157:H7 str. TW14588 Escherichia coli O145:NM str. 2012C-4479 Escherichia coli O157:H7 str. ZAP430 Escherichia coli O145:NM str. 2012C-4480 Escherichia coli O157:119 Escherichia coli O145:NM str. 8235 Escherichia coli O157:HNM Escherichia coli O149:H10 Escherichia coli O157:NM Escherichia coli O153:H21 Escherichia coli O15:H34 Escherichia coli O153:H7 Escherichia coli O15:NM Escherichia coli O154:H9 Escherichia coli O16 Escherichia coli O157 Escherichia coli O16 str. Fill 19-41 Escherichia coli 3.4880 Escherichia coli O169:H− Escherichia coli 7.1982 Escherichia coli O17 Escherichia coli 95.0083 Escherichia coli O17 str. K12a Escherichia coli ATCC 700728 Escherichia coli O174:H21 Escherichia coli O157 str. NCCP15738 Escherichia coli O177:H11 Escherichia coli O157 str. NCCP15739 Escherichia coli O18 Escherichia coli PA11 Escherichia coli O18 str. F10018-41 Escherichia coli PA13 Escherichia coli O180:H− Escherichia coli PA19 Escherichia coli O19 Escherichia coli PA35 Escherichia coli O19 str. F8188-41 Escherichia coli O157:12 Escherichia coli O20 Escherichia coli O157:H− Escherichia coli O20 str. P7a Escherichia coli O157:H− str. 493-89 Escherichia coli O23 Escherichia coli O157:H− str. H 2687 Escherichia coli O23 str. P7a Escherichia coli O157:H12 Escherichia coli O25 Escherichia coli O157:H16 Escherichia coli O25 str. E39a Escherichia coli O157:H37 Escherichia coli O25b:H4 Escherichia coli O157:H39 Escherichia coli O25b:H4-ST131 str. EC958 Escherichia coli O157:H43 Escherichia coli O25b:ST131 Escherichia coli O157:H43 str. T22 Escherichia coli O26 Escherichia coli O157:H45 Escherichia coli O26 str. RM10386 Escherichia coli O157:H7 Escherichia coli O26 str. RM8426 Escherichia coli O157:117 str. 1044 Escherichia coli O26:11− Escherichia coli O157:H7 str. 1125 Escherichia coli O26:H11 Escherichia coli O157:H7 str. 121 Escherichia coli O26:H11 str. 10140 Escherichia coli O157:H7 str. 262 Escherichia coli O26:H11 str. 11368 Escherichia coli O157:117 str. 611 Escherichia coli O26:1111 str. 6629 Escherichia coli O157:H7 str. EC10 Escherichia coli O26:H11 str. CFSAN001629 Escherichia coli O157:H7 str. EC1212 Escherichia coli O26:H11 str−. CVM10021 Escherichia coli O157:H7 str. EC4009 Escherichia coli O26:H11 str. CVM 10026 Escherichia coli O157:H7 str. EC4024 Escherichia coli O26:H11 str. CVM10030 Escherichia coli O157:H7 str. EC4042 Escherichia coli O26:H11 sir. CVM10224 Escherichia coli O157:H7 str. EC4045 Escherichia coli O26:H11 str. CVM9942 Escherichia coli O157:H7 str. EC4076 Escherichia coli O26:H11 str. CVM9952 Escherichia coli O157:H7 str. EC4084 Escherichia coli O26:H11:K60 Escherichia coli O157:H7 str. EC4113 Escherichia coli O26:NM Escherichia coli O157:H7 str. EC4115 Escherichia coli O27 Escherichia coli O157:H7 str. EC4127 Escherichia coli O27 str. E47a Escherichia coli O157:H7 str. EC4191 Escherichia coli O28ac:H− Escherichia coli O157:H7 str. EC4192 Escherichia coli O29 Escherichia coli O1 57:H7 str. EC4196 Escherichia coli O29 str. Su4338-41 Escherichia coli O157:H7 str. EC4205 Escherichia coli O30 Escherichia coli O157.−H7 str. EC4206 Escherichia coli O30 str. P2a Escherichia coli O157:H7 str. EC4401 Escherichia coli O32:H37 Escherichia coli O1 57:H7 str. EC4486 Escherichia coli O32:H37 str. P4 Escherichia coli O157:H7 str. EC4501 Escherichia coli O33 Escherichia coli O157:−H7 str. EC508 Escherichia coli O33 str. E40 Escherichia coli O157:H7 str. EC536 Escherichia coli O34 Escherichia coli O157:H7 str. EC869 Escherichia coli O34 str. H304 Escherichia coli O157:H7 str. EDL933 Escherichia coli O41:H− Escherichia coli O157:H7 str. F8092B Escherichia coli O42:H37 Escherichia coli O157:H7 str. FRIK2000 Escherichia coli O44:H 18 Escherichia coli O157:F£7 str. FRIK966 Escherichia coli O42 Escherichia coli O157:H7 str. G5101 Escherichia coli O45:H2 Escherichia coli O157:H7 str. GZ-021210/cattle Escherichia coli O45:H2 str. 03-EN-705 Escherichia coli O157:117 str. II093800014 Escherichia coli O45:NM Escherichia coli O157:H7 str. LSU-61 Escherichia coli O45:NM str. G4 Escherichia coii O5 Escherichia coli P0298942.7 Escherichia coli O5 str. TJ1-41 Escherichia coli P0298942.8 Escherichia coli O5:K4(L):H4 str. ATCC 23502 Escherichia coli P0298942.9 Escherichia coli O51:H− Escherichia coli P0299438.10 Escherichia coli O55:H2 Escherichia coli P0299438.11 Escherichia coli O55:H51 Escherichia coli P0299438.2 Escherichia coli O55:TI6 Escherichia coli P0299438.3 Escherichia coli O55:H7 Escherichia coli P0299438.4 Escherichia coli O55:H7 str. 3256-97 Escherichia coli P0299438.5 Escherichia coli O55:H7 str. CB9615 Escherichia coli P0299438.6 Escherichia coli O55:H7 str. RM12579 Escherichia coli P0299438.7 Escherichia coli O55:H7 str. USDA 5905 Escherichia coli P0299438.8 Escherichia coli O5:H− Escherichia coli P0299438.9 Escherichia coli O6 Escherichia coli P0299483.1 Escherichia coli O6 str. Bi7458-41 Escherichia coli P0299483.2 Escherichia coli O63:H6 Escherichia coli P0299483.3 Escherichia coli O63:HNM Escherichia coli P02997067.6 Escherichia coli O6:HNM Escherichia coli P0299917.1 Escherichia coli O70:NM Escherichia coli P0299917.10 Escherichia coli O75:H2 Escherichia coli P0299917.2 Escherichia coli O78:H9 Escherichia coli P0299917.3 Escherichia coli IMT2125 Escherichia coli P0299917.4 Escherichia coli O7:K1 Escherichia coli P0299917.5 Escherichia coli O7:K1 str. CE10 Escherichia coli P0299917.6 Escherichia coli OS Escherichia coli P02999I7.7 Escherichia coli O8 str. G3404-41 Escherichia coli P0299917.8 Escherichia coli O83:H1 Escherichia coli P0299917.9 Escherichia coli O83:H1 str. NRG 85 7C Escherichia coli P0301867.1 Escherichia coli O84:H− Escherichia coli P0301867.11 Escherichia coli O86a:H34 Escherichia coli P0301867.13 Escherichia coli O86a:H40 Escherichia coli P0301867.2 Escherichia coli O9 Escherichia coli P0301867.3 Escherichia coli O9 str. Bi316-42 Escherichia coli P0301867.4 Escherichia coli O90:H8 Escherichia coli P0301867.5 Escherichia coli O91 Escherichia coli P0301867.7 Escherichia coli O91 str. RM7190 Escherichia coli P0301867.8 Escherichia coli O91:H21 Escherichia coli P0301904.3 Escherichia coli O91:H21 str. B2F1 Escherichia coli P0302293.10 Escherichia coli O9:H51 Escherichia coli P0302293.2 Escherichia coli OK1114 Escherichia coli P0302293.3 Escherichia coli OK1180 Escherichia coli P0302293.4 Escherichia coli OK1357 Escherichia coli P0302293.6 Escherichia coli ONT:H− Escherichia coli P0302293.7 Escherichia coli ONT:H10 Escherichia coli P0302293.8 Escherichia coli ONT:H25 Escherichia coli P0302293.9 Escherichia coli ONT:H33 Escherichia coli P0302308.1 Escherichia coli ONT:H33 str. C48/93 Escherichia coli P0302308.10 Escherichia coli OP50 Escherichia coli P0302308.11 Escherichia coli Orough:H12 Escherichia coli P0302308.12 Escherichia coli Orough:H19 Escherichia coli P0302308.13 Escherichia coli Orough:H34 Escherichia coli P0302308.14 Escherichia coli Orough:H37 Escherichia coli P0302308.2 Escherichia coli Orough:H9 Escherichia coli P0302308.3 Escherichia coli OUT:HI 2 Escherichia coli P0302308.4 Escherichia coli OUT:H18 Escherichia coli P0302308.5 Escherichia coli OUT:H45 Escherichia coli P0304777.1 Escherichia coli OUT:H6 Escherichia coli P0304777.10 Escherichia coli OUT:H7 Escherichia coli P0304777.1 1 Escherichia coli OUT:HNM Escherichia coli P0304777.12 Escherichia coli OUT:NM Escherichia coli P0304777.13 Escherichia coli P0298942.1 Escherichia coli P0304777.14 Escherichia coli P0298942.10 Escherichia coli P0304777.15 Escherichia coli P0298942.11 Escherichia coli P0304777.2 Escherichia coli P0298942.12 Escherichia coli P0304777.3 Escherichia coli P0298942.14 Escherichia coli P0304777.4 Escherichia coli P0298942.15 Escherichia coli P0304777.5 Escherichia coli P0298942.2 Escherichia coli P0304777.7 Escherichia coli P0298942.3 Escherichia coli P0304777.8 Escherichia coli P0298942.4 Escherichia coli P0304777.9 Escherichia coli P0298942.6 Escherichia coli P0304799.3 Escherichia coli P0304816.1 Escherichia coli PA49 Escherichia coli P0304816.10 Escherichia coli PA5 Escherichia coli P0304816.11 Escherichia coli PA7 Escherichia coli P0304816.12 Escherichia coli PA8 Escherichia coli P0304816.13 Escherichia coli PA9 Escherichia coli P0304816.14 Escherichia coli PB10 Escherichia coli P0304816.15 Escherichia coli PDA1 Escherichia coli P0304816.2 Escherichia coli PBA5 Escherichia coli P0304816.3 Escherichia coli PBA9 Escherichia coli P0304816.4 Escherichia coli PBB13 Escherichia coli P0304816.5 Escherichia coli PBB4 Escherichia coli P0304816.6 Escherichia coli PBB5 Escherichia coli P0304816.7 Escherichia coli PBB6 Escherichia coli P0304816.8 Escherichia coli PBC20 Escherichia coli P0304816.9 Escherichia coli PBC22 Escherichia coli P0305260.1 Escherichia coli PBC3 Escherichia coli P0305260.10 Escherichia coli PBC6 Escherichia coli P0305260.11 Escherichia coli PBC7 Escherichia coli P0305260.12 Escherichia coli PBD1 Escherichia coli P0305260.13 Escherichia coli PBD11 Escherichia coli P0305260.1 5 Escherichia coli PBD16 Escherichia coli P0305260.2 Escherichia coli PBD19 Escherichia coli P0305260.3 Escherichia coli PBD2 Escherichia coli P0305260.4 Escherichia coli PBD20 Escherichia coli P0305260.5 Escherichia coli PBD21 Escherichia coli P0305260.6 Escherichia coli PBD22 Escherichia coli P0305260.7 Escherichia coli PBD24 Escherichia coli P0305260.8 Escherichia coli PBD3 Escherichia coli P0305260.9 Escherichia coli PBD7 Escherichia coli p0305293.1 Escherichia coli PCN009 Escherichia coli p0305293.10 Escherichia coli PCN033 Escherichia coli p0305293.11 Escherichia coli PCN042 Escherichia coli p0305293.12 Escherichia coli PCN079 Escherichia coli p0305293.13 Escherichia coli PCN097 Escherichia coli p0305293.14 Escherichia coli PMV-1 Escherichia coli p0305293.15 Escherichia coli PS Escherichia coli p0305293.2 Escherichia coli PUTI459 Escherichia coli p0305293.3 Escherichia coli R424 Escherichia coli p0305293.4 Escherichia coli R527 Escherichia coli p0305293.5 Escherichia coli R529 Escherichia coli p0305293.6 Escherichia coli RDEC-1 (10f) Escherichia coli p0305293.7 Escherichia coli REL606 Escherichia coli p0305293.8 Escherichia coli RN587/1 Escherichia coli p0305293.9 Escherichia coli RS218 Escherichia coli PI2b Escherichia coli S17 Escherichia coli P4-96 Escherichia coli S88 Escherichia coli P4-NR Escherichia coli SCD1 Escherichia coli PA 10 Escherichia coli SCD2 Escherichia coli PA 14 Escherichia coli SCI-07 Escherichia coli PA 15 Escherichia coli SE11 Escherichia coli PA2 Escherichia coli SE15 Escherichia coli PA22 Escherichia coli SEPT362 Escherichia coli PA23 Escherichia coli SEQ895 Escherichia coli PA24 Escherichia coli SMS-3-5 Escherichia coli PA25 Escherichia coli STEC_7v Escherichia coli PA28 Escherichia coli STEC_94C Escherichia coli PA3 Escherichia coli STEC_B2F1 Escherichia coli PA31 Escherichia coli STEC_CI 65-02 Escherichia coli PA32 Escherichia coli STEC_DG131-3 Escherichia coli PA33 Escherichia coli STEC_EH250 Escherichia coli PA34 Escherichia coli STEC_H.1.8 Escherichia coli PA38 Escherichia coli STEC_MHI813 Escherichia coli PA39 Escherichia coli STEC_031 Escherichia coli PA4 Escherichia coli STEC_SI 191 Escherichia coli PA40 Escherichia coli STHG79 Escherichia coli PA41 Escherichia coli str. ‘clone D il4’ Escherichia coli PA42 Escherichia coli str. ‘clone D i2’ Escherichia coli PA45 Escherichia coli str. Deng Escherichia coli PA47 Escherichia coli SWW33 Escherichia coli PA48 Escherichia coli T1282_01 Escherichia coli T1840 97 Escherichia coli TW10491 Escherichia coli T234_00 Escherichia coli TW10503 Escherichia coli T408 Escherichia coli TW10509 Escherichia coli T426 Escherichia coli TW10512 Escherichia coli T924 01 Escherichia coli TW10518 Escherichia coli TA004 Escherichia coli TW10519 Escherichia coli TA007 Escherichia coli TW10523 Escherichia coli TA008 Escherichia coli TW10526 Escherichia coli TA014 Escherichia coli TW10530 Escherichia coli TA024 Escherichia coli TW10537 Escherichia coli TA054 Escherichia coli TW10545 Escherichia coli TA103 Escherichia coli TW 10547 Escherichia coli TA124 Escherichia coli TW10564 Escherichia coli TA141 Escherichia coli TW10568 Escherichia coli TA143 Escherichia coli TW 10595 Escherichia coli TA144 Escherichia coli TW10598 Escherichia coli TA155 Escherichia coli TW10619 Escherichia coli TA206 Escherichia coli TW10664 Escherichia coli TA249 Escherichia coli TW10722 Escherichia coli TA255 Escherichia coli TW10738 Escherichia coli TA271 Escherichia coli TW10742 Escherichia coli TA280 Escherichia coli TW10747 Escherichia coli TA435 Escherichia coli TW10785 Escherichia coli TA445 Escherichia coli TW10818 Escherichia coli TA447 Escherichia coli TW10828 Escherichia coli TA464 Escherichia coli TW10880 Escherichia coli ThroopD Escherichia coli TW10894 Escherichia coli TOP2386 Escherichia coli TW10899 Escherichia coli TOP2396-1 Escherichia coli TW11039 Escherichia coli TOP2396-2 Escherichia coli TW11606 Escherichia coli TOP2396-3 Escherichia coli TW11638 Escherichia coli TOP2515 Escherichia coli TW11651 Escherichia coli TOP2522-1 Escherichia coli TW11666 Escherichia coli TOP2522-3 Escherichia coli TW11681 Escherichia coli TOP2652 Escherichia coli TW11685 Escherichia coli TOP2662-1 Escherichia coli TW11690 Escherichia coli TOP2662-2 Escherichia coli KTE230 Escherichia coli TOP2662-3 Escherichia coli KTE231 Escherichia coli TOP2662-4 Escherichia coli KTE232 Escherichia coli TOP291 Escherichia coli KTE233 Escherichia coli TOP293-1 Escherichia coli KTE234 Escherichia coli TOP293-2 Escherichia coli KTE235 Escherichia coli TOP293-3 Escherichia coli KTE236 Escherichia coli TOP293-4 Escherichia coli KTE237 Escherichia coli TOP379 Escherichia coli KTE24 Escherichia coli TOP382-1 Escherichia coli KTE240 Escherichia coli TOP382-2 Escherichia coli KTE25 Escherichia coli TOP382-3 Escherichia coli KTE26 Escherichia coli TOP498 Escherichia coli KTE27 Escherichia coli TOP550-1 Escherichia coli KTE28 Escherichia coli TOP550-2 Escherichia coli KTE29 Escherichia coli TOP550-3 Escherichia coli KTE3 Escherichia coli TOP550-4 Escherichia coli KTE31 Escherichia coli TT12B Escherichia coli KTE33 Escherichia coli TW00353 Escherichia coli KTE34 Escherichia coli TW06591 Escherichia coli KTE35 Escherichia coli TW07509 Escherichia coli KTE36 Escherichia coli TW07793 Escherichia coli KTE37 Escherichia coli TW07945 Escherichia coli KTE38 Escherichia coli TW09098 Escherichia coli KTE39 Escherichia coli TW09109 Escherichia coli KTE4 Escherichia coli TW09195 Escherichia coli KTE40 Escherichia coli TW10119 Escherichia coli KTE41 Escherichia coli TW10245 Escherichia coli KTE42 Escherichia coli TW10246 Escherichia coli KTE43 Escherichia coli TW10470 Escherichia coli KTE44 Escherichia coli TW10481 Escherichia coli KTE45 Escherichia coli TW10483 Escherichia coli KTE46 Escherichia coli TW10484 Escherichia coli KTE47 Escherichia coli TW10485 Escherichia coli KTE48 Escherichia coli HS Escherichia coli LT-62 Escherichia coli HT115 Escherichia coli LT-68 Escherichia coli HUSEC2001 Escherichia coli LY180 Escherichia coli HUSEO2011 Escherichia coli M056 Escherichia coli KTE52 Escherichia coli M1 Escherichia coli KTE53 Escherichia coli M10 Escherichia coli KTE54 Escherichia coli M11 Escherichia coli KTE55 Escherichia coli M114 Escherichia coli KTE56 Escherichia coli M12 Escherichia coli KTES7 Escherichia coli M13 Escherichia coli KTES8 Escherichia coli M14 Escherichia coli KTE59 Escherichia coli Ml5 Escherichia coli KTE6 Escherichia coli M16 Escherichia coli KTE60 Escherichia coli M17 Escherichia coli KTE61 Escherichia coli Ml8 Escherichia coli KTE62 Escherichia coli M19 Escherichia coli KTE63 Escherichia coli M2 Escherichia coli KTE64 Escherichia coli M20 Escherichia coli KTE65 Escherichia coli M21 Escherichia coli KTE66 Escherichia coli M22 Escherichia coli KTE67 Escherichia coli M23 Escherichia coli KTE68 Escherichia coli M3 Escherichia coli KTE69 Escherichia coli M4 Escherichia coli KTE7 Escherichia coli M5 Escherichia coli KTE70 Escherichia coli M6 Escherichia coli KTE71 Escherichia coli M605 Escherichia coli KTE72 Escherichia coli M646 Escherichia coli KTE73 Escherichia coli M7 Escherichia coli KTE74 Escherichia coli M718 Escherichia coli KTE75 Escherichia coli M8 Escherichia coli KTE76 Escherichia coli M863 Escherichia coli KTE77 Escherichia coli M9 Escherichia coli KTE78 Escherichia coli M919 Escherichia coli KTE79 Escherichia coli UMEA 3687-1 Escherichia coli KTE8 Escherichia coli UMEA 3693-1 Escherichia coli KTE80 Escherichia coli UMEA 3694-1 Escherichia coli KTE81 Escherichia coli UMEA 3702-1 Escherichia coli KTE82 Escherichia coli UMEA 3703-1 Escherichia coli KTE83 Escherichia coli UMEA 3705-1 Escherichia coli KTE84 Escherichia coli UMEA 3707-1 Escherichia coli KTE85 Escherichia coli UMEA 3718-1 Escherichia coli KTE86 Escherichia coli UMEA 3805-1 Escherichia coli KTE87 Escherichia coli UMEA 3821-1 Escherichia coli KTE88 Escherichia coli UMEA 3834-1 Escherichia coli KTE89 Escherichia coli UMEA 3889-1 Escherichia coli KTE9 Escherichia coli UMEA 3893-1 Escherichia coli KTE90 Escherichia coli UMEA 3899-1 Escherichia coli KTE91 Escherichia coli UMEA 3955-1 Escherichia coli KTE93 Escherichia coli UMEA 4075-1 Escherichia coli KTE94 Escherichia coli CTMEA 4076-1 Escherichia coli KTE95 Escherichia coli UMEA 4207-1 Escherichia coli KTE96 Escherichia coli UMN026 Escherichia coli KTE97 Escherichia coli UMNF18 Escherichia coli KTE98 Escherichia coli LTMNK88 Escherichia coli KTE99 Escherichia coli UTI89 Escherichia coli LAU-EC1 Escherichia coli VDP Escherichia coli LAU-EC10 Escherichia coli Vir68 Escherichia coli EALI-EC2 Escherichia coli VI.2732 Escherichia coli LAU-EC3 Escherichia coli VI.2874 Escherichia coli LAU-EC4 Escherichia coli VR50 Escherichia coli LAU-EC5 Escherichia coli W Escherichia coli LAU-EC6 Escherichia coli W113 Escherichia coli LAU-EC 7 Escherichia coli W181 Escherichia coli LAU-EC8 Escherichia coli W202 Escherichia coli LAU-EC9 Escherichia coli W26 Escherichia coli LCT-EC106 Escherichia coli Wa1 Escherichia coli LCT-EC52 Escherichia coli Wa2 Escherichia coli LCT-EC59 Escherichia coli WC1 Escherichia coli LF82 Escherichia coli WC2 Escherichia coli LT-41 Escherichia coli WV_060327 Escherichia coli XH001 Escherichia coli UMEA 3155-1 Escherichia coli XH140A Escherichia coli UMEA 3159-1 Escherichia coli Xuzhou21 Escherichia coli UMEA 3160-1 Escherichia coli TW11694 Escherichia coli UMEA 3161-1 Escherichia coli TW11699 Escherichia coli UMEA 3162-1 Escherichia coli TW11704 Escherichia coli UMEA 3 163-1 Escherichia coli TW11728 Escherichia coli UMEA 3172-1 Escherichia coli TW11737 Escherichia coli UMEA 3173-1 Escherichia coli TW11741 Escherichia coli UMEA 3174-1 Escherichia coli TW11756 Escherichia coli UMEA 3 175-1 Escherichia coli TW11767 Escherichia coli UMEA 3176-1 Escherichia coli TW11786 Escherichia coli UMEA 3178-1 Escherichia coli TW11816 Escherichia coli UMEA 3180-1 Escherichia coli TW11833 Escherichia coli UMEA 3185-1 Escherichia coli TW11839 Escherichia coli UMEA 3190-1 Escherichia coli TW11890 Escherichia coli UMEA 3193-1 Escherichia coli TW11906 Escherichia coli UMEA 3199-1 Escherichia coli TW11917 Escherichia coli UMEA 3200-1 Escherichia coli TW11950 Escherichia coli UMEA 3201-1 Escherichia coli TW11951 Escherichia coli UMEA 3203-1 Escherichia coli TW11973 Escherichia coli UMEA 3206-1 Escherichia coli TW 12001 Escherichia coli UMEA 3208-1 Escherichia coli TW12002 Escherichia coli UMEA 3212-1 Escherichia coli TW 12009 Escherichia coli UMEA 3215-1 Escherichia coli TW12014 Escherichia coli UMEA 3216-1 Escherichia coli TW12019 Escherichia coli UMEA 3217-1 Escherichia coli TW12023 Escherichia coli UMEA 3220-1 Escherichia coli TW12033 Escherichia coli UMEA 3221-1 Escherichia coli TW12082 Escherichia coli UMEA 3222-1 Escherichia coli TW12086 Escherichia coli UMEA 3230-1 Escherichia coli TW12093 Escherichia coli UMEA 3233-1 Escherichia coli TW12101 Escherichia coli UMEA 3240-1 Escherichia coli TW14301 Escherichia coli UMEA 3244-1 Escherichia coli TW14313 Escherichia coli UMEA 3252-1 Escherichia coli TW14380 Escherichia coli UMEA 3257-1 Escherichia coli TW14390 Escherichia coli UMEA 3264-1 Escherichia coli TW14397 Escherichia coli UMEA 3268-1 Escherichia coli KTE49 Escherichia coli UMEA 3271-1 Escherichia coli KTE5 Escherichia coli UMEA 3290-1 Escherichia coli KTE50 Escherichia coli UMEA 3292-1 Escherichia coli KTE51 Escherichia coli UMEA 3298-1 Escherichia coli TW14711 Escherichia coli UMEA 3304-1 Escherichia coli TW15901 Escherichia coli UMEA 3314-1 Escherichia coli Txl686 Escherichia coli UMEA 3317-1 Escherichia coli TX1999 Escherichia coli UMEA 3318-1 Escherichia coli Tx3800 Escherichia coli UMEA 3323-1 Escherichia coli UM146 Escherichia coli UMEA 3329-1 Escherichia coli UMEA 3014-1 Escherichia coli UMEA 3336-1 Escherichia coli UMEA 3022-1 Escherichia coli UMEA 3337-1 Escherichia coli EIMEA 3033-1 Escherichia coli UMEA 3341-1 Escherichia coli UMEA 3041-1 Escherichia coli UMEA 3342-1 Escherichia coli UMEA 3052-1 Escherichia coli UMEA 3355-1 Escherichia coli UMEA 3053-1 Escherichia coli LTMEA 3391-1 Escherichia coli UMEA 3065-1 Escherichia coli UMEA 3426-1 Escherichia coli UMEA 3087-1 Escherichia coli UMEA 3489-1 Escherichia coli UMEA 3088-1 Escherichia coli UMEA 3490-1 Escherichia coli UMEA 3097-1 Escherichia coli LTMEA 3585-1 Escherichia coli UMEA 3108-1 Escherichia coli UMEA 3592-1 Escherichia coli UMEA 3113-1 Escherichia coli UMEA 3609-1 Escherichia coli UMEA 3117-1 Escherichia coli UMEA 3617-1 Escherichia coli UMEA 3121-1 Escherichia coli UMEA 3632-1 Escherichia coli UMEA 3122-1 Escherichia coli UMEA 3652-1 Escherichia coli UMEA 3124-1 Escherichia coli UMEA 3656-1 Escherichia coli UMEA 3139-1 Escherichia coli UMEA 3662-1 Escherichia coli UMEA 3140-1 Escherichia coli UMEA 3671-1 Escherichia coli UMEA 3144-1 Escherichia coli UMEA 3682-1 Escherichia coli UMEA 3148-1 Escherichia coli TW14435 Escherichia coli UMEA 3150-1 Escherichia coli TW14406 Escherichia coli UMEA 3151-1 Escherichia coli TW14425 Escherichia coli UMEA 3152-1 Escherichia coli TW14427 Escherichia faecaiis Escherichia sp. ASG34 Escherichia fergusonii Escherichia sp. B1147 Escherichia fergusonii ATCC 35469 Escherichia sp. B1225 Escherichia fergusonii B253 Escherichia sp. B4 Escherichia fergusonii ECD227 Escherichia sp. B49 Escherichia hermannii Escherichia sp. B646 Escherichia hermannii NDRC 105704 Escherichia sp. B685 Escherichia senegalensis Escherichia sp. B827 Escherichia vulneris Escherichia sp. BBDP20 Escherichia vulneris NBRC 102420 Escherichia sp. BBDP27 Escherichia sp. 003.10 Escherichia sp. BV24 Escherichia sp. 003.14 Escherichia sp. BV25 Escherichia sp. 003.22 Escherichia sp. CO13(2010) Escherichia sp. 003.23 Escherichia sp. CPD32 Escherichia sp. 006.16 Escherichia sp. daliu Escherichia sp. 006.18 Escherichia sp. dayi Escherichia sp. 006.33 Escherichia sp. DGM MC1E Escherichia sp. 1.1-11 Escherichia sp. DGM MC3E Escherichia sp. 1.3-02 Escherichia sp. DGM MC4E Escherichia sp. 1.9-16 Escherichia sp. DJM1A6 Escherichia sp. 104.10 Escherichia sp. DJM1A8 Escherichia sp. 105.12 Escherichia sp. DJM1B4 Escherichia sp. 105.16 Escherichia sp. DJM1B6 Escherichia sp. 105.17 Escherichia sp. DJM1C4 Escherichia sp. 105.3 Escherichia sp. DM104 Escherichia sp. 105.30 Escherichia sp. DSD31 Escherichia sp. 105.6 Escherichia sp. DSP Escherichia sp. 115 Escherichia sp. E1118 Escherichia sp. 12 Escherichia sp. E195 Escherichia sp. 1_1_43 Escherichia sp. E1196 Escherichia sp. 2.2.5-13 Escherichia sp. E1492 Escherichia sp. 21CR Escherichia sp. E24-PCAi-T2P21 Escherichia sp. 22 Escherichia sp. E25-PCAi-T2P21 Escherichia sp. 23 Escherichia sp. E471 Escherichia sp. 23CR Escherichia sp. E472 Escherichia sp. 253b Escherichia sp. E5-PCAi-T2P21 Escherichia sp. 26N Escherichia sp. E620 Escherichia sp. 28N Escherichia sp. E7-PCAi-T2P21 Escherichia sp. 3-26(2010) Escherichia sp. E807 Escherichia sp. 32 Escherichia sp. EC3 Escherichia sp. 33 Escherichia sp. EECC-575 Escherichia sp. 34 Escherichia sp. EECC-590 Escherichia sp. 3_2_53FAA Escherichia sp. EMB 210 Escherichia sp. 4 Escherichia sp. EMB 339 Escherichia sp. 4067 Escherichia sp. ES13 Escherichia sp. 4094 Escherichia sp. F24-PCAi-T3P21 Escherichia sp. 41 Escherichia sp. FH12 Escherichia sp. 42 Escherichia sp. FH14 Escherichia sp. 43 Escherichia sp. FHM101 Escherichia sp. 49 Escherichia sp. FHM102 Escherichia sp. 49A Escherichia sp. FHM106 Escherichia sp. 4_1_40B Escherichia sp. FHM113 Escherichia sp. 4B Escherichia sp. G3 Escherichia sp. 54 Escherichia sp. GDR06 Escherichia sp. 63 Escherichia sp. H442 Escherichia sp. 64 Escherichia sp. H605 Escherichia sp. 68 Escherichia sp. HPCKc-45 Escherichia sp. 6B Escherichia sp. 16 Escherichia sp. 6CR Escherichia sp. IICFP6 Escherichia sp. 75R Escherichiasp. II_B13 Escherichia sp. 7CR Escherichia sp. July_KB 1F3 Escherichia sp. 80 Escherichia sp. July_NA2A8 Escherichia sp. 88 Escherichia sp. July_TSA2A8 Escherichia sp. A422 Escherichia sp. Kaveri_River_12 Escherichia sp. A441 Escherichia sp. M1108 Escherichia sp. A741 Escherichia sp. M1N2G03 Escherichia sp. A94 Escherichia sp. M2T9B5 Escherichia sp. AF4 Escherichia sp. M863 Escherichia sp. AI(2010) Escherichia sp. ML-11 Escherichia sp. AJ(2010) Escherichia sp. ML2-46 Escherichia sp. MSCB-10 Escherichia sp. ZHS050713 Escherichia sp. NBRC 13921 Escherichia sp. ZHS050714 Escherichia sp. Nil Escherichia sp. ZY-2006a Escherichia sp. Nj-91 Escherichia sp. 4 Escherichia sp. NMU-ST2 environmental samples Escherichia sp. OES18 Escherichia coli CAG:4 Escherichia sp. P14 Escherichia sp. enrichment culture clone 01-084 Escherichia sp. PF7 Escherichia sp. enrichment culture clone 02-023 Escherichia sp. RL325/96 Escherichia sp. enrichment culture clone 03-018 Escherichia sp. S4-AA1-4 Escherichia sp. enrichment culture clone 03-426 Escherichia sp. Sam130-5B Escherichia sp. enrichment culture clone 04 Escherichia sp. Sam130-6A Escherichia sp. enrichment culture clone 1(2012) Escherichia sp. SC-C4-4 Escherichia sp. enrichment culture clone 11(2012) Escherichia sp. SDT20 Escherichia sp. enrichment culture clone 12 Escherichia sp. Sflu5 Escherichia sp. enrichment culture clone 16 Escherichia sp. SI-56 Escherichia sp. enrichment culture clone 17 Escherichia sp. SO-A5-32 Escherichia sp. enrichment culture clone 19(2012) Escherichia sp. SO-Y1-39 Escherichia sp. enrichment culture clone 23 Escherichia sp. SOD-7317 Escherichia sp. enrichment culture clone 3(2012) Escherichia sp. Souza-207 Escherichia sp. enrichment culture clone 9(2012) Escherichia sp. Souza-273 Escherichia sp. enrichment culture clone AVCTGRB2A Escherichia sp. Souza-57 Escherichia sp. enrichment culture clone AVCTGRB2B Escherichia sp. SR2-18-f Escherichia sp. enrichment culture clone CMX Escherichia sp. SVUB6 Escherichia sp. enrichment culture clone Jdgsrb051 Escherichia sp. SW86 Escherichia sp. enrichment culture clone Jdgsrb055 Escherichia sp. SWM Isolation 4 Escherichia sp. enrichment culture clone Jdgsrb056 Escherichia sp. SZ-6 Escherichia sp. enrichment culture clone NBAR001 Escherichia sp. T2 Escherichia sp. enrichment culture clone NBAR004 Escherichia sp. TA04 Escherichia sp. enrichment culture clone NBAR005 Escherichia sp. TA290 Escherichia sp. enrichment culture clone NBAR006 Escherichia sp. TW09231 Escherichia sp. enrichment culture clone NBAR013 Escherichia sp. TW09254 Escherichia sp. enrichment culture clone NBAR015 Escherichia sp. TW09266 Escherichia sp. enrichment culture clone NBAR018 Escherichia sp. TW09276 Escherichia sp. enrichment culture clone NBAR020 Escherichia sp. TW09308 Escherichia sp. enrichment culture clone NBAR022 Escherichia sp. TW10509 Escherichia sp. enrichment culture clone NBAR023 Escherichia sp. TW11930 Escherichia sp. enrichment culture clone NBAR024 Escherichia sp. TW11966 Escherichia sp. enrichment culture clone NX Escherichia sp. TW14182 Escherichia sp. enrichment culture clone R_1017-3_OTU3 Escherichia sp. TW 14263 Escherichia sp. enrichment culture clone R_8m3_OTU3 Escherichia sp. TW 14264 Escherichia sp. enrichment culture clone SRC_NBA4 Escherichia sp. TW 14265 Escherichia sp. enrichment culture clone SRC_NBA7 Escherichia sp. TW 14266 Escherichia sp. enrichment culture clone SRC_NBA8 Escherichia sp. TW 14267 Escherichia sp. enrichment culture clone SunHY Escherichia sp. TW15838 Escherichia sp. enrichment culture clone V-S5SRC 1-51 Escherichia sp. TX3 Escherichia sp. enrichment culture DGGE band D5 Escherichia sp. V2M20 Escherichia sp. oral clone 3RH-30 Escherichia sp. V3M66 uncultured Escherichia clone MT9 Escherichia sp. VA17 uncultured Escherichia sp. Escherichia sp. VF2(2010) uncultured Escherichia sp. FR039 Escherichia sp. W8-PCAi-E14 uncultured Escherichia sp. FR040 Escherichia sp. Z205 Genus: Firmicutes Bacilli Lactobacillales Baci Hales Aerococcaceae Alicyclobacillaceae Carnobacteriaceae Bacillaceae Enterococcaceae Listeriaceae Lactobacillaceae Paenibacillaceae Leuconostocaceae Pasteuriaceae Streptococcaceae Planococcaceae unclassified Lactobacillales Sporolactobacillaceae environmental samples Staphylococcaceae unclassified Bacilli Thermoactinomycetaceae Bacilli bacterium 01A unclassified Bacillales Bacilli bacterium 04A Bacillales incertae sedis Bacilli bacterium 08A environmental samples Bacilli bacterium 09A Bacilli bacterium 12B Clostridia bacterium enrichment culture clone Bacilli bacterium A3-lb D2CL_Bac_16S_Clone 18 Bacilli bacterium AD51 Clostridia bacterium enrichment culture clone Bacilli bacterium BC6 D2CL_Bac_16S_Clone 19 Bacilli bacterium BG 5a Clostridia bacterium enrichment culture clone Bacilli bacterium f50-7-u8f D2CL_Bac_16S_Clone 20 Bacilli bacterium JAM-FM0401 Clostridia bacterium enrichment culture clone IIB_114 Bacilli bacterium JGI BulkO13H05 Clostridia bacterium enrichment culture clone HB_117 Bacilli bacterium JW22.2a Clostridia bacterium enrichment culture clone HB_90 Bacilli bacterium oral taxon C35 Clostridia bacterium enrichment culture clone L11_1_31 Bacilli bacterium oral taxon C43 Clostridia bacterium enrichment culture clone L35B 10 Bacilli bacterium PF61 Clostridia bacterium enrichment culture clone L35B_105 Bacilli bacterium TSW19BA3 Clostridia bacterium enrichment culture clone L35B_145 bacterium 103NT4 Clostridia bacterium enrichment culture clone L35B_146 bacterium 105NT4 Clostridia bacterium enrichment culture clone L35B_152 bacterium 17N1 Clostridia bacterium enrichment culture clone L35B_154 bacterium 18N1 Clostridia bacterium enrichment culture clone L35B_2 bacterium 3E1 Clostridia bacterium enrichment culture clone L35B_30 bacterium 64B4 Clostridia bacterium enrichment culture clone L35B_66 bacterium 66B4 Clostridia bacterium enrichment culture clone L35B_85 bacterium 95LM4 Clostridia bacterium enrichment culture clone L35B_89 bacterium 9B1 Clostridia bacterium enrichment culture clone L35B_99 bacterium WE 1 Clostridia bacterium enrichment culture clone L55B-110 bacterium WE4 Clostridia bacterium enrichment culture clone L55B-127 bacterium WN16 Clostridia bacterium enrichment culture clone L55B-129 environmental samples Clostridia bacterium enrichment culture clone L55B-21 Bacilli bacterium enrichment culture clone 1-2-1 Clostridia bacterium enrichment culture clone L55B-30 Bacilli bacterium enrichment culture clone YFZ9 Clostridia bacterium enrichment culture clone L55B-38 uncultured Bacilli bacterium Clostridia bacterium enrichment culture clone L55B-41 Clostridia Clostridia bacterium enrichment culture clone L55B-44 Clostridiales Clostridia bacterium enrichment culture clone L55B-73 Caldicoprobacteraceae Clostridia bacterium enrichment culture clone L55B-80 Catabacteriaceae Clostridia bacterium enrichment culture clone SIP1 ID Christensenellaceae Clostridia bacterium enrichment culture clone SIP3C Clostridiaceae Clostridia bacterium enrichment culture clone SIP4D Defluviitaleaceae Clostridia bacterium enrichment culture clone WIP10m2D Eubacteriaceae Clostridia bacterium enrichment culture clone WSC-26 Gracilibacteraceae Clostridia bacterium enrichment culture clone WSC-8 Heliobacteriaceae Clostridia bacterium enrichment culture clone WSC-9 Lachnospiraceae Clostridia bacterium enrichment culture DGGE band 1 Osci Hospiraceae Clostridia bacterium enrichment culture RD-M/D-OTU C Peptococcaceae uncultured Clostridia bacterium Peptostreptococcaceae Erysipelotrichia Ruminococcaceae Erysipelotrichales Syntrophomonadaceae Erysipelotrichaceae unclassified Clostridiales unclassified Erysipelotrichales Clostridiales incertae sedis environmental samples environmental samples environmental samples Halanaerobiales Erysipelotrichi bacterium enrichment culture clone Y12 Halanaerobiaceae uncultured Erysipelotrichi bacterium Halobacteroidaceae Negativicutes unclassified Halanaerobiales Selenomonadales environmental samples Acidaminococcaceae Natranaerobiales Veilionellaceae Natranaerobiaceae environmental samples environmental samples environmental samples Thermoanaerobacterales uncultured Negativicutes bacterium Thermoanaerobacteraceae Thermolithobacteria Thermodesuifobiaceae Thermolithobacterales unclassified Thermoanaerobacterales Thermolithobacteraceae Thermoanaerobacterales Family III. Incertae Sedis unclassified Firmicutes sensu stricto Thermoanaerobacterales Family IV. Incertae Sedis unclassified Firmicutes sensu stricto (miscellaneous) environmental samples anaerobic bacterium TOL unclassified Clostridia bacterial str. vp184 unclassified Clostridia (miscellaneous) bacterial str. vp188 environmental samples bacterium ASF 500 Clostridia bacterium enrichment culture clone 40D01 alkaliphilic eubacterium 163-26 Clostridia bacterium enrichment culture clone BF anaerobic bacterium ‘strain 7’ Clostridia bacterium enrichment culture clone bacterium CBM5-27 D2CL_Bac_16S_Clonel7 bacterium CBM5-49 bacterium TC8 Firmicutes bacterium CPB4 blackwater bioreactor bacterium BW21 Firmicutes bacterium CSC3 endosymbiont ‘TCI’ of Trimyema compressum Firmicutes bacterium CSC8 Firmicutes bacterium OODQ7 Firmicutes bacterium DJF VP44 Firmicutes bacterium OODQ8 Firmicutes bacterium DJF VR50 Firmicutes bacterium OODQ9 Firmicutes bacterium EG14 Firmicutes bacterium OOYDA Firmicutes bacterium EG 16 Firmicutes bacterium OOYDC Firmicutes bacterium EG18 Firmicutes bacterium OOYJS Firmicutes bacterium EG20 Firmicutes bacterium OOYK2 Firmicutes bacterium EG24 Firmicutes bacterium OOYDJ Firmicutes bacterium FA1 Firmicutes bacterium OOYDK Firmicutes bacterium FA1a Firmicutes bacterium OOYDM Firmicutes bacterium FAB2 Firmicutes bacterium OOYDS Firmicutes bacterium G6-4 Firmicutes bacterium OOYDU Firmicutes bacterium GM12 Firmicutes bacterium OOYFJ Firmicutes bacterium GM21 Firmicutes bacterium OOYFM Firmicutes bacterium GM29 Firmicutes bacterium OOYFP Firmicutes bacterium GM64 Firmicutes bacterium OOYFR Firmicutes bacterium AV4-2 Firmicutes bacterium OOYIV Firmicutes bacterium B4 5 Firmicutes bacterium OOYI7. Firmicutes bacterium JGT 0000119-C08 Firmicutes bacterium OOYJ3 Firmicutes bacterium JGI 0000119-P10 Firmicutes bacterium OOYJ4 Firmicutes bacterium JGI 0001003-N4 Firmicutes bacterium OOYJQ Firmicutes bacterium JGI 0002005-C11 Firmicutes bacterium 7d3-2 Firmicutes bacterium JS13 Firmicutes bacterium 7d4-l Firmicutes bacterium K-2054 Firmicutes bacterium 7d4-2 Firmicutes bacterium K-2061 Firmicutes bacterium AD3-1 Firmicutes bacterium K-2063 Firmicutes bacterium AD3-3 Firmicutes bacterium HF1 Firmicutes bacterium Apb7 Firmicutes bacterium HF2 Firmicutes bacterium ASFSOO Firmicutes bacterium HF4 Firmicutes bacterium AV4-1 Firmicutes bacterium HF5 Firmicutes bacterium 01QG4 Firmicutes bacterium HF6 Firmicutes bacterium 10827 Firmicutes bacterium HKl Firmicutes bacterium 109-1 Firmicutes bacterium HK11 Firmicutes bacterium 120-6-24 Firmicutes bacterium HK13 Firmicutes bacterium 1229-IDA Firmicutes bacterium HK14 Firmicutes bacterium 1UG Firmicutes bacterium HK15 Firmicutes bacterium 215-38 Firmicutes bacterium HK16 Firmicutes bacterium 215-68 Firmicutes bacterium KK17 Firmicutes bacterium 255-2 Firmicutes bacterium HK19 Firmicutes bacterium 293-12 Firmicutes bacterium HK2 Firmicutes bacterium 309-58 Firmicutes bacterium HK20 Firmicutes bacterium 351UG Firmicutes bacterium HK21 Firmicutes bacterium 43-3 Firmicutes bacterium HK22 Firmicutes bacterium 7dl5-2 Firmicutes bacterium HK23 Firmicutes bacterium 7d2-l Firmicutes bacterium HK24 Firmicutes bacterium 7d2-2 Firmicutes bacterium HK25 Firmicutes bacterium 7d3-l Firmicutes bacterium HK26 Firmicutes bacterium baku-08 Firmicutes bacterium HK28 Firmicutes bacterium BAL8 Firmicutes bacterium HK3 Firmicutes bacterium BAL9 Firmicutes bacterium HK30 Firmicutes bacterium BC1 Firmicutes bacterium HK4 Firmicutes bacterium RCOT-I 5 Firmicutes bacterium HK6 Firmicutes bacterium BCOT-3 Firmicutes bacterium HK7 Firmicutes bacterium BCOT-6 Firmicutes bacterium HK8 Firmicutes bacterium BCOT-9 Firmicutes bacterium InGiAl Firmicutes bacterium RD7-1 Firmicutes bacterium TS2605 Firmicutes bacterium BD7-2 Firmicutes bacterium IS3105 Firmicutes bacterium BD7-3 Firmicutes bacterium Jbgl Firmicutes bacterium BL80 Firmicutes bacterium Jbg2 Firmicutes bacterium BS-02 Firmicutes bacterium Jbg3 Firmicutes bacterium Bt aa 02 Firmicutes bacterium Jbg4 Firmicutes bacterium BTY6 Firmicutes bacterium Jbg5 Firmicutes bacterium BV9-1 Firmicutes bacterium Jbg6 Firmicutes bacterium BV9-3a Firmicutes bacterium Jbg7 Firmicutes bacterium BV9-4a Firmicutes bacterium JGI 0000059-A33 Firmicutes bacterium canine oral taxon 309 Firmicutes bacterium JGI 0000059-D05 Firmicutes bacterium CP4.1 Firmicutes bacterium JGI 0000059-G16 Firmicutes bacterium CP4.3 Firmicutes bacterium JGI 0000059-H17 Firmicutes bacterium Mexcell3.3 Firmicutes bacterium K16 Firmicutes bacterium Mexcell7 Firmicutes bacterium K17 Firmicutes bacterium Mexdttl Firmicutes bacterium K23 Firmicutes bacterium MMD11 Firmicutes bacterium K24 Firmicutes bacterium MMD12 Firmicutes bacterium K3 Firmicutes bacterium OR-167 Firmicutes bacterium K4 Firmicutes bacterium oral taxon A55 Firmicutes bacterium K7 Firmicutes bacterium oral taxon C68 Firmicutes bacterium K9 Firmicutes bacterium oral taxon D73 Firmicutes bacterium Kam1851 Firmicutes bacterium oral taxon F03 Firmicutes bacterium L10-A08 Firmicutes bacterium oral taxon F06 Firmicutes bacterium LC 13R Firmicutes bacterium oral taxon G23 Firmicutes bacterium LM4605 Firmicutes bacterium ORNL 20R SB 170 Firmicutes bacterium LX-B Firmicutes bacterium OS-13B Firmicutes bacterium LX-D Firmicutes bacterium PI Firmicutes bacterium M10-2 Firmicutes bacterium P4 Firmicutes bacterium M28 Firmicutes bacterium PD5-2 Firmicutes bacterium M29 Firmicutes bacterium PM1 Firmicutes bacterium M34 Firmicutes bacterium PM15 Firmicutes bacterium M38 Firmicutes bacterium PM33 Firmicutes bacterium M39 Firmicutes bacterium PM39 Firmicutes bacterium M40 Firmicutes bacterium PM49 Firmicutes bacterium M42 Firmicutes bacterium PV6-lb Firmicutes bacterium M53 Firmicutes bacterium PV6-4 Firmicutes bacterium M71D119 Firmicutes bacterium Rl 1 Firmicutes bacterium M71 D94 Firmicutes bacterium R24 Firmicutes bacterium M71 S54 Firmicutes bacterium RBE2CD-62 Firmicutes bacterium Macell 1.1 Firmicutes bacterium RD1-3 Firmicutes bacterium Macell3.1 Firmicutes bacterium RD1-6 Firmicutes bacterium Mad1 Firmicutes bacterium rif200828 Firmicutes bacterium Mad4 Firmicutes bacterium RV2-2 Firmicutes bacterium Madtt6 Firmicutes bacterium SC-6EZ3-F-Cy56 Firmicutes bacterium Madttd2.1 Firmicutes bacterium SC-6EZ3-F-Cy62 Firmicutes bacterium Madttd2.2 Firmicutes bacterium SCGC AAA028-E02 Firmicutes bacterium Manl7 Firmicutes bacterium SCGC AAA028-K20 Firmicutes bacterium MCF99 Firmicutes bacterium SCGC AAA041-M19 Firmicutes bacterium Mecdtt4 Firmicutes bacterium SCGC AAA041-N22 Firmicutes bacterium Mecdtt5 Firmicutes bacterium SCGC AAA043-A02 Firmicutes bacterium Mexcdtt7 Firmicutes bacterium SCGC AAA043-F09 Firmicutes bacterium Mexcell2 Firmicutes bacterium SCGC AAA044-J20 Firmicutes bacterium TII-G17 Firmicutes bacterium SCGC AAA044-P03 Firmicutes bacterium TH-H12 Firmicutes bacterium SCGC AAA160-B08 Firmicutes bacterium TH-H16 Firmicutes bacterium SCGC AAA278-I09 Firmicutes bacterium TH-N38 Firmicutes bacterium SCGC AAA280-N09 Firmicutes bacterium TH-N39 Firmicutes bacterium SCGC AAA487-F07 Firmicutes bacterium TH-S33 Firmicutes bacterium SCGC AAA487-G07 Firmicutes bacterium TH-S35 Firmicutes bacterium SCGC AB-670-A06 Firmicutes bacterium TH-S40 Firmicutes bacterium SCGC AB-670-B05 Firmicutes bacterium TH-S57 Firmicutes bacterium SCGC AB-670-E02 Firmicutes bacterium TH-S64 Firmicutes bacterium SCGC AB-670-J02 Firmicutes bacterium TH-S70 Firmicutes bacterium SCGC AB-670-K04 Firmicutes bacterium TP 160 Firmicutes bacterium SCGC AB-670-L02 Firmicutes bacterium TP271 Firmicutes bacterium SCGC AB-670-O02 Firmicutes bacterium TP425 Firmicutes bacterium SCGC AB-670-P10 Firmicutes bacterium TP84 Firmicutes bacterium SCGC AB-674-M10 Firmicutes bacterium TP86 Firmicutes bacterium SCGC AC-310-C05 Firmicutes bacterium TP94 Firmicutes bacterium SCGC AC-310-E10 Firmicutes bacterium UFLA03-11 Firmicutes bacterium SCGC AC-310-F10 Firmicutes bacterium VAS32 Firmicutes bacterium SCGC AC-310-FT6 Firmicutes bacterium VAS38 Firmicutes bacterium SCGC AC-310-G06 Firmicutes bacterium VAS39 Firmicutes bacterium SCGC AC-310-G07 Firmicutes bacterium VAS40 Firmicutes bacterium SCGC AC-310-107 Firmicutes bacterium VAS41 Firmicutes bacterium SCGC AC-310-M02 Firmicutes bacterium VAS48 Firmicutes bacterium SCGC AC-310-M09 Firmicutes bacterium VAS49 Firmicutes bacterium SCGC AC-310-M17 Firmicutes bacterium VAS50 Firmicutes bacterium SCGC AC-310-M18 Firmicutes bacterium VAS51 Firmicutes bacterium SCGC AC-3 J0-NO9 Firmicutes bacterium VAS52 Firmicutes bacterium SCGC AC-310-N17 Firmicutes bacterium VAS53 Firmicutes bacterium SCGC AC-310-009 Firmicutes bacterium VNs03 Firmicutes bacterium K11 Firmicutes bacterium VNs39 Firmicutes bacterium VNs41 low G + C Gram-positive bacterium M53 Firmicutes bacterium VNs44 low G + C Gram-positive bacterium M54 Firmicutes bacterium VNs59 low G + C Gram-positive bacterium M5 5 Firmicutes bacterium W-2006 low G + C Gram-positive bacterium MPD-62 Firmicutes bacterium W-2017 low G + C Gram-positive bacterium MPD-63 Firmicutes bacterium W-2018 low G + C Gram-positive bacterium MPD-67 Firmicutes bacterium Washl 1.2 low G + C Gram-positive bacterium MPD-76 Firmicutes bacterium Wash5 low G + C Gram-positive bacterium R2A161 Firmicutes bacterium WD116 low G + C Gram-positive bacterium R2A180 Firmicutes bacterium WD117 low G + C Gram-positive bacterium R2A28 Firmicutes bacterium WD121 low G 1 C Gram-positive bacterium S-N(0)-17C Firmicules baclerium WD3 low G + C Gram-positive baclerium S-N(l)-3 Firmicutes bacterium WD526 low G + C Gram-positive bacterium S-St(l)-6A Firmicutes bacterium WD6 low G + C Gram-positive bacterium S-St(nd)-7D2 Firmicutes bacterium WD80 low G + C Gram-positive bacterium S-Su(l)-8A Firmicutes bacterium WD83 low G + C Gram-positive bacterium S-Su(2)-18 Firmicutes bacterium WH009142s low G + C Gram-positive bacterium S4 Firmicutes bacterium WSF2-15 low G + C Gram-positive bacterium S5 Firmicutes bacterium X3 low G 1 C Gram-positive bacterium SA-5 Firmicutes bacterium YJF1-16 low G + C Gram-positive bacterium SSCA31 low G + C Gram-positive bacterium B773 Firmicutes bacterium SCGC AC-310-O15 low G + C Gram-positive bacterium B775 Firmicutes bacterium SCGC AC-310-020 low G + C Gram-positive bacterium BALI28 Firmicutes bacterium SCGC AC-310-O21 low G + C Gram-positive bacterium D-N(0)-4D Firmicutes bacterium SCGC AC-310-P16 low G + C Gram-positive bacterium D-N(l)-11A Firmicutes bacterium SCGC AC-699-C23 low G + C Gram-positive bacterium D-N(1)-1B Firmicutes bacterium SCGC AC-699-M18 low G + C Gram-positive bacterium D-N(1)-1C Firmicutes bacterium SD1 low G + C Gram-positive bacterium D-N(1)-1D Firmicutes bacterium SE1905 low G + C Gram-positive bacterium D-N(1)-2A Firmicutes bacterium SE2005 low G + C Gram-positive bacterium D-N(1)-3C Firmicutes bacterium SE2105 low G + C Gram-positive bacterium D-N(2)-1A Firmicutes bacterium SH-4-1 low G + C Gram-positive bacterium D-N(2)-2B Firmicutes bacterium SH-4-3-1 low G + C Gram-positive bacterium D-N(2)-2C Firmicutes bacterium SH-5-2 low G + C Gram-positive bacterium D-N(2)-3A Firmicutes bacterium SL-6 low G + C Gram-positive bacterium D-N(2)-3B2 Firmicutes bacterium SM22 low G + C Gram-positive bacterium D-St(l)-3 Firmicutes bacterium SM60 low G + C Gram-positive bacterium D-Su(l)-14A Firmicutes bacterium SP83 low G + C Gram-positive bacterium D-Su(l)-19B Firmicutes bacterium SRC01-ECW low G + C Gram-positive bacterium D-Su(l)-21A Firmicutes bacterium T17b-60 low G + C Gram-positive bacterium D-Su(l)-21B Firmicutes bacterium T17b-64 low G + C Gram-positive bacterium D-Su(l)-21C Firmicutes bacterium T28-15 low G + C Gram-positive bacterium D-Su(l)-22 Firmicutes bacterium T28-20a low G + C Gram-positive bacterium D-Su(l)-25 Firmicutes bacterium T28-9b low G 1 C Gram-positive bacterium D-Su(l)-4B Firmicutes bacterium T30b-36 low G + C Gram-positive bacterium D-Su(l)-5 Firmicutes bacterium TAT AC-10 low G + C Gram-positive bacterium D-Su(l)-6B Firmicutes bacterium TG10 low G + C Gram-positive bacterium D-Su(l)-7B Firmicutes bacterium TG11 low G + C Gram-positive bacterium D-Su(l)-7C Firmicutes bacterium TG14 low G + C Gram-positive bacterium D-Su(2)-10 Firmicutes bacterium TGI 5 low G + C Gram-positive bacterium HTA1415 Firmicutes bacterium TG17 low G + C Gram-positive bacterium HTA1416 Firmicutes bacterium TGI8 low G + C Gram-positive bacterium HTA1417 Firmicutes bacterium TGI9 low G + C Gram-positive bacterium HTA1418 Firmicutes bacterium TG2 low G + C Gram-positive bacterium HTA1420 Firmicutes bacterium TG20 low G + C Gram-positive bacterium HTA1422 Firmicutes bacterium TG21 low G + C Gram-positive bacterium HTA426 Firmicutes bacterium TG24 low G + C Gram-positive bacterium HTA437 Firmicutes bacterium TG25 low G + C Gram-positive bacterium HTA454 Firmicutes bacterium TG26 low G + C Gram-positive bacterium HTA462 Firmicutes bacterium TG27 low G + C Gram-positive bacterium HTA484 Firmicutes bacterium TG29 low G + C Gram-positive bacterium HTA506 Firmicutes bacterium TG3 low G + C Gram-positive bacterium HTA563 Firmicutes bacterium TG30 low G + C Gram-positive bacterium HTE856 Firmicutes bacterium TG32 low G + C Gram-positive bacterium IRB 1 Firmicutes bacterium TG34 low G + C Gram-positive bacterium L23 Firmicutes bacterium TG39 low G + C Gram-positive bacterium LVS-50 Firmicutes bacterium TG4 low G + C Gram-positive bacterium M33 Firmicutes bacterium TG6 low G + C Gram-positive bacterium M34 Firmicutes bacterium TG7 low G + C Gram-positive bacterium M51 Firmicutes bacterium TG8 low G + C Gram-positive bacterium M52 Firmicutes bacterium TG9 Firmicutes bacterium TGT3-6A Firmicutes bacterium C AG:170 Firmicutes bacterium TGT5-5A Firmicutes bacterium CAG:176 Firmicutes bacterium TGT5-5B Firmicutes bacterium CAG:194 Firmicutes bacterium TGTM-5A Firmicutes bacterium CAG:212 Firmicutes bacterium TGTM-5B Firmicutes bacterium CAG:227 Firmicutes bacterium TH-G1 Firmicutes bacterium CAG:238 low G + C Gram-positive bacterium zo05 Firmicutes bacterium CAG:24 low GC Gram-positive bacterium strain AHT28 Firmicutes bacterium CAG:240 low GC Gram-positive bacterium strain AHT29 Firmicutes bacterium CAG:270 marine bacterium NBF29 Firmicutes bacterium CAG:272 marine bacterium NBF32 Firmicutes bacterium CAG:308 marine bacterium SIMO IS-S76-284 Firmicutes bacterium CAG:313 marine bacterium SIMO-IS120 Firmicutes bacterium CAG:321 marine bacterium SIMO-IS131 Firmicutes bacterium CAG:341 marine bacterium SIMO-IS186 Firmicutes bacterium CAG:345 marine bacterium SIMO-IS188 Firmicutes bacterium CAG:41 marine bacterium SIMO-IS189 Firmicutes bacterium CAG:424 marine bacterium SIMO-IS191 Firmicutes bacterium CAG:449 marine bacterium SIMO-IS194 Firmicutes bacterium CAG:460 marine bacterium SIMO-IS197 Firmicutes bacterium CAG:466 marine bacterium SIMO-TS206 Firmicutes bacterium CAG:475 marine bacterium SIMO-IS209 Firmicutes bacterium CAG:534 marine bacterium SIMO-IS212 Firmicutes bacterium CAG:536 marine bacterium SIMO-IS214 Firmicutes bacterium CAG:552 marine bacterium SIMO-TS215 Firmicutes bacterium CAG:555 marine bacterium SIMO-IS216 Firmicutes bacterium CAG:56 marine firmicute 1P07AA Firmicutes bacterium CAG:582 marine firmicute HTB096 Firmicutes bacterium CAG:631 marine firmicute HTB113 Firmicutes bacterium CAG:646 mixed culture isolate koll!3 Firmicutes bacterium CAG:65 segmented filamentous bacterium Firmicutes bacterium CAG:791 low G + C Gram-positive bacterium SSCS10 Firmicutes bacterium CAG:822 low G + C Gram-positive bacterium SSCS20 Firmicutes bacterium CAG:83 low G + C Gram-positive bacterium SSCS21-2 Firmicutes bacterium CAG:882 low G + C Gram-positive bacterium SSCS28 Firmicutes bacterium CAG:884 low G + C Gram-positive bacterium SSCS35 Firmicutes bacterium CAG:94 low G + C Gram-positive bacterium SSCS42 Firmicutes bacterium CAG:95 low G + C Gram-positive bacterium SSCT75 Firmicutes bacterium enrichment culture clone 0-6F07 low G + C Gram-positive bacterium SSCT76 Firmicutes bacterium enrichment culture clone 106MTBE low G + C Gram-positive bacterium SSCT84-2 Firmicutes bacterium enrichment culture clone 16695 ECW 20 low G + C Gram-positive bacterium T134 Firmicutes bacterium enrichment culture clone 16695 ECW 21 low G + C Gram-positive bacterium T135 Firmicutes bacterium enrichment culture clone 16695 ECW 22 low G + C Gram-positive bacterium T152 Firmicutes bacterium enrichment culture clone 16695 ECW 24 low G I C Gram-positive bacterium T155 Firmicutes bacterium enrichment culture clone 16695 ECW 6 low G + C Gram-positive bacterium TR1 Firmicutes bacterium enrichment culture clone 16695 ECW 8 low G + C Gram-positive bacterium wo 11 Firmicutes bacterium enrichment culture clone 4.17b Bac band 1 low G + C Gram-positive bacterium wo47 Firmicutes bacterium enrichment culture clone 4.17b Bac band 2 unidentified low G + C gram-positive bacterium RS10 Firmicutes bacterium enrichment culture clone 4.17b Bac band 3 unidentified low G + C gram-positive bacterium RS13 Firmicutes bacterium enrichment culture clone 4.17b Bac band 4 unidentified low G + C gram-positive bacterium RS16 Firmicutes bacterium enrichment culture clone A17 unidentified low G + C gram-positive bacterium RSI9 Firmicutes bacterium enrichment culture clone B31179 swine manure bacterium PC9 Firmicutes bacterium enrichment culture clone BSK 1 thermophilic bacterium JA2 Firmicutes bacterium enrichment culture clone BSK 108 Firmicutes symbiont of Osedax sp. Firmicutes bacterium enrichment culture clone BSK 11 unidentified bacterium Par64 Firmicutes bacterium enrichment culture clone BSK 114 unidentified low G + C gram-positive bacterium RS20 Firmicutes bacterium enrichment culture clone BSK 125 unidentified low G + C gram-positive bacterium RS21 Firmicutes bacterium enrichment culture clone BSK 23 unidentified low G + C gram-positive bacterium RS21 a Firmicutes bacterium enrichment culture clone BSK 30 unidentified low G + C gram-positive bacterium RS3 Firmicutes bacterium enrichment culture clone BSK 36 unidentified low G + C gram-positive bacterium RS5 Firmicutes bacterium enrichment culture clone BSK 37 unidentified low G + C gram-positive bacterium SI2 Firmicutes bacterium enrichment culture clone BSK 40 environmental samples Firmicutes bacterium enrichment culture clone BSK 41 Firmicutes bacterium CAG:102 Firmicutes bacterium enrichment culture clone BSK 48 Firmicutes bacterium CAG:103 Firmicutes bacterium enrichment culture clone BSK 52 Firmicutes bacterium CAG:110 Firmicutes bacterium enrichment culture clone BSK 58 Firmicutes bacterium CAG:114 Firmicutes bacterium enrichment culture clone BSK 60 Firmicutes bacterium C AG:124 Firmicutes bacterium enrichment culture clone BSK 67 Firmicutes bacterium CAG:129 Firmicutes bacterium enrichment culture clone BSK 88 Firmicutes bacterium CAG:137 Firmicutes bacterium enrichment culture clone BSK 94 Firmicutes bacterium CAG:145 Firmicutes bacterium enrichment culture clone BSK 96 Firmicutes bacterium enrichment culture clone BSK 97 Firmicutes bacterium enrichment culture clone CTBE CDB 1009D09 Firmicutes bacterium enrichment culture clone BSK 98 Firmicutes bacterium enrichment culture clone CTBE CDB1009D10 Firmicutes bacterium enrichment culture clone BSK 99 Firmicutes bacterium enrichment culture clone CTBE CDB 1009D11 Firmicutes bacterium enrichment culture clone CTBE CDB1001A07 Firmicutes bacterium enrichment culture clone CTBE CDB1009E02 Firmicutes bacterium enrichment culture clone CTBE CDB1001H03 Firmicutes bacterium enrichment culture clone CTBE CDB1009E03 Firmicutes bacterium enrichment culture clone CTBE CDB1006A02 Firmicutes bacterium enrichment culture clone CTBE CDB1009E04 Firmicutes bacterium enrichment culture clone CTBE CDB 1006A04 Firmicutes bacterium enrichment culture clone CTBE CDB1009E05 Firmicutes bacterium enrichment culture clone CTBE CDB1006A06 Firmicutes bacterium enrichment culture clone CTBE CDB1009E06 Firmicutes bacterium enrichment culture clone CTBE CDB1006A07 Firmicutes bacterium enrichment culture clone CTBE CDB1009E07 Firmicutes bacterium enrichment culture clone CTBE CDB1006A08 Firmicutes bacterium enrichment culture clone CTBE CDB1009E10 Firmicutes bacterium enrichment culture clone CTBE CDB1006A09 Firmicutes bacterium enrichment culture clone CTBE CDB 1009F03 Firmicutes bacterium enrichment culture clone CTBE CDB1006A10 Firmicutes bacterium enrichment culture clone CTBE CDB1009F04 Firmicutes bacterium enrichment culture clone CTBE CDB1006B01 Firmicutes bacterium enrichment culture clone CTBE CDB1009F05 Firmicutes bacterium enrichment culture clone CTBE CDB1006B07 Firmicutes bacterium enrichment culture clone CTBE CDB1009F06 Firmicutes bacterium enrichment culture clone CTBE CDB1006B10 Firmicutes bacterium enrichment culture clone CTBE CDB1009F07 Firmicutes bacterium enrichment culture clone CTBE CDB1006B11 Firmicutes bacterium enrichment culture clone CTBE CDB1009F12 Firmicutes bacterium enrichment culture clone CTBE CDB1006B12 Firmicutes bacterium enrichment culture clone CTBE CDB1009G02 Firmicutes bacterium enrichment culture clone CTBE CDB 1006C06 Firmicutes bacterium enrichment culture clone CTBE CDB1009G07 Firmicutes bacterium enrichment culture clone CTBE CDB1006C07 Firmicutes bacterium enrichment culture clone CTBE CDB1009G08 Firmicutes bacterium enrichment culture clone CTBE CDB1006C09 Firmicutes bacterium enrichment culture clone CTBE CDB1009G12 Firmicutes bacterium enrichment culture clone CTBE CDB1006C10 Firmicutes bacterium enrichment culture clone CTBE CDB1009H01 Firmicutes bacterium enrichment culture clone CTBE CDB1006C11 Firmicutes bacterium enrichment culture clone CTBE CDB 1009H02 Firmicutes bacterium enrichment culture clone CTBE CDB1006C12 Firmicutes bacterium enrichment culture clone CTBE CDB1009H04 Firmicutes bacterium enrichment culture clone CTBE CDB1006D05 Firmicutes bacterium enrichment culture clone CTBE CDB1009H05 Firmicutes bacterium enrichment culture clone CTBE CDB 1006D06 Firmicutes bacterium enrichment culture clone CTBE CDB1009H07 Firmicutes bacterium enrichment culture clone CTBE CDB 1006D07 Firmicutes bacterium enrichment culture clone C TBE CDB1009H09 Firmicutes bacterium enrichment culture clone CTBE CDB 1006D08 Firmicutes bacterium enrichment culture clone CTBE CDB1009H10 Firmicutes bacterium enrichment culture clone CTBE CDB1006D10 Firmicutes bacterium enrichment culture clone CTBE CDB1010A02 Firmicutes bacterium enrichment culture clone CTBE CDB1006D11 Firmicutes bacterium enrichment culture clone CTBE CDB1010A03 Firmicutes bacterium enrichment culture clone CTBE CDB1006E04 Firmicutes bacterium enrichment culture clone CTBE CDB1010A04 Firmicutes bacterium enrichment culture clone CTBE CDB1006E07 Firmicutes bacterium enrichment culture clone CTBE CDB1010A07 Firmicutes bacterium enrichment culture clone CTBE CDB1006E08 Firmicutes bacterium enrichment culture clone CTBE CDB1010A08 Firmicutes bacterium enrichment culture clone CTBE CDB1006E09 Firmicutes bacterium enrichment culture clone CTBE CDB1010A09 Firmicutes bacterium enrichment culture clone CTBE CDB1006E10 Firmicutes bacterium enrichment culture clone C TBE CDB1010A12 Firmicutes bacterium enrichment culture clone CTBE CDB1006E11 Firmicutes bacterium enrichment culture clone CTBE CDB1010B02 Firmicutes bacterium enrichment culture clone CTBE CDB1006F02 Firmicutes bacterium enrichment culture clone CTBE CDB1010B04 Firmicutes bacterium enrichment culture clone CTBE CDB 1006F06 Firmicutes bacterium enrichment culture clone CTBE CDB1010B07 Firmicutes bacterium enrichment culture clone CTBE CDB 1006F07 Firmicutes bacterium enrichment culture clone CTBE CDB1010B10 Firmicutes bacterium enrichment culture clone CTBE CDB1006F08 Firmicutes bacterium enrichment culture clone CTBE CDB1010B11 Firmicutes bacterium enrichment culture clone CTBE CDB 1006F11 Firmicutes bacterium enrichment culture clone CTBE CDB1010C01 Firmicutes bacterium enrichment culture clone CTBE CDB1006G03 Firmicutes bacterium enrichment culture clone CTBE CDB1010C02 Firmicutes bacterium enrichment culture clone CTBE CDB1006G06 Firmicutes bacterium enrichment culture clone CTBE CDB1010C03 Firmicutes bacterium enrichment culture clone CTBE CDB1006G07 Firmicutes bacterium enrichment culture clone CTBE CDB1010C05 Firmicutes bacterium enrichment culture clone CTBE CDB1006G08 Firmicutes bacterium enrichment culture clone CTBE CDB1010C06 Firmicutes bacterium enrichment culture clone CTBE CDB1006G10 Firmicutes bacterium enrichment culture clone CTBE CDB 1010C07 Firmicutes bacterium enrichment culture clone CTBE CDB1006H06 Firmicutes bacterium enrichment culture clone CTBE CDB1010C08 Firmicutes bacterium enrichment culture clone CTBE CDB1006H07 Firmicutes bacterium enrichment culture clone CTBE CDB 1010C11 Firmicutes bacterium enrichment culture clone CTBE CDB 1006H08 Firmicutes bacterium enrichment culture clone CTBE CDB1010C12 Firmicutes bacterium enrichment culture clone CTBE CDB1006H09 Firmicutes bacterium enrichment culture clone CTBE CDB1010D07 Firmicutes bacterium enrichment culture clone CTBE CDB1006H10 Firmicutes bacterium enrichment culture clone CTBE CDB1010D08 Firmicutes bacterium enrichment culture clone CTBE CDB1006H11 Firmicutes bacterium enrichment culture clone CTBE CDB1010D10 Firmicutes bacterium enrichment culture clone CTBE CDB1006H12 Firmicutes bacterium enrichment culture clone CTBE CDB1010D12 Firmicutes bacterium enrichment culture clone CTBE CDB1009A05 Firmicutes bacterium enrichment culture clone CTBE CDB1010E04 Firmicutes bacterium enrichment culture clone CTBE CDB1009A08 Firmicutes bacterium enrichment culture clone CTBE CDB1010E06 Firmicutes bacterium enrichment culture clone CTBE CDB1009A10 Firmicutes bacterium enrichment culture clone CTBE CDB1010E07 Firmicutes bacterium enrichment culture clone CTBE CDB1009A12 Firmicutes bacterium enrichment culture clone CTBE CDB 1010E10 Firmicutes bacterium enrichment culture clone CTBE CDB1009B03 Firmicutes bacterium enrichment culture clone CTBE CDB1010E11 Firmicutes bacterium enrichment culture clone CTBE CDB 1009B04 Firmicutes bacterium enrichment culture clone CTBE CDB1010F0I Firmicutes bacterium enrichment culture clone CTBE CDB 1009B07 Firmicutes bacterium enrichment culture clone C TBE CDB1010F03 Firmicutes bacterium enrichment culture clone CTBE CDB1009B08 Firmicutes bacterium enrichment culture clone CTBE CDB1010F04 Firmicutes bacterium enrichment culture clone CTBE CDB 1009C03 Firmicutes bacterium enrichment culture clone CTBE CDB1010F06 Firmicutes bacterium enrichment culture clone CTBE CDB 1009C04 Firmicutes bacterium enrichment culture clone CTBE CDB1010F07 Firmicutes bacterium enrichment culture clone CTBE CDB 1009C06 Firmicutes bacterium enrichment culture clone CTBE CDB1010F08 Firmicutes bacterium enrichment culture clone CTBE CDB1009C08 Firmicutes bacterium enrichment culture clone CTBE CDB1010G02 Firmicutes bacterium enrichment culture clone CTBE CDB1009C11 Firmicutes bacterium enrichment culture clone CTBE CDB1010G03 Firmicutes bacterium enrichment culture clone CTBE CDB1009D03 Firmicutes bacterium enrichment culture clone CTBE CDB1010G05 Firmicutes bacterium enrichment culture clone CTBE CDB1009D04 Firmicutes bacterium enrichment culture clone CTBE CDB1010G06 Firmicutes bacterium enrichment culture clone CTBE CDB1009D05 Firmicutes bacterium enrichment culture clone CTBE CDB1010G07 Firmicutes bacterium enrichment culture clone CTBE CDB1009D06 Firmicutes bacterium enrichment culture clone CTBE CDB1010G12 Firmicutes bacterium enrichment culture clone CTBE CDB1009D08 Firmicutes bacterium enrichment culture clone CTBE CDB1010H01 Firmicutes bacterium enrichment culture clone CTBE CDB1010H05 uncultured feedlot manure bacterium A54 Firmicutes bacterium enrichment culture clone CTBE CDB1010H09 uncultured feedlot manure bacterium A77 Firmicutes bacterium enrichment culture clone CTBE CDB1010H11 uncultured feedlot manure bacterium A84 Firmicutes bacterium enrichment culture clone DhRA2/LM-A04 uncultured feedlot manure bacterium B1 Firmicutes bacterium enrichment culture clone E197 uncultured feedlot manure bacterium B101 Firmicutes bacterium enrichment culture clone E200 uncultured feedlot manure bacterium B117 Firmicutes bacterium enrichment culture clone J uncultured feedlot manure bacterium B126 Firmicutes bacterium enrichment culture clone j220 uncultured feedlot manure bacterium B17 Firmicutes bacterium enrichment culture clone L12 uncultured feedlot manure bacterium B2 Firmicutes bacterium enrichment culture clone MLSB6m7B uncultured feedlot manure bacterium B29 Firmicutes bacterium enrichment culture clone MS LAC Ull uncultured feedlot manure bacterium B51 Firmicutes bacterium enrichment culture clone MS NAP N15 uncultured feedlot manure bacterium B56 Firmicutes bacterium enrichment culture clone MS NAP N4 uncultured feedlot manure bacterium B6 Firmicutes bacterium enrichment culture clone otu Fl uncultured feedlot manure bacterium B7 Firmicutes bacterium enrichment culture clone phylotype P9 uncultured feedlot manure bacterium B78 Firmicutes bacterium enrichment culture clone VNABa03 uncultured feedlot manure bacterium B8 Firmicutes bacterium enrichment culture clone VNBB003 uncultured feedlot manure bacterium B81 Firmicutes bacterium enrichment culture clone VNBB004 uncultured feedlot manure bacterium B82 Firmicutes bacterium enrichment culture clone VNC1B071 uncultured feedlot manure bacterium B85 Firmicutes bacterium enrichment culture clone WSC-21 uncultured feedlot manure bacterium B87 Firmicutes bacterium enrichment culture clone WSC-32 uncultured feedlot manure bacterium B90 Firmicutes bacterium oral clone 24-91 uncultured fermented cassava bacterium M10 hydrogen production community clone HPB-G1-14 uncultured fermented cassava bacterium M2 metal-contaminated soil clone K20-13 uncultured fermented cassava bacterium M4 metal-contaminated soil clone K20-14 uncultured fermented cassava bacterium M5 metal-contaminated soil clone K20-66 uncultured fermented cassava bacterium M6 uncultured bacterium #0319-23G15 uncultured fermented cassava bacterium M7 uncultured bacterium #0319-7G4 uncultured fermented cassava bacterium MS uncultured bacterium #0319-7J14 uncultured fermented cassava bacterium M9 uncultured bacterium CLEAR-17 uncultured Firmicutes bacterium uncultured bacterium CLEAR-33 uncultured hydrocarbon seep bacterium BPC043 uncultured bacterium CLEAR-6 uncultured hydrocarbon seep bacterium BPC060 uncultured bacterium EKHO-4 uncultured hydrocarbon seep bacterium BPC094 uncultured bacterium mlel-9 uncultured Low G + C gram positive bacterium Kmlps3-23 uncultured bacterium O11D9 uncultured low G + C gram positive bacterium MT35 uncultured bacterium SCALE-16 uncultured low G + C gram positive bacterium MT38 uncultured bacterium SJA-112 uncultured low G + C gram positive bacterium n35r uncultured bacterium SJA-118 uncultured low G + C Gram-positive bacterium uncultured bacterium SJA-131 uncultured low G + C Gram-positive bacterium 102ev uncultured bacterium SJA-136 uncultured low G + C Gram-positive bacterium 105ev uncultured bacterium SJA-143 uncultured low G + C Gram-positive bacterium 108ev uncultured bacterium SJA-173 uncultured low G + C Gram-positive bacterium lOev uncultured bacterium SJA-29 uncultured low G + C Gram-positive bacterium 11 lev uncultured bacterium SJA-65 uncultured low G 1 C Gram-positive bacterium 119ev uncultured bacterium SJA-84 uncultured low G + C Gram-positive bacterium 121ev uncultured bacterium tbrl-1 uncultured low G + C Gram-positive bacterium 129ev uncultured bacterium tbrl-10 uncultured low G + C Gram-positive bacterium 12ev uncultured bacterium tbrl-8 uncultured low G + C Gram-positive bacterium 132cv uncultured bacterium tbrl-9 uncultured low G + C Gram-positive bacterium 135ev uncultured bacterium tbr4-15 uncultured low G + C Gram-positive bacterium 13ev uncultured bacterium tbr4-78 uncultured low G + C Gram-positive bacterium 145ev uncultured eubacterium WCHA1-17 uncultured low G + C Gram-positive bacterium 146cv uncultured eubacterium WCHA1-45 uncultured low G + C Gram-positive bacterium 15lev− uncultured eubacterium WCHA1-53 uncultured low G + C Gram-positive bacterium 178ev uncultured eubacterium WCHB1-20 uncultured low G + C Gram-positive bacterium 17ev uncultured eubacterium WCHB 1-21 uncultured low G + C Gram-positive bacterium 188ev uncultured eubacterium WCHB 1-49 uncultured low G + C Gram-positive bacterium 208ev uncultured eubacterium WCHB 1-54 uncultured low G + C Gram-positive bacterium 20ev uncultured eubacterium WCHB 1-71 uncultured low G + C Gram-positive bacterium 219ev uncultured eubacterium WCHB 1-77 uncultured low G + C Gram-positive bacterium 225ev uncultured eubacterium WCHB 1-82 uncultured low G + C Gram-positive bacterium 228ev uncultured eubacterium WCHB 1-84 uncultured low G + C Gram-positive bacterium 236ev uncultured eubacterium WCHB 1-89 uncultured low G + C Gram-positive bacterium 243ev uncultured eubacterium WFeAl-16 uncultured low G + C Gram-positive bacterium 248ev uncultured eubacterium WsCH 1 uncultured low G + C Gram-positive bacterium 26lev uncultured eubacterium WsCH5 uncultured low G + C Gram-positive bacterium 274ev uncultured eubacterium WsCHS uncultured low G + C Gram-positive bacterium 275ev uncultured feedlot manure bacterium A13 uncultured low G + C Gram-positive bacterium 28ev uncultured feedlot manure bacterium A18 uncultured low G + C Gram-positive bacterium 29lev uncultured feedlot manure bacterium A20 uncultured low G + C Gram-positive bacterium 29ev uncultured low G + C Gram-positive bacterium 301ev unidentified rumen bacterium JW19 uncultured low G + C Gram-positive bacterium 303ev unidentified rumen bacterium JW21 uncultured low G + C Gram-positive bacterium 306ev unidentified rumen bacterium JW23 uncultured low G + C Gram-positive bacterium 307ev unidentified rumen bacterium JW24 uncultured low G + C Gram-positive bacterium 31 Oev unidentified rumen bacterium JW25 uncultured low G + C Gram-positive bacterium 33ev unidentified rumen bacterium JW26 uncultured low G + C Gram-positive bacterium 340ev unidentified rumen bacterium JW28 uncultured low G + C Gram-positive bacterium 355ev unidentified rumen bacterium JW29 uncultured low G + C Gram-positive bacterium 35 Sev unidentified rumen bacterium JW3 uncultured low G + C Gram-positive bacterium 370ev unidentified rumen bacterium JW32 uncultured low G + C Gram-positive bacterium 37lev unidentified rumen bacterium JW33 uncultured low G + C Gram-positive bacterium 372ev unidentified rumen bacterium JW5 uncultured low G + C Gram-positive bacterium 377ev unidentified rumen bacterium JW6 uncultured low G + C Gram-positive bacterium 380ev unidentified rumen bacterium RC15 uncultured low G + C Gram-positive bacterium 398cv unidentified rumen bacterium RC6 uncultured low G + C Gram-positive bacterium 400ev unidentified rumen bacterium RCP1 uncultured low G + C Gram-positive bacterium 41 lev unidentified rumen bacterium RF3 uncultured low G + C Gram-positive bacterium 414ev uncultured low G 1 C Gram-positive bacterium 430ev uncultured low G + C Gram-positive bacterium 433ev uncultured low G + C Gram-positive bacterium 437ev uncultured low G + C Gram-positive bacterium 43ev uncultured low G + C Gram-positive bacterium 444cv uncultured low G + C Gram-positive bacterium 48ev uncultured low G + C Gram-positive bacterium 53ev uncultured low G + C Gram-positive bacterium 59ev uncultured low G + C Gram-positive bacterium 5ev uncultured low G + C Gram-positive bacterium 75ev uncultured low G + C Gram-positive bacterium 77ev uncultured low G + C Gram-positive bacterium 78ev uncultured low G + C Gram-positive bacterium 7ev uncultured low G + C Gram-positive bacterium 82ev uncultured low G + C Gram-positive bacterium 9lev uncultured low G + C Gram-positive bacterium 92ev uncultured low G + C Gram-positive bacterium 98ev uncultured low G + C Gram-positive bacterium clone OPB54 uncultured low G + C Gram-positive bacterium SHD-209 uncultured Low G + C Gram-positive bacterium Sva0855 uncultured Low G + C Gram-positive bacterium Sval064 uncultured low-GC gram+ bacterium kpa86rc uncultured marine Gram-positive bacterium DH148-Z18 uncultured sludge bacterium A28 uncultured synthetic wastewater bacterium tmbrl 1-29 uncultured synthetic wastewater bacterium tmbrl 1-6 uncultured synthetic wastewater bacterium tmbrl 1-7 uncultured synthetic wastewater bacterium tmbrl5-12 uncultured synthetic wastewater bacterium tmbrl 5-20 uncultured synthetic wastewater bacterium tmbrl 5-26 unidentified eubacterium RB04 unidentified eubacterium RB05 unidentified eubacterium RB07 unidentified eubacterium RB08 unidentified eubacterium RB16 unidentified eubacterium RB17 unidentified eubacterium RB29 unidentified eubacterium RB38 unidentified low G + C gram-positive bacterium unidentified oil field bacterium KUBA7 unidentified oii field bacterium SYNK4 unidentified rumen bacterium 12-110 unidentified rumen bacterium 12-116 unidentified rumen bacterium 12-124 unidentified rumen bacterium 12-128 unidentified rumen bacterium 12-74 unidentified rumen bacterium 12-76 unidentified rumen bacterium 30-2 unidentified rumen bacterium 30-20 unidentified rumen bacterium JW11 unidentified rumen bacterium JW13 unidentified rumen bacterium JW18 Genus: Bacteroidetes Bacteroidia Flavobacteria bacterium PG2S01 Bacteroidales Flavobacteria bacterium S1-62 Bacteroidaceae Flavobacteria bacterium SC2 Marinilabiliaceae Flavobacteria bacterium SC4 Porphyromonadaceae Flavobacteria bacterium SG-13 Prevotellaceae Flavobacteria bacterium SG-18 Rikenellaceae Flavobacteria bacterium SO53PV unclassified Bacteroidales Flavobacteria bacterium SOMB059 environmental samples Flavobacteria bacterium SR3 unclassified Bacteroidia Flavobacteria bacterium TW-JL-17 Bacteroidia bacterium canine oral taxon 041 Flavobacteria bacterium TW-JL-80 Bacteroidia bacterium canine oral taxon 187 Flavobacteria bacterium UST061013-075 Bacteroidia bacterium canine oral taxon 301 Flavobacteria bacterium UST061013-076 Bacteroidia bacterium canine oral taxon 387 Flavobacteria bacterium Yb001 environmental samples Flavobacteria bacterium Yb004 uncultured Bacteroidia bacterium Flavobacteria bacterium Yb008 Cytopfiagia Flavobacteria bacterium Yb009 Cytopfiagales Flavobacteria bacterium Yb011 Cyclobacteriaceae Flavobacteria bacterium ZL-3 Cytophagaceae Flavobacteria bacterium ZL-4 Flammeovirgaceae Flavobacteria endosymbiont of Homalodisca coagulata unclassified Cytophagales Flavobacteria symbiont 1 of Acromyrmcx otcospinosus environmental samples Flavobacteria symbiont 2 of Acromyrmex otcospinosus uncultured Cytophagia bacterium Flavobacteria symbiont 3 of Acromyrmex otcospinosus Flavobacteriia Flavobacteria symbiont 4 of Acromyrmex otcospinosus Flavobacteriales Flavobacteria symbiont 5 of Acromyrmex otcospinosus B lattabacteiiaceae Flavobacteriia bacterium limp mda_pilot_Jcvi 0014 Cryomorphaceae marine bacterium MB TCI 357 Flavobacteriaceae marine bacterium P99-3 Schleiferiaceae Flavobacteria sp. MaPt5 unclassified Flavobacteriales environmental samples environmental samples Flavobacteria bacterium enrichment culture clone SMEC3 unclassified Flavobacteriia Flavobacteria bacterium enrichment culture clone YYS1 aquatic bacterium STS_R2A_06 Flavobacteria bacterium enrichment culture clone YYS3 Flavobacteria bacterium ‘BSD S1 20’ Flavobacteriia bacterium enrichment culture clone 1-4-3 Flavobacteria bacterium 7515 Flavobacteriia bacterium enrichment culture clone 2-1-3 Flavobacteria bacterium 7531 Flavobacteriia bacterium enrichment culture clone 2-3-2 Flavobacteria bacterium 7536 Flavobacteriia bacterium enrichment culture clone 2-3-3 Flavobacteria bacterium 7538 Flavobacteriia bacterium enrichment culture clone 2-4-3 Flavobacteria bacterium 7575 Flavobacteriia bacterium enrichment culture clone AB5 Flavobacteria bacterium 7583 uncultured bacterium #0319-8B8 Flavobacteria bacterium 7586 uncultured bacterium//0319-8J1 Flavobacteria bacterium b42 uncultured bacterium BURTON-13 Flavobacteria bacterium B6 ZZ-2008 uncultured bacterium BURTON-18 Flavobacteria bacterium BBFL7 uncultured bacterium BLTRTON-20 Flavobacteria bacterium BR4 uncultured bacterium BURTON-28 Flavobacteria bacterium CC-AMO-30D uncultured bacterium BURTON-31 Flavobacteria bacterium Ellin6119 uncultured bacterium BURTON-3 8 Flavobacteria bacterium Ellin6120 uncultured bacterium BLTRTON-44 Flavobacteria bacterium FB1 uncultured bacterium BURTON-50 Flavobacteria bacterium HMD 1033 uncultured bacterium BURTON-52 Flavobacteria bacterium HMD 1041 uncultured bacterium BURTON-55 Flavobacteria bacterium HMD1051 uncultured bacterium CEEAR-5 Flavobacteria bacterium HTCC2962 uncultured bacterium ORGAN 1C-5 Flavobacteria bacterium IAJ6 uncultured bacterium ORGANIC-6 Flavobacteria bacterium Ib01 uncultured bacterium ORGANIC-7 Flavobacteria bacterium Ib002 uncultured bacterium TAYNAYA-16 Flavobacteria bacterium Ib003 uncultured bacterium TAYNAYA-4 Flavobacteria bacterium Ib004 uncultured bacterium TAYNAYA-5 Flavobacteria bacterium Ib005 uncultured bacterium TAYNAYA-6 Flavobacteria bacterium Ib006 uncultured bacterium TAYNAYA-7 Flavobacteria bacterium KF030 uncultured eubacterium 4-19 Flavobacteria bacterium MS024-2A uncultured eubacterium 4-36 Flavobacteria bacterium MS024-3C uncultured Flavobacteriia bacterium Flavobacteria bacterium MS 190-IF uncultured flavobacterium DGGE band PSBAC-1 Flavobacteria bacterium NAMAF006 Sphingobacteriia Sphingobacteriaies Cardinium endosymbiont of Culicoides iungchiensis Chitinophagaceae Cardinium endosymbiont of Culicoides ohmorii Saprospiraceae Cardinium endosymbiont of Culicoides peregrinus Sphingobacteriaceae Cardinium endosymbiont of Cybaeota nana unclassified Sphingobacteriales Cardinium endosymbiont of Cybaeus chauliodous Sphingobacteriales genera incertae sedis Cardinium endosymbiont of Cybaeus chaulodious environmental samples Cardinium endosymbiont of Cybaeus eutypus unclassified Sphmgobacteriia Cardinium endosymbiont of Cybaeus hesper barley rhizosphere bacterium JJ-1452 Cardinium endosymbiont of Cybaeus morosus barley rhizosphere bacterium JJ-1607 Cardinium endosymbiont of Cybaeus multnoma barley rhizosphere bacterium JJ-1618 Cardinium endosymbiont of Cybaeus paralypropriapus barley rhizosphere bacterium JJ-1649 Cardinium endosymbiont of Cybaeus penedenlatus barley rhizosphere bacterium JJ-1870 Cardinium endosymbiont of Cybaeus reticulatus barley rhizosphere bacterium JJ-1894 Cardinium endosymbiont of Cybaeus sanbruno barley rhizosphere bacterium JJ-2060 Cardinium endosymbiont of Cybaeus signifcr barley rhizosphere bacterium JJ-220 Cardinium endosymbiont of Cybaeus somesbar barley rhizosphere bacterium JJ-2607 Cardinium endosymbiont of Cybaeus waynei barley rhizosphere bacterium JJ-3208 Cardinium endosymbiont of Dermanyssus gallinae barley rhizosphere bacterium JJ-3210 Cardinium endosymbiont of Encarsia hispida barley rhizosphere bacterium JJ-3233 Cardinium endosymbiont of Encarsia inaron barley rhizosphere bacterium J.T-3427 Cardinium endosymbiont of Encarsia pergandiella barley rhizosphere bacterium JJ-3776 Cardinium endosymbiont of Eotetranychus suginamensis barley rhizosphere bacterium JJ-394 Cardinium endosymbiont of Euidcs speciosa barley rhizosphere bacterium JJ-4019 Caidinium endosymbiont of Formica cinerea glacier bacterium FJS5 Cardinium endosymbiont of Harmalia sirokata marine bacterium MSCT Cardinium endosymbiont of Hemiberiesia paimae Sphingobacteria bacterium 2790 Cardinium endosymbiont of Holocnemus pluchei Sphingobacteria bacterium BC4 Caidinium endosymbiont of honey bee mite Sphingobacteria bacterium Ellin6121 Cardinium endosymbiont of Howardia biclavis Sphingobacteria bacterium GWS-BW-H154 Cardinium endosymbiont of Indozuriel dantur Sphingobacteria bacterium GWS-BW-H159 Cardinium endosymbiont of Ixodes scapularis Sphingobacteria bacterium JAM-BA0302 Cardinium endosymbiont of Leiobunum vittatum Sphingobacteria bacterium ROi22 Cardinium endosymbiont of Lepidosaphes pinnaeformis Sphingobacteria bacterium RYG Cardinium endosymbiont of Leucaspis pusilla Sphingobacteria bacterium SH-52 Cardinium endosymbiont of Nitocra spinipes Sphingobacteria bacterium SKA50 Cardinium endosymbiont of Oceanaspidiotus spinosus Sphingobacteria bacterium SKA51 Cardinium endosymbiont of Oedothorax gibbosus Sphingobacteria bacterium WF20 Cardinium endosymbiont of Oedothorax retusus Sphingobacteria bacterium WWH129 Cardinium endosymbiont of Oligonychus ilicis environmental samples Cardinium endosymbiont of Palinaspis quohogiformis Sphingobacteria bacterium enrichment culture clone AB7 Cardinium endosymbiont of Pallulaspis ephedrae Sphingobacteria bacterium enrichment culture DGGE band 8 Cardinium endosymbiont of Panonychus ulmi Sphingobacteria bacterium enrichment culture DGGE band 9 Cardinium endosymbiont of Petrobia harti uncultured Sphingobacteria bacterium Cardinium endosymbiont of Phalangium opilio Sunxiuqinia Cardinium endosymbiont of Plagiomerus diaspidis Sunxiuqinia elliptica Cardinium endosymbiont of Poliaspis media Sunxiuqinia sp. CAU1234 Cardinium endosymbiont of Protargionia larreae Sunxiuqinia sp. JNU-J035 Cardinium endosymbiont of Rilacna triangularis Sunxiuqinia sp. JNU-SGY008 Cardinium endosymbiont of Scaphoideus titanus Sunxiuqinia sp. SCSIO N0430 Cardinium endosymbiont of Sogatella furcifera unclassified Bacteroidetes Cardinium endosymbiont of Tetranychus cinnabarinus Bifissio Cardinium endosymbiont of Tetranychus pucraricola Bifissio spartinae Cardinium endosymbiont of Tetranychus urticae environmental samples Cardinium endosymbiont of Tetranychus urticae red form A Candidatus Amoebophilus Cardinium endosymbiont of Tetranychus urticae red form B Candidatus Amoebophilus asiaticus Cardinium endosymbiont of Tetranychus urticae red form C endosymbiont of Acanthamoeba sp. (Hungarian isolate) Cardinium endosymbiont of Unaspis euonymi environmental samples Cardinium symbiont of Neoseiulus paspalivorus Candidatus Cardinium Candidatus Cardinium sp. Sigean4 Candidatus Cardinium hertigii Cardinium endosymbiont of Anyphaenidae sp. Cardinium endosymbiont of Abgrallaspis degenerata Cardinium endosymbiont of Aonidomytilus sp. Cardinium endosymbiont of Aleurodicus dispersus Cardinium endosymbiont of Aphytis sp. Cardinium endosymbiont of Amphitetranychus quercivorus Cardinium endosymbiont of Araneidae sp. Cardinium endosymbiont of Aspediotus paranerii Cardinium endosymbiont of Brevipalpus sp. Cardinium endosymbiont of Aspidiotus nerii Cardinium endosymbiont of Chaetodactylus sp. Cardinium endosymbiont of Bemisia tabaci Cardinium endosymbiont of Leiobunum sp. Cardinium endosymbiont of Bryobia rubrioculus Cardinium endosymbiont of Marietta sp. Cardinium endosymbiont of Bryobia sarothamni Cardinium endosymbiont of Melanaspis sp. Cardinium endosymbiont of Chionaspis heterophyllae Cardinium endosymbiont of Prodigiaspis sp. Cardinium endosymbiont of Culicoides arakawae Cardinium endosymbiont of Pseudoparlatoria sp. Cardinium endosymbiont of Rilaena sp. bacterium Phenol-4 Cardinium endosymbiont of Salticidae sp. bacterium SB 12 Cardinium endosymbiont of Tetragnathidae sp. bacterium XB45 Cardinium endosymbiont of Theridiidae sp. Bacteroidetes bacterium ‘10.5 MW-13’ environmental samples Bacteroidetes bacterium ‘10.5 MW-17’ Candidatus Paenicardinium Bacteroidetes bacterium ‘13.5 MW-13’ Candidatus Paenicardinium endonii Bacteroidetes bacterium ‘13.5 MW-16’ Marinifilum Bacteroidetes bacterium ‘14.5 MW-30’ Marinifilum fragile Bacteroidetes bacterium ‘5.5 MW-14’ Marinifilum sp. CECT 7448 Bacteroidetes bacterium ‘5.6 MW-6’ Marinifilum sp. JNU-H032 Bacteroidetes bacterium ‘6.5 MW-11’ Marinifilum sp. JNU-H036 Bacteroidetes bacterium ‘7.3 MW-12’ Marinifilum sp. JNU-J034 Bacteroidetes bacterium ‘7.5 MW-10’ Marinifilum sp. KYW 585 Bacteroidetes bacterium ‘7.5 MW-12’ environmental samples Bacteroidetes bacterium ‘8.3 MW-7 Prolixibacter Bacteroidetes bacterium‘9.3 MW-13’ Prolixibacter bellariivorans Bacteroidetes bacterium ‘Oral Taxon 274’ environmental samples Bacteroidetes bacterium ‘PS-7’ truffle symbionts Bacteroidetes bacterium 0-9 Tuber borcliii symbiont b-lORA Bacteroidetes bacterium 109-13 Tuber borchii symbiont b-1 7BO Bacteroidetes bacterium 1 IB Tuber borchii symbiont b-1 BO Bacteroidetes bacterium 13456 Tuber borchii symbiont b-Z43 Bacteroidetes bacterium 1 (MB) 12.9mbsf Venteria Bacteroidetes bacterium 20/6 Venteria marina Bacteroidetes bacterium 21 5-60 unclassified Bacteroidetes (miscellaneous) Bacteroidetes bacterium 215-9 abyssal strain AID Bacteroidetes bacterium 23-9 abyssal strain AIII4 Bacteroidetes bacterium 2bG Antarctic bacterium L2 Bacteroidetes bacterium 3-6 Antarctic bacterium R-7515 Bacteroidetes bacterium 37LGx-1 Antarctic bacterium R-7550 Bacteroidetes bacterium 37LGy-2 Antarctic bacterium R-7572 Bacteroidetes bacterium 4 C16 35 Antarctic bacterium R-7579 Bacteroidetes bacterium 4F6B Antarctic bacterium R-7666 Bacteroidetes bacterium 5-4 Antarctic bacterium R-7933 Bacteroidetes bacterium 5-5 Antarctic bacterium R-8963 Bacteroidetes bacterium 6E Antarctic bacterium R-9003 Bacteroidetes bacterium 7-11 Antarctic bacterium R-9033 Bacteroidetes bacterium 7 (MB) 12.9mbsf Antarctic bacterium R-9217 Bacteroidetes bacterium 8 (MB) 12.9mbsf Arctic sea ice bacterium AWS-4M1 Bacteroidetes bacterium A973 Arctic sea ice bacterium AWS-4M3 Bacteroidetes bacterium ABF3A Arctic sea ice bacterium AWS-4M4 Bacteroidetes bacterium Acht4 Arctic sea ice bacterium AWS-4M5 Bacteroidetes bacterium AH23 Arctic sea ice bacterium AWS-4M6 Bacteroidetes bacterium AH26 Arctic sea ice bacterium AWS-4M7 Bacteroidetes bacterium AH7 Arctic sea ice bacterium AWS-4M8 Bacteroidetes bacterium AH8 Arctic sea ice bacterium AWS-4U1 Bacteroidetes bacterium AK43 6.1 Arctic sea ice bacterium AWS-6B2 Bacteroidetes bacterium AKB-K1-255 Arctic sea ice bacterium AWS-7B1 Bacteroidetes bacterium AL33 9.1 Arctic sea ice bacterium AWS-7B3 Bacteroidetes bacterium AL42 2.1 Arctic sea ice bacterium AWS-7B4 Bacteroidetes bacterium ALI-INI1 Arctic sea ice bacterium AWS-7BS Bacteroidetes bacterium ALI-INI12 bacterium 1.3.10 Bacteroidetes bacterium ALI-INI24 bacterium 5.3.10 Bacteroidetes bacterium Anal bacterium AG Bacteroidetes bacterium Ana2 bacterium AH47 Bacteroidetes bacterium ANT9105 bacterium BA Bacteroidetes bacterium ANT9285 bacterium BD Bacteroidetes bacterium ARK1 0264 bacterium BE Bacteroidetes bacterium ArSB bacterium D21 Bacteroidetes bacteriumblbl bacterium H-S3 Bacteroidetes bacterium b lb2 bacterium KHN36A Bacteroidetes bacterium b lb3 bacterium Kml Bacteroidetes bacterium BAL102 bacterium Km4 Bacteroidetes bacterium BAL103 bacterium Km5 Bacteroidetes bacterium BAL120 bacterium KmC Bacteroidetes bacterium BAL138 bacterium ML24 Bacteroidetes bacterium BAL139 bacterium P16L8 41 Bacteroidetes bacterium BAL140 bacterium P2G231 Bacteroidetes bacterium BAL141 bacterium PB90-2 Bacteroidetes bacterium BAL142 Bacteroidetes bacterium BALI47 Bacteroidetes bacterium G4 Bacteroidetes bacterium BALI51 Bacteroidetes bacterium G8 24 Bacteroidetes bacterium BALI51.1 Bacteroidetes bacterium GCM36 Bacteroidetes bacterium BALI51.2 Bacteroidetes bacterium GCM63 Bacteroidetes bacterium BAL152 Bacteroidetes bacterium GCM65 Bacteroidetes bacterium BAL153 Bacteroidetes bacterium GCM68 Bacteroidetes bacterium BAL154 Bacteroidetes bacterium GCM69 Bacteroidetes bacterium BAL175 Bacteroidetes bacterium GM10 Bacteroidetes bacterium BALI76 Bacteroidetes bacterium GM14 Bacteroidetes bacterium BALI80 Bacteroidetes bacterium GM19 Bacteroidetes bacterium BALI92 Bacteroidetes bacterium GM24 Bacleroideles baclerium BAL210 Bacleroideles baclerium GM31 Bacteroidetes bacterium BAL214 Bacteroidetes bacterium GM34 Bacteroidetes bacterium BAL215 Bacteroidetes bacterium GM36 Bacteroidetes bacterium BAL216 Bacteroidetes bacterium GM51 Bacteroidetes bacterium BAL222 Bacteroidetes bacterium GM57 Bacteroidetes bacterium BAL223 Bacteroidetes bacterium GM61 Bacteroidetes bacterium BAL224 Bacteroidetes bacterium GM71 Bacteroidetes bacterium BAL232 Bacteroidetes bacterium GM80 Bacteroidetes bacterium BAL240 Bacteroidetes bacterium GMD13F04 Bacteroidetes bacterium BAL241 Bacteroidetes bacterium GMD1 5A07 Bacteroidetes bacterium BAL242 Bacteroidetes bacterium GMD16C04 Bacteroidetes bacterium BAL254 Bacteroidetes bacterium GMD16C10 Bacteroidetes bacterium BAL256 Bacteroidetes bacterium GMD37F7 Bacteroidetes bacterium BAL257 Bacteroidetes bacterium GMD38C4 Bacteroidetes bacterium BAL268 Bacteroidetes bacterium GMDJE10E6 Bacteroidetes bacterium BAL269 Bacteroidetes bacterium GMDsbC3 Bacteroidetes bacterium BAL273 Bacteroidetes bacterium GMDsbC7 Bacteroidetes bacterium BAL63 Bacteroidetes bacterium GMDsbM5 Bacteroidetes bacterium BAL64 Bacteroidetes bacterium GS Bacteroidetes bacterium BAL65 Bacteroidetes bacterium GWS-BW-H4M Bacteroidetes bacterium BAL81 Bacteroidetes bacterium GWS-BW-H70M Bacteroidetes bacterium BAL84 Bacteroidetes bacterium H30 Bacteroidetes bacterium BAL87 Bacteroidetes bacterium HH42 Bacteroidetes bacterium BAL93 Bacteroidetes bacterium HNR18 Bacteroidetes bacterium BAL97 Bacteroidetes bacterium IIPC1 Bacteroidetes bacterium BC2TSA1F2 Bacteroidetes bacterium HY2 Bacteroidetes bacterium beta la-PC Ai-E3-2 Bacteroidetes bacterium HY3 Bacteroidetes bacterium beta2a-PCAi-E3-2 Bacteroidetes bacterium 1-116-1 Bacteroidetes bacterium C-l Bacteroidetes bacterium II-116-5 Bacteroidetes bacterium C-l2 Bacteroidetes bacterium J2012s Bacteroidetes bacterium C-l9 Bacteroidetes bacterium J2051s Bacteroidetes bacterium C-3 Bacteroidetes bacterium J2117m Bacteroidetes bacterium C-7 Bacteroidetes bacterium J879 Bacteroidetes bacterium CHli Bacteroidetes bacterium Jbgl7 Bacteroidetes bacterium CH6i Bacteroidetes bacterium Jbgl8 Bacteroidetes bacterium CHC10 Bacteroidetes bacterium Jbgl9 Bacteroidetes bacterium CHC2 Bacteroidetes bacterium Jbg20 Bacteroidetes bacterium CHNCT12 Bacteroidetes bacterium Jbg21 Bacteroidetes bacterium CK32 5.3 Bacteroidetes bacterium Jbg22 Bacteroidetes bacterium CN19M LM14 Bacteroidetes bacterium JC-3 Bacteroidetes bacterium CN3G2-10 Bacteroidetes bacterium JGI 0000113-A17 Bacteroidetes bacterium CN9 LM99 Bacteroidetes bacterium JGI 0000113-N05 Bacteroidetes bacterium CNC19 Bacteroidetes bacterium JGI 0001001-A08 Bacteroidetes bacterium CNTJ-914 Bacteroidetes bacterium JGI 0002002-N21 Bacteroidetes bacterium CNX-216 Bacteroidetes bacterium JGI 0002003-008 Bacteroidetes bacterium CSC16 Bacteroidetes bacterium JGI 0002005-G08 Bacteroidetes bacterium D295 Bacteroidetes bacterium JGI 0002005-110 Bacteroidetes bacterium E42 Bacteroidetes bacterium JGI 0002005-J14 Bacteroidetes bacterium EC2 Bacteroidetes bacterium JGI 0002005-K22 Bacteroidetes bacterium ectosymbiont of Rimicaris exoculata Bacteroidetes bacterium JS5 Bacteroidetes bacterium Eg28 Bacteroidetes bacterium K2 Bacteroidetes bacterium EK-I72 Bacteroidetes bacterium K3 Bacteroidetes bacterium endosymbiont of Bemisia tabaci Bacteroidetes bacterium K383 Bacteroidetes bacterium endosymbiont of Sogatella furcifera Bacteroidetes bacterium K4 Bacteroidetes bacterium FH4 Bacteroidetes bacterium K5 Bacteroidetes bacterium FH5 Bacteroidetes bacterium K6-27 Bacteroidetes bacterium G13a-B Bacteroidetes bacterium KILT1 Bacteroidetes bacterium G22 Bacteroidetes bacterium KJY Bacteroidetes bacterium G33 Bacteroidetes bacterium Ko310 Bacteroidetes bacterium Ko510 Bacteroidetes bacterium oral taxon 281 Bacteroidetes bacterium Ko706 Bacteroidetes bacterium oral taxon 318 Bacteroidetes bacterium Ko710 Bacteroidetes bacterium oral taxon 320 Bacteroidetes bacterium KT JAC3043 cb 68 Bacteroidetes bacterium oral taxon 321 Bacteroidetes bacterium L2-109 Bacteroidetes bacterium oral taxon 365 Bacteroidetes bacterium LaBonte algl 1 Bacteroidetes bacterium oral taxon 436 Bacteroidetes bacterium LC9 Bacteroidetes bacterium oral taxon 503 Bacteroidetes bacterium LD83 Bacteroidetes bacterium oral taxon 505 Bacteroidetes bacterium LD84 Bacteroidetes bacterium oral taxon 507 Bacteroidetes bacterium LJ Bacteroidetes bacterium oral taxon 509 Bacteroidetes bacterium LYH Bacteroidetes bacterium oral taxon 511 Bacleroideles bacterium M-phe-1 Bacteroidetes bacterium oral taxon 516 Bacteroidetes bacterium M2 Bacteroidetes bacterium oral taxon B68 Bacteroidetes bacterium M3 Bacteroidetes bacterium oral taxon D27 Bacteroidetes bacterium M4 Bacteroidetes bacterium oral taxon E48 Bacteroidetes bacterium M5 Bacteroidetes bacterium oral taxon F31 Bacteroidetes bacterium M5H2 Bacteroidetes bacterium oral taxon F44 Bacteroidetes bacterium M6 Bacteroidetes bacterium oral taxon F60 Bacteroidetes bacterium M7 Bacteroidetes bacterium oral taxon F69 Bacteroidetes bacterium M775 Bacteroidetes bacterium oral taxon F70 Bacteroidetes bacterium MAO51 Bacteroidetes bacterium oral taxon G44 Bacteroidetes bacterium MA052 Bacteroidetes bacterium oral taxon G83 Bacteroidetes bacterium Mo-0.2plat-K3 Bacteroidetes bacterium ORNL_lUT_ORNL_28 Bacteroidetes bacterium Mo-0.2plat-K5 Bacteroidetes bacterium OS-21A Bacteroidetes bacterium MOI 7 Bacteroidetes bacterium OS-26C Bacteroidetes bacterium MO 18 Bacteroidetes bacterium P073B Bacteroidetes bacterium M048 Bacteroidetes bacterium P2 Bacteroidetes bacterium M049 Bacteroidetes bacterium P3 Bacteroidetes bacterium M054 Bacteroidetes bacterium P3(2010) Bacteroidetes bacterium MO LA 103 Bacteroidetes bacterium P373 Bacteroidetes bacterium MOLA 411 Bacteroidetes bacterium P4 Bacteroidetes bacterium MOLA 450 Bacteroidetes bacterium P4(2013) Bacteroidetes bacterium MU1 Bacteroidetes bacterium PD4-MRL Bacteroidetes bacterium MU2 Bacteroidetes bacterium PM13 Bacteroidetes bacterium MWH-CFBk5 Bacteroidetes bacterium PM24 Bacteroidetes bacterium Mwo 1 Bacteroidetes bacterium PM25 Bacteroidetes bacterium N03AW1 Bacteroidetes bacterium PM29 Bacteroidetes bacterium N04ML10 Bacteroidetes bacterium PMR-D Bacteroidetes bacterium N04ML7 Bacteroidetes bacterium PP2 Bacteroidetes bacterium N04ML8 Bacteroidetes bacterium PPf50E2 Bacteroidetes bacterium N114 Bacteroidetes bacterium PPM04 Bacteroidetes bacterium NlmML10c Bacteroidetes bacterium PS-KroKl Bacteroidetes bacterium NlmML12 Bacteroidetes bacterium PS-T12W Bacteroidetes bacterium NlmML3 Bacteroidetes bacterium R-38326 Bacteroidetes bacterium NlmML4 Bacteroidetes bacterium R-38398 Bacteroidetes bacterium N2 Bacteroidetes bacterium R-39049 Bacteroidetes bacterium N2yMLl Bacteroidetes bacterium R0L5 Bacteroidetes bacterium N3mISl Bacteroidetes bacterium R2-Dcc-MIB-3 Bacteroidetes bacterium N3mISlO Bacteroidetes bacterium R2A10 Bacteroidetes bacterium N3mMLl Bacteroidetes bacterium R2A103 Bacteroidetes bacterium N3mML6 Bacteroidetes bacterium R2A132 Bacteroidetes bacterium N83 Bacteroidetes bacterium R2A5 Bacteroidetes bacterium N90 Bacteroidetes bacterium R43 Bacteroidetes bacterium NQrnTS13 Bacteroidetes bacterium R634 Bacteroidetes bacterium NAB 18 Bacteroidetes bacterium R8-Ret-T12-1 Id Bacteroidetes bacterium NeomS2D4 Bacteroidetes bacterium R8-Ret-T53-23g Bacteroidetes bacterium NP-X Bacteroidetes bacterium RAS63 Bacteroidetes bacterium O-O14 Bacteroidetes bacterium RBE2CD-I 32 Bacteroidetes bacterium O32B_LM98 Bacteroidetes bacterium RBE2CD-50 Bacteroidetes bacterium ONB11 Bacteroidetes bacterium RBE2CD-54 Bacteroidetes bacterium ONB 13 Bacteroidetes bacterium RD4.3 Bacteroidetes bacterium ONC1 Bacteroidetes bacterium RG1-1 Bacteroidetes bacterium ONC2 Bacteroidetes bacterium RI121 Bacteroidetes bacterium OR-1 Bacteroidetes bacterium RI269 Bacteroidetes bacterium OR-219 Bacteroidetes bacterium RL-C Bacteroidetes bacterium OR-43 Bacteroidetes bacterium RM22 Bacteroidetes bacterium OR-53 Bacteroidetes bacterium RM23 Bacteroidetes bacterium oral taxon 272 Bacteroidetes bacterium RM69 Bacteroidetes bacterium oral taxon 274 Bacteroidetes bacterium RNC11 Bacteroidetes bacterium oral taxon 280 Bacteroidetes bacterium RNC12 Bacteroidetes bacterium RNC6 Bacteroidetes bacterium SCGC AAA043-M05 Bacteroidetes bacterium RP28 Bacteroidetes bacterium SCGC AAA043-N02 Bacteroidetes bacterium RX233 Bacteroidetes bacterium SCGC AAA043-O14 Bacteroidetes bacterium SI Bacteroidetes bacterium SCGC AAA043-P05 Bacteroidetes bacterium S10/1 Bacteroidetes bacterium SCGC AAA076-B23 Bacteroidetes bacterium SI 0/2 Bacteroidetes bacterium SCGC AAA158-A05 Bacteroidetes bacterium SI 10(26)-1 Bacteroidetes bacterium SCGC AAA158-J09 Bacteroidetes bacterium SI 5-4 Bacteroidetes bacterium SCGC AAA160-A02 Bacteroidetes bacterium S22-33 Bacteroidetes bacterium SCGC AAA160-A08 Bacteroidetes bacterium S22-34 Bacteroidetes bacterium SCGC AAA160-A14 Bacteroidetes bacterium S22-35 Bacteroidetes bacterium SCGC AAA160-A21 Bacteroidetes bacterium S3 Bacteroidetes bacterium SCGC AAA160-B09 Bacteroidetes bacterium S7 Bacteroidetes bacterium SCGC AAA160-C05 Bacteroidetes bacterium S923 Bacteroidetes bacterium SCGC AAA160-D03 Bacteroidetes bacterium SAC2 Bacteroidetes bacterium SCGC AAA160-E07 Bacteroidetes bacterium SB27 Bacteroidetes bacterium SCGC AAA160-E08 Bacteroidetes bacterium SC-1 Bacteroidetes bacterium SCGC AAA160-E20 Bacteroidetes bacterium SCGC AAA008-C03 Bacteroidetes bacterium SCGC AAA160-F07 Bacteroidetes bacterium SCGC AAA015-O21 Bacteroidetes bacterium SCGC AAA160-F08 Bacteroidetes bacterium SCGC AAA023-B19 Bacteroidetes bacterium SCGC AAA160-F18 Bacteroidetes bacterium SCGC AAA023-E22 Bacteroidetes bacterium SCGC AAA160-GI0 Bacteroidetes bacterium SCGC AAA023-J07 Bacteroidetes bacterium SCGC AAA160-G14 Bacteroidetes bacterium SCGC AAA023-K17 Bacteroidetes bacterium SCGC AAA160-I16 Bacteroidetes bacterium SCGC AAA023-M10 Bacteroidetes bacterium SCGC AAA160-L03 Bacteroidetes bacterium SCGC AAA023-N17 Bacteroidetes bacterium SCGC AAA160-E04 Bacteroidetes bacterium SCGC AAA024-A13 Bacteroidetes bacterium SCGC AAA160-L09 Bacteroidetes bacterium SCGC AAA024-B16 Bacteroidetes bacterium SCGC AAA160-L15 Bacteroidetes bacterium SCGC AAA024-E18 Bacteroidetes bacterium SCGC AAA160-L18 Bacteroidetes bacterium SCGC AAA024-I08 Bacteroidetes bacterium SCGC AAA160-L19 Bacteroidetes bacterium SCGC AAA024-M07 Bacteroidetes bacterium SCGC AAA160-N02 Bacteroidetes bacterium SCGC AAA024-N18 Bacteroidetes bacterium SCGC AAA160-N18 Bacteroidetes bacterium SCGC AAA024-O02 Bacteroidetes bacterium SCGC AAA160-N19 Bacteroidetes bacterium SCGC AAA024-O05 Bacteroidetes bacterium SCGC AAA160-O17 Bacteroidetes bacterium SCGC AAA024-P05 Bacteroidetes bacterium SCGC AAA160-P02 Bacteroidetes bacterium SCGC AAA024-P11 Bacteroidetes bacterium SCGC AAA160-P09 Bacteroidetes bacterium SCGC AAA027-A23 Bacteroidetes bacterium SCGC AAA163-F15 Bacteroidetes bacterium SCGC AAA027-C18 Bacteroidetes bacterium SCGC AAA164-L19 Bacteroidetes bacterium SCGC AAA027-D09 Bacteroidetes bacterium SCGC AAA166-B07 Bacteroidetes bacterium SCGC AAA027-D11 Bacteroidetes bacterium SCGC AAA166-B16 Bacteroidetes bacterium SCGC AAA027-D14 Bacteroidetes bacterium SCGC AAA166-C08 Bacteroidetes bacterium SCGC AAA027-D22 Bacteroidetes bacterium SCGC AAA166-G16 Bacteroidetes bacterium SCGC AAA027-E17 Bacteroidetes bacterium SCGC AAA166-I10 Bacteroidetes bacterium SCGC AAA027-F10 Bacteroidetes bacterium SCGC AAA166-J04 Bacteroidetes bacterium SCGC AAA027-F20 Bacteroidetes bacterium SCGC AAA166-O05 Bacteroidetes bacterium SCGC AAA027-G08 Bacteroidetes bacterium SCGC AAA166-P21 Bacteroidetes bacterium SCGC AAA027-G09 Bacteroidetes bacterium SCGC AAA168-G15 Bacteroidetes bacterium SCGC AAA027-J08 Bacteroidetes bacterium SCGC AAA204-D06 Bacteroidetes bacterium SCGC AAA027-J16 Bacteroidetes bacterium SCGC AAA204-N13 Bacteroidetes bacterium SCGC AAA027-K06 Bacteroidetes bacterium SCGC AAA206-C09 Bacteroidetes bacterium SCGC AAA027-L16 Bacteroidetes bacterium SCGC AAA206-D16 Bacteroidetes bacterium SCGC AAA027-L18 Bacteroidetes bacterium SCGC AAA206-E07 Bacteroidetes bacterium SCGC AAA027-M16 Bacteroidetes bacterium SCGC AAA206-I05 Bacteroidetes bacterium SCGC AAA027-M20 Bacteroidetes bacterium SCGC AAA206-J13 Bacteroidetes bacterium SCGC AAA027-N15 Bacteroidetes bacterium SCGC AAA206-P04 Bacteroidetes bacterium SCGC AAA027-N20 Bacteroidetes bacterium SCGC AAA240-A06 Bacteroidetes bacterium SCGC AAA027-N21 Bacteroidetes bacterium SCGC AAA240-K15 Bacteroidetes bacterium SCGC AAA027-O02 Bacteroidetes bacterium SCGC AAA278-L16 Bacteroidetes bacterium SCGC AAA027-O08 Bacteroidetes bacterium SCGC AAA280-A07 Bacteroidetes bacterium SCGC AAA027-P03 Bacteroidetes bacterium SCGC AAA288-M09 Bacteroidetes bacterium SCGC AAA027-P14 Bacteroidetes bacterium SCGC AAA3O0-E18 Bacteroidetes bacterium SCGC AAA028-D13 Bacteroidetes bacterium SCGC AAA487-A10 Bacteroidetes bacterium SCGC AAA028-G19 Bacteroidetes bacterium SCGC AAA487-A14 Bacteroidetes bacterium SCGC AAA028-N16 Bacteroidetes bacterium SCGC AAA487-E10 Bacteroidetes bacterium SCGC AAA041-C10 Bacteroidetes bacterium SCGC AAA487-F20 Bacteroidetes bacterium SCGC AAA041-L03 Bacteroidetes bacterium SCGC AAA487-G14 Bacteroidetes bacterium SCGC AAA041-P16 Bacteroidetes bacterium SCGC AAA487-G22 Bacteroidetes bacterium SCGC AAA041-P17 Bacteroidetes bacterium SCGC AAA487-I22 Bacteroidetes bacterium SCGC AAA043-A05 Bacteroidetes bacterium SCGC AAA487-J05 Bacteroidetes bacterium SCGC AAA043-A17 Bacteroidetes bacterium SCGC AAA487-N10 Bacteroidetes bacterium SCGC AAA043-I08 Bacteroidetes bacterium SCGC AAA487-O06 Bacteroidetes bacterium SCGC AAA487-021 Bacteroidetes bacterium WD584 Bacteroidetes bacterium Schreyahn Kolonie Aster 14 Bacteroidetes bacterium WD59 Bacteroidetes bacterium SDX12 Bacteroidetes bacterium WD65 Bacteroidetes bacterium SED4 Bacteroidetes bacterium WD7 Bacteroidetes bacterium SF1 Bacteroidetes bacterium WD96 Bacteroidetes bacterium SF11 Bacteroidetes bacterium WF73 Bacteroidetes bacterium SF12 Bacteroidetes bacterium WII009150s Bacteroidetes bacterium SF2 Bacteroidetes bacterium wo21 Bacteroidetes bacterium SF47 Bacteroidetes bacterium wo31 Bacteroidetes bacterium SM21 Bacteroidetes bacterium X3-d Bacteroidetes bacterium SM23 Bacteroidetes bacterium ZHC17 Bacleroideles bacterium SM26 Bacteroidetes bacterium ZHC20 Bacteroidetes bacterium SM32 Bacteroidetes bacterium zj02 Bacteroidetes bacterium SM35 Bacteroidetes bacterium zj05 Bacteroidetes bacterium SM46 Bacteroidetes bacterium ZNB16 Bacteroidetes bacterium SM55 Bacteroidetes bacterium zo30 Bacteroidetes bacterium SM57 Bacteroidetes bacterium zo31 Bacteroidetes bacterium Smarlab 3301186 Bacteroidetes bacterium zo34 Bacteroidetes bacterium so23 Bacteroidetes bacterium zo35 Bacteroidetes bacterium so40 Bacteroidetes CHI2 Bacteroidetes bacterium so46 Bacteroidetes endosymbiont of Aspidiotus destmctor Bacteroidetes bacterium SOMOC25 Bacteroidetes endosymbiont of Metaseiulus occidentalis Bacteroidetes bacterium SOVtolO Bacteroidetes oral taxon 274 Bacteroidetes bacterium SSI Bacteroidetes symbiont of Icerya purcliasi Bacteroidetes bacterium SSI 2 CFB group bacterium 22(2010) Bacteroidetes bacterium SS14.29 CFB group bacterium A0653 Bacteroidetes bacterium SS14.30 CFB group bacterium A1002 Bacteroidetes bacterium SS14.31 CFB group bacterium GOBB3-210 Bacteroidetes bacterium SS4 CFB group bacterium GOBB3-308 Bacteroidetes bacterium SS9.12 CFB group bacterium GOBB3-CL142 Bacteroidetes bacterium SS9.38 CFB group bacterium ikaite c9 Bacteroidetes bacterium SSL04 CFB group bacterium kbal3f Bacteroidetes bacterium SW15 CFB group bacterium kba28f Bacteroidetes bacterium SW4 CFB group bacterium kbc05f Bacteroidetes bacterium T213BY3 CFB group bacterium kbcl3 Bacteroidetes bacterium T4-KAD-strl CFB group bacterium KbC5-B2 Bacteroidetes bacterium TDB-023 CFB group bacterium KbC5-B3 Bacteroidetes bacterium TDB-148 CFB group bacterium KbN1-B1 Bacteroidetes bacterium TDB-212 CFB group bacterium OI-l-l Bacteroidetes bacterium Tf 235 CFB group bacterium OT-1-2 Bacteroidetes bacterium TH-G48 CFB group bacterium OT-1-4 Bacteroidetes bacterium TH-G49 CFB group bacterium OI-14-4 Bacteroidetes bacterium THS CFB group bacterium OI-15-2 Bacteroidetes bacterium TRS1-A1 CFB group bacterium OI-20-1 Bacteroidetes bacterium TSW03CA1B CFB group bacterium OI-9-1 Bacteroidetes bacterium U-3 CFB group bacterium SFLA10 Bacteroidetes bacterium ft_5 CFB group bacterium SI-9-3 Bacteroidetes bacterium ft_9 CFB-group bacterium QA93A Bacteroidetes bacterium UBF2 cilia-associated respiratory baclerium Bacteroidetes bacterium UBF3 cilia-associated respiratory bacterium 243-54 Bacteroidetes bacterium UBF5 cilia-associated respiratory bacterium 246-57 Bacteroidetes bacterium UBF7 cilia-associated respiratory bacterium 95-15405 Bacteroidetes bacterium UBF9 cilia-associated respiratory bacterium 96-1590 Bacteroidetes bacterium FTF2 cilia-associated respiratory bacterium 96-4763 Bacteroidetes bacterium fta/ps cilia-associated respiratory bacterium Ml Bacteroidetes bacterium VAS35 cilia-associated respiratory bacterium Rl Bacteroidetes bacterium VAS36 cilia-associated respiratory bacterium R2 Bacteroidetes bacterium W-2003a cilia-associated respiratory bacterium R3 Bacteroidetes bacterium W21 cilia-associated respiratory bacterium R4 Bacteroidetes bacterium WD195 Coleomegilla maculata male-killing endosymbiont Bacteroidetes bacterium WD250 Cytophagales str. AND6 Bacteroidetes bacterium WD300 Cytophagales str. B6 Bacteroidetes bacterium WD309 Cytophagales str. KAT4 Bacteroidetes bacterium WD317 Cytophagales str. KAT5 Bacteroidetes bacterium WD385 Cytophagales str. KAT7 Bacteroidetes bacterium WD411 Cytophagales str. MBIC4147 Bacteroidetes bacterium WD501 Cytophagales str. MEDIO Bacteroidetes bacterium WD509 Cytophagales str. MED 11 Bacteroidetes bacterium WD537 Cytophagales str. MED21 Bacteroidetes bacterium WD538 Cytophagales str. MED25 Cytophagales str. MED9 marine CFB-group bacterium MBIC04466 Cytophagales str. QSSC5-1 marine CFB-group bacterium MBIC04467 Elbe River snow isolate Iso8 marine CFB-group bacterium MBIC04468 Encarsia berlesei endosymbiont marine CFB-group bacterium MBIC04469 Encarsia citrina endosymbiont marine CFB-group bacterium MBIC04470 Encarsia hispida endosymbiont marine CFB-group bacterium MBIC04471 Encarsia pergandiella asexual line endosymbiont marine CFB-group bacterium MBIC04472 Encarsia pergandiella sexual line endosymbiont marine CFB-group bacterium MBIC04473 endosymbiont of Aphytis lingnanensis marine CFB-group bacterium MBIC04474 endosymbiont of Aspidiotus nerii marine CFB-group bacterium MBIC04475 endosymbiont of Bemisia tabaci (biotype A) marine CFB-group bacterium MBIC04476 endosymbiont of Brevipalpus californicus marine CFB-group bacterium MBIC04477 endosymbiont of Brevipalpus lewisi marine CFB-group bacterium MBIC04478 endosymbiont of Brevipalpus obovatus marine CFB-group bacterium MBIC04487 endosymbiont of Brevipalpus phocnicis marine CFB-group bacterium MBIC05204 endosymbiont of Diaspis echinocacti marine CFB-group bacterium MBIC05558 endosymbiont of Dicranotropis hamata marine CFB-group bacterium N43 endosymbiont of Encarsia lutea marine CFB-group bacterium S3 endosymbiont of Encarsiella noyesi marine CFB-group bacterium SB 12 endosymbiont of Metaseiulus occidentalis marine CFB-group bacterium SB 15 endosymbiont of Oppiella nova marine CFB-group bacterium SB 17 endosymbiont of Petrobia harti marine CFB-group bacterium SB9 endosymbiont of Zigia versicolor marine CFB-group bacterium SY009 enrichment culture LET-13 marine CFB-group bacterium SY010 Eubostrichus dianae epibacterium 1 60 marine CFB-group bacterium SY011 filamentous bacterium Plant 1 IsolOB marine CF B-group bacterium SY013 filamentous bacterium Plantl Iso8 marine CFB-group bacterium SY022 freshwater obligate oligotroph IO-95 marine CFB-group bacterium SY023 gut bacterium S2 of Coptotermes formosanus marine CFB-group bacterium SY024 marine bacterium 13731 marine CFB-group bacterium SY038 marine bacterium GY9 marine CFB-group bacterium SY040 marine bacterium MC8 marine CFB-group bacterium SY049 marine bacterium NBF6 marine CFB-group bacterium SY088 marine bacterium SIMO-IS 106 marine CFB-group bacterium SY121 marine bacterium SIMO-IS 107 marine CFB-group bacterium SY156 marine bacterium SIMO-IS 108 marine CFB-group bacterium SY186 marine bacterium SIMO-IS 109 marine CFB-group bacterium SY204 marine bacterium SIMO-IS 110 marine CFB-group bacterium SY221 marine bacterium SIMO-IS 111 marine CFB-group bacterium SY224 marine bacterium SIMO-IS 112 marine CFB-group bacterium SY226 marine bacterium SIMO-IS 113 marine CFB-group bacterium SY227 marine bacterium SIMO-IS 114 marine CFB-group bacterium SY229 marine bacterium SIMO-IS 115 marine CFB-group bacterium SY231 marine bacterium SIMO-IS 117 marine CFB-group bacterium SY244 marine bacterium SIMO-IS 118 marine psychrophile ACAM210 marine bacterium SIMO-IS 122 marine psychrophile ICO 54 marine bacterium SIMO-IS 129 marine psychrophile IC076 marine bacterium SIMO-IS 130 marine psychrophile IC148 marine bacterium SIMO-IS 132 marine psychrophile IC157 marine bacterium SIMO-IS 190 marine psychrophile IC 159 marine Bacteroidetes bacterium RS.Sph.009 marine psychrophile IC164 marine CFB-group bacterium MBIC01539 marine psychrophile SW17 marine CFB-group bacterium MBIC01599 monochloroacetic-acid-degrading bacterium ‘Band E’ marine CFB-group bacterium MBIC04441 monochloroacetic-acid-degrading bacterium ‘Band F’ marine CFB-group bacterium MBIC04442 obligately oligotrophic bacteria POC-121 marine CFB-group bacterium MBIC04443 obligately oligotrophic bacteria POC-122 marine CFB-group bacterium MBIC04444 obligately oligotrophic bacteria POC-8 marine CFB-group bacterium MBIC04445 obligately oligotrophic bacteria POCPN-73 marine CFB-group bacterium MB1C04446 obligately oligotrophic bacteria POCPN-74 marine CFB-group bacterium MBIC04447 saltmarsh sediment bacterium NRL-CB18 marine CFB-group bacterium MBIC04449 saltmarsh sediment bacterium NRL-CB19 marine CFB-group bacterium MBIC04450 saltmarsh sediment bacterium NRL-SS36 marine CFB-group bacterium MBIC04451 saltmarsh sediment bacterium NRL-TS20 marine CFB-group bacterium MBIC04452 Bacteroidetes sp. BG31 marine CFB-group bacterium MBIC04453 Bacteroidetes sp. MG12 marine CFB-group bacterium MBIC04454 Bacteroidetes sp. MG21 marine CFB-group bacterium MBIC04455 Bacteroidetes sp. OL02 marine CFB-group bacterium MBIC04456 Bacteroidetes sp. OM02 marine CFB-group bacterium MBIC04458 Bacteroidetes sp. OM05 marine CFB-group bacterium MBIC04465 Bacteroidetes symbiont of Osedax sp. endosymbiont of Acanthamoeba sp. KA/E21 Bacteroidetes bacterium enrichment culture clone HB 77 endosymbiont of Aphytis sp. 3 Bacteroidetes bacterium enrichment culture clone HB 86 endosymbiont of Aphytis sp. 4 Bacteroidetes bacterium enrichment culture clone HB 97 endosymbiont of Balaustium sp. Bacteroidetes bacterium enrichment culture clone LI endosymbiont of Encarsia sp. 2 Bacteroidetes bacterium enrichment culture clone L11_2_53 endosymbiont of Encarsia sp. 3 Bacteroidetes bacterium enrichment culture clone L35B_118 Robbea sp. associated bacterium 4 Bacteroidetes bacterium enrichment culture clone L35B_121 Stilbonema sp. associated bacterium 2 Bacteroidetes bacterium enrichment culture clone L35B_13 Stilbonema sp. associated bacterium 3 Bacteroidetes bacterium enrichment culture clone L35B_144 Stilbonema sp. associated bacterium 4 Bacteroidetes bacterium enrichment culture clone L35B_21 Stilbonema sp. associated bacterium 5 Bacteroidetes bacterium enrichment culture clone L35B_50 Stilbonema sp. associated baclerium 6 Bacteroidetes bacterium enrichment culture clone L35B_72 Stilbonema sp. associated bacterium 7 Bacteroidetes bacterium enrichment culture clone L35B_83 unidentified bacterium WP13 Bacteroidetes bacterium enrichment culture clone L35B_95 Bacteroidetes Order II. Incertae sedis Bacteroidetes bacterium enrichment culture clone L4 Rhodothermaceae Bacteroidetes bacterium enrichment culture clone L55B-11 Rhodothermus Bacteroidetes bacterium enrichment culture clone L55B-120 Rubricoecus Bacteroidetes bacterium enrichment culture clone L55B-124 Salinibacter Bacteroidetes bacterium enrichment culture clone L55B-131 Salisaeta Bacteroidetes bacterium enrichment culture clone L55B-36 unclassified Rhodothermaceae Bacteroidetes bacterium enrichment culture clone L55B-60 environmental samples Bacteroidetes bacterium enrichment culture clone L55B-63 Bacteroidetes Order III. Incertae sedis Bacteroidetes bacterium enrichment culture clone L55B-81 Thermonema Bacteroidetes bacterium enrichment culture clone LiTJU-12-16 Thermonema lapsum Bacteroidetes bacterium enrichment culture clone LiUU-12-52 Thermonema rossianum Bacteroidetes bacterium enrichment culture clone LiUU-12-67 environmental samples Bacteroidetes bacterium enrichment culture clone LiUU-12-81 environmental samples Bacteroidetes bacterium enrichment culture clone LiTJU-15-341 Bacteriodetes bacterium enrichment culture clone AP-FeEnrich3 Bacteroidetes bacterium enrichment culture clone LiTJU-15-745 Bacteriodetes bacterium enrichment culture clone AP-FeEnrich4 Bacteroidetes bacterium enrichment culture clone LiUU-15-762 Bacteriodetes bacterium enrichment culture clone AP-FeEnrich5 Bacteroidetes bacterium enrichment culture clone LiUU-15-773 Bacteriodetes bacterium enrichment culture clone AP-FeEnrich6 Bacteroidetes bacterium enrichment culture clone LiTJU-15-794 Bacteroidetes bacterium enrichment culture C41 Bacteroidetes bacterium enrichment culture clone LiUU-16-310 Bacteroidetes bacterium enrichment culture clone 06-1235251-117 Bacteroidetes bacterium enrichment culture clone LiUU-16-703 Bacteroidetes bacterium enrichment culture clone 12 Bacteroidetes bacterium enrichment culture clone LiUU-16-715 Bacteroidetes bacterium enrichment culture clone 293MTBE Bacteroidetes bacterium enrichment culture clone LiUU-16-729 Bacteroidetes bacterium enrichment culture clone 4.17a Bac band 1 Bacteroidetes bacterium enrichment culture clone LiUU-16-748 Bacteroidetes bacterium enrichment culture clone 4.17b Bac band 6 Bacteroidetes bacterium enrichment culture clone LiUU-16-756 Bacteroidetes bacterium enrichment culture clone 4.17b Bac band 7 Bacteroidetes bacterium enrichment culture clone LiUU-16-769 Bacteroidetes bacterium enrichment culture clone 4.17c Bac band 1 Bacteroidetes bacterium enrichment culture clone LiUU-16-794 Bacteroidetes bacterium enrichment culture clone AQ1-2 Bacteroidetes bacterium enrichment culture clone LiUU-17-320 Bacteroidetes bacterium enrichment culture clone AVCTGRB7A Bacteroidetes bacterium enrichment culture clone LiUU-17-363 Bacteroidetes bacterium enrichment culture clone AVCTGRB9A Bacteroidetes bacterium enrichment culture clone LiUU-17-386 Bacteroidetes bacterium enrichment culture clone AVCTGRB9B Bacteroidetes bacterium enrichment culture clone LiUU-17-389 Bacteroidetes bacterium enrichment culture clone Bl-B-73 Bacteroidetes bacterium enrichment culture clone LiUU-17-737 Bacteroidetes bacterium enrichment culture clone B2 Bacteroidetes bacterium enrichment culture clone LiUU-17-770 Bacteroidetes bacterium enrichment culture clone B20 Bacteroidetes bacterium enrichment culture clone LiUU-17-793 Bacteroidetes bacterium enrichment culture clone 820(2010) Bacteroidetes bacterium enrichment culture clone LiUU-17-795 Bacteroidetes bacterium enrichment culture clone CTBE Bacteroidetes bacterium enrichment culture clone LiUU-18-303 CDB1001B01 Bacteroidetes bacterium enrichment culture clone LiUU-18-376 Bacteroidetes bacterium enrichment culture clone Bacteroidetes bacterium enrichment culture clone LiUU-18-385 D2CL_Bac_16S_Clonc21 Bacteroidetes bacterium enrichment culture clone LiUU-18-392 Bacteroidetes bacterium enrichment culture clone Bacteroidetes bacterium enrichment culture clone LiUU-18-713 D2CE_Bac_l 6S_Clone22 Bacteroidetes bacterium enrichment culture clone LiUU-1 8-728 Bacteroidetes bacterium enrichment culture clone Bacteroidetes bacterium enrichment culture clone LiUU-18-740 D2CL_Bac_16S_Clone23 Bacteroidetes bacterium enrichment culture clone LiUU-18-765 Bacteroidetes bacterium enrichment culture clone DT-1962 Bacteroidetes bacterium enrichment culture clone LiUU-18-791 Bacteroidetes bacterium enrichment culture clone EAMFC7 Bacteroidetes bacterium enrichment culture clone NKiF2Sl Bacteroidetes bacterium enrichment culture clone EE2-III Bacteroidetes bacterium enrichment culture clone phylotype PI 1 Bacteroidetes bacterium enrichment culture clone EE2-IV Bacteroidetes bacterium enrichment culture clone SI Bacteroidetes bacterium enrichment culture clone EE2-V Bacteroidetes bacterium enrichment culture clone SGLB4-2 Bacteroidetes bacterium enrichment culture clone EE2-VII Bacteroidetes bacterium enrichment culture clone SGLB4-22 Bacteroidetes bacterium enrichment culture clone H12 2 55 Bacteroidetes bacterium enrichment culture clone VNC3B008 Bacteroidetes bacterium enrichment culture clone HB 102 Bacteroidetes bacterium enrichment culture clone WIP20mlH Bacteroidetes bacterium enrichment culture clone HB 110 Bacteroidetes bacterium enrichment culture clone YFZ3 Bacteroidetes bacterium enrichment culture clone HB120 Bacteroidetes bacterium enrichment culture clone YFZ5 Bacteroidetes bacterium enrichment culture clone HB 53 Bacteroidetes bacterium enrichment culture clone YYS7 Bacteroidetes bacterium enrichment culture clone HB 61 Bacteroidetes bacterium enrichment culture DGGE band 39 Bacteroidetes bacterium enrichment culture clone IIB 63 Flexibacter maritimus-like bacterium S3C18 Bacteroidetes bacterium enrichment culture clone HB 71 Flexibacter maritimus-like bacterium S3C19 Flexibacter maritimus-like bacterium S3C20 uncultured bacterium 1AFESB3 marine eubacterium ‘DDGE band 3’ uncultured bacterium KC303 metal-contaminated soil clone K20-37 uncultured bacterium KC305 metal-contaminated soil clone K20-51 uncultured bacterium KC307 metal-contaminated soil clone K20-54 uncultured bacterium KC309 metal-contaminated soil clone K20-69 uncultured bacterium KC310 Bacteroidetes sp. oral clone FX069 uncultured bacterium KC312 uncultured bacterium #0319-2D9 uncultured bacterium KC318 uncultured bacterium #0319-6J10 uncultured bacterium KC319 uncultured bacterium #0319-7J6 uncultured bacterium KC320 uncultured bacterium #0319-7K9 uncultured bacterium KC328 uncultured bacterium #0319-8P19 uncultured bacterium KC429 uncultured bacterium B6 uncultured bacterium KC430 uncultured bacterium BA11 uncultured bacterium MKO1 uncultured bacterium BA12 uncultured bacterium MK02 uncultured bacterium BA13 uncultured bacterium MK03 uncultured bacterium BA2 uncultured bacterium MK04 uncultured bacterium BA5 uncultured bacterium MK05 uncultured bacterium BA6 uncultured bacterium MK06 uncultured bacterium BA7 uncultured bacterium MK07 uncultured bacterium RA8 uncultured bacterium MK08 uncultured bacterium BA9 uncultured bacterium MK09 uncultured bacterium BAx 1 uncultured bacterium MK10 uncultured bacterium BAx3 uncultured bacterium MK11 uncultured bacterium RAx4 uncultured bacterium MK12 uncultured bacterium BAxS uncultured bacterium MK13 uncultured bacterium BS1 uncultured bacterium MK14 uncultured bacterium BS2 uncultured bacterium MK 15 uncultured bacterium BS3 uncultured bacterium MK16 uncultured bacterium RS4 uncultured bacterium MK17 uncultured bacterium BS5 uncultured bacterium MK18 uncultured bacterium BS7 uncultured bacterium MK19 uncultured bacterium BURTON-43 uncultured bacterium MK21 uncultured bacterium BLTRTON-6 uncultured bacterium MK22 uncultured bacterium FukuN104 uncultured bacterium MK23 uncultured bacterium FukuN21 uncultured bacterium MK24 uncultured bacterium FukuN23 uncultured bacterium mlel-2 uncultured bacterium FukuN24 uncultured bacterium O11Dl uncultured bacterium FukuN3 uncultured bacterium PHOS-HC26 uncultured bacterium FukuN36 uncultured bacterium PIIOS-IIC44 uncultured bacterium FukuN47 uncultured bacterium PHOS-HC48 uncultured bacterium FukuN50 uncultured bacterium PHOS-HD32 uncultured bacterium FukuN54 uncultured bacterium PHOS-HE19 uncultured bacterium FukuN63 uncultured bacterium PHOS-HE25 uncultured bacterium FukuS140 uncultured bacterium PHOS-HE28 uncultured bacterium FukuS188 uncultured bacterium PHOS-HE31 uncultured bacterium FukuS20 uncultured bacterium PHOS-HE35 uncultured bacterium FukuS59 uncultured bacterium PHOS-HE45 uncultured baclerium GKS2-106 uncultured bacterium PHOS-HE51 uncultured bacterium GKS2-111 uncultured bacterium PHOS-HE61 uncultured bacterium GKS2-112 uncultured bacterium PHOS-HE62 uncultured bacterium GKS2-120 uncultured bacterium PHOS-HE67 uncultured bacterium GKS2-121 uncultured bacterium PHOS-HE77 uncultured bacterium GKS2-1 42 uncultured bacterium PHOS-HE79 uncultured bacterium GKS2-15 uncultured bacterium PHOS-HE99 uncultured bacterium GKS2-155 uncultured bacterium PL1 uncultured bacterium GKS2-164 uncultured bacterium Pn9 uncultured bacterium GKS2-1 9 uncultured bacterium TAYNAYA-1 7 uncultured bacterium GKS2-205 uncultured bacterium 1AYNAYA-27 uncultured bacterium GKS2-207 uncultured bacterium TX2 uncultured bacterium GKS2-208 uncultured bacterium TX3 uncultured bacterium GKS2-217 uncultured bacterium UASBTL54 uncultured bacterium GKS2-232 uncultured Bacteroidetes bacterium uncultured bacterium GKS2-33 uncultured Bacteroidetes bacterium ‘SB 12-18 P41A3’ uncultured bacterium GKS2-63 uncultured Bay of Fundy bacterium BA10-1C uncultured bacterium GKS2-7 uncultured Bay of Fundy bacterium BA10-1D uncultured bacterium GKS2-70 uncultured Bay of Fundy bacterium BA10-1E uncultured bacterium GKS2-88 uncultured CFB group bacterium B2M39 uncultured bacterium GR-WP33-44 uncultured CFB group bacterium B2M41 uncultured bacterium IAFESA5 uncultured CFB group bacterium B2M45 uncultured CFB group bacterium CtaxAus-22 uncultured Eake Michigan sediment bacterium LMBA1 uncultured CFB group bacterium CtaxAus-4 uncultured Lake Michigan sediment bacterium LMBA22 uncultured CFB group bacterium CtaxAus-7 uncultured Lake Michigan sediment bacterium LMBA29 uncultured CFB group bacterium CtaxMed-1 uncultured Lake Michigan sediment bacterium LMBA40 uncultured CFB group bacterium CtaxMed-15 uncultured Lake Michigan sediment bacterium LMBGA6-26 uncultured CFB group bacterium CtaxMed-18 uncultured marine bacterium AY-32 uncultured CFB group bacterium CtaxMed-37 uncultured marine bacterium AY-33 uncultured CFB group bacterium CtaxMed-46 uncultured marine bacterium AY-37 uncultured CFB group bacterium CtaxMed-5 uncultured marine bacterium AY-38 uncultured CFB group bacterium CtaxPhil-13 uncultured marine bacterium AY-56 uncultured CFB group bacterium CtaxTah-24 uncultured marine bacterium BY-19 uncultured CFB group bacterium EBAC322 uncultured marine baclerium BY-64 uncultured CFB group bacterium EBAC34 uncultured marine bacterium BY-65 uncultured CFB group bacterium EBAC391 uncultured marine bacterium BY-66 uncultured CFB group bacterium EBAC40 uncultured marine bacterium BY-7 uncultured CFB group bacterium EBAC43 uncultured marine bacterium BY-71 uncultured CFB group bacterium kpal3rc uncultured marine bacterium pC2-105 uncultured CFB group bacterium kpc103f uncultured marine bacterium pM-36 uncultured CFB group bacterium kpc 113rc uncultured marine bacterium ZD0203 uncultured CFB group bacterium kpc 116rc uncultured marine bacterium ZD0255 uncultured CFB group bacterium kpc26 uncultured marine bacterium ZD0403 uncultured CFB group bacterium kpc29 uncultured marine cytophaga DHB-3 uncultured CFB group bacterium kpjl lrc uncultured marine Cytophaga MBE2 uncultured CFB group bacteriumkpjl67rc uncultured marine Cytophaga MBE7 uncultured CFB group bacterium kpj254f uncultured marine eubacterium OTU A uncultured CFB group bacterium kpj43 If uncultured marine eubacterium OTU B uncultured CFB group bacterium kpj56rc uncultured marine eubacterium OTU C uncultured CFB group bacterium kpj 57rc uncultured marine eubacterium OTU D uncultured CFB group bacterium kpj 59rc uncultured rumen bacterium 109pARRO uncultured CFB group bacterium kpj60f uncultured rumen bacterium 119pARRO uncultured CFB groupbacterium NAC60-3 uncultured rumen bacterium 120pARRO uncultured CFB-group bacterium 107ev uncultured rumen bacterium 122pARRO uncultured CFB-group bacterium 122ev uncultured rumen bacterium 125cARRO uncultured CFB-group bacterium 168ev uncultured rumen bacterium 194pARRO uncultured CFB-group bacterium 204ev uncultured rumen bacterium 231cARRO uncultured CFB-group bacterium 22ev uncultured rumen bacterium 242pARRO uncultured CFB-group bacterium 240ev uncultured rumen bacterium 243pARRO uncultured CFB-group bacterium 279ev uncultured rumen bacterium 262pARRO uncultured CFB-group bacterium 338ev uncultured rumen bacterium 268pARRO uncultured CFB-group bacterium 36ev uncultured rumen bacterium 343pARRO uncultured CFB-group bacterium 416ev uncultured rumen bacterium 351pARRO uncultured CFB-group bacterium 421ev uncultured rumen bacterium 353pARRO uncultured CFB-group bacterium 429ev uncultured rumen bacterium 362cARRO uncultured CFB-group bacterium 42ev uncultured rumen bacterium 445pARRO uncultured CFB-group bacterium 439ev uncultured rumen bacterium 509cARRO uncultured CFB-group bacterium 6 lev uncultured rumen bacterium 509pARRO uncultured CFB-group bacterium 65ev uncultured rumen bacterium 523cARRO uncultured CFB-group bacterium 87cv uncultured rumen bacterium 588cARRO uncultured CFB-group bacterium 93ev uncultured rumen bacterium 5cARRO uncultured coastal Alaskan Arctic bacterium AWS98-1 Id uncultured rumen bacterium 626pARRO uncultured coastal Alaskan Arctic bacterium AWS98-19d uncultured rumen bacterium 62pARRO uncultured coastal Alaskan Arctic bacterium AWS98-7d uncultured rumen bacterium 635cARRO uncultured cytophaga DCM-FREE-10 uncultured rumen bacterium C36cARRO uncultured cytophaga DCM-FREE-35 uncultured rumen bacterium 637cARRO uncultured eubacterium DgEPI2 uncultured rumen bacterium 648pARRO uncultured eubacterium DgEPI6 uncultured rumen bacterium 68pARRO uncultured eubacterium WCHA1-01 uncultured rumen bacterium 90cARRO uncultured eubacterium WCFTA1 -1 4 uncultured rumen bacterium jlRRT uncultured eubacterium WCHA2-47 uncultured rumen bacterium j2RRl uncultured eubacterium WCHB 1-29 uncultured rumen bacterium j 3 RRI uncultured eubacterium WCHB 1-32 uncultured rumen bacterium j4RRI uncultured eubacterium WCHB 1-53 uncultured rumen bacterium jwl 1 RRI uncultured eubacterium WsCH39 uncultured rumen bacterium jwl 2RRI uncultured fecal bacterium TB101 uncultured rumen bacterium jwl 3RRI uncultured fecal bacterium TB106 uncultured rumen bacterium jwl4RRI uncultured fecal bacterium TB13 uncultured rumen bacterium jwl5RRI uncultured fecal bacterium TB135 uncultured rumen bacterium jw!81RRI uncultured fecal bacterium TB141 uncultured rumen bacterium jw2-7RRI uncultured fecal bacterium TB146 uncultured rumen bacterium jw20RRI uncultured fecal bacterium TB147 uncultured rumen bacterium jw22RRI uncultured mmen bacterium jw25 RRI unidentified Cytophagales OPB73 uncultured mmen bacterium jw26RRI unidentified Cytophagales OPB88 uncultured mmen bacterium jw27RRI unidentified Cytophagales OPS 1 uncultured rumen bacterium jw29RRI unidentified eubacterium clone ESH167E uncultured mmen bacterium jw30RRI unidentified eubacterium clone ESH30-3 uncultured mmen bacterium jw5RRI unidentified eubacterium clone LGA//1 uncultured mmen bacterium jw6RRI unidentified eubacterium clone LGB#27 uncultured mmen bacterium jw7RRI unidentified eubacterium clone PS#8 uncultured mmen bacterium jw&lRRI unidentified eubacterium SCB37 uncultured mmen bacterium jw9RRl unidentified eubacterium SCB38 uncultured sludge bacterium A12b unidentified eubacterium SCB40 unidentified cytophagales groupA unidentified eubacterium SCB41 unidentified cytophagales groupB unidentified eubacterium SCB45 unidentified cytophagales groupG unidentified eubacterium SCB49 Genus: Lactobacillus Lactobacillus acetotolerans Lactobacillus coleohominis Lactobacillus acetotolerans JCM 3825 Lactobacillus coleohominis 101-4-CHN Lactobacillus acidifarinae Lactobacillus coleohominis DSM 14060 Lactobacillus acidipiscis Lactobacillus collinoides Lactobacillus acidipiscis KCTC 13900 Lactobacillus composti Lactobacillus acidophilus Lactobacillus concavus Lactobacillus acidophilus 30SC Lactobacillus coryniformis Lactobacillus acidophilus ATCC 4796 Lactobacillus coryniformis subsp. coryniformis Lactobacillus acidophilus CIP 76.13 Lactobacillus coryniformis subsp. coiyniformis CECT 5711 Lactobacillus acidophilus CIRM-BIA 442 Lactobacillus coryniformis subsp. coiyniformis KCTC 3167 Lactobacillus acidophilus CIRM-BIA 445 Lactobacillus coryniformis subsp. torquens Lactobacillus acidophilus CRBIP 24179 Lactobacillus coryniformis subsp. torquens KCTC 3535 Lactobacillus acidophilus DSM 20242 Lactobacillus crispatus Lactobacillus acidophilus DSM 9126 Lactobacillus crispatus 125-2-CHN Lactobacillus acidophilus JV3179 Lactobacillus crispatus 2029 Lactobacillus acidophilus La-14 Lactobacillus crispatus 214-1 Lactobacillus acidophilus NCFM Lactobacillus crispatus CTV-05 Lactobacillus agilis Lactobacillus crispatus EX533959VC01 Lactobacillus algidus Lactobacillus crispatus EX533959VC03 Lactobacillus alimentarius Lactobacillus crispatus EX533959VC04 Lactobacillus alvei Lactobacillus crispatus EX533959VC05 Lactobacillus alvi Lactobacillus crispatus EX533959VC06 Lactobacillus amylolyticus Lactobacillus crispatus EX533959VC07 Lactobacillus amylolyticus DSM 11664 Lactobacillus crispatus EX533959VC13 Lactobacillus amylophilus Lactobacillus crispatus EX849587VC01 Lactobacillus amylophilus JCM 1125 Lactobacillus crispatus EX849587VC02 Lactobacillus amylotrophicus Lactobacillus crispatus EX849587VC04 Lactobacillus amylovorus Lactobacillus crispatus EX849587VC07 Lactobacillus amylovorus DSM 16698 Lactobacillus crispatus EX849587VC08 Lactobacillus amylovorus GRI. 1112 Lactobacillus crispatus FB049-03 Lactobacillus amylovoms GRL 1115 Lactobacillus crispatus FB077-07 Lactobacillus amylovoms GRL1118 Lactobacillus crispatus JCM 1185 Lactobacillus animalis Lactobacillus crispatus JV-V01 Lactobacillus animalis KCTC 3501 Lactobacillus crispatus MV-lA-tJS Lactobacillus animata Lactobacillus crispatus MV-3A-FTS Lactobacillus antri Lactobacillus crispatus SJ-3C-US Lactobacillus antri DSM 16041 Lactobacillus crispatus ST1 Lactobacillus apis Lactobacillus crustorum Lactobacillus apodemi Lactobacillus crustorum FH4 Lactobacillus aquaticus Lactobacillus curvatus Lactobacillus aviarius Lactobacillus curvatus CRL 705 Lactobacillus aviarius subsp. araffinosus Lactobacillus curvatus F16 9 Lactobacillus aviarius subsp. aviarius Lactobacillus curvatus JCM 1096 Lactobacillus backi Lactobacillus curvatus WSU1 Lactobacillus bifermentans Lactobacillus brevisimilis Lactobacillus brantae Lactobacillus buchneri Lactobacillus brevis Lactobacillus buchneri ATCC 11577 Lactobacillus brevis AG48 Lactobacillus buchneri CD034 Lactobacillus brevis ATCC 14869 Lactobacillus buchneri NRRL B-30929 Lactobacillus brevis ATCC 367 Lactobacillus cacaonum Lactobacillus brevis KB290 Lactobacillus camelliae Lactobacillus brevis subsp. gravesensis Lactobacillus capillatus Lactobacillus brevis subsp. gravesensis ATCC 27305 Lactobacillus casei group Lactobacillus casei Lactobacillus delbrueckii subsp. bulgaricus 2038 Lactobacillus casei 12A Lactobacillus delbrueckii subsp. bulgaricus ATCC 11842 Lactobacillus casei 21/1 Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365 Lactobacillus casei 32G Lactobacillus delbrueckii subsp. bulgaricus CNCM 1-1519 Lactobacillus casei A2-362 Lactobacillus delbrueckii subsp. bulgaricus CNCM 1-1632 Lactobacillus casei ATCC 334 Lactobacillus delbrueckii subsp. bulgaricus ND02 Lactobacillus casei DD-II Lactobacillus delbrueckii subsp. bulgaricus PB2003/044-T3-4 Lactobacillus casei BL23 Lactobacillus delbrueckii subsp. delbrueckii Lactobacillus casei CRF28 Lactobacillus delbrueckii subsp. indicus Lactobacillus casei DN-114001 Lactobacillus delbrueckii subsp. lactis Lactobacillus casei Lc-10 Lactobacillus delbrueckii subsp. lactis CRL581 Lactobacillus casei LC2W Lactobacillus delbrueckii subsp. lactis DSM 20072 Lactobacillus casei LcA Lactobacillus delbrueckii subsp. sunkii Lactobacillus casei LcY Lactobacillus delbrueckii ZN7a-9 Lactobacillus casei LOCK919 Lactobacillus dcxtrinicus Lactobacillus casei Lpc-37 Lactobacillus diolivorans Lactobacillus casei M36 Lactobacillus equi Lactobacillus casei str. Zhang Lactobacillus equicursoris Lactobacillus casei subsp. casei ATCC 393 Lactobacillus equicursoris CIP 110162 Lactobacillus casei T71499 Lactobacillus equigenerosi Lactobacillus casei UCD174 Lactobacillus fabifermentans Lactobacillus casei UW1 Lactobacillus faeni Lactobacillus casei UW4 Lactobacillus farciminis Lactobacillus casei W56 Lactobacillus farciminis KCTC 3681 Lactobacillus paracasei Lactobacillus farraginis Lactobacillus paracasei COM0101 Lactobacillus fermentum Lactobacillus paracasei subsp. paracasei Lactobacillus fermentum 28-3-CHN Lactobacillus paracasei subsp. tolerans Lactobacillus fermentum 3872 Lactobacillus paracasei TXW Lactobacillus fermentum ATCC 14931 Lactobacillus zeae Lactobacillus fermentum CECT 5716 Lactobacillus zeae KCTC 3804 Lactobacillus fermentum F-6 Lactobacillus sp. LA601 Lactobacillus fermentum FTDC8312 Lactobacillus sp. Od.76 Lactobacillus fermentum IFO 3956 Lactobacillus catenefornis Lactobacillus fermentum Lfl Lactobacillus catenefornis DSM 20559 Lactobacillus fermentum MTCC 8711 Lactobacillus ceti Lactobacillus floricola Lactobacillus ceti DSM 22408 Lactobacillus riorum Lactobacillus fuchuensis Lactobacillus florum 2F Lactobacillus futsaii Lactobacillus florum 8D Lactobacillus gallinarum Lactobacillus fornicalis Lactobacillus gasseri Lactobacillus fructivorans Lactobacillus gasseri 2016 Lactobacillus fructivorans KCTC 3543 Lactobacillus gasseri 202-4 Lactobacillus frumenti Lactobacillus gasseri 224-1 Lactobacillus mali Lactobacillus gasseri ADL-35 1 Lactobacillus mali KCTC 3596 = DSM 20444 Lactobacillus gasseri ATCC 33323 Lactobacillus manihotivorans Lactobacillus gasseri CECT 5714 Lactobacillus mindensis Lactobacillus gasseri EX336960VC01 Lactobacillus mobilis Lactobacillus gasseri EX336960VC02 Lactobacillus mucosae Lactobacillus gasseri EX336960VC03 Lactobacillus mucosae LM1 Lactobacillus gasseri EX336960VC06 Lactobacillus murinus Lactobacillus gasseri EX336960VC07 Lactobacillus murinus ASF361 Lactobacillus gasseri EX336960VC10 Lactobacillus guizhouensis Lactobacillus gasseri EX336960VC13 Lactobacillus halophilus Lactobacillus gasseri EX336960VC15 Lactobacillus hammesii Lactobacillus gasseri JV-V03 Lactobacillus hamsteri Lactobacillus gasseri K7 Lactobacillus harbinensis Lactobacillus gasseri MV-22 Lactobacillus harbinensis DSM 16991 Lactobacillus gasseri SJ-9E-US Lactobacillus hayakitensis Lactobacillus gasseri SV-16A-US Lactobacillus helveticus Lactobacillus gastricus Lactobacillus helveticus CIRM-BIA 101 Lactobacillus gastricus PS3 Lactobacillus helveticus CIRM-BIA 103 Lactobacillus genomosp. CT Lactobacillus helveticus CIRM-BIA 104 Lactobacillus genomosp. C2 Lactobacillus helveticus CIRM-BIA 951 Lactobacillus ghanensis Lactobacillus helveticus CIRM-BIA 953 Lactobacillus gigeriorum Lactobacillus helveticus CNRZ32 Lactobacillus gigeriorum CRBIP 24.85 Lactobacillus helveticus DPC 4571 Lactobacillus graminis Lactobacillus helveticus DSM 20075 Lactobacillus delbrueckii Lactobacillus helveticus 1110 Lactobacillus delbrueckii subsp. bulgaricus Lactobacillus helveticus H9 Lactobacillus helveticus MTCC 5463 Lactobacillus kunkeei Lactobacillus helveticus R0052 Lactobacillus larvae Lactobacillus helveticus subsp. jugurti Lactobacillus leichmannii Lactobacillus heterohiochii Lactobacillus letivazi Lactobacillus hilgardii Lactobacillus lindneri Lactobacillus hilgardii ATCC 8290 Lactobacillus malefermentans Lactobacillus hokkaidonensis Lactobacillus malefermentans KCTC 3548 Lactobacillus hominis Lactobacillus sunkii Lactobacillus hominis CRBIP 24.179 Lactobacillus taiwanensis Lactobacillus homohiochii Lactobacillus thailandensis Lactobacillus hordei Lactobacillus tucceti Lactobacillus iatae Lactobacillus ultunensis Lactobacillus iners Lactobacillus ultunensis DSM 16047 Lactobacillus iners AB-1 Lactobacillus uvarum Lactobacillus iners ACS-070-V-Col3 Lactobacillus vaccinostcrcus Lactobacillus iners ATCC 55195 Lactobacillus vaginalis Lactobacillus iners DSM 13335 Lactobacillus vaginalis ATCC 49540 Lactobacillus iners LactinV OlVl-a Lactobacillus vaginalis EX336960VC05 Lactobacillus iners LactinV 03Vl-b Lactobacillus vaginalis EX336960VC11 Lactobacillus iners LactinV 09V1-C Lactobacillus vaginalis EX336960VC12 Lactobacillus iners LactinV 11VI-d Lactobacillus vermiforme Lactobacillus iners LEAF 2052A-d Lactobacillus versmoldensis Lactobacillus iners LEAF 2053A-b Lactobacillus versmoldensis KCTC 3814 Lactobacillus iners LEAF 2062A-hl Lactobacillus vini Lactobacillus iners LEAF 3008A-a Lactobacillus vini DSM 20605 Lactobacillus iners SPIN 1401G Lactobacillus vini JP7.8.9 Lactobacillus iners SPIN 2503V10-D Lactobacillus zymae Lactobacillus iners UPII 143-D Lactobacillus sp. Lactobacillus iners UPII 60-B Lactobacillus sp. O-C-2 Lactobacillus ingluviei Lactobacillus sp. 1-3-3 Lactobacillus ingluviei str. Autruche 4 Lactobacillus sp. 1.1424 Lactobacillus insectis Lactobacillus nagelii Lactobacillus intermedius Lactobacillus namurensis Lactobacillus intestinalis Lactobacillus nantensis Lactobacillus japonicus Lactobacillus nasuensis Lactobacillus jensenii Lactobacillus nodensis Lactobacillus jensenii 115-3-CHN Lactobacillus nodensis NBRC 107160 Lactobacillus jensenii 1153 Lactobacillus odoratitoflii Lactobacillus jensenii 208-1 Lactobacillus oeni Lactobacillus jensenii 269-3 Lactobacillus oligofermentans Lactobacillus jensenii 27-2-CHN Lactobacillus oligofermentans LMG 22743 Lactobacillus jensenii EX533959VC02 Lactobacillus oris Lactobacillus jensenii EX849587VC03 Lactobacillus oris F0423 Lactobacillus jensenii EX849587VC05 Lactobacillus oris PB013-T2-3 Lactobacillus jensenii EX849587VC06 Lactobacillus oryzae Lactobacillus jensenii JV-V16 Lactobacillus otakiensis Lactobacillus jensenii MD HE-70(2) Lactobacillus otakiensis JCM 15040 Lactobacillus jensenii SJ-7A-US Lactobacillus ozcnsis Lactobacillus johnsonii Lactobacillus panis Lactobacillus johnsonii 135-1 -CHN Lactobacillus pantheris Lactobacillus johnsonii 16 Lactobacillus parabrevis Lactobacillus johnsonii ATCC 33200 Lactobacillus parabrevis ATCC 53295 Lactobacillus johnsonii DPC 6026 Lactobacillus parabuchneii Lactobacillus johnsonii FT9785 Lactobacillus paracollinoides Lactobacillus johnsonii NCC 533 Lactobacillus parafarraginis Lactobacillus johnsonii pfOl Lactobacillus parafarraginis F0439 Lactobacillus kalixensis Lactobacillus parakefiri Lactobacillus kefiranofaciens Lactobacillus paralimentarius Lactobacillus kefiranofaciens subsp. kefiranofaciens Lactobacillus parapiantarum Lactobacillus kefiranofaciens subsp. kefirgranum Lactobacillus pasteurii Lactobacillus kefiranofaciens ZW3 Lactobacillus pasteurii CRBIP 24.76 Lactobacillus kefiri Lactobacillus pentosus Lactobacillus kefiri JCM 5818 Lactobacillus pentosus IG1 Lactobacillus kimchicus Lactobacillus pentosus KCA1 Lactobacillus kimchicus JCM 15530 Lactobacillus pentosus MP-10 Lactobacillus kimchiensis Lactobacillus perolens Lactobacillus kimchii Lactobacillus plantarum Lactobacillus kisonensis Lactobacillus plantarum 16 Lactobacillus kisonensis F0435 Lactobacillus plantarum 2025 Lactobacillus kitasatonis Lactobacillus plantarum 2165 Lactobacillus plantarum 4_3 Lactobacillus mminis Lactobacillus plantamm AY01 Lactobacillus mminis ATCC 25644 Lactobacillus plantamm CMPG5300 Lactobacillus mminis ATCC 27782 Lactobacillus plantarum DOMLa Lactobacillus mminis SPM0211 Lactobacillus plantamm EGD-AQ4 Lactobacillus saerimneri Lactobacillus plantamm IPLA88 Lactobacillus saerimneri 30a Lactobacillus plantamm JDM1 Lactobacillus saerimneri DSM 16049 Lactobacillus plantarum subsp. argentoratensis Lactobacillus sakei Lactobacillus plantamm subsp. plantarum Lactobacillus sakei dgh6 Lactobacillus plantamm subsp. plantamm ATCC 14917 Lactobacillus sakei L45 Lactobacillus plantamm subsp. plantarum KCA-1 Lactobacillus sakei subsp. carnosus Lactobacillus plantarum subsp. plantarum NC8 Lactobacillus sakei subsp. carnosus DSM 15831 Lactobacillus plantamm subsp. plantamm P-8 Lactobacillus sakei subsp. sakei Lactobacillus plantamm subsp. plantamm R0403 Lactobacillus sakei subsp. sakei 23K Lactobacillus plantamm subsp. plantamm ST-III Lactobacillus sakei subsp. sakei LS25 Lactobacillus plantarum UCMA 3037 Lactobacillus salivarius Lactobacillus plantamm WCFS1 Lactobacillus salivarius ACS-116-V-Col5a Lactobacillus plantamm ZJ316 Lactobacillus salivarius ATCC 11741 Lactobacillus pobuzihii Lactobacillus salivarius B-30514 Lactobacillus pobuzihii E100301 Lactobacillus salivarius CECT 5713 Lactobacillus pontis Lactobacillus salivarius CELA2 Lactobacillus psittaci Lactobacillus salivarius cp400 Lactobacillus psittaci DSM 15354 Lactobacillus salivarius DPC 6502 Lactobacillus rapi Lactobacillus salivarius GJ-24 Lactobacillus rennini Lactobacillus salivarius NTAS840 Lactobacillus reuteri Lactobacillus salivarius SMXD51 Lactobacillus reuteri 100-23 Lactobacillus salivarius str. Ren Lactobacillus reuteri 1063 Lactobacillus salivarius UCC118 Lactobacillus reuteri ATCC 53608 Lactobacillus sanfranciscensis Lactobacillus reuteri CF48-3A Lactobacillus sanfranciscensis TMW 1.1304 Lactobacillus reuteri DSM 20016 Lactobacillus saniviri Lactobacillus reuteri F275 Lactobacillus satsumensis Lactobacillus reuteri 15007 Lactobacillus secaliphilus Lactobacillus reuteri JCM 1112 Lactobacillus senioris Lactobacillus reuteri lpuph Lactobacillus senmaizukei Lactobacillus reuteri mlc3 Lactobacillus senmaizukei NBRC 103853 Lactobacillus reuteri MM2-2 Lactobacillus sharpeae Lactobacillus reuteri MM2-3 Lactobacillus sharpeae JCM 1186 Lactobacillus reuteri MM4-1A Lactobacillus shenzhenensis Lactobacillus reuteri SD2112 Lactobacillus shenzhenensis LY-73 Lactobacillus reuteri TD1 Lactobacillus silagei Lactobacillus rhamnosus Lactobacillus siliginis Lactobacillus rhamnosus 2166 Lactobacillus similis Lactobacillus rhamnosus ATCC 21052 Lactobacillus similis JCM 2765 Lactobacillus rhamnosus ATCC 8530 Lactobacillus spicheri Lactobacillus rhamnosus CASL Lactobacillus sucicola Lactobacillus rhamnosus CRL1505 Lactobacillus suebicus Lactobacillus rhamnosus DSM 14870 Lactobacillus suebicus KCTC 3549 Lactobacillus rhamnosus GG Lactobacillus sp. 14.2.14 Lactobacillus rhamnosus LMG 25859 Lactobacillus sp. 14.2.15 Lactobacillus rhamnosus LMG 27229 Lactobacillus sp. 14.2.18 Lactobacillus rhamnosus HN001 Lactobacillus sp. 14.2.20 Lactobacillus rhamnosus K32 Lactobacillus sp. 14.2.30 Lactobacillus rhamnosus L31 Lactobacillus sp. 1 4.2.31 Lactobacillus rhamnosus L33 Lactobacillus sp. 14.2.33 Lactobacillus rhamnosus L34 Lactobacillus sp. 14.2.37 Lactobacillus rhamnosus L35 Lactobacillus sp. 14.2.39 Lactobacillus rhamnosus Ec 705 Lactobacillus sp. 14.2.4 Lactobacillus rhamnosus LMS2-1 Lactobacillus sp. 14.2.41 Lactobacillus rhamnosus LOCK900 Lactobacillus sp. 14.2.46 Lactobacillus rhamnosus LOCK908 Lactobacillus sp. 14.2.48 Lactobacillus rhamnosus LRHMDP2 Lactobacillus sp. 14.2.9 Lactobacillus rhamnosus LRHMDP3 Lactobacillus sp. 14.8.15 Lactobacillus rhamnosus MSUIS1 Lactobacillus sp. 14.8.19 Lactobacillus rhamnosus MTCC 5462 Lactobacillus sp. 14.8.23 Lactobacillus rhamnosus NBRC 3425 Lactobacillus sp. 14.8.24 Lactobacillus rhamnosus R0011 Lactobacillus sp. 14.8.36 Lactobacillus rogosae Lactobacillus sp. 14.8.40 Lactobacillus rossiae Lactobacillus sp. 14.8.43 Lactobacillus rossiae DSM 15814 Lactobacillus sp. 14.8.44 Lactobacillus sp. 14.8.6 Lactobacillus sp. 7.8.26 Lactobacillus sp. 14.8.7 Lactobacillus sp. 7.8.27 Lactobacillus sp. 14B10 Lactobacillus sp. 7.8.33 Lactobacillus sp. 166 Lactobacillus sp. 7.8.6 Lactobacillus sp. 16DCCH01MX Lactobacillus sp. 70811 Lactobacillus sp. 18BSM Lactobacillus sp. 70819 Lactobacillus sp. 19-2 Lactobacillus sp. 71 Lactobacillus sp. 19DCCH01MX Lactobacillus sp. 711 Lactobacillus sp. 1L Lactobacillus sp. 100-23 Lactobacillus sp. 20(2010) Lactobacillus sp. 100-5 Lactobacillus sp. 2011 Ileo VSA CI Lactobacillus sp. 11050 Lactobacillus sp. 2011 Ileo VSA C5 Lactobacillus sp. 11102 Lactobacillus sp. 2011 Ileo VSA D2 Lactobacillus sp. 120-6-20 Lactobacillus sp. 2011 Ileo VSA E2 Lactobacillus sp. 12IB Lactobacillus sp. 201 l_Oral_VSA C7 Lactobacillus sp. 123B Lactobacillus sp. 20326H4L1 Lactobacillus sp. 14-3-19 Lactobacillus sp. 24DCCH01 MX Lactobacillus sp. 14.2.12 Lactobacillus sp. 3-6 Lactobacillus sp. 14.2.13 Lactobacillus sp. 3.1.1 Lactobacillus sp. Anhor4 Lactobacillus sp. 3.2.22 Lactobacillus sp. Aiilioto7 Lactobacillus sp. 3.2.35 Lactobacillus sp. Anhoto8 Lactobacillus sp. 3.8.18 Lactobacillus sp. Anuhmtol3 Lactobacillus sp. 3.8.40 Lactobacillus sp. Anuhmto23 Lactobacillus sp. 3.8.42 Lactobacillus sp. ARB2 Lactobacillus sp. 3.8.8 Lactobacillus sp. Arif Mardan- Lactobacillus sp. 30.2.8 Lactobacillus sp. AS5 Lactobacillus sp. 30A Lactobacillus sp. ASF360 Lactobacillus sp. 30BPM Lactobacillus sp. ATCC 8291 Lactobacillus sp. 326 Lactobacillus sp. Atm5 Lactobacillus sp. 34-10B Lactobacillus sp. Autruche 4 Lactobacillus sp. 39D2CCL02MX Lactobacillus sp. Autruche 5 Lactobacillus sp. 39DCCL02MX Lactobacillus sp. B 225 Lactobacillus sp. 3AB9 Lactobacillus sp. B 226 Lactobacillus sp. 3b Lactobacillus sp. B 227 Lactobacillus sp. 3d Lactobacillus sp. B 228 Lactobacillus sp. 3F11 Lactobacillus sp. B 229 Lactobacillus sp. 41DCCL02MX Lactobacillus sp. B 230 Lactobacillus sp. 43D2CCL02MX Lactobacillus sp. B 236 Lactobacillus sp. 43DCCL02MX Lactobacillus sp. B 237 Lactobacillus sp. 45 Lactobacillus sp. B 238 Lactobacillus sp. 459 Lactobacillus sp. B 239 Lactobacillus sp. 46-211 Lactobacillus sp. B 245 Lactobacillus sp. 47DCCL02MX Lactobacillus sp. B 246 Lactobacillus sp. 49DCCL02MX Lactobacillus sp. B 247 Lactobacillus sp. 4B13 Lactobacillus sp. B 248 Lactobacillus sp. 4B31 Lactobacillus sp. B 249 Lactobacillus sp. 5-1-2 Lactobacillus sp. B 250 Lactobacillus sp. 52A Lactobacillus sp. B 251 Lactobacillus sp. 54DCEP01MX Lactobacillus sp. B 252 Lactobacillus sp. 59DCEP01MX Lactobacillus sp. B 253 Lactobacillus sp. 5D32 Lactobacillus sp. B 254 Lactobacillus sp. 6225121 Lactobacillus sp. B 255 Lactobacillus sp. 6225335 Lactobacillus sp. B10 Lactobacillus sp. 6225616 Lactobacillus sp. B13 Lactobacillus sp. 62DACEP01MX Lactobacillus sp. B16 Lactobacillus sp. 66c Lactobacillus sp. B164 Lactobacillus sp. 6D3 Lactobacillus sp. B18 Lactobacillus sp. 7-19 Lactobacillus sp. B2 Lactobacillus sp. 7.2.21 Lactobacillus sp. B21 Lactobacillus sp. 7.2.29 Lactobacillus sp. B22 Lactobacillus sp. 7.2.33 Lactobacillus sp. B3 Lactobacillus sp. 7.2.35 Lactobacillus sp. B3(2009) Lactobacillus sp. 7.2.36 Lactobacillus sp. B4 Lactobacillus sp. 7.2.40 Lactobacillus sp. B5 Lactobacillus sp. 7.2.46 Lactobacillus sp. B5406 Lactobacillus sp. 7.2.48 Lactobacillus sp. B5407 Lactobacillus sp. 7.2.49 Lactobacillus sp. B6 Lactobacillus sp. 7.2.50 Lactobacillus sp. B6(2012) Lactobacillus sp. 7.8.15 Lactobacillus sp. B7 Lactobacillus sp. 7.8.17 Lactobacillus sp. B8 Lactobacillus sp. B9 Lactobacillus sp. Adhmtol Lactobacillus sp. BB9 Lactobacillus sp. Adhmtol5 Lactobacillus sp. BBDP73 Lactobacillus sp. Adhmtol9 Lactobacillus sp. BCRC16000 Lactobacillus sp. Adhmto21 Lactobacillus sp. BH0900 Lactobacillus sp. Adporo6 Lactobacillus sp. 713 Lactobacillus sp. AF20(2010) Lactobacillus sp. 74(2011) Lactobacillus sp. AF26(2010) Lactobacillus sp. 7 1 47FAA Lactobacillus sp. Afhotl Lactobacillus sp. 7b Lactobacillus sp. AFL13-2 Lactobacillus sp. 8525126 Lactobacillus sp. AFL17-5 Lactobacillus sp. 88 Lactobacillus sp. AFL18-2 Lactobacillus sp. 8BAM Lactobacillus sp. AFL18-5 Lactobacillus sp. 9C4 Lactobacillus sp. AFL19-3 Lactobacillus sp. 9C6 Lactobacillus sp. Afpor8 Lactobacillus sp. 9D10 Lactobacillus sp. Afpotol3 Lactobacillus sp. 9D6 Lactobacillus sp. Afpolol4 Lactobacillus sp. 9D8 Lactobacillus sp. Afpoto7 Lactobacillus sp. AA Lactobacillus sp. AI197 Lactobacillus sp. Aabbtol6 Lactobacillus sp. AI460 Lactobacillus sp. Aabbto7 Lactobacillus sp. AI461 Lactobacillus sp. Aahmrol5 Lactobacillus sp. AK11 3 Lactobacillus sp. Aahmtol2 Lactobacillus sp. AK21 Lactobacillus sp. Aahonto7 Lactobacillus sp. Akhmbto4 Lactobacillus sp. ABO 15 Lactobacillus sp. Akhmr6 Lactobacillus sp. AB032 Lactobacillus sp. Akhmro 1 Lactobacillus sp. ABO 5 Lactobacillus sp. Akhmtol8 Lactobacillus sp. ABO 5-1 Lactobacillus sp. Aldimto2 Lactobacillus sp. AB06 Lactobacillus sp. Akpobrol Lactobacillus sp. ab2 Lactobacillus sp. Akporo7 Lactobacillus sp. ab3-wl Lactobacillus sp. AL2 Lactobacillus sp. AB511 Lactobacillus sp. AL5 Lactobacillus sp. AB511-2 Lactobacillus sp. Alhmlto4 Lactobacillus sp. AB5115-9 Lactobacillus sp. Alhm2tol 1 Lactobacillus sp. AB5216-2 Lactobacillus sp. Alhonto3 Lactobacillus sp. AB523-1 Lactobacillus sp. Alhonto4 Lactobacillus sp. AB5252 Lactobacillus sp. Am 09 Lactobacillus sp. AB5261-2 Lactobacillus sp. AMC1 Lactobacillus sp. AB5262 Lactobacillus sp. AMC2 Lactobacillus sp. AB5281 Lactobacillus sp. AmmhmR15 Lactobacillus sp. AB5282 Lactobacillus sp. AmmhmR3 Lactobacillus sp. ab6 Lactobacillus sp. AmmhmR5 Lactobacillus sp. ABRIINW-GOL4 Lactobacillus sp. AmmhmT7 Lactobacillus sp. ABRIINW.F58 Lactobacillus sp. AmmohmiT Lactobacillus sp. ABT LI Lactobacillus sp. Ammohmr22 Lactobacillus sp. ABT L2 Lactobacillus sp. Ammohml5 Lactobacillus sp. AbxANB3 Lactobacillus sp. Ammoporl3 Lactobacillus sp. AbxANB4 Lactobacillus sp. Ammopor2 Lactobacillus sp. ACD7 Lactobacillus sp. AmmpolR3 Lactobacillus sp. Achmtol6 Lactobacillus sp. AmmpolR6 Lactobacillus sp. Achmto2 Lactobacillus sp. Amsbbrl7 Lactobacillus sp. AcjLac1 Lactobacillus sp. Amsbbrl9 Lactobacillus sp. AcjLac10 Lactobacillus sp. Amsbbr2 Lactobacillus sp. AcjLac11 Lactobacillus sp. Amsbbr24 Lactobacillus sp. AcjLac12 Lactobacillus sp. Amsbbrfi Lactobacillus sp. AcjLac13 Lactobacillus sp. Amsbbtll Lactobacillus sp. AcjLac14 Lactobacillus sp. DSM 15502 Lactobacillus sp. AcjLac15 Lactobacillus sp. DSM 20197 Lactobacillus sp. AcjLac16 Lactobacillus sp. DumLac1 Lactobacillus sp. AcjLac17 Lactobacillus sp. DumLac10 Lactobacillus sp. AcjLac18 Lactobacillus sp. DumLac11 Lactobacillus sp. AcjLac3 Lactobacillus sp. DumLac12 Lactobacillus sp. AcjLac4 Lactobacillus sp. DumLac13 Lactobacillus sp. AcjLac5 Lactobacillus sp. DumLac14 Lactobacillus sp. AcjLac6 Lactobacillus sp. DumLac15 Lactobacillus sp. AcjLac7 Lactobacillus sp. DumLac17 Lactobacillus sp. AcjLac8 Lactobacillus sp. DumLac18 Lactobacillus sp. AcjLac9 Lactobacillus sp. DumLac19 Lactobacillus sp. Acpor9 Lactobacillus sp. DumLac2 Lactobacillus sp. Adhmro12 Lactobacillus sp. DumLac20 Lactobacillus sp. Adhmro7 Lactobacillus sp. DumLac21 Lactobacillus sp. DumLac22 Lactobacillus sp. GL1 Lactobacillus sp. DumLac23 Lactobacillus sp. GL2 Lactobacillus sp. DuiuLac24 Lactobacillus sp. GM 01 Lactobacillus sp. DumLac25 Lactobacillus sp. GS21 Lactobacillus sp. DumLac26 Lactobacillus sp. GTH1 Lactobacillus sp. DumLac27 Lactobacillus sp. GTH10 Lactobacillus sp. DumLac28 Lactobacillus sp. GTH13 Lactobacillus sp. DumLac29 Lactobacillus sp. GTH15 Lactobacillus sp. DumLac3 Lactobacillus sp. GTH17 Lactobacillus sp. DumLac30 Lactobacillus sp. GTH18 Lactobacillus sp. DumLac31 Lactobacillus sp. GTH2 Lactobacillus sp. DumLac32 Lactobacillus sp. GTH20 Lactobacillus sp. DuinLac33 Lactobacillus sp. GTH22 Lactobacillus sp. DumLac34 Lactobacillus sp. GTH24 Lactobacillus sp. DumLac3 5 Lactobacillus sp. GTH26 Lactobacillus sp. DumLac36 Lactobacillus sp. GTH28 Lactobacillus sp. DumLac37 Lactobacillus sp. GTH29 Lactobacillus sp. DumLac38 Lactobacillus sp. GTH30 Lactobacillus sp. DumLac39 Lactobacillus sp. GTH32 Lactobacillus sp. DuniLac4 Lactobacillus sp. GTH33 Lactobacillus sp. DumLac40 Lactobacillus sp. GTH5 Lactobacillus sp. DumLac41 Lactobacillus sp. GTH6 Lactobacillus sp. DumLac42 Lactobacillus sp. GTH7 Lactobacillus sp. DumLac43 Lactobacillus sp. GTH8 Lactobacillus sp. DuniLac44 Lactobacillus sp. GTP1 Lactobacillus sp. DumLac45 Lactobacillus sp. GTP2 Lactobacillus sp. DumLac46 Lactobacillus sp. GTP3 Lactobacillus sp. DuuiLac47 Lactobacillus sp. GTP4 Lactobacillus sp. DumLac48 Lactobacillus sp. GTP5 Lactobacillus sp. DumLac49 Lactobacillus sp. GTP6 Lactobacillus sp. DumLac5 Lactobacillus sp. GTR1 Lactobacillus sp. DuniLac50 Lactobacillus sp. GTR2 Lactobacillus sp. DumLac51 Lactobacillus sp. GTS2 Lactobacillus sp. DumLac5 2 Lactobacillus sp. GV6 Lactobacillus sp. DumLac53 Lactobacillus sp. H1HS25N Lactobacillus sp. DumLac54 Lactobacillus sp. II1IIS38N Lactobacillus sp. DumLac6 Lactobacillus sp. H4 Lactobacillus sp. DumLac8 Lactobacillus sp. H4bbl8N Lactobacillus sp. DumLac9 Lactobacillus sp. H4BP4N Lactobacillus sp. El2 Lactobacillus sp. II6IIS1N Lactobacillus sp. EG 12 Lactobacillus sp. H6HS21N Lactobacillus sp. EL3 Lactobacillus sp. H6HS25N Lactobacillus sp. EL6 Lactobacillus sp. H6HS28N Lactobacillus sp. EL7 Lactobacillus sp. Hadi Naser-1 Lactobacillus sp. EMML 3041 Lactobacillus sp. Hadi Tajabadi-1 Lactobacillus sp. F-2 Lactobacillus sp. HG209 Lactobacillus sp. F1 Lactobacillus sp. HJ1 Lactobacillus sp. Fl 1 Lactobacillus sp. HJ2 Lactobacillus sp. F16 Lactobacillus sp. HL7 Lactobacillus sp. F2 Lactobacillus sp. Hma11N Lactobacillus sp. F2(2009) Lactobacillus sp. Hma2 Lactobacillus sp. F31 Lactobacillus sp. Hma2N Lactobacillus sp. F52 Lactobacillus sp. Hma8 Lactobacillus sp. F7 Lactobacillus sp. HmaSN Lactobacillus sp. Faegheh Dilah-1 Lactobacillus sp. Hon2 Lactobacillus sp. Faegheh Hadi-1 Lactobacillus sp. Hon2N Lactobacillus sp. FAM-02 Lactobacillus sp. HRPRS2 Lactobacillus sp. FAM-04 Lactobacillus sp. HRPRTF.3 Lactobacillus sp. fhon 13 Lactobacillus sp. HRRO′lT Lactobacillus sp. Fhonl3N Lactobacillus sp. HRROT3 Lactobacillus sp. Fhon2N Lactobacillus sp. HRROTE4 Lactobacillus sp. FKTJ23 Lactobacillus sp. HumaH4 Lactobacillus sp. FL1 Lactobacillus sp. HumL3 Lactobacillus sp. FL2 Lactobacillus sp. ID9203 Lactobacillus sp. FL4 Lactobacillus sp. IDLAc Lactobacillus sp. FS1111 Lactobacillus sp. IDSAc Lactobacillus sp. FT Lactobacillus sp. IJ-K2 Lactobacillus sp. Gl Lactobacillus sp. IL3 Lactobacillus sp. G24 Lactobacillus sp. IV-132 Lactobacillus sp. GB001 Lactobacillus sp. BH1398 Lactobacillus sp. BH1480 Lactobacillus sp. CL6 Lactobacillus sp. Bin4 Lactobacillus sp. CL8 Lactobacillus sp. Bin4N Lactobacillus sp. CL9 Lactobacillus sp. Biut2 Lactobacillus sp. CLE-4 Lactobacillus sp. Biut2N Lactobacillus sp. Com4 Lactobacillus sp. BJ H8-4 Lactobacillus sp. CPP1 Lactobacillus sp. BJ32B3 Lactobacillus sp. CR-609S Lactobacillus sp. BJ32B4D Lactobacillus sp. CR-6AS Lactobacillus sp. BJ32B4S Lactobacillus sp. CR-7AS Lactobacillus sp. BJ4-6B Lactobacillus sp. CRA21 Lactobacillus sp. BL263 Lactobacillus sp. CS10 Lactobacillus sp. BL301 Lactobacillus sp. CS24.2 Lactobacillus sp. BL302 Lactobacillus sp. CWBI/B-659/(E912) Lactobacillus sp. BL303 Lactobacillus sp. CY1 Lactobacillus sp. BL304 Lactobacillus sp. D2-2-1 Lactobacillus sp. BLB1a Lactobacillus sp. D5-2 Lactobacillus sp. BLB 1b Lactobacillus sp. D6-4 Lactobacillus sp. BLB1c Lactobacillus koreensis Lactobacillus sp. BLB2 Lactobacillus sp. DCY65 Lactobacillus sp. BLB3 Lactobacillus sp. DCY75 Lactobacillus sp. Bma5 Lactobacillus sp. DF1 Lactobacillus sp. Bma5N Lactobacillus sp. DI71 Lactobacillus sp. BS-05 Lactobacillus sp. DI83 Lactobacillus sp. BS-09 Lactobacillus sp. Dilah Makhdzir-1 Lactobacillus sp. BS-10 Lactobacillus sp. DJF R156 Lactobacillus sp. BS-11 Lactobacillus sp. DJF CR11 Lactobacillus sp. BS-15 Lactobacillus sp. DJF RP24 Lactobacillus sp. BS-19 Lactobacillus sp. DJF SLA41 Lactobacillus sp. BS-22 Lactobacillus sp. DJF WC57 Lactobacillus sp. BS-27 Lactobacillus sp. DL-DW Lactobacillus sp. BS-29 Lactobacillus sp. DL3 Lactobacillus sp. BS-32 Lactobacillus sp. DL6 Lactobacillus sp. BS-33 Lactobacillus sp. Dorsata Lactobacillus sp. BS-36 Lactobacillus sp. DSA-8Z Lactobacillus sp. BS1 Lactobacillus sp. L24 Lactobacillus sp. BT6 Lactobacillus sp. L25 Lactobacillus sp. BTLCH M1/2 Lactobacillus sp. L26 Lactobacillus sp. C30An22 Lactobacillus sp. L27 Lactobacillus sp. C30An7 Lactobacillus sp. L28 Lactobacillus sp. C30An8 Lactobacillus sp. L29 Lactobacillus sp. C33LV5 Lactobacillus sp. L3 Lactobacillus sp. C56 Lactobacillus sp. L30 Lactobacillus sp. C9 Lactobacillus sp. L31 Lactobacillus sp. CCC 96S9L Lactobacillus sp. L32 Lactobacillus sp. CCTCC ‘M 2011381’ Lactobacillus sp. L33 Lactobacillus sp. CD6 Lactobacillus sp. L34 Lactobacillus sp. cemb29 Lactobacillus sp. L35 Lactobacillus sp. CF38 Lactobacillus sp. L37 Lactobacillus sp. CHU-R Lactobacillus sp. L376 Lactobacillus sp. CIA-04 Lactobacillus sp. L38 Lactobacillus sp. CTA-40BC Lactobacillus sp. L39 Lactobacillus sp. CIDCA 83110 Lactobacillus sp. L4 Lactobacillus sp. CIDCA 83111 Lactobacillus sp. L40 Lactobacillus sp. CIDCA 83116 Lactobacillus sp. L41 Lactobacillus sp. CIDCA 8314 Lactobacillus sp. L42 Lactobacillus sp. CIDCA 8315 Lactobacillus sp. L43 Lactobacillus sp. CIDCA 8317 Lactobacillus sp. L44 Lactobacillus sp. CIDCA 8321 Lactobacillus sp. L45 Lactobacillus sp. CIDCA 8325 Lactobacillus sp. L5gt Lactobacillus sp. CIDCA 8326 Lactobacillus sp. L5km Lactobacillus sp. CIDCA 8332 Lactobacillus sp. L6 Lactobacillus sp. CIDCA 8337 Lactobacillus sp. L6 N139 Lactobacillus sp. CIDCA 8343 Lactobacillus sp. L6 N18 Lactobacillus sp. CIDCA 8345 Lactobacillus sp. L6 N23 Lactobacillus sp. CIDCA 8347 Lactobacillus sp. L6 N6 Lactobacillus sp. CIDCA 8348 Lactobacillus sp. L6 N68 Lactobacillus sp. CL Lactobacillus sp. L63(2011) Lactobacillus sp. CL11 Lactobacillus sp. L67 Lactobacillus sp. CL3 Lactobacillus sp. L7 Lactobacillus sp. CL5 Lactobacillus sp. L8 Lactobacillus sp. L8(2006) Lactobacillus sp. MA Lactobacillus sp. L9 Lactobacillus sp. Makhdzir Dilah-1 Lactobacillus sp. L9(2006) Lactobacillus sp. Makhdzir Mardan-1 Lactobacillus sp. L9(2008) Lactobacillus sp. Makhdzir Naser-1 Lactobacillus sp. LA-6 Lactobacillus sp. Mardan Mustafa-1 Lactobacillus sp. LAB-1 Lactobacillus sp. Mardan Naser-1 Lactobacillus sp. LAB-3 Lactobacillus sp. Mardan Yazid-1 Lactobacillus sp. LAB 10 Lactobacillus sp. Mardanium Lactobacillus sp. lab 11 Lactobacillus sp. mashak 26 Lactobacillus sp. lab 13 Lactobacillus sp. MB1A Lactobacillus sp. Iab2 Lactobacillus sp. MB1C Lactobacillus sp. Lac 1 Lactobacillus sp. MB1D Lactobacillus sp. Lac 2 Lactobacillus sp. MbBbr1 Lactobacillus sp. Lac 3 Lactobacillus sp. MbBipro17 Lactobacillus sp. Lac 4 Lactobacillus sp. MbBipro19 Lactobacillus sp. Lac 5 Lactobacillus sp. MbBipro7 Lactobacillus sp. Lac 6 Lactobacillus sp. MbBipto3 Lactobacillus sp. Lact01 Lactobacillus sp. MbHmrol Lactobacillus sp. Lact02 Lactobacillus sp. MbHmro5 Lactobacillus sp. Lact03 Lactobacillus sp. Mbhoto3 Lactobacillus sp. Lact04 Lactobacillus sp. Mbhsr5 Lactobacillus sp. Lact05 Lactobacillus sp. Mbobb2r6 Lactobacillus sp. Lact06 Lactobacillus sp. Mbohmt7 Lactobacillus sp. Lact0S Lactobacillus sp. Mboho2r2 Lactobacillus sp. Lact09 Lactobacillus sp. Mbohs2rl 2 Lactobacillus sp. Lact11 Lactobacillus sp. Mbohs2t2 Lactobacillus sp. Lact12 Lactobacillus sp. Mbohs2t7 Lactobacillus sp. Lact13 Lactobacillus sp. Mbopo2r2 Lactobacillus sp. Lact14 Lactobacillus sp. Mbopo2t4 Lactobacillus sp. Lact15 Lactobacillus sp. Mbopo2t6 Lactobacillus sp. Ib01 Lactobacillus sp. MBUL75 Lactobacillus sp. LB1 Lactobacillus sp. MD-1 Lactobacillus sp. LB6 Lactobacillus sp. MEB1 Lactobacillus sp. LBS-27 Lactobacillus sp. MF-07 Lactobacillus sp. ljubLlr Lactobacillus sp. MF1 Lactobacillus sp. ljubL4to Lactobacillus sp. MF19(2010) Lactobacillus sp. LM-17 Lactobacillus sp. MF213 Lactobacillus sp. LMG 17676 Lactobacillus sp. MF41(2010) Lactobacillus sp. LOOC279 Lactobacillus sp. MF44(2010) Lactobacillus sp. LQC 1642 Lactobacillus sp. MIB1 Lactobacillus sp. LQC 1677 Lactobacillus sp. MMP239 Lactobacillus sp. LQC 1693 Lactobacillus sp. MMP241 Lactobacillus sp. LQC 1930 Lactobacillus sp. MMP242 Lactobacillus sp. LQC 1937 Lactobacillus sp. MNFS-3 Lactobacillus sp. LQC 1938 Lactobacillus sp. MONT4 Lactobacillus sp. LQC 1942 Lactobacillus sp. MR-1 Lactobacillus sp. LQC 1951 Lactobacillus sp. MR-2 Lactobacillus sp. LQC 1954 Lactobacillus sp. MRS-II22 Lactobacillus sp. LQC 1958 Lactobacillus sp. MRS-III06 Lactobacillus sp. LQC 1959 Lactobacillus sp. MRSB Lactobacillus sp. LSI Lactobacillus sp. MSUGMIR-3 Lactobacillus sp. LS3 Lactobacillus sp. MWBPC 1-3-1 Lactobacillus sp. LS7 Lactobacillus sp. MYMRS/TEN2 Lactobacillus sp. Is79 Lactobacillus sp. MYMRS/TLLT1 Lactobacillus sp. LS8 Lactobacillus sp. MYMRS/TLU1-T Lactobacillus sp. Lu3 Lactobacillus sp. MYTPY/TEN3 Lactobacillus sp. Lu5 Lactobacillus sp. Nl-5-2 Lactobacillus sp. Lu7 Lactobacillus sp. N19 Lactobacillus sp. M.U.L2 Lactobacillus sp. N2-7-1 Lactobacillus sp. Ml Lactobacillus sp. N20 Lactobacillus sp. M1T3B2 Lactobacillus sp. N27 Lactobacillus sp. M1T4B2 Lactobacillus sp. N3-1-1 Lactobacillus sp. M20 Lactobacillus sp. N3-10-1 Lactobacillus sp. M23 Lactobacillus sp. N3-6 Lactobacillus sp. M2T2B4 Lactobacillus sp. N4-4 Lactobacillus sp. M3T1B1 Lactobacillus sp. N4-6 Lactobacillus sp. M3T1B2 Lactobacillus sp. N4-9 Lactobacillus sp. M3T1B5 Lactobacillus sp. N54 Lactobacillus sp. M8 Lactobacillus sp. Naser Makhdzir-1 Lactobacillus sp. M9-1 Lactobacillus sp. Naser Tajabadi-1 Lactobacillus sp. NBRC 101665 Lactobacillus sp. NBRC 107254 Lactobacillus sp. NBRC 101976 Lactobacillus sp. NBRC 107255 Lactobacillus sp. NBRC 106011 Lactobacillus sp. NBRC 107257 Lactobacillus sp. NBRC 106019 Lactobacillus sp. NBRC 107258 Lactobacillus sp. NBRC 106020 Lactobacillus sp. NBRC 107259 Lactobacillus sp. NBRC 106022 Lactobacillus sp. NBRC 107261 Lactobacillus sp. NBRC 106024 Lactobacillus sp. NBRC 107262 Lactobacillus sp. NBRC 106029 Lactobacillus sp. NBRC 107263 Lactobacillus sp. NBRC 106038 Lactobacillus sp. NBRC 107265 Lactobacillus sp. NBRC 106039 Lactobacillus sp. NBRC 107266 Lactobacillus sp. NBRC 106040 Lactobacillus sp. NBRC 107267 Lactobacillus sp. NBRC 106041 Lactobacillus sp. NBRC 107268 Lactobacillus sp. NBRC 106042 Lactobacillus sp. NBRC 107270 Lactobacillus sp. NBRC 106044 Lactobacillus sp. NBRC 107273 Lactobacillus sp. NBRC 106045 Lactobacillus sp. NBRC 107274 Lactobacillus sp. NBRC 106046 Lactobacillus sp. NBRC 107275 Lactobacillus sp. NBRC 106047 Lactobacillus sp. NBRC 107276 Lactobacillus sp. NBRC 107174 Lactobacillus sp. NBRC 107279 Lactobacillus sp. NBRC 107175 Lactobacillus sp. NBRC 107282 Lactobacillus sp. NBRC 107177 Lactobacillus sp. NBRC 107283 Lactobacillus sp. NRRC 1071 79 Lactobacillus sp. NRRC 107284 Lactobacillus sp. NBRC 107180 Lactobacillus sp. NBRC 107285 Lactobacillus sp. NBRC 107181 Lactobacillus sp. NBRC 107286 Lactobacillus sp. NBRC 107182 Lactobacillus sp. NBRC 107288 Lactobacillus sp. NRRC 1071 83 Lactobacillus sp. NBRC 1 07289 Lactobacillus sp. NBRC 107184 Lactobacillus sp. NBRC 107290 Lactobacillus sp. NBRC 107185 Lactobacillus sp. NBRC 107292 Lactobacillus sp. NBRC 107187 Lactobacillus sp. NBRC 107293 Lactobacillus sp. NBRC 107188 Lactobacillus sp. NBRC 107294 Lactobacillus sp. NBRC 107191 Lactobacillus sp. NBRC 107295 Lactobacillus sp. NBRC 107192 Lactobacillus sp. NBRC 107297 Lactobacillus sp. NBRC 107194 Lactobacillus sp. NBRC 107298 Lactobacillus sp. NBRC 107195 Lactobacillus sp. NBRC 107300 Lactobacillus sp. NBRC 107196 Lactobacillus sp. NBRC 107301 Lactobacillus sp. NBRC 107197 Lactobacillus sp. NBRC 107302 Lactobacillus sp. NBRC 107198 Lactobacillus sp. NBRC 107304 Lactobacillus sp. NBRC 107199 Lactobacillus sp. NBRC 107305 Lactobacillus sp. NBRC 107200 Lactobacillus sp. NBRC 107307 Lactobacillus sp. NBRC 107201 Lactobacillus sp. NBRC 107308 Lactobacillus sp. NBRC 107202 Lactobacillus sp. NBRC 107311 Lactobacillus sp. NBRC 107203 Lactobacillus sp. NBRC 107312 Lactobacillus sp. NRRC 107205 Lactobacillus sp. NBRC 107313 Lactobacillus sp. NBRC 107207 Lactobacillus sp. NBRC 107315 Lactobacillus sp. NBRC 107208 Lactobacillus sp. NBRC 107316 Lactobacillus sp. NBRC 107210 Lactobacillus sp. NBRC 107318 Lactobacillus sp. NRRC 107211 Lactobacillus sp. NBRC 107320 Lactobacillus sp. NBRC 107212 Lactobacillus sp. NBRC 107321 Lactobacillus sp. NBRC 107214 Lactobacillus sp. NBRC 107323 Lactobacillus sp. NBRC 107215 Lactobacillus sp. NBRC 107324 Lactobacillus sp. NBRC 107216 Lactobacillus sp. NBRC 107325 Lactobacillus sp. NBRC 107220 Lactobacillus sp. NBRC 107326 Lactobacillus sp. NBRC 107223 Lactobacillus sp. NBRC 107327 Lactobacillus sp. NBRC 107224 Lactobacillus sp. NBRC 107328 Lactobacillus sp. NRRC 107226 Lactobacillus sp. NBRC 107329 Lactobacillus sp. NBRC 107227 Lactobacillus sp. NBRC 107330 Lactobacillus sp. NBRC 107228 Lactobacillus sp. NBRC 107332 Lactobacillus sp. NBRC 107229 Lactobacillus sp. NBRC 107334 Lactobacillus sp. NRRC 107232 Lactobacillus sp. NBRC 1 07336 Lactobacillus sp. NBRC 107233 Lactobacillus sp. NBRC 107337 Lactobacillus sp. NBRC 107234 Lactobacillus sp. NBRC 107338 Lactobacillus sp. NBRC 107236 Lactobacillus sp. NBRC 107339 Lactobacillus sp. NBRC 107237 Lactobacillus sp. NBRC 107340 Lactobacillus sp. NBRC 107238 Lactobacillus sp. NBRC 107341 Lactobacillus sp. NBRC 107239 Lactobacillus sp. NBRC 107342 Lactobacillus sp. NBRC 107240 Lactobacillus sp. NBRC 107347 Lactobacillus sp. NBRC 107242 Lactobacillus sp. NBRC 107348 Lactobacillus sp. NRRC 107246 Lactobacillus sp. NBRC 107349 Lactobacillus sp. NBRC 107249 Lactobacillus sp. NBRC 107351 Lactobacillus sp. NBRC 107252 Lactobacillus sp. NBRC 107352 Lactobacillus sp. NBRC 107253 Lactobacillus sp. NBRC 14511 Lactobacillus sp. NBRC 14512 Lactobacillus sp. JCM 8637 Lactobacillus sp. NBRC 14513 Lactobacillus sp. JCM 8652 Lactobacillus sp. NBRC 3229 Lactobacillus sp. JCM 8653 Lactobacillus sp. NBRC 3231 Lactobacillus sp. JCM 9717 Lactobacillus sp. NBRC 3914 Lactobacillus sp. JCM 9721 Lactobacillus sp. NBRC 3954 Lactobacillus sp. JN05 Lactobacillus sp. NEQAS6172 Lactobacillus sp. JN1 Lactobacillus sp. NGRI 0001 Lactobacillus sp. JN10 Lactobacillus sp. NGRI 0130 Lactobacillus sp. JN2 Lactobacillus sp. NGRI 0130Q Lactobacillus sp. JN3 Lactobacillus sp. NGRI 0304 Lactobacillus sp. JN4 Lactobacillus sp. NGRI 0305 Lactobacillus sp. JN5 Lactobacillus sp. NIR2 Lactobacillus sp. JN6 Lactobacillus sp. NIR20 Lactobacillus sp. JN7 Lactobacillus sp. NIR24 Lactobacillus sp. JN8 Lactobacillus sp. NIR4 Lactobacillus sp. JN9 Lactobacillus sp. NIR5 Lactobacillus sp. JSB1 Lactobacillus sp. NIR6 Lactobacillus sp. JV-2006 Lactobacillus sp. NIR7 Lactobacillus sp. JW04 Lactobacillus sp. NIR8 Lactobacillus sp. KC19 Lactobacillus sp. NIRD-P2 Lactobacillus sp. KC35b Lactobacillus sp. NM120-1 Lactobacillus sp. KC36a Lactobacillus sp. NM191-2 Lactobacillus sp. KC36b Lactobacillus sp. NM191-3 Lactobacillus sp. KC38 Lactobacillus sp. NM48-2 Lactobacillus sp. KC45a Lactobacillus sp. IV-136 Lactobacillus sp. KC45b Lactobacillus sp. IV-145 Lactobacillus sp. KLB46 Lactobacillus sp. IWT246 Lactobacillus sp. KLB58 Lactobacillus sp. IWT248 Lactobacillus sp. KLB79 Lactobacillus sp. j0227 Lactobacillus sp. KLDS 1.0701 Lactobacillus sp. j0228 Lactobacillus sp. KLDS 1.0702 Lactobacillus sp. j0230 Lactobacillus sp. KLDS 1.0703 Lactobacillus sp. j0238 Lactobacillus sp. KLDS 1.0704 Lactobacillus sp. j0383 Lactobacillus sp. KLDS 1.0705 Lactobacillus sp. JC-11 Lactobacillus sp. KLDS 1.0706 Lactobacillus sp. JCM 1013 Lactobacillus sp. KLDS 1.0707 Lactobacillus sp. JCM 1033 Lactobacillus sp. KLDS 1.0708 Lactobacillus sp. JCM 1034 Lactobacillus sp. KLDS 1.0709 Lactobacillus sp. JCM 1035 Lactobacillus sp. KLDS 1.0710 Lactobacillus sp. JCM 1088 Lactobacillus sp. KLDS 1.0711 Lactobacillus sp. JCM 1102 Lactobacillus sp. KLDS 1.0712 Lactobacillus sp. JCM 11039 Lactobacillus sp. KLDS 1.0713 Lactobacillus sp. JCM 1177 Lactobacillus sp. KLDS 1.0714 Lactobacillus sp. JCM 1179 Lactobacillus sp. KLDS 1.0715 Lactobacillus sp. JCM 1183 Lactobacillus sp. KLDS 1.0716 Lactobacillus sp. JCM 1552 Lactobacillus sp. KLDS 1.0717 Lactobacillus sp. JCM 1555 Lactobacillus sp. KLDS 1.0718 Lactobacillus sp. JCM 20043 Lactobacillus sp. KLDS 1.0719 Lactobacillus sp. JCM 20061 Lactobacillus sp. kvahm3N Lactobacillus sp. JCM 2010 Lactobacillus sp. L-YJ Lactobacillus sp. JCM 20147 Lactobacillus sp. L01 Lactobacillus sp. JCM 2048 Lactobacillus sp. L02 Lactobacillus sp. JCM 2049 Lactobacillus sp. L03 Lactobacillus sp. JCM 2761 Lactobacillus sp. LI Lactobacillus sp. JCM 2762 Lactobacillus sp. L10 Lactobacillus sp. JCM 2763 Lactobacillus sp. LI 1 Lactobacillus sp. JCM 2764 Lactobacillus sp. L12 Lactobacillus sp. JCM 2768 Lactobacillus sp. LI3 Lactobacillus sp. JCM 2770 Lactobacillus sp. L13(2006) Lactobacillus sp. JCM 2774 Lactobacillus sp. L14 Lactobacillus sp. JCM 5867 Lactobacillus sp. L15 Lactobacillus sp. JCM 5868 Lactobacillus sp. L17 Lactobacillus sp. JCM 5869 Lactobacillus sp. LI8 Lactobacillus sp. JCM 7524 Lactobacillus sp. L19 Lactobacillus sp. JCM 7525 Lactobacillus sp. L2 Lactobacillus sp. JCM 7527 Lactobacillus sp. L20 Lactobacillus sp. JCM 8601 Lactobacillus sp. L21 Lactobacillus sp. JCM 8609 Lactobacillus sp. L215 Lactobacillus sp. JCM 8616 Lactobacillus sp. L22 Lactobacillus sp. JCM 8633 Lactobacillus sp. L23 Lactobacillus sp. SR2 Lactobacillus sp. TBZ3 Lactobacillus sp. SW201 Lactobacillus sp. TFC 4301 Lactobacillus sp. SWM Isolation 3 Lactobacillus sp. THK-024 Lactobacillus sp. SXVIII10(2011) Lactobacillus sp. THK-V2 Lactobacillus sp. SXVIII11(2011) Lactobacillus sp. THK-V8 Lactobacillus sp. SXVIII9(2011) Lactobacillus sp. THK-W28 Lactobacillus sp. T057 Lactobacillus sp. TIIK-W4 Lactobacillus sp. T059 Lactobacillus sp. Thmrol5 Lactobacillus sp. T11g2 Lactobacillus sp. Thmro2 Lactobacillus sp. T13/5 Lactobacillus sp. Thmro6 Lactobacillus sp. T17/4D Lactobacillus sp. Thoto2 Lactobacillus sp. T17/4F Lactobacillus sp. TL33a Lactobacillus sp. T1R1C12 Lactobacillus sp. TL35 Lactobacillus sp. T1R2C3 Lactobacillus sp. TLMP1 Lactobacillus sp. T1R3C2 Lactobacillus sp. TLMP2 Lactobacillus sp. T23/3 Lactobacillus sp. TLMP3 Lactobacillus sp. T2R1C4 Lactobacillus sp. TLMP4 Lactobacillus sp. T2R2C12 Lactobacillus sp. TLMP5 Lactobacillus sp. T2R4C3 Lactobacillus sp. TMW 1.1309 Lactobacillus sp. T3R1C1 Lactobacillus sp. TNG 15 Lactobacillus sp. T3R2C12 Lactobacillus sp. TN627 Lactobacillus sp. T3R2C13 Lactobacillus sp. TN644 Lactobacillus sp. T4R2C14 Lactobacillus sp. Tporo2 Lactobacillus sp. T4R3C18 Lactobacillus sp. TR7.2.20 Lactobacillus sp. T5 R1C10 Lactobacillus sp. TR7.3.1 7 Lactobacillus sp. T5R3C15 Lactobacillus sp. TR7.4.12 Lactobacillus sp. T5R3C19 Lactobacillus sp. TRC1 Lactobacillus sp. T5R3C24 Lactobacillus sp. TRC7 Lactobacillus sp. T5R4C21 Lactobacillus sp. TRF5 Lactobacillus sp. TAB-OI Lactobacillus sp. TRF7 Lactobacillus sp. TAB-02 Lactobacillus sp. TRF8 Lactobacillus sp. TAB-03 Lactobacillus sp. TS1 Lactobacillus sp. TAB-04 Lactobacillus sp. TS2 Lactobacillus sp. TAB-05 Lactobacillus sp. TS3 Lactobacillus sp. TAB-06 Lactobacillus sp. TS4 Lactobacillus sp. TAB-07 Lactobacillus sp. TSK G32-2 Lactobacillus sp. TAB-08 Lactobacillus sp. TTp12 Lactobacillus sp. TAB-09 Lactobacillus sp. TTp13 Lactobacillus sp. TAB-10 Lactobacillus sp. TTp14 Lactobacillus sp. TAB-11 Lactobacillus sp. TTp4 Lactobacillus sp. TAB-13 Lactobacillus sp. TTp6 Lactobacillus sp. TAB-15 Lactobacillus sp. V2 Lactobacillus sp. TAB-16 Lactobacillus sp. VITPRS49 Lactobacillus sp. TAB-19 Lactobacillus sp. VM9 Lactobacillus sp. TAB-20 Lactobacillus sp. W2 Lactobacillus sp. TAB-21 Lactobacillus sp. W20 Lactobacillus sp. TAB-22 Lactobacillus sp. W56 Lactobacillus sp. TAB-23 Lactobacillus sp. WC2 Lactobacillus sp. TAB-24 Lactobacillus sp. WDC04 Lactobacillus sp. TAB-25 Lactobacillus sp. WK2S-6B Lactobacillus sp. TAB-26 Lactobacillus sp. WX131 Lactobacillus sp. TAB-29 Lactobacillus sp. WX212 Lactobacillus sp. TAB-30 Lactobacillus sp. WX213 Lactobacillus sp. TAB-31 Lactobacillus sp. XI Lactobacillus sp. TAB-33 Lactobacillus sp. Y10 Lactobacillus sp. Taj Amir-1 Lactobacillus sp. Yazid Arash-1 Lactobacillus sp. Taj Mahdi Lactobacillus sp. Yazid Taj-1 Lactobacillus sp. Taj Mar-1 Lactobacillus sp. YE06 Lactobacillus sp. Taj Mustafa-1 Lactobacillus sp. YE07 Lactobacillus sp. Taj Naser-1 Lactobacillus sp. YE08 Lactobacillus sp. Taj Yazid-1 Lactobacillus sp. YE 10 Lactobacillus sp. Taj-KH107 Lactobacillus sp. YFPB2BMX Lactobacillus sp. Taj-KH109 Lactobacillus sp. YW Lactobacillus sp. Taj-KH123 Lactobacillus sp. YYS Lactobacillus sp. Taj-KS164 Lactobacillus sp. ZL7 Lactobacillus sp. Taj-KS82 Lactobacillus sp. ZYM7 Lactobacillus sp. Tajabadi-I Lactobacillus sp. A A18 Lactobacillus sp. Tbbtol5 Lactobacillus sp. A A21 Lactobacillus sp. TBZ Lactobacillus sp. A A25 Lactobacillus sp. TBZ2 Lactobacillus sp. A A29 Lactobacillus sp. A A3 5 Lactobacillus sp. r2 Lactobacillus sp. A A44 Lactobacillus sp. R4B Lactobacillus sp. A A45 Lactobacillus sp. R4C Lactobacillus sp. A A48 Lactobacillus sp. r5-wl0 Lactobacillus sp. A A49 Lactobacillus sp. r7 Lactobacillus sp. A A85 Lactobacillus sp. r8 Lactobacillus sp. A A96 Lactobacillus sp. RA2053 Lactobacillus sp. B A100 Lactobacillus sp. RA2062 Lactobacillus sp. B A101 Lactobacillus sp. RA2066 Lactobacillus sp. B A102 Lactobacillus sp. RA2113 Lactobacillus sp. B A103 Lactobacillus sp. RA2120 Lactobacillus sp. B A12 Lactobacillus sp. rennanqilfy 10 Lactobacillus sp. B A13 Lactobacillus sp. rennanqilfy 1 1 Lactobacillus sp. B A14 Lactobacillus sp. rennanqilfy 14 Lactobacillus sp. B A16 Lactobacillus sp. rennanqilfy 15 Lactobacillus sp. B A19 Lactobacillus sp. rennanqilfy 16 Lactobacillus sp. B A20 Lactobacillus sp. rennanqilfy 17 Lactobacillus sp. B A23 Lactobacillus sp. rennanqilfy 19 Lactobacillus sp. B A31 Lactobacillus sp. rennanqilfy 2 Lactobacillus sp. B A33 Lactobacillus sp. rennanqilfy20 Lactobacillus sp. NM59-6 Lactobacillus sp. rennanqilfy32 Lactobacillus sp. NR1006 Lactobacillus sp. rennanqilfy34 Lactobacillus sp. NRCT-KU 1 Lactobacillus sp. rennanqilfy61 Lactobacillus sp. NS 111 Lactobacillus sp. rennanqilyf 13 Lactobacillus sp. NS123 Lactobacillus sp. rennanqilyf4 Lactobacillus sp. NS133 Lactobacillus sp. rennanqilyf5 Lactobacillus sp. Oh-3 Lactobacillus sp. rennanqilyf7 Lactobacillus sp. Oh-4 Lactobacillus sp. rennanqilyfiS Lactobacillus sp. OR 11 Lactobacillus sp. rennanqilyf? Lactobacillus sp. OR 9 Lactobacillus sp. RIC11-BK004 Lactobacillus sp. OR1 Lactobacillus sp. RIC11-BK008 Lactobacillus sp. OR6 Lactobacillus sp. RIC11-BK009 Lactobacillus sp. oral taxon 052 Lactobacillus sp. RIC11-MK006 Lactobacillus sp. oral taxon 418 Lactobacillus sp. RIC11-MK010 Lactobacillus sp. oral taxon 424 Lactobacillus sp. RIC12-Oh002 Lactobacillus sp. oral taxon 461 Lactobacillus sp. RIC12-Oh004 Lactobacillus sp. oral taxon A89 Lactobacillus sp. RKY2 Lactobacillus sp. oral taxon B73 Lactobacillus sp. RMS3-1 Lactobacillus sp. oral taxon B80 Lactobacillus sp. Rnm4 Lactobacillus sp. oral taxon D06 Lactobacillus sp. Rrv5 Lactobacillus sp. oral taxon G15 Lactobacillus sp. RU1 Lactobacillus sp. oral taxon G16 Lactobacillus sp. SI Lactobacillus sp. oral taxon G18 Lactobacillus sp. S14 Lactobacillus sp. oral taxon G19 Lactobacillus sp. SI5 Lactobacillus sp. oral taxon G98 Lactobacillus sp. S16 Lactobacillus sp. oral taxon H08 Lactobacillus sp. S19 Lactobacillus sp. oral taxon H12 Lactobacillus sp. S4-3 Lactobacillus sp. oral taxon H14 Lactobacillus sp. S4B Lactobacillus sp. oral taxon H25 Lactobacillus sp. S4C Lactobacillus sp. OS 10 Lactobacillus sp. Sal8 Lactobacillus sp. OS72 Lactobacillus sp. SCA34 Lactobacillus sp. P22 Lactobacillus sp. SCA39 Lactobacillus sp. P23 Lactobacillus sp. SCA52 Lactobacillus sp. P8 Lactobacillus sp. SCA7 Lactobacillus sp. PC-3 Lactobacillus sp. SD2 Lactobacillus sp. PC121B Lactobacillus sp. SDR1 Lactobacillus sp. pep8 Lactobacillus sp. SH.Z4 Lactobacillus sp. Probio-24 Lactobacillus sp. sh.zhl Lactobacillus sp. Probio-27 Lactobacillus sp. sfi.zh2 Lactobacillus sp. QOX-01BC Lactobacillus sp. sh.zh3 Lactobacillus sp. QOX-02BC Lactobacillus sp. Shuhaimi Arash-1 Lactobacillus sp. QOX-06BC Lactobacillus sp. Shuhaimi Mardan-1 Lactobacillus sp. QOX-10BC Lactobacillus sp. Shuhaimi naser-1 Lactobacillus sp. QOX-20G Lactobacillus sp. Shuhaimi Taj-1 Lactobacillus sp. R-17510 Lactobacillus sp. Shuhaimi Yazid-1 Lactobacillus sp. R-17516 Lactobacillus sp. SK007 Lactobacillus sp. R-17818 Lactobacillus sp. SL Lactobacillus sp. R-21386 Lactobacillus sp. SRI Lactobacillus sp. R-42633 Lactobacillus sp. B AB1 Lactobacillus sp. rlw3 Lactobacillus sp. B CGI Lactobacillus sp. B CG3 Lactobacillus sp. B A98 Lactobacillus sp. B CG53 Lactobacillus sp. B CG71 Lactobacillus sp. B CG63 Lactobacillus sp. B CG76 Lactobacillus sp. B A34 environmental samples Lactobacillus sp. B A36 Lactobacillus amylovorus CAG:719 Lactobacillus sp. B A37 Lactobacillus mminis CAG:367 Lactobacillus sp. B A41 Lactobacillus sp. DGGE band 26 Lactobacillus sp. B A42 Lactobacillus sp. DGGE band 29 Lactobacillus sp. B A52 Lactobacillus sp. enrichment culture clone 1 Lactobacillus sp. B A53 Lactobacillus sp. enrichment culture clone 58 Lactobacillus sp. B A64 Lactobacillus sp. enrichment culture clone PSR03 Lactobacillus sp. B A65 Lactobacillus sp. enrichment culture clone PSR2 Lactobacillus sp. B A76 Lactobacillus sp. enrichment culture clone PTmrs6 Lactobacillus sp. B A78 Lactobacillus sp. enrichment culture DGGE gel band 10 Lactobacillus sp. B A81 Lactobacillus sp. enrichment culture DGGE gel band 12 Lactobacillus sp. B A86 Lactobacillus sp. enrichment culture DGGE gel band 4 Lactobacillus sp. B A87 Lactobacillus sp. enrichment culture DGGE gel band 8 Lactobacillus sp. B A89 Lactobacillus sp. enrichment culture DGGE gel band 9 Lactobacillus sp. B A90 Lactobacillus sp. oral clone CX036 Lactobacillus sp. B A91 Lactobacillus sp. oral clone HT002 Lactobacillus sp. B A95 1 Lactobacillus sp. oral clone HT070 Lactobacillus sp. B A97 uncultured Lactobacillus sp. Genus: Bifidobacterium Bifidobacterium adolescentis Bifidobacterium breve EX336960VC18 Bifidobacterium adolescentis ATCC′ 15703 Bifidobacterium breve EX336960VC19 Bifidobacterium adolescentis L2-32 Bifidobacterium breve EX336960VC21 Bifidobacterium angulatum Bifidobacterium breve EX533959VC21 Bifidobacterium angulatum DSM 20098 = JCM 7096 Bifidobacterium breve HPH0326 Bifidobacterium angulatum F16 22 Bifidobacterium breve JCP7499 Bifidobacterium animalis Bifidobacterium breve S27 Bifidobacterium animalis subsp. animalis Bifidobacterium breve UCC2003 Bifidobacterium animalis subsp. animalis ATCC 25527 Bifidobacterium callitrichos Bifidobacterium animalis subsp. lactis Bifidobacterium catenulatum Bifidobacterium animalis subsp. lactis AD011 Bifidobacterium catenulatum DSM 16992 = JCM 1194 Bifidobacterium animalis subsp. lactis ATCC 27673 Bifidobacterium chocrinum Bifidobacterium animalis subsp. lactis B420 Bifidobacterium choerinum DSM 20434 Bifidobacterium animalis subsp. lactis BB-12 Bifidobacterium coryneforme Bifidobacterium animalis subsp. lactis Bi-07 Bifidobacterium crudilactis Bifidobacterium animalis subsp. lactis Bl-04 Bifidobacterium cuniculi Bifidobacterium animalis subsp. lactis B112 Bifidobacterium dentium Bifidobacterium animalis subsp. lactis BLC1 Bifidobacterium dentium ATCC 27678 Bifidobacterium animalis subsp. lactis BS 01 Bifidobacterium dentium ATCC 27679 Bifidobacterium animalis subsp. lactis CNCM 1-2494 Bifidobacterium dentium Bd 1 Bifidobacterium animalis subsp. lactis DSM 10140 Bifidobacterium dentium JCM 1195 Bifidobacterium animalis subsp. lactis HN019 Bifidobacterium dentium JCVTHMP022 Bifidobacterium animalis subsp. lactis V9 Bifidobacterium gallicum Bifidobacterium asteroides Bifidobacterium gallicum DSM 20093 Bifidobacterium asteroides PRL2011 Bifidobacterium gallinarum Bifidobacterium biavatii Bifidobacterium indicum Bifidobacterium bifidum Bifidobacterium bifidum ATCC 29521 - JCM 1255 Bifidobacterium indicum LMG 11587 Bifidobacterium bifidum BGN4 Bifidobacterium kashiwanohense Bifidobacterium bifidum CECT 7366 Bifidobacterium kashiwanohense JCM 15439 Bifidobacterium bifidum DSM 20215 Bifidobacterium longum Bifidobacterium bifidum IPLA 20015 Bifidobacterium longum 3 1 37DFAAB Bifidobacterium bifidum JCM 1254 Bifidobacterium longum AGR2137 Bifidobacterium bifidum LMG 13195 Bifidobacterium longum BORI Bifidobacterium bifidum NCI MB 41171 Bifidobacterium longum D2957 Bifidobacterium bifidum PRL2010 Bifidobacterium longum DJO10A Bifidobacterium bifidum S17 Bifidobacterium longum El 8 Bifidobacterium bombi Bifidobacterium longum NCC2705 Bifidobacterium bombi DSM 19703 Bifidobacterium longum subsp. infantis Bifidobacterium bourn Bifidobacterium longum subsp. infantis 157F Bifidobacterium breve Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 Bifidobacterium breve ACS-071 -V-Sch8b Bifidobacterium longum subsp. infantis CCUG 52486 Bifidobacterium breve CECT 7263 Bifidobacterium longum subsp. longum Bifidobacterium breve DPC 6330 Bifidobacterium longum subsp. longum 1-5B Bifidobacterium breve DSM 20213 = JCM 1192 Bifidobacterium longum subsp. longum 1-6B Bifidobacterium longum subsp. longum 17-1B Bifidobacterium sp. 234 Bifidobacterium longum subsp. longum 2-2B Bifidobacterium sp. 265 Bifidobacterium longum subsp. longum 35B Bifidobacterium sp. 266 Bifidobacterium longum subsp. longum 44B Bifidobacterium sp. 27 Bifidobacterium longum subsp. longum 7-IB Bifidobacterium sp. 272 Bifidobacterium longum subsp. longum ATCC 55813 Bifidobacterium sp. 283 Bifidobacterium longum subsp. longum BBMN68 Bifidobacterium sp. 286 Bifidobacterium longum subsp. longum CECT 7347 Bifidobacterium sp. 316 Bifidobacterium longum subsp. longum CMCC P0001 Bifidobacterium sp. 320 Bifidobacterium longum subsp. longum F8 Bifidobacterium sp. 323 Bifidobacterium longum subsp. longum GT15 Bifidobacterium sp. 33 Bifidobacterium longum subsp. longum JCM 1217 Bifidobacterium sp. 343 Bifidobacterium longum subsp. longum JDM301 Bifidobacterium sp. 344 Bifidobacterium longum subsp. longum KACC 91563 Bifidobacterium sp. 360 Bifidobacterium longum subsp. suis Bifidobacterium sp. 397 Bifidobacterium magnum Bifidobacterium sp. 401 Bifidobacterium magnum DSM 20222 Bifidobacterium sp. 434 Bifidobacterium merycicum Bifidobacterium sp. 445 Bifidobacterium minimum Bifidobacterium sp. 470 Bifidobacterium minimum DSM 20102 Bifidobacterium sp. 471 Bifidobacterium mongoliense Bifidobacterium sp. 65947 Bifidobacterium pseudocatenulatum Bifidobacterium sp. 69 Bifidobacterium pseudocatenulatum D2CA Bifidobacterium sp. 7101 Bifidobacterium pseudocatenulatum DSM 20438 - JCM 1200 Bifidobacterium sp. 77 Bifidobacterium pseudolongum Bifidobacterium sp. 84 Bifidobacterium pseudolongum AGR2145 Bifidobacterium sp. 98 Bifidobacterium pseudolongum subsp. globosum Bifidobacterium sp. Al Bifidobacterium pseudolongum subsp. pseudolongum Bifidobacterium sp. Al 1 Bifidobacterium psychraerophilum Bifidobacterium sp. Al 5 Bifidobacterium pullorum Bifidobacterium sp. A24 Bifidobacterium pullorum ATCC 49618 Bifidobacterium sp. A30 Bifidobacterium reuteri Bifidobacterium sp. Aabbtol9 Bifidobacterium ruminantium Bifidobacterium sp. Aahmro6 Bifidobacterium saeculare Bifidobacterium sp. Aahmto9 Bifidobacterium saguini Bifidobacterium sp. Acbbto5 Bifidobacterium scardovii Bifidobacterium sp. Achmrol 1 Bifidobacterium scardovii JCM 12489 Bifidobacterium sp. AcjBFl Bifidobacterium simiae Bifidobacterium sp. AcjBFlO Bifidobacterium stellenboschense Bifidobacterium sp. AcjBFl 1 Bifidobacterium stercoris Bifidobacterium sp. AcjBF2 Bifidobacterium subtile Bifidobacterium sp. AcjBF3 Bifidobacterium subtile DSM 20096 Bifidobacterium sp. AcjBF4 Bifidobacterium thermaeidophilum Bifidobacterium sp. AcjBF5 Bifidobacterium thermacidophilum subsp. porcinum Bifidobacterium sp. AcjBF6 Bifidobacterium thermacidophilum subsp. thermacidophilum Bifidobacterium sp. AcjBF7 Bifidobacterium thermacidophilum subsp. thermacidophilum DSM Bifidobacterium sp. AcjBF8 15837 Bifidobacterium sp. AcjBF9 Bifidobacterium thcrmophilum Bifidobacterium sp. Adhmto 10 Bifidobacterium Ihermophilum RBL67 Bifidobacterium sp. AFB22-4 Bifidobacterium tsurumiense Bifidobacterium sp. Afporl 1 Bifidobacterium tsurumiense DSM 17777 Bifidobacterium sp. Afpor3 Bifidobacterium sp. Bifidobacterium sp. Afpotol9 Bifidobacterium sp. 103 Bifidobacterium sp. AGR2158 Bifidobacterium sp. 108 Bifidobacterium sp. Alhonro l Bifidobacterium sp. 11-5-G Bifidobacterium sp. Ammopor6 Bifidobacterium sp. 113 Bifidobacterium sp. Ammpo1R4 Bifidobacterium sp. 120 Bifidobacterium sp. AmsbbiTO Bifidobacterium sp. 126 Bifidobacterium sp. Amsbbt12 Bifidobacterium sp. 129 Bifidobacterium sp. Amshmr9 Bifidobacterium sp. 12147BFAA Bifidobacterium sp. Amshor11 Bifidobacterium sp. 138 Bifidobacterium sp. Anbbr2 Bifidobacterium sp. 150 Bifidobacterium sp. Anuhmto12 Bifidobacterium sp. 17 Bifidobacterium sp. B4 Bifidobacterium sp. 172 Bifidobacterium sp. BBDP69 Bifidobacterium sp. 176 Bifidobacterium sp. BcRW10 Bifidobacterium sp. 182 Bifidobacterium sp. Bin2 Bifidobacterium sp. 197 Bifidobacterium sp. Bin7 Bifidobacterium sp. 202 Bifidobacterium sp. Bisn6 Bifidobacterium sp. 215 Bifidobacterium sp. Bma6 Bifidobacterium sp. 216 Bifidobacterium sp. CB38 Bifidobacterium sp. CB8 Bifidobacterium sp. M45 Bifidobacterium sp. CFAR 172 Bifidobacterium sp. M7 Bifidobacterium sp. CJ59 Bifidobacterium sp. Mbobb2r3 Bifidobacterium sp. CJ75 Bifidobacterium sp. Mbobb2t2 Bifidobacterium sp. CS16 Bifidobacterium sp. Mbpor2 Bifidobacterium sp. CS2 Bifidobacterium sp. MSTE12 Bifidobacterium sp. CS30 Bifidobacterium sp. MSX5B Bifidobacterium sp. CWCAST32 Bifidobacterium sp. MW-222 Bifidobacterium sp. CWCAST40 Bifidobacterium sp. MW-613 Bifidobacterium sp. CWSAB40 Bifidobacterium sp. MW-623 Bifidobacterium sp. CWSAB6 Bifidobacterium sp. MW-81 Bifidobacterium sp. DJF_RP64kl Bifidobacterium sp. N33 Bifidobacterium sp. DJF WC44 Bifidobacterium sp. oral strain A32ED Bifidobacterium sp. DPTE6 Bifidobacterium sp. oral strain H6-M4 Bifidobacterium sp. DPVI-TET3 Bifidobacterium sp. PB24 Bifidobacterium sp. DPVI-TET6 Bifidobacterium sp. PEB0163 Bifidobacterium sp. F-10 Bifidobacterium sp. PFGE 14 Bifidobacterium sp. F-ll Bifidobacterium sp. PFGE 18 Bifidobacterium sp. F2 Bifidobacterium sp. PFGE 8 Bifidobacterium sp. F8 Bifidobacterium sp. PFGE 9a Bifidobacterium sp. G29 Bifidobacterium sp. PG10 Bifidobacterium sp. GC61 Bifidobacterium sp. PG12A Bifidobacterium sp. group 1-3 Bifidobacterium sp. PG12B Bifidobacterium sp. group II-3 Bifidobacterium sp. PG13 Bifidobacterium sp. group TII-3 Bifidobacterium sp. PG1 5 Bifidobacterium sp. hl2 Bifidobacterium sp. PG18 Bifidobacterium sp. HGAT1 Bifidobacterium sp. PG19 Bifidobacterium sp. HGAT10 Bifidobacterium sp. PG2 Bifidobacterium sp. HGAT2 Bifidobacterium sp. PG22 Bifidobacterium sp. HGAT3 Bifidobacterium sp. PG30 Bifidobacterium sp. HGAT4 Bifidobacterium sp. PG9 Bifidobacterium sp. HGAT5 Bifidobacterium sp. PL1 Bifidobacterium sp. HGAT6 Bifidobacterium sp. S-10 Bifidobacterium sp. HGAT7 Bifidobacterium sp. S13-05 Bifidobacterium sp. HGAT8 Bifidobacterium sp. S18-11 Bifidobacterium sp. HGAT9 Bifidobacterium sp. SLPYG-1 Bifidobacterium sp. Hma3 Bifidobacterium sp. SMst02 Bifidobacterium sp. HMLN1 Bifidobacterium sp. SRW-001 Bifidobacterium sp. HMLN12 Bifidobacterium sp. SRW-002 Bifidobacterium sp. HMLN13 Bifidobacterium sp. SRW-003 Bifidobacterium sp. HMLN14 Bifidobacterium sp. SRW-004 Bifidobacterium sp. HMLN5 Bifidobacterium sp. Tbbto10 Bifidobacterium sp. HMLN8 Bifidobacterium sp. Thsr10 Bifidobacterium sp. HMSFfl Bifidobacterium sp. Thsr18 Bifidobacterium sp. HMSH2 Bifidobacterium sp. Thsr2 Bifidobacterium sp. HMSH5 Bifidobacterium sp. TM-7 Bifidobacterium sp. IR007-108 Bifidobacterium sp. Trm9 Bifidobacterium sp. IR007-113 environmental samples Bifidobacterium sp. IR007-15 Bifidobacterium adolescentis CAG:119 Bifidobacterium sp. IR007-57 Bifidobacterium bifidum CAG:234 Bifidobacterium sp. IR007-93 Bifidobacterium longum CAG:69 Bifidobacterium sp. IR007-94 Bifidobacterium pscudocatcnulatum CAG:263 Bifidobacterium sp. IS03519 Bifidobacterium sp. enrichment culture DGGE gel band 6 Bifidobacterium sp. JCM 6439 Bifidobacterium sp. enrichment culture DGGE gel band 7 Bifidobacterium sp. JCM 7013 Bifidobacterium sp. oral clone 5RH-30 Bifidobacterium sp. JCM 7022 Bifidobacterium sp. oral clone CX010 Bifidobacterium sp. JCM 7023 uncultured Bifidobacterium sp. Bifidobacterium sp. JCM 7027 uncultured Bifidobacterium sp. 1-2A Bifidobacterium sp. JCM 7028 uncultured Bifidobacterium sp. 1-2B Bifidobacterium sp. JCM 7042 uncultured Bifidobacterium sp. 1-5A Bifidobacterium sp. JEMLUCVII-1 uncultured Bifidobacterium sp. 13D Bifidobacterium sp. JEMLUCVIII-4 uncultured Bifidobacterium sp. 15A Bifidobacterium sp. LISLUCII-P2 uncultured Bifidobacterium sp. 15B Bifidobacterium sp. LISLUCIII-2 uncultured Bifidobacterium sp. 15D Bifidobacterium sp. LISLUCIII-P2 uncultured Bifidobacterium sp. 16B Bifidobacterium sp. LISPASI-P3 uncultured Bifidobacterium sp. 16C Bifidobacterium sp. LLS001 uncultured Bifidobacterium sp. 16F Bifidobacterium sp. LUCL-P3 uncultured Bifidobacterium sp. 2-3A Bifidobacterium sp. LUCL-W4 uncultured Bifidobacterium sp. 3-3A Bifidobacterium sp. M24 uncultured Bifidobacterium sp. 3-4A uncultured Bifidobacterium sp. 3-4B uncultured Bifidobacterium sp. 9A uncultured Bifidobacterium sp. 7B uncultured Bifidobacterium sp. 9B uncultured Bifidobacterium sp. 7G uncultured Bifidobacterium sp. 9C Genus: Acidopholus Lactobacillus acidophilus 

1-33. (canceled)
 34. A method of treating or preventing cancer comprising administering to a subject in need thereof a composition comprising at least one non-pathogenic bacterial cell, wherein the non-pathogenic bacterial cell comprises at least a first and a second nucleic acid sequence, the first nucleic acid sequence comprising at least one non-constitutive promoter operably linked to the second nucleic acid sequence, the second nucleic acid encoding at least one therapeutic agent comprising a cellular toxin, wherein the non-constitutive promoter is an exogenous inducible promoter responsive to at least one stimuli and the at least one stimuli comprises the presence of a certain density or a certain number of bacterial cells comprising the first and second nucleic acid sequences.
 35. The method of claim 34, wherein the method further comprises a step of administering one or more stimuli external to the subject in order to induce expression of the at least one therapeutic agent in the subject.
 36. The method of claim 34, wherein the method does not comprise administering any stimuli external to the body of the subject in order to induce expression of the at least one therapeutic agent in the subject.
 37. The method of claim 34, wherein the method further comprises a step of measuring the presence, absence or quantity of therapeutic agent in the subject one or more times subsequent to administration of the composition.
 38. A method of reducing the growth of a cancer cell, solid tumor, or cell associated with a hyperproliferative disorder comprising administering to a subject in need thereof a composition comprising at least one non-pathogenic bacterial cell, wherein the non-pathogenic bacterial cell comprises at least a first and a second nucleic acid sequence, the first nucleic acid sequence comprising at least one non-constitutive promoter operably linked to the second nucleic acid sequence, the second nucleic acid encoding at least one therapeutic agent comprising a cellular toxin, wherein the non-constitutive promoter is an exogenous inducible promoter responsive to at least one stimuli and the at least one stimuli comprises the presence of a certain density or a certain number of bacterial cells comprising the first and second nucleic acid sequences.
 39. The method of claim 38, wherein the method further comprises a step of administering one or more stimuli external to the subject in order to induce expression of the at least one therapeutic agent in the subject.
 40. The method of claim 38, wherein the method does not comprise administering any stimuli external to the body of the subject in order to induce expression of the at least one therapeutic agent in the subject.
 41. The method of claim 38, wherein the method further comprises a step of measuring the presence, absence or quantity of therapeutic agent in the subject one or more times subsequent to administration of the composition.
 42. A method of delivering one or more therapeutic agents to a tumor in a subject comprising administering to the subject a composition comprising at least one non-pathogenic bacterial cell, wherein the non-pathogenic bacterial cell comprises at least a first and a second nucleic acid sequence, the first nucleic acid sequence comprising at least one non-constitutive promoter operably linked to the second nucleic acid sequence, the second nucleic acid encoding at least one therapeutic agent comprising a cellular toxin, wherein the non-constitutive promoter is an exogenous inducible promoter responsive to at least one stimuli and the at least one stimuli comprises the presence of a certain density or a certain number of bacterial cells comprising the first and second nucleic acid sequences.
 43. The method of claim 42, wherein the method further comprises a step of administering one or more stimuli external to the subject in order to induce expression of the at least one therapeutic agent in the subject.
 44. The method of claim 42, wherein the method does not comprise administering any stimuli external to the body of the subject in order to induce expression of the at least one therapeutic agent in the subject.
 45. The method of claim 42, wherein the method further comprises a step of measuring the presence, absence or quantity of therapeutic agent in the subject one or more times subsequent to administration of the composition.
 46. A method of reducing tolerance to a therapeutic agent in a subject in need thereof comprising administering to the subject a composition comprising at least one non-pathogenic bacterial cell, wherein the non-pathogenic bacterial cell comprises at least a first and a second nucleic acid sequence, the first nucleic acid sequence comprising at least one non-constitutive promoter operably linked to the second nucleic acid sequence, the second nucleic acid encoding at least one therapeutic agent comprising a cellular toxin, wherein the non-constitutive promoter is an exogenous inducible promoter responsive to at least one stimuli and the at least one stimuli comprises the presence of a certain density or a certain number of bacterial cells comprising the first and second nucleic acid sequences.
 47. The method of claim 46, wherein the method further comprises a step of administering one or more stimuli external to the subject in order to induce expression of the at least one therapeutic agent in the subject.
 48. The method of claim 46, wherein the method does not comprise administering any stimuli external to the body of the subject in order to induce expression of the at least one therapeutic agent in the subject. 49-55. (canceled) 